If you were my teacher for my biology class in UK, I would end up with the highest grade ever! Your lectures are the first point of learning source I visit to actually learn the topic before using books! I wish you continue teaching us! :D May god bless you long life.
I have thanked you before and I just want to thank you again. I recommend my classmates to you. Not everyone can teach but you are certainly been giving the gift to teach and I am forever thankful that you share your knowledge with all of us out here.!!!!!
I'm sitting for Cambridge A-level exam in May/June & I am so thankful for discovering your channel. It definitely clears all my doubts & make me understand my course even more. Would love to thank you for this,you're an inspiration.
Wow, professor Fink, this is deep, but so interesting!!!! You are so great, wonderful, amazing, nice, super-duper, FANTASTIC, marvelous. I truly, deeply,thank you for your lecture.
professorfink would you say that caffeine's phosphodeisterase inhibition plays a stronger role than it's adenosine receptor antagonism in it's "energy" producing effect?
Sir, If epinephrine is a sympathomimetic and increases heart rate, electrical conduction, contractility, and constricts blood vessels and a phosphodiasterase inhibitor is suppose to increase those effects by not allowing the breakdown of cAMP, then how would a drug such as sildenafil cause vasodilation. Phosphodiasterase Inhibitors are contraindicated when giving nitroglycerine for chest pain due to the combined vasodilatory effects.
Firstly, epinephrine constricts most blood vessels of the body (through its action on alpha-1 receptors), but dilates other blood vessels in the body (through its action on beta-2 receptors). Epinephrine activates the enzyme adenyl cyclase, increasing cAMP (cyclic AMP) in cells. I present this information on the Video Lecture: Professor Fink's Lecture on the AUTONOMIC NERVOUS SYSTEM; PART 3:th-cam.com/video/nPQ2UYVm4Rg/w-d-xo.html (at about 3l:00 elapsed time) Nitroglycerine mimics the neurotransmitter nitric oxide (NO), which activates the enzyme guanylate cyclase, which increases cGMP (cyclic GMP) within cells. Sildenifil (Viagra) specifically blocks Phosphodiesterase-6, also causing an increase in cGMP (cyclic GMP) within cells. So both nitroglycerine and sildenafil cause an increased cGMP in the vascular smooth muscle cells in the blood vessels of the penis, that leads to vasodilation. Good Question. All of this is better understood after studying Pharmacology.
More thorough explanation of GABA and the benzodiazepine receptor sites and the use of benzodiazepine drugs can be found in the Video Lecture:PHARMACOLOGY; ANTI ANXIETY & SSRI DRUGS by Professor Fink th-cam.com/video/Pzb1qW3EnyE/w-d-xo.html (see time elapsed 10:50)
Thank you very much. You are absolutely my favorite teacher that I've found on youtube. I'm a paramedic looking to master my field and go on to higher levels of medicine. Your lectures have helped me a great deal. Thanks
![เจ็บที่ยังฮัก - ม่อน วรวิทย์ [ Official Mv ] จอนนี่มิวสิค](http://i.ytimg.com/vi/KALIGSRSjFs/mqdefault.jpg)
![กี่หมื่นฟ้า | Your Sky Series EP.1 [2/4]](http://i.ytimg.com/vi/qJbQs_nhjD4/mqdefault.jpg)
If you were my teacher for my biology class in UK, I would end up with the highest grade ever! Your lectures are the first point of learning source I visit to actually learn the topic before using books! I wish you continue teaching us! :D
May god bless you long life.
Can not thank you enough. Simply amazing. God bless you with many many years
I have thanked you before and I just want to thank you again. I recommend my classmates to you. Not everyone can teach but you are certainly been giving the gift to teach and I am forever thankful that you share your knowledge with all of us out here.!!!!!
Dear Shelley, Thank you for your kind words; I sincerely appreciate it! Best Wishes for your SUCCESS! -- professor fink
@@professorfink You are so talented. Your lectures are amazing. Most ultimately, your love for teaching is endless.
dr fenk, i just want to thank you very much and from my heart i confess you arethe best professor have been ever seen. may god bless you.
I'm sitting for Cambridge A-level exam in May/June & I am so thankful for discovering your channel. It definitely clears all my doubts & make me understand my course even more. Would love to thank you for this,you're an inspiration.
Dr. Fink, I salute you!
Wow, professor Fink, this is deep, but so interesting!!!! You are so great, wonderful, amazing, nice, super-duper, FANTASTIC, marvelous. I truly, deeply,thank you for your lecture.
Thanks from my heart ♥️
This class is tuff.
Physiology is incredible but tuff.
Thanks 👍
Thank you Prof Fink, the contents that u teach is useful and applicable to my work. :) love all your lessons!
Thank you so much.
The first page of the article in Science 'Food Affects Human Behaviour' can be read here. www.sciencemag.org/content/218/4578/1209.extract
you're amazinggg!!!!
Another excellent lecture prof! And you're funny:)
awesome, thank you
he is amazing
It sounds like Dr. Fink is running a call center out of that classroom with the phone ringing all the time
Michael Myers was calling, too.
professorfink would you say that caffeine's phosphodeisterase inhibition plays a stronger role than it's adenosine receptor antagonism in it's "energy" producing effect?
Thanks ! XD
Wait Vicodine? you can still get Vicodine in USA?
Clostridium are Gram positive rod shape.
Sir, If epinephrine is a sympathomimetic and increases heart rate, electrical conduction, contractility, and constricts blood vessels and a phosphodiasterase inhibitor is suppose to increase those effects by not allowing the breakdown of cAMP, then how would a drug such as sildenafil cause vasodilation. Phosphodiasterase Inhibitors are contraindicated when giving nitroglycerine for chest pain due to the combined vasodilatory effects.
Firstly, epinephrine constricts most blood vessels of the body (through its action on alpha-1 receptors), but dilates other blood vessels in the body (through its action on beta-2 receptors). Epinephrine activates the enzyme adenyl cyclase, increasing cAMP (cyclic AMP) in cells. I present this information on the Video Lecture: Professor Fink's Lecture on the AUTONOMIC NERVOUS SYSTEM; PART 3:th-cam.com/video/nPQ2UYVm4Rg/w-d-xo.html (at about 3l:00 elapsed time) Nitroglycerine mimics the neurotransmitter nitric oxide (NO), which activates the enzyme guanylate cyclase, which increases cGMP (cyclic GMP) within cells. Sildenifil (Viagra) specifically blocks Phosphodiesterase-6, also causing an increase in cGMP (cyclic GMP) within cells. So both nitroglycerine and sildenafil cause an increased cGMP in the vascular smooth muscle cells in the blood vessels of the penis, that leads to vasodilation. Good Question. All of this is better understood after studying Pharmacology.
I'm suprised that more emphasis wasn't put on GABA as many emergency drugs (benzodiazepines) are given to treat seizure activity in the brain
More thorough explanation of GABA and the benzodiazepine receptor sites and the use of benzodiazepine drugs can be found in the Video Lecture:PHARMACOLOGY; ANTI ANXIETY & SSRI DRUGS by Professor Fink th-cam.com/video/Pzb1qW3EnyE/w-d-xo.html (see time elapsed 10:50)
Thank you very much. You are absolutely my favorite teacher that I've found on youtube. I'm a paramedic looking to master my field and go on to higher levels of medicine. Your lectures have helped me a great deal. Thanks
1 political sciences student disliked this video.
Why!
Nilda Gamez they get made fun of by saying political science is not a real science.
@@victorochoa3662 Ochoa!