Yeah, I don't see why not. You may have to adjust your metronome settings to your liking. When I was recording music, I usually left it in comp mode, but there wouldn't be any reason you couldn't try it this way. The only advantage of not using this, would be having the multiple takes be more easily accessible in case you wanted something from each run through of your vocals. But Reaper is non-destructive so you could recover them, it might just be a little tedious.
I want to do this as a recording artist for recording over beats. Would this work for that too?
Yeah, I don't see why not. You may have to adjust your metronome settings to your liking. When I was recording music, I usually left it in comp mode, but there wouldn't be any reason you couldn't try it this way. The only advantage of not using this, would be having the multiple takes be more easily accessible in case you wanted something from each run through of your vocals. But Reaper is non-destructive so you could recover them, it might just be a little tedious.