TWiV 1135: Resistance is not always futile
ฝัง
- เผยแพร่เมื่อ 8 ก.ย. 2024
- TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.
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I’m Vincent Racaniello, Earth’s Virology Professor, and I believe that education should be free.
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#microbe #viruses #coronavirus #pandemic
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_TH-cam timestamps by Les_
05:19 Please help support science edutainment
05:56 *Biology News (courtesy of Dr Amy Rosenfeld)*
What’s going on with measles? (J Virol)
15:53 Global Resurgence of Measles in the Vaccination Era and
Influencing Factors (intl. J ID)
16:50 Poliovirus in Gaza (Science)
21:59 Sanitation concerns in Gaza (AP)
Community vaccine beliefs (PLoS One)
24:36 14 year old dies of Nipah in India (Hindustan Times)
26:36 Selection of nirmatrelvir resistance mutants (Sci Adv)
43:41 CCHFV monoclonal antibodies (Cell Rep)
44:39 CCHFV vaccine (TWiV 565)
Prometheus Project (TWiV 578)
45:16 TWiV at USAMRIID (TWiV 1015)
*Your correspondence answered by scientists*
see microbe.tv/twiv/twiv-1135-letters/
1:16:22 Susan
1:19:09 Steve
1:20:21 Pina
1:25:47 suelen
1:31:38 Charles
_Audio Timestamps by Jolene. Thanks!_
*Weekly Picks*
1:35:42 Angela - Animal research is not always king
1:50:57 Brianne - Why the US has more tornadoes than any other country
1:53:43 Dickson - Earth’s core has slowed so much it’s moving backward
1:57:50 Alan - Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove
2:01:26 Vincent - Seventh patient ‘cured’ of HIV: why scientists are excited
*Listener Pick*
2:03:30 Charles - An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr
So enjoyed TWiV this morning. Thank you as always.
When Angela read SueEllen's email, I thought, "Wait a second, did I write an email in my sleep? This sounds just like me!” Sue Ellen perfectly summed up how I suspect many of us listeners/viewers feel about the MicrobeTV family. We're so, so grateful for your knowledge and heart. You really make a difference.
(And I would also cancel my subscription to the Times, but I'm also addicted to the games.)
Much love and gratitude to you all.
I too am addicted to the Games in the Times- especially Wordle.😊
😂yes yes yes. So truly expressive of many of us listeners.💛
Thanks for your time .Very informative and enjoyable as well
Vaccine hesitancy, “all due to Andrew Wakefield.” With all due respect, it’s not “all” due to Wakefield
True. But he was originator, the prime mover if you will.
Yay! TWiV
I recently listened to TWiV 1135, another great example of your collective art. I comment to Allen, a man I respect like all the other good science educators. I rather wished he would have said I am 80% vegan, I just can't go the entire way. The machoman toned "I'm not going vegan..." lends credence to others to do the same. Nothing we can do would approach the benefit or just leaving the living things live. Row crops, irrigation, deforestation, killing the predators, alfalfa in the desert, keystone species declines on and on.
Love all you folks and love the show...!
“Lapsed” anti-viral scientist here. The Pfizer resistance studies are pretty standard in the space. It’s a lot of work indeed. I too even went the extent of getting crustal structures of the various “mutants”. These studies are actually required by the regulators. They want to know what might happen in the clinic and what to look for. What typically happens is that there is a long list of “mutations” that we see in vitro and then in clinical studies we look for them. What happens clinically, is that we often see a few of the in vitro mutations. Occasionally we’ll get a new one in the clinic that didn’t appear in the invitro studies but that’s not especially common. Generally speaking, you only worry about >100 fold resistance. 20-fold is manageable clinically as long as you have decent PK. Resistance for acute viral infections is generally lower certainly compared to chronic infections like HCV or HIV. That short duration of viral load is to our benefit. You see their same thing in RSV for example. Nice work from Pfizer. But to be clear this will be a regulatory requirement from FDA (and EMA)
Always time well spent listening.
Do you take the full dose of heroin right at the beginning, or do you inject half at first, and finish it off after 1.5+ hours into the program?
I love how pleased Brianne is with that "murder of crows" comment - I would be too! :D
"Never doubt that a small group of thoughtful, committed, citizens can change the world. Indeed, it is the only thing that ever has." -- Margaret Mead
Oddly my ex-gf grew up on the upper west side and has lived in Park Slope since the 90s so Steven from Carrboro NC is on to something about well educated CNN watching folk.
She does not have any interest in TWiV despite (or maybe because) her dad was a scientist and a physician. She’s a lovely woman, but in some ways prefers to stay in her bubble than challenge what the NYT, The Atlantic, etc dispenses. She IS evolving but it’s a slow process and primarily due to outside influences (mostly me)
They are primarily “vote blue no matter who” types who truly mean well as they argue at the co-op about whether or not said policy is just and good for the proletariat even though all them are well above that in terms of income. I can’t really talk about the upper west side except to say a lot of the folk who grew up there in the 70s like she did have ended up in Park Slope(2 of her childhood friends live there too coincidentally not by design)
Famous Park Slope denizens include former mayor de Blasio, Senator Schumer, and author Paul Auster(RIP)
I once Got diagnosed with a rare disease, got sent a trial drug to my door, was supposed to inject myself. Never did...And now no more talk of that nine yrs later...Feeling fine..fyi
Regarding the herpes meganucleases gene editing paper, there was some significant damage to the trigeminal neurons (supplement table 3) after the treatment. Also liver necrosis.
53:15 Yes, people need to remember to cover up (including hair, blouse your boots) before taking a walk in the woods/pasture, and check yourself upon returning.
the picks appear when I listen to the RSS feed but not in the TH-cam?!?!?
Go McGill!!
Re Alan's Amtrak comment @3:11, Amtrak announced in June that it would not reopen service between Saratoga Springs and Montreal until after Labor Day. I haven't seen any announcement that it has reopened early, just did a search and looks like the Adirondack line is still only operating as far as Saratoga Springs.
We are on our way to carbon net zero😊