I’ve been trying to find good histology channels on TH-cam for a while and I’m so glad I found your channel. Your slides are so clear an explanation as to the point with real slides is great thank you so much.
Thanks, that's great to hear. There are some great histology videos out there but many were made before digital slides which make it so much easier to provide clear direction.
Thank you for making these videos. It's been a while ago now, but I'm sorry for your loss as well. To Florence, thank you for your contribution to the education world. Would love to see the nodules, but i suppose it's been a while ago
I'm glad you like the videos, I hope they're useful! I'm just planning the video over next few months, had to divert my attention to other things for a while but hope to get back to making more videos now :).
That's great, I'm glad it was useful. I was actually looking for an idea for the next video so kidney it is! Might take me a while, but it'll get published eventually.
Is it true that in a healthy liver the vessels should not contain blood visible under a microscope? When you show the portal triad, are those red spots blood?
I have the task of comparing photos of a healthy liver and one with cirrhosis. I have no idea how to go about it and what to write, these photos look the same to me
No it's not true. Finding blood in the vessels is normal in all organs and stains red with the standard H&E stain. Sometimes there might be more blood than normal in capillaries or sinusoids. This is quite subjective and is usually a non-specific or incidental finding.
Bear in mind that my work is focused on animals rather than humans - but I imagine the process is the same. Cirrhosis is essentially chronic liver damage which has three features on histology: fibrosis, regeneration and possibly necrosis. For fibrosis, you would generally be looking for increased collagen around the portal tracts. There's often a proliferation of small calibre bile ducts within the fibrous tissue. There might be regenerative nodules of hepatocytes. The cells tend to be larger (hypertrophic) compared to normal hepatocytes.
Sir,but how to differentiate between the bile ductules,and hepatic artery ,fine the portal vein is collapsed,but why the columnar epithelium of bile ductule which you called handsome basal cells only seen,and why endothelium nuceli of hepatic arterioles is not seen?...I mean how to differentiate between these? It would be helpful if you could please say once...
Hi! Thanks for your question. The "basal" refers to the position of the nucleus in the cell - that it is positioned close to the basilar membrane (away from the lumen). There are some other features that can help you distinguish between bile ducts and arterioles. Look for the smooth muscle around arteries - bile ducts have no smooth muscle. Generally you can also see erythrocytes in the lumen of arteries. Hopefully these features should help you out.
I'm afraid I don't have any videos on gross dissection. My plan is to concentrate on histology for the moment, but my output is quite slow as I'm studying for exams in February. Afterwards there'll be some more! Let me know if you have any organ system you'd particularly like to know about :)
thank you, florence 💗 you are an angel 💗
I’ve been trying to find good histology channels on TH-cam for a while and I’m so glad I found your channel. Your slides are so clear an explanation as to the point with real slides is great thank you so much.
Thanks, that's great to hear. There are some great histology videos out there but many were made before digital slides which make it so much easier to provide clear direction.
Thank you for making these videos. It's been a while ago now, but I'm sorry for your loss as well. To Florence, thank you for your contribution to the education world. Would love to see the nodules, but i suppose it's been a while ago
I'm glad you like the videos, I hope they're useful! I'm just planning the video over next few months, had to divert my attention to other things for a while but hope to get back to making more videos now :).
tank you Florence! I wish you all the best little darling
I love this! Thanks, learned a lot here. Please make a video on histology of the kidney.
That's great, I'm glad it was useful. I was actually looking for an idea for the next video so kidney it is! Might take me a while, but it'll get published eventually.
What an amazing video. Thank you ❤
Thanks! Glad it was useful.
Thank you so so much
Thank you Florence❤️
Any time :), glad it was helpful.
absolutely love these..instant sub
Thanks! Glad you like the videos :)
Such a beautiful video for such a beautiful organ, you earned another subscriber :)
Great! The liver is a favourite of mine :)
ive missed this! Thanks so much to youtube for bringing me back to it
The TH-cam algorithm was just waiting for the right moment!
Is it true that in a healthy liver the vessels should not contain blood visible under a microscope? When you show the portal triad, are those red spots blood?
I have the task of comparing photos of a healthy liver and one with cirrhosis. I have no idea how to go about it and what to write, these photos look the same to me
No it's not true. Finding blood in the vessels is normal in all organs and stains red with the standard H&E stain. Sometimes there might be more blood than normal in capillaries or sinusoids. This is quite subjective and is usually a non-specific or incidental finding.
Bear in mind that my work is focused on animals rather than humans - but I imagine the process is the same. Cirrhosis is essentially chronic liver damage which has three features on histology: fibrosis, regeneration and possibly necrosis. For fibrosis, you would generally be looking for increased collagen around the portal tracts. There's often a proliferation of small calibre bile ducts within the fibrous tissue. There might be regenerative nodules of hepatocytes. The cells tend to be larger (hypertrophic) compared to normal hepatocytes.
@@DownTheScopeMicroscopy thanks a lot ❤️♥️🥹
Sir,but how to differentiate between the bile ductules,and hepatic artery ,fine the portal vein is collapsed,but why the columnar epithelium of bile ductule which you called handsome basal cells only seen,and why endothelium nuceli of hepatic arterioles is not seen?...I mean how to differentiate between these?
It would be helpful if you could please say once...
Hi! Thanks for your question. The "basal" refers to the position of the nucleus in the cell - that it is positioned close to the basilar membrane (away from the lumen). There are some other features that can help you distinguish between bile ducts and arterioles. Look for the smooth muscle around arteries - bile ducts have no smooth muscle. Generally you can also see erythrocytes in the lumen of arteries. Hopefully these features should help you out.
Thanks, do you have videos that deals dissection procedure for Liver and other organs. I am a newbie in histology.
I'm afraid I don't have any videos on gross dissection. My plan is to concentrate on histology for the moment, but my output is quite slow as I'm studying for exams in February. Afterwards there'll be some more! Let me know if you have any organ system you'd particularly like to know about :)
❤❤❤❤❤❤❤❤
its not odd
wow wow wooow!!
sir can you provide me your contact number?? i need some help about histopathology in my thesis writeup
Sure, you can always fill out the contact form on my website and I'll see if I can give you some advice: downthescope.co.uk/contact/