@@chemistryofquestionablequa6252 although they were completely normal companies before the Nazis, they didn't start as a product of Nazism like VW did.
Well done, thank you. A medical professor of mine who had done volunteer work in SE Asia in the late 70s told us about a patient who presented with the chief complaint of "ants drinking my urine." The patient knew from local folk medicine that it meant he had diabetes.
Yes! I came across a similar story while reading for this video! The Ayurvedic text referred to diabetes as "madhumeha" which I'm told translates to "honey urine"
@@PatKellyTeaches yep! "madhu" is still hindi for honey, and "meha" is Sanskrit for urine. It's super interesting how the same sign got picked up around the world, like a convergent evolution of sorts
Type II runs in my family. I've seen how it kills. I'm so grateful to have any treatments at all. Insulin really is a miracle drug. I am looking forward to the ozempic video!
Have you tried a ketogenic diet that excludes carbs and sugar? A lot of people have anecdotally reported reversal of t2d including a Harvard study. "About 60% of those using insulin stopped needing it entirely. Medication use went down a lot in the keto group, unlike the control group where it stayed the same or went up. Overall, 47% of people on the keto diet achieved remission or reversal after one year and 38% after two years."
@EricAnimeFreak did I ask for medical or diet advice? I'm sure you mean well but I'm here for "hooray insulin" day not "tell Courtney what to eat" day.
@@EricAnimeFreakketo normally only works in the short term and gives people false hope. Their symptoms will go away and they’ll slowly go back to their old diet. Then they’ll start losing weight because of high blood sugar. But that weight loss is a sign of the damage the high blood sugar is doing not the half keto diet.
After 47 years of type 1 diabetes I can confirm that insulin (along with pumps and continuous glucose monitors) works. The vast majority of my medical complaints are now down to middle age 😂. Great video. Well done.
I recently went to New Orleans and stopped at the pharmacy museum there, I believe after hearing about it from one of your videos. It was awesome, and I attribute my relatively recent interest in medicine to your videos too! Keep it up!
> One of the people watching the talk was the research director for the pharmaceutical company Eli Lilly. And after the talk, he called Macleod and said "if you ever need help scaling up production, let us know". HAAANK HANK DONT DO IT HAAANK!!!!
Thanks Dr. Kelly. It's wonderful that videos like this exist on the Internet. I strongly suspect that this video will lead to others that tell additional details about diabetes.
Interestingly, a gentleman named William Banting published a self published pamphlet called "Letter on Corpulence", in 1863. In which he described a low carbohydrate diet he used to treat his own diabetes and gout. In fact he was one of the first people to popularize a low carb diet! Was he a doctor? No, ironically he was an undertaker!
Great video. Let me just add the obvious, that is, ancient and medieval physicians weren't checking the colour, consistency, smell and taste of the patient's urine to look for signs of diabetes, but rather to be able to give a prognosis on how the disease will evolve over the course of time, and say whether the patient will live or die. Also, they seem to have connected urine to sufficient or insufficient digestion, and that to disease, too.
I was expecting a longer video but nevertheless will wait for the second one. I wish you finish the video with Flame of Hope as a fitting tribute to the selflessness of Banting. Amazing narration indeed.
@@theodorekorehonen They are, indeed. This one in particular required a lot of fact-checking. The good news is that I've got 2 more videos written and ready to go!
Another great video, your channel needs a lot more attention. Consider reaching out to scishow and/or Hank Green. I bet they would love you as a guest.
4:28 I think this is my favourite side note of any video, ever. 😂 As a Type 1, thank you so much for this video. It’s one thing to understand all the stuff to live with it; a completely different thing to understand how we got here.
Diabetes runs strongly in my family. My mom who was obese most of her life strangely is type one but her brother who was 120lbs(I say was because he died of cancer a few years ago) had type two.
I love your channel🙏 Always extremely interesting and very well researched; a fascinating subject presented by quite a knowledgeable fellow! Thank you for all the wonderful content!!
@@xwolpertinger it’s a tangent that I couldn’t quite tie in smoothly, but the procedures for measuring blood glucose evolved a ton during those early days of insulin research. So you’re totally right. The blood sugar probably wasn’t 0mg/dL but that’s what they measured
“It’s weird, sometimes when we give this extract to rabbits they get convulsions and then go into a coma. Also, WE SHOULD START HUMAN TRIALS IMMEDIATELY!”
That definitely sounds bad ha haha. It’s worth pointing out that Collip was the one doing the rabbit experiments, while Banting and Best decided to go a little rogue and do the human trial on Gilcrest. One of the authors I read speculated that they rushed into a human trial so that they could claim they were first. But again, that’s speculation
Type 2 Diabetic here and the question of "if you could live in any other time when would it be" never. I'm fine right here. We've only had insulin for 100 years and even as far back as like 50 years ago we didn't have at home blood sugar testing methods. This disease is already hard to control and deal with in modern times. No thank you lol
This is weird. So all the had to do was use ethanol to extract insulin from mammalian pancreas? How has no one tried that before them? Isnt alcohol an extremely common solvent in medicine?
you're tellin' me some doctor thought he was on the cutting edge of science by shooting up with gonad juice? thanks for once again reminding me that this period of history maybe isn't all that bad
Probably how language has changed over the last 150 years. I wonder if "meats" only included red meats and poultry was also a different category back then.
at 15:41 you state that by using the fetal pancreas extracts, they were able to drop blood sugar to 0. wouldn't that just kill the dog? maybe they had a different way of measuring? or were they measuring urine sugar, and not blood sugar? that would make more sense if the urine sugar dropped to 0.
Critically important in the treatment of Type I DM, in which islet cells are non-functional. Absolutely preposterously misused in the "treatment" of Type II DM, in which giving insulin makes patients even more insulin resistant over time, when dietary modification completely cures the disease in all but the most advanced cases.
I'll get into other drugs like metformin, insulin sensitizers, and GLP1s in the follow up videos. I felt like original insulin still deserved its own video though!
I've been waiting a MONTH for this video and it is only 23 minutes long?! Alright...I'll take it but you're on thin ice young man! But really in all seriousness I am PSYCHED!
There are no essential carbs or sugar. Glucose that is chronically elevated is inflammatory in the body, takes as little as 20 to 100 grams of carbs or sugar. Glucose uses the same cell pathways in the body as the body uses to adsorb micro nutrients, thus when glucose is elevated, micro nutrients uptake is reduced, "commonly know as bio availability". Micro nutrients can be depleted when body oxidizes cells during inflammation and potentially cause kidney stones. Carbs and sugar release dopamine in the brain similar to some schedule 1 drugs based on mri scanning based studies. Elevated glucose causes hormonal dysfunction when consumed in amounts the body cannot handle. Your body is capable of creating it's own glucose without dietary intake.
Yes. The Eber's Papyrus, the Egyptian reference, mentions treatments for polyuria, which historians have interpreted as the excessive urination that's symptomatic of diabetes. You can find the reference in the English translation here: babel.hathitrust.org/cgi/pt?id=coo.31924073200077&seq=121. The ancient Indian text, the Charaka Samhita, describes urinary disorders as well. English translation can be found here: www.wisdomlib.org/hinduism/book/charaka-samhita-english/d/doc629258.html In the future, you can always find my references in the description, and a fully annotated script linked on Patreon. Thanks for weatching!
@@PatKellyTeachesit's a great video and something that people need to know about! People don't realize how diabetes was a death sentence sin the past. Everyone romanticizes the past and they don't realize that it was hell! And people died all the time from things that today are nothing!
![[TH] 2024 PMGC League | Survival Stage วันที่ 1 | PUBG MOBILE Global Championship](http://i.ytimg.com/vi/FVFT-PFwU80/mqdefault.jpg)
Banting also weaponized anthrax but that's probably not the reason my highschool was named after him. Lol
Volkswagen: no history before 1945!
@@Sakuyushilol, same for Bayer, BASF and a bunch of other companies strangely enough.
That's a real thing. I read about that for a Patreon exclusive vid a while ago. Here's a good overview: pubmed.ncbi.nlm.nih.gov/26386727/
@@chemistryofquestionablequa6252 although they were completely normal companies before the Nazis, they didn't start as a product of Nazism like VW did.
Banting stuck well to the Canadian moto of "It's never a war crime the first time"
Well done, thank you. A medical professor of mine who had done volunteer work in SE Asia in the late 70s told us about a patient who presented with the chief complaint of "ants drinking my urine." The patient knew from local folk medicine that it meant he had diabetes.
Yes! I came across a similar story while reading for this video! The Ayurvedic text referred to diabetes as "madhumeha" which I'm told translates to "honey urine"
@@PatKellyTeaches yep! "madhu" is still hindi for honey, and "meha" is Sanskrit for urine. It's super interesting how the same sign got picked up around the world, like a convergent evolution of sorts
Type II runs in my family. I've seen how it kills. I'm so grateful to have any treatments at all. Insulin really is a miracle drug.
I am looking forward to the ozempic video!
Have you tried a ketogenic diet that excludes carbs and sugar? A lot of people have anecdotally reported reversal of t2d including a Harvard study. "About 60% of those using insulin stopped needing it entirely. Medication use went down a lot in the keto group, unlike the control group where it stayed the same or went up. Overall, 47% of people on the keto diet achieved remission or reversal after one year and 38% after two years."
@@courtneybermack thank you! I’m trying hard to get the GLP1 video out before the new year, but TBD.
@EricAnimeFreak did I ask for medical or diet advice? I'm sure you mean well but I'm here for "hooray insulin" day not "tell Courtney what to eat" day.
@@courtneybermack Well I wish you the best regardless.
@@EricAnimeFreakketo normally only works in the short term and gives people false hope. Their symptoms will go away and they’ll slowly go back to their old diet. Then they’ll start losing weight because of high blood sugar. But that weight loss is a sign of the damage the high blood sugar is doing not the half keto diet.
After 47 years of type 1 diabetes I can confirm that insulin (along with pumps and continuous glucose monitors) works. The vast majority of my medical complaints are now down to middle age 😂. Great video. Well done.
Patrick you have swiftly become one of my favorite video essayists
@@DavidJamesHenry I sincerely appreciate that. Thank you! 🙏
I recently went to New Orleans and stopped at the pharmacy museum there, I believe after hearing about it from one of your videos. It was awesome, and I attribute my relatively recent interest in medicine to your videos too! Keep it up!
That means a ton to me, thank you! I'm glad to hear you enjoyed the museum too!
Brown-Séquard self medicating like that was nuts!
*Buh dum chh*
Dude must have been the moat jacked old man of the 19th century
My A1C was 17 when I was diagnosed. I wish people understood how bad t1d is. Thank you for the video.
Shocked your channel isn't bigger for how well produced these videos are! Your storytelling really made this one fly by, great work!
You tell so good a story I don't even blink for fear of missing something. Mad respect. 🙏
Please blink. It's important.
@@lotfibouhedjeur I appreciate that, thank you! Shoutout to the Canadian historians for making the primary sources so accessible
> One of the people watching the talk was the research director for the pharmaceutical company Eli Lilly. And after the talk, he called Macleod and said "if you ever need help scaling up production, let us know".
HAAANK HANK DONT DO IT HAAANK!!!!
@@jeremy7934 you’re either gonna love or hate the next video
Fantastic video! Always so well researched, explained, and with great visuals. I always look forward to the next one. :)
Thank you! I worked extra hard to get the permission to use these visuals. U of T was super kind
Thanks Dr. Kelly. It's wonderful that videos like this exist on the Internet. I strongly suspect that this video will lead to others that tell additional details about diabetes.
Thanks for the kind words, I appreciate it! Although, quick clarification, I am not a doctor.
Interestingly, a gentleman named William Banting published a self published pamphlet called "Letter on Corpulence", in 1863. In which he described a low carbohydrate diet he used to treat his own diabetes and gout. In fact he was one of the first people to popularize a low carb diet! Was he a doctor? No, ironically he was an undertaker!
And apparently he is a distant relative of Frederick Banting, the one mentioned in this video
Love your channel, extremely underrated for the high quality content.
I appreciate that. I'm still stoked on making videos regardless of how many people are watching
@@PatKellyTeaches I was genuinely surprised your channel had under 1M subs
I was diagnosed type 1 just a few weeks ago. Really happy to see this video and love your content!
I've tried watching this like 4 times now and I just can't stomach it, that sucks for me because i absolutely love Patrick Kelly videos
I appreciate the effort. I know the dog experiments can be hard to get through. The next video in the series is much easier to digest
Great video. Let me just add the obvious, that is, ancient and medieval physicians weren't checking the colour, consistency, smell and taste of the patient's urine to look for signs of diabetes, but rather to be able to give a prognosis on how the disease will evolve over the course of time, and say whether the patient will live or die. Also, they seem to have connected urine to sufficient or insufficient digestion, and that to disease, too.
Babe wake up new Patrick Kelly video 🎉😮
Fun fact: Banting died in a plane crash. I'm not saying a dog had something to do with it, but it seems suspiciously timed
I was expecting a longer video but nevertheless will wait for the second one. I wish you finish the video with Flame of Hope as a fitting tribute to the selflessness of Banting. Amazing narration indeed.
Hey people another Patrick Kelly video dropped.
Come one, come all!
I've been missing seeing more videos from you but I'd assume they are a lot of work!
@@theodorekorehonen They are, indeed. This one in particular required a lot of fact-checking. The good news is that I've got 2 more videos written and ready to go!
Another great video, your channel needs a lot more attention. Consider reaching out to scishow and/or Hank Green. I bet they would love you as a guest.
@@Hi_Im_Akward I got my start in science writing by writing videos for SciShow! I’m still a big fan of Hank and Complexly
@@PatKellyTeaches OMG that's amazing!
Great video, as always!
Wow! So cool! I really wish my father in law was still alive, he’d love this so much! Big “advances in medicine” nerd, he was!❤
You're always so good...thanks.
So glad to see you back in the sub box. Set up with a coffee and ready to learn
Wooohoooo new vid🎉
I am always waiting for Patrick to drop a new video
Thank you for being you. Regards Al from down under. This island is not what you think it is.
nicely made video
4:28 I think this is my favourite side note of any video, ever. 😂
As a Type 1, thank you so much for this video. It’s one thing to understand all the stuff to live with it; a completely different thing to understand how we got here.
1:15 Ooh ooh ooh ✋✋✋!
FUN FACT!! Diabetes, in Vietnamese is bệnh tiểu đường, which literally means sugar urine sickness!!!!!!
And the Danish name is sugar sickness, “sukkersyge”.
Duck litigation? How did they get ducks to pass BAR?
🤓love it all "champing" at the bit
Diabetes runs strongly in my family. My mom who was obese most of her life strangely is type one but her brother who was 120lbs(I say was because he died of cancer a few years ago) had type two.
Patrick, what's your favourite Neurotransmitter? One of those nerdy questions I know lol. I'm quite a fan of acetylcholine tbh.
@@SnailShoes I have a serotonin molecule tattoo on my foot. I think I have to say that one!
1:54 this is why we're hereeeee!
I love your channel🙏 Always extremely interesting and very well researched; a fascinating subject presented by quite a knowledgeable fellow! Thank you for all the wonderful content!!
Awesome
"and eventually got the blood sugar down to zero."
Oh no, I hope not! That would be pretty bad.
@@xwolpertinger it’s a tangent that I couldn’t quite tie in smoothly, but the procedures for measuring blood glucose evolved a ton during those early days of insulin research. So you’re totally right. The blood sugar probably wasn’t 0mg/dL but that’s what they measured
“It’s weird, sometimes when we give this extract to rabbits they get convulsions and then go into a coma. Also, WE SHOULD START HUMAN TRIALS IMMEDIATELY!”
That definitely sounds bad ha haha. It’s worth pointing out that Collip was the one doing the rabbit experiments, while Banting and Best decided to go a little rogue and do the human trial on Gilcrest. One of the authors I read speculated that they rushed into a human trial so that they could claim they were first. But again, that’s speculation
As a type 1 diabetic insulin is a miracle every day. It's hard to believe that we are all out here living like this, lol.
Don't mind me just commenting for the algorithm
Such a cliffhanger
I wonder how many illnesses today will turn out to have such miraculous cures a century from now
So 100 years from signs of a viable treatment to signs of a viable cure. I call that signs of exponential progress.
Type 2 Diabetic here and the question of "if you could live in any other time when would it be" never. I'm fine right here. We've only had insulin for 100 years and even as far back as like 50 years ago we didn't have at home blood sugar testing methods. This disease is already hard to control and deal with in modern times. No thank you lol
Banting's name lives in Swedish as the verb "banta" (starve oneself, be on a diet).
Woah, what a coincidence
@@PatKellyTeaches The verb comes from his name actually!
This is weird. So all the had to do was use ethanol to extract insulin from mammalian pancreas? How has no one tried that before them? Isnt alcohol an extremely common solvent in medicine?
Acappelascience has a great song about Bantings work:
th-cam.com/video/He7X5jGt8lY/w-d-xo.htmlsi=0lnl_XB3JEHdIxev
Hell yeah
hell yeah brother
you're tellin' me some doctor thought he was on the cutting edge of science by shooting up with gonad juice? thanks for once again reminding me that this period of history maybe isn't all that bad
"Meats, fat, and pork." What inspires such redundancy?
Probably how language has changed over the last 150 years. I wonder if "meats" only included red meats and poultry was also a different category back then.
at 15:41 you state that by using the fetal pancreas extracts, they were able to drop blood sugar to 0. wouldn't that just kill the dog? maybe they had a different way of measuring? or were they measuring urine sugar, and not blood sugar? that would make more sense if the urine sugar dropped to 0.
No, he stated they were able to drop the glucose in the URINE to zero! Glucose in urine is NOT the same thing as glucose in blood!!
Critically important in the treatment of Type I DM, in which islet cells are non-functional. Absolutely preposterously misused in the "treatment" of Type II DM, in which giving insulin makes patients even more insulin resistant over time, when dietary modification completely cures the disease in all but the most advanced cases.
main issue with type II diabietes is that diets are hard, thats why things like ozempic exist, its basically willpower in a needle.
You got em
I'll get into other drugs like metformin, insulin sensitizers, and GLP1s in the follow up videos. I felt like original insulin still deserved its own video though!
This comment with the last name is so funny. Maybe its a troll but sometimes the life writes the best stories
@@PatKellyTeachesyes yes yes!
I've been waiting a MONTH for this video and it is only 23 minutes long?! Alright...I'll take it but you're on thin ice young man!
But really in all seriousness I am PSYCHED!
the glare in your eyes is brainwashing me to donate to your patreon
There are no essential carbs or sugar. Glucose that is chronically elevated is inflammatory in the body, takes as little as 20 to 100 grams of carbs or sugar. Glucose uses the same cell pathways in the body as the body uses to adsorb micro nutrients, thus when glucose is elevated, micro nutrients uptake is reduced, "commonly know as bio availability". Micro nutrients can be depleted when body oxidizes cells during inflammation and potentially cause kidney stones. Carbs and sugar release dopamine in the brain similar to some schedule 1 drugs based on mri scanning based studies. Elevated glucose causes hormonal dysfunction when consumed in amounts the body cannot handle. Your body is capable of creating it's own glucose without dietary intake.
Definitely. That's why all our ancestors go include the great apes evolved to eat fruit.... Because it filled them en masse .... 🙄🙄🙄🙄
orginal recipe
That's right. The next video is about all the improvements to the recipe
Bro mentions nothing about Nicolae Paunescu. This video is not so well documented :/
Check again starting at 7:08
Collip was a blatant flocculator. 😉
I'm just 🤔 did they taste the dogs urine?
"If you take beta, you'll be beta."
-Shawn Baker, M.D., probably
probably
funny piss pun
Did you actually read those ancient texts! Or are you just repeating nonsense each!
Yes. The Eber's Papyrus, the Egyptian reference, mentions treatments for polyuria, which historians have interpreted as the excessive urination that's symptomatic of diabetes. You can find the reference in the English translation here: babel.hathitrust.org/cgi/pt?id=coo.31924073200077&seq=121. The ancient Indian text, the Charaka Samhita, describes urinary disorders as well. English translation can be found here: www.wisdomlib.org/hinduism/book/charaka-samhita-english/d/doc629258.html
In the future, you can always find my references in the description, and a fully annotated script linked on Patreon. Thanks for weatching!
Do you want video editor and thumbnail designer
First taste of sacrificng the unborn for medicine
75 views in 7 minutes, bro fell off
It's alright. I make these videos for fun. I'll be making them regardless of how many people watch. Thanks for sticking around
@@PatKellyTeachesif patrick kelly has 0 viewers im dead
@@PatKellyTeacheshe's just doing an overused TH-cam comment 'joke' lol. You can see the same comment on every video on yt, it's almost annoying now
@@PatKellyTeachesit's a great video and something that people need to know about! People don't realize how diabetes was a death sentence sin the past. Everyone romanticizes the past and they don't realize that it was hell! And people died all the time from things that today are nothing!