ฝัง
- เผยแพร่เมื่อ 16 มิ.ย. 2017
- Today we are going to be making chlorobutanol. It was historically used as a hypnotic sedative and it is currently used as an antibacterial/preservative. I think it has a pleasant minty/camphor like smell to it.
Chloroform video: • Making Chloroform
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Nile talks about lab safety: • Chemistry is dangerous.
Music in credits (Neon Stars by Cypher): / neon-stars-beginnings-ep - วิทยาศาสตร์และเทคโนโลยี
![[UNCUT]"เศรษฐา" โดนบีบให้ลาออก เผยดีลลับ "ทักษิณ" ต้องต่อโปร ไม่งั้นเจอจุดจบ! I คนดังนั่งเคลียร์](http://i.ytimg.com/vi/XlH3k81dxmE/mqdefault.jpg)
When I was in rehab over ten years ago the doctor there prescribed Chloral Hydrate to everyone so they could sleep through their withdrawals, and that shit is STRONG. I actually loved it lol. Felt like Xanax times infinity. I went back to that rehab a year after the first time and the doctor said he can’t prescribe it anymore because it had since been completely taken off the market. I guess it was a pretty ancient drug, but it worked soooo well. Especially when you’re going through withdrawals and can’t sleep. (I’ve been clean for 2.5 years now if anyone cares about that part of the story)
Hey, I care :) that shit is one hell of a demon and I'm glad you were able to make it out on the brighter side. I'm proud of you and thank you for sharing your anecdote
I'm glad you're clean. Contrasts 💐💙
congratulations on getting clean! that's a hell of a thing to overcome
congrats on getting clean! shit ain't easy, and I'm proud of you
well done
"Today, we're going to be extracting uranium-234 out of a cheesecake and refining it to weapons grade."
Go right ahead. U-234 is not fissile, so your device, should the somehow be rich with the stuff, wouldn't even fizzle.
I make a weapns grade Chocolate Cheesecake. It a weapon of mass induction. Even one slice will induce a substantial increase in mass.
@@spvillano wut?
@@originalketchup7498 uranium 244 isn't all that radioactive, uranium 245 is the one used in nuclear reactors
@@Thugstenium no, U-238 is the main ingredient in natural and high enriched uranium, U-235 is fissile, the thermal neutrons then transmute the U-238 into fissile fuel. U-238 is fertile, but not fissile.
There is no such thing as U-245. U-238 is the heaviest isotope of uranium, with plutonium starting at 239. Curium has an atomic mass of 248.
Still, U-235 isn't exceptionally radioactive either, given its half-life of 7.04x10^8 years. The shorter the half-life, the more radioactive the element is.
"We need to wait for it to cool to around 50-60°C. We don't need a thermometer or anything for this, we just need to wait until it stops hurting to touch it"
Words of a true scientist
That's how we did it in ny school
Yes- but does it still taste like shit?
lmfao
😃
Lol
If anyone is interested, the "black box" technique that Nile stumbled across to precipitate the crude after it initially oiled out is referred to as "trituration." The term is not really used in the chemical world outside of organic synthetic work; however, it is a common term in pharmacy, meaning "to create a fine powder" (e.g. crushing a hydrated solid with a mortar and pestle prior to compounding). For organic chemists, trituration is (much like recrystallization) a bit of a shot in the dark--polarity and weak/strong solvent interactions are not easily trended on linear axes, so finding the right addition solvent/temperature/conditions is often an exercise in trial and error.
I'm not good at chemistry myself, but i really do enjoy watching Nile's videos, they're really well made and he gives a really thorough explanation.
Will I hated chem and was bad at it in high school but jsut took it again and really like it. It seemed to click a lot easier maybe it just takes some time. Or keep staying engaged with it. Also videos like this that relate it to real life help connect those neurons!
You don't even really need to be interested in chem to like them either they are just unique and he does things that most people wouldn't
Me neither but they are relaxing to watch.
I liked the Biology touch on this one.
Thanks!
its pretty epic
"In today's video, I'll be demonstrating how to synthesize a felony charge."
~ NileRed.
With items you may already have at home!
@@seanp9157 you'd be amazed at the amount of very illegal shit you could make with ingredients you probably have at home
imo better than that anal lube cocaine cutter synthesis
@@Sp00kq DMT extraction is just a matter of isopropyl alcohol and patience.
That's funny, coming from someone with a profile pic on google that looks like a "lineup" pic from the county lockup lol
As a dude who failed chem/psysics/all that jazz in school as a kid I just wanna say that your passion and pure knowlegde of these subjects is a joy to behold.. I might not get all the techincal details or lingo and i might confused one name chlorobutanol with chloroethanol but I get the feeling that i understand more and more with each passing video.. So keep it up mate, you are doing good work and honestly better than many other teachers
Even literature!?
chloro=chlorine, -ol=alcohol, butane=4 carbon chain, ethane=2 carbon.
Yo Nile. You forgot to test the "hypnotic sedative" bit on camera 🙄
He is not Cody to do so...
give it to Cody then...
Though he did test acids on his hand.
Most acids are not so horrible as someone's thoughts.
Wie Schade 😂
Nile you taught me what a year for chemistry couldn't do.i could never understand how it works but I have watched enough to see it work...thank you keep up the great content
:)
thank you for including the mechanism i love when it gets technical
"All I need is acetone, chloroform and sodium or potassium hydroxide", also known colloquially as a "Ted Bundy"
But what if you used all your acetone to make the chloroform?
@@Phantom0fTheRouter It's pretty cheap online
@@BlooCollaGal - that whooshing noise was definitely a ghost Ray... not you being clueless.
@@Phantom0fTheRouter great reply man.
Too soon
Edible Chem - Chlorobutanol
Hahahaahhahahahaa
come on. One-year-olds only put everything into their mouth.
@@thomasgarbe8354 and? I make tch and cbd edibles all the time. It's the adults responsibility to be a grown up and put things away out of reach.
NaCl technically edible and a chem
Any one else not understand this?
For those saying it should be "1,1,1-trichloro-2-methylpropan-2-ol"
this is chlorinated tert-butanol and it is shortened to chlorobutanol, no chemist uses the systematic names after high school.
Imagine professionals performing time sensitive reactions asking across the lab, which is more practical?
"hey can you weigh out 5 mmol of beta-carotene?"
or
"hey can you weigh of 5 mmol of 1,3,3-Trimethyl-2-[3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohex-1-en-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]cyclohex-1-ene?"
hmm?
Ay Bo0o0o0oSs the second one is more practical dumb ASS
I have a borderline-vexing amount of respect for this globally-available short-form statement which has been digitally uploaded in order to be available to the public audiences of the domain known as TH-cam, run by Google.
I like this comment.
Ay Bo0o0o0oSs what about isomers? Also i like the long names but I wouldn't point it out like that one stupid wise guy
For isomers, just specify the part that makes the difference
CodeBurger yeah, i knew that in the back of my head somewhere
When you tested the anti microbial properties, my jaw dropped. One of the most interesting videos I've ever seen on TH-cam!
making the stuff yourself and then proving its efectiveness makes for a pretty damn cool video!
Hey Nile, Im a chemical lab technician in apprentice and your videos are literally perfect for my interests. But I would found it really interesting if you could do some kind of analysis, for example a tlc, it's very simple and fastly done to show the qualitive purity of your product. Keep it up!
….or, if you have a mass spectrometer laying around you could use that.
Your addition of the reagents in the ice bath bring back nightmares of my nitrations. This was really fun, keep it up.
I’m not surprised a mix of acetone chloroform and potash sterilizes things 😂
Watching these videos is inspiring me to start actually trying to learn about chemistry. Idk if or when I'll do it on my own time but I'm thinking about taking some kind of chemistry class when I go to college. High school was never good at making topics interesting to me, and when I started learning about some of these topics after graduation and on my own time I notice it's much easier to take an interest in it because it's not restricted to what you have to learn in school. And after doing this I feel like it'll be much easier to not feel bored or uninterested in a classroom setting
Just an info regarding the usage of chloral hydrate: It's commonly used in the analysis of plant powder drugs, because it causes the powder to swell up and you can see everything better with the microscope
These videos are so interesting, and chemistry is so far removed from my daily concerns that I find it relaxing. Not to mention the calm presentation. Thanks to this, I watch NileRed to help me sleep.
I guess you can say this video is also a Hypnotic Sedative.
Underrated joke lol
I have no idea what just happened but I know I’m super excited 😆 I think you make me wanna be a chemist when I grow up!
These videos help me fall asleep, thank youuuu. Your voice is relaxing and these videos are interesting but calming
Hey Nile, great job with this video!
I ESPECIALLY liked the way you dealt with the oil. Even if you lose out on yield, I always appreciate it when someone takes the time to properly purify a compound, so thanks a lot for doing that!
PS. Are you able to do melting point analysis with your current setup, without it being to much of a hassle? If so, it might be worth while to check the mp at the end of a synthesis, just to make sure that the reaction didn't take a completely different pathway or something? (Not really applicable to this synthesis; I was just wondering in general)
This reminds me of all the hours my small class and I spent in the organic chem lab. Looking back on it, those times were a great bonding experience with future professionals in the science field.
And then there's me, a film student, who watches these just for funzies and because his voice is nice to listen to
This was my first synthesis done as an amateur chemist hobbyist - inspired by this video. Thanks NR!
In the pathology bacteriology lab we used a solution of choral hydrate (tinted with a green dye for visibility) to draw lines on agar plates, creating segments and stopping different bacterial species migrating into other segments of the plate.
NileRed, I wanted to thank you for how much you have taught me in consideration to how unavailable this knowledge seems to be. You have helped me immensely and I cannot thank you enough. They don't even teach you what an Erlenmeyer flask is in chemistry.
Another great synthesis ! Very pleased to see you test the antiseptic against real bacteria.
Usually an antiseptic / antibiotic is tested by growing bacteria in a dish and then laying on the bacteria culture a disk of filter paper containing the sample of the antiseptic / antibiotic. The result should be a clear ring (devoid of bacteria) around the paper disk.
I completed on College Chemistry course this year.
I love science because it always gives me knowledge that explains why and how things exist.
I learned a lot in Chemistry class.
you explain chemistry so well nilered
This was the first multi step organic synthesis I ever performed. :) memories
It sublimes at room temperature and makes beautiful crystals that smells like camphor.
AureaPersona; But this was a single step reaction though?
The 17 year old me did not own any chloroform, so I had to figure out how to do the haloform reaction first.
Many reactions that are recorded as a single reaction equation are in fact made up of a series of elementary steps.
Did you eat it
how'd the high feel?
Especially enjoyed the anti-microbial test. Please do more similar tests of the chemicals you synthesize!
I just replicated this at home. I'm a novice chemist with little experience (though im building it up), so i figured this would be worth a try, and you're certainly correct when you said it would be an easy synthesis. Thanks for the instructional video! (Which is excellent quality as well)
I never had any interest of chemistry but you really explain things in a way that 10 years of education (up to Uni year 2) never managed to get through. I wish you were a teacher in my UNI!
Thanks for showing the antifungal anti bacterial effect... it is very interesting!
I like the follow-up experiment.
As someone who used to work in a bio lab with lots of Petri dishes, I really had a visceral reaction to Nile rubbing his fingers all over the plates lol
Felt that pain as a mycologist, last year had someone who was taking care of my pets while i was out of town touch a few mycelium samples i had lying around and they all got contaminated
When I graduated from high school two years ago we had to do a research project/paper for every class. For my chem class I ended up making chlorobutanol and testing it on agar plates and I used this video to help me do the procedure, so thank you Nigel for helping me graduate! My percent yield was terrible though, 5.7%, but given that I didn't have any of this professional equipment I'm just glad it worked
I love this channel
You know what? Nile is the only person I wouldn’t be suspicious of casually having chloroform laying around. And there’s not a lot of people that I would say that about.
i agree, i think he is somehow more trustworthy than those that watch his videos...including myself...lol
It's actually not all that uncommon of a lab reagent. Obviously, one uses it under a fume hood.
did you even graduate kindergarten?
@@SnakeBush did you get credit for skipping every day of kindergarten?
Its a pretty common solvent, like ether. Media pushed it out of proportion.
I'm an undergrad Microbiologist, and I love these chemistry videos! They make my organic chemistry class so much more engaging. For the agar plates, you can actually just add a small amount of chlorobutanol in a small pellet and you'll get something called a zone of inhibition which you can actually use to measure how toxic something is to an organism. It might not be as helpful since you don't have a single culture of microbes but would still be cool to look at. Keep up the good work, you're making me want to switch to Biochemistry
Nice experiment Nile!
Really cool video, thanks!
Please explore more antibiotic compounds like penicilin or azitromicyn. :D
NileRed, when will you synthesize caffeine? I'm really looking forward to it.
Nigel’s voice is so calming
NileRed videos often make me wish I chose a different profession. Keep them interesting; curiosity keeps us going.
lol. youtube suggested the chlorform video to me earlier today. the alorithm really is improving.
Well, technically it's a self learning AI, so one it starts figuring things out it should improve faster and faster. Provided they don't make too many adjustments to the weighting in too little time and confuse it. Not even Google knows what the AI does inside, they just give it goals, most likely increase watch time and ad revenue, and provide it feedback such as likes, views, etc to help determine future decisions. Really complex stuff. XD
theLuigiFan0007 they ve famously got no clue what it s doing so they just cant xD i guess it picked up on this video sitting there waiting to publish
Definitely possible, with the amount of data at it's disposal I'm not surprised at all.
Literally laughed out loud.
Really? Seems to me the algorithm is about as smart as a brain damaged child.
Nile, Is there any chance you could do a series on manafacturing anti-biotics like Pencillin? Its a drug that seems like it would be extremely useful to manafacture in some kind of survival situation.
I am also interested in how medicine is created
Thirded
has penicillin been synthesized? genuine question
@@jordanwardan7588 yes but most is produced via processing grown mould
Very nice. I find something relaxing in watching chemicals change. Don't know why.
>complains that No one gives the proportions
>proceeds to not give proportions of ethanol-water mixture
@nilered
your agar plates contain to little nutrients for bacteria, using some peptone or beefbroth gives better (faster) results.
i found adding a 1cm cube of ham( for 6 dishes ) wile heat the agar(remove ham after heating ) works well for stinky arm pit and foot bacteria .
Yeah I figured. Ill try that next time
or just add sugar or something like that to agar ?
chuckcrunch1 Thats a bit better than heading to the butcher for the ingredients to make Brain-Heart Infusion.
Not really. Agar is itself a medium for growth. It's not hard at all to get bacterial and fungal colonies on properly dosed agar.
"we need to wait for it to cool to around 50-60°C. we don't need a thermometer or anything for this, we just need to wait until it stops hurting to touch it" me cooking
Nice.
I read your short biography under the section 'About'. Hope you are finishing your grad degree or aim to. I know it was really important for me to do so and the long time I had waited made it a bit more challenging for a bit.
this is way over my head but is fun to watch need more videos plz.
This is very interesting NileRed. The oil formation is what is known as Liquid-Liquid Phase Separation while the crystallization is a Liquid-Solid Phase Separation. Substances that do both LLPS and LSPS in similar conditions are very rare. Proteins are an example, they can form aggregates, crystals or droplets. Perhaps you can explore this property of chlorobutanol and discuss why it solidifies at a sudden temperature drop while 'oils out' other times?
You are a genius when it comes to chemistry, You know so much! Why didnt you use salt in the ice bath to reduce the temp further? lol
Thanks for the medical use list I need it
This was so good.
Today I performed this practical in my college lab
the way he says “agar” and how he “infected” the plates 😂😂😂 microbiologists watching this video bout to bust a blood vessel to get this man to say “inoculated” just once
mrlaserguy2 Ohh yeah. Can absolutely relate to this. Another thing I have been waiting for is him adding even a little bit of luria broth or just yeast extract but nope. He „infected“ the pure agar plates and smeared them with his fingers as if he was a butcher. This made my inner microbiologist die from a stroke
When he didn't flip the plates when the agar had set...reeeeeeeeeee
@@GreenCaulerpa glad someone else cringed at the "not adding nutrients to the agar" bit lmao
Alexandra Johnson yeah, that made me cringe so hard 😅
All wrong!! Lmao!
Nice demo
Interesting ! Tnx take care ! Peace ✌️ from Welland Ontario Canada 🇨🇦
I really liked the video, especially the experiment you did in the end. Could you test and compare multiple antimicrobial substances?
I will be testing sulfanilamide when that video is posted
NileRed Great!
My father had no background experience in chemistry nor a formal education yet he could synthesize the perfect hypnotic sedative. He used corn, sugar, yeast, water and various other fruits or grains. Once he ran them through a device he called "the dream machine" he could hypnotize or sedate anyone with the moonshine.
Haha awesome, very cool dad. Cheers to him 🍻
I really enjoyed the bacteria test!
In an RI lecture I saw, they demonstrated antibiotics by soaking a small piece of paper in a solution of the compound and put it in the middle of the petri dish. It makes for a really striking contrast.
Cool! Loving organic chemistry .
O Chem is the best Chem!
Great videos! Long live chemistry! By the way, try using a seed crystal to avoid oiling.
Another great video! Keep up the good work. Btw you are basically my chemistry teacher.
The bargellini reaction has this mechanism pretty well explored.
I just wanted to ask if the same reaction would be possible for other haloforms such as iodoform or bromoform and / or different ketones, such as MEK or Benzophenone.
I don't necessarily need to hear anything about activity (sedative or inhibiting bacterial growth), although that would be a plus :)
And of course, nobody is going to ingest anything of the probable products
Wow, this is really great stuff. I used to be prescribed that solution, choral hydrate. It’s kinda good. Not as good as a benzodiazepine, and it’s effectiveness wears off as you build a tolerance rather swiftly. Again, this was perfect 👌🏻 to teach. Thank you. edit, and then I looked at your channel....🤯😝👍🏻I’m totally subscribed.
Thank you #NileRed ☃️
Either you choose reactions that use cold water extraction for convenience, or a heck of a lot of reactions use it.
The power of seed crystals! Reminds me of the times I've had stuff suddenly violently boil the moment I touch it lol
Can you do some experiments with ergot fungus? It would be pretty interesting!
I can vote on that one, specifically ergotamine tartarate in large quantities ahahaha
are people tryna get him audited by the DEA lol
😆 🤣 😂
Scratching the inner part of the beaker with a glass stirring rod may induce crystallization.
When using ice bath smear a layer on tooth paste on the pyrex dish then lightly rinse. You won't have to keep wiping the dish.
Wow, the stuff you can find on TH-cam.
so when are we getting a video on making methamphetamine
That is one of those things where one probably shouldn't be doing it if you need an instructional video.
@@bsadewitz Perhaps, but there's an argument to be made that if the crazy traphouse next door had access to educational how to videos the chance that I get blown up as collateral damage might decrease.
@@coreysayre1376 Oh, well, why didn't you say so? ;-)
@@coreysayre1376What I meant, though, is that anyone who knows enough chemistry to carry that out would know which reference materials to consult for anything they'd ever want to know, just as a chef would know how to find and prepare a recipe from a cookbook. Honestly, it might be a better use of your time to find information on proper lab technique and safety precautions.
@@bsadewitz I get what your saying. More than anything my comment was meant as in half jest, half contempt for the failure that is prohibition in all it's forms. Ppl who wanna do drugs, will. The real collateral damage is that as a supposedly free American, I cant do the things I enjoy the most in life, as parts of them gradually are regulated out of reach.
Sorry for the tangent--How humans have not figured out that prohibition invariably has the opposite of intended effect, especially when there is hard scientific showing this--This vexes me greatly.
as an IIT JEE aspirant i have studied this stuff in high school (theory only) in organic chem.....love to see this stuff happening in front of my eyes
I don't know a damn thing about chemistry, but I really find it fascinating & ur vids are great. I think ur Diomand water vid was the 1st 1 I saw, very entertaining & interesting
Shit, I thought you were gonna test it's hypnotic properties...
Hello Nile Red, good work as always :) If chlorobutanol tends to sublimate, it may be a good idea to purify it by sublimation instead of recrystallization, to increase the final yield (there's no solvent that has to be evaporated away and there's no loss of product), am I wrong?
Daniele Mirante good idea!
That might be an idea. I just dont have a proper sublimation (cold finger) setup, so I felt recryst was easier. But yeah, it is definitely a viable and probably better option
NileRed yeah, I understand, I need so much glassware that I haven't got to prepare so many compounds I'd like to prepare! Anyway, thank you for the answer :)
email your shipping address to goldleaflabs@gmail.com. Ill send you a bunch of free glassware
Goldleaf Scientific Are you sure? I'm from Italy ahahaha
Would actually love seeing Chloral Hydrate done as I have need some for Metzler's Reagent.
I guessed Chloral Hydrate.
I wasn't too far off.
It has interested me ever since I found out Hank Williams used and abused it to try to get some sleep. (He had chronic back pain that kept him awake).
Chloral Hydrate also shows up in Mickey Spillane's Mike Hammer books as "Knock Out Drops" a time or 2.
But doesn't the purity of the product decrease if you cool it down too quickly?
and cool video dude, keep up the great job!
For future tests:
Agar must have a separate nutrient added.
Chloral hydrate was the active ingredient in the infamous “knockout drops” that were used to “shanghai” sailors and so forth, circa 1900.
Fascinating!
Nile I love your videos! I googled this and I found something super fucking cool. Apparently it makes sea urchins start the process of birth without fertilization. Thought I'd share.
I totally forgot to talk about that!
I really don't understand any of the process involved, but that is just incredibly interesting to me. have a nice day!
Eloquen that's really interesting. Shit like this just amazes me, crazy how things work.
how the f**k do you keep finding interesting compounds to synthesize that are SO SIMPLE. Every single thing I look up requires some next level chemicals like some coked up enzyme that won a Nobel prize to synthesize 😤
Spooky Wizard it helps to research inventions from the 1700s through early 1900s. Lots of intetesting tech from that time period is now achievable in the home lab.
AC0KG Where to start?
Spooky Wizard depends on what you are interested in. A good option is to just read about notable chemists from the 1800s. When you see something interesting, see if you can find Royal Society publications on the topic. When you find something that looks good, look it up on Wikipedia and published papers to see what the modern methods are. Also there several forums for amateur chemistry where you can read other people's ideas and get input from lots of very knowledgeable people.
AC0KG thanks! that's a good idea. I've been looking at sciencemadness haha it is pretty useful
I just stumble on them. I keep reading about one thing and then it mentions something else.
That's the stuff they used in the time of my grand parents and great grand parents. That stuff clearly worked as an antibacterial product even if it's consired toxic to todays standard, but back then they used stuff that help. But in the last 20 years these product vanish to be replaced by nothing or by fancy cleaners. Who remembers Pinesol, that stuff can desinfect and clean in the same process. I remember when I went to the store last spring, the shelves with all the modern cleaning products were all emply, the only shelf that had something was the shelf with bottles of Pinesol. This genration won't use popular products that were used to clean in the 50's 60's, 70's and 80's up to mid 90's. The amazing thing these few old cleaning products are still available today. And the few that are still out there still work great.
Add some nutrient to your agar and you'll see growth much faster. 3-6% is usually ideal. It can be anything from light malt extract, to brown rice flour, to dog food
"Chloroform recipe in description"
*Me skipping this video and going straight to that one*
Turns out it's just super easy to make
Tldr?
Agar? When did Nile start doing Bio?!? :)
Thanks so much
Oh my god I made some of this as a kid using homemade chloroform. I was 16 or 17. It definitely knocks you out good!!!