In the above example is the inbreeding coefficient 7/16 (about 44%)? If not can you show how to calculate the inbreeding coefficient? I have watched your videos of calculating inbreeding coefficients, do you have one that shows how to calculate the inbreeding coefficient when individuals in the pedigree are also inbred?
In this example you said that dog 4 would be 75% homozygous. Would that not ONLY be true if DOG 2 is fully homozygous. As the 75% only represents the percentage of genetic material transferred from DOG 2. If DOG 2 is heterozygous and DOG 4 is 75% related it would not necessarily be 75% homozygous. Similarly the 25% from the other parent does not represent heterozygous percentage unless DOG 1 is also completely homozygous for different alleles than DOG 2.
In order to do exact calculations we need to know genetic relationship between the dogs and initial coefficient of inbreeding. This was just example that with each round of inbreeding loss of heterozygosity would be 50% .
@@GeneticsLessons thank you, but we select it trait by trait with selection and culling until we produced the homzygous domnt. is inbreeding in dogs highly risky that can produced undesirable traits? thanks
Hello, I'm in a situation where (even as a breeder I know these basics) I have now bought 3 female dogs of great importance in a specific breed ( basically closest to the source, time of breed creation ) but due to that I one of them even have unknown (no data) dogs or even cross breed dogs from before it even became a breed close as 4. 5. generation back... But one of them is a direct daughter of the oldest dog of the one of the first bloodlines that's still alive on the planet... And I have frozen semen of that dog, but only for one time use. Now, I have access to her sibling brother for breeding also, and because their mother is the best bitch from serious kennel who breeds for working, health, performance...etc that mother side of pedigree have hips elbows eyes..etc checked and info about that many generations back... But the old blood dog has an immense amount of courage, defense and fight drives ( new blood (mother side is protection work competition dogs but it's based on prey drive) now I would like to inbred and create a bloodline of HD-A hips and etc .. but with mindset and inborn instincts of old time tuff dogs that lived hard life in hard times serving to humans risking their lives for real not just playing on competitions.... So, because these females and that sperm are priceless. I will need to hire someone with a degree and book knowledge in genetics to guide me through this process... Are you interested in something like this and if so, please just give me a personal email to show you the details and online pedigree data base
@@GeneticsLessons "behavior" No.1 most important is the mindset, the will. there is no use in dog being able to do something if he don't want to. No.2 Health No.3 Comes the body (don't know if that is what you consider by "appearance") they do need to be heavy enough for man stopping, yet not short, heavy boned, wide chest and wide short muzzle head (impressive bodybuilder appearance). But longer legs, deeper chest, thinner but longer neck, lighter head with longer muzzle...etc ( that means, faster running, deep chest more lung capacity, longer neck is like longer arms in boxing-reach, better breathing when holding the bite with longer muzzle) higher ass than shoulders, tail starting lower the better, back legs proportion of lower and upper bone (sorry English is not my first language) how much opened angles of back legs, paws longer or shorter fingers... That's all appearance but for purpose of practical and performance benefits... If you meant by "appearance" on will dog be black or white, blue or yellow eyes... That I don't care about 😁 Is it better to have a dog that is not able to protect you, a chihuahua for example, but wants so much that he dies trying.. German shepherd who is strong and able, but because he is hungry, tired, wounded... Now he wants to eat, pain to stop hurting him and to go sleep, so he stops fighting and simply just quit Or huge, scary looking, fearless mastiff 150 pounds of muscle laying on your porch but have hip dysplasia so can't get up
@@GeneticsLessons just type in TH-cam search "pitbul dog' you'll see the new blood based on appearance only, then type 'pitbul grand champions of history' and you'll see ugly, skinny but immensely athletic healthy dogs with personality of battle heroes warriors.. Mine breed is perro de presa canario... But same thing happening (cross breeding with mastiffs to get larger more intimidating looking dogs, but calming temper so pups can be sold to inexperienced people and kids... All because of the damn money
First of all, inbreeding is not a goal (it can be a goal in lab rats though) . Pure line when phenotypic traits are stable in a progeny. Inbreeding is a bad thing due to "inbreeding depression" and if possible you should avoid it.
Let say by chance you got a dog with blue fur- none of the puppets of this dog have this trait (cause it is recessive and all puppet are heterozygous) - you need to cross this dog to all the progeny of the opposite sex (aaxAa) - and 1/2 of the progeny will have this trait as homozygous recessive (aa) - you got pure line for this trait only after one cross.
You can not inbreed for long - dogs are not mice - and you will see inbreeding depression in them. Dogs would be sick and will have many genetic problems. Next step would be to cross with another inbred line to increase heterozygosity - and health.
Nikolay's Genetics Lessons woww that is perfect you are king if you can example 5 generations it will be Good, if you can also write i can give you email also dadiplavi84@gmail.com thanks thanks king
Here is additional information for you: The queen naturally mates with up to 20 drones, making the colony a collection of many subfamilies (half sisters with the same mother, but different fathers).
My greetings sir. Please am into rabbits. So I have this one male 🐇 and two females 🐇 that i believe are all crossed breeds. So I need to build a better rabbits from them. Please how do I program my breeding
@@GeneticsLessons my goal is to produce a fast growing and good feed to meat conversation rabbits. The male is a cross of chinchilla and hyla, the females are Dutch and chinchilla crossed
But these 2 examples are the simplest and need only 2-3 inbreeding crosses to fix the trait. In most cases traits are under the control of many genes - in those cases more inbreeding crosses needed to fix many genes (loci). Could be 3-4-5-6-7 close relative crosses.
In a purebred strain or breed, the goal is that the organism will "breed true" for the breed-relevant traits. The sooner you get such characteristics the better, no need to inbreed more - this may cause inbreeding depression.
you need to review genetics, your talking on bloodcoeficient, genes always pass 50% to its offspring and in the law of independent segregation offsprings of the same litter possess different genes depends on the genotype of their parent. imposible to have 75%genes
So a bunch of dogs fucking ? jaja im kiding but i am not agree with the breeding of the same race of gens . the croos breeding with unspected strains is always better for the progenie.
Largest fault of this theory is that the successive breed lost immunity in every step , so best way is to mix inbreed and outbreed ....that is why always thumbs down for this pure line breeding theory....
I'm happy to have found this channel 😀
Excellent video. Very useful to me as a dog breeder. Anyway this is COR right?
What is COR?
In the above example is the inbreeding coefficient 7/16 (about 44%)? If not can you show how to calculate the inbreeding coefficient? I have watched your videos of calculating inbreeding coefficients, do you have one that shows how to calculate the inbreeding coefficient when individuals in the pedigree are also inbred?
I have such videos - just search my channel for "inbreeding".
In this example you said that dog 4 would be 75% homozygous. Would that not ONLY be true if DOG 2 is fully homozygous. As the 75% only represents the percentage of genetic material transferred from DOG 2. If DOG 2 is heterozygous and DOG 4 is 75% related it would not necessarily be 75% homozygous. Similarly the 25% from the other parent does not represent heterozygous percentage unless DOG 1 is also completely homozygous for different alleles than DOG 2.
In order to do exact calculations we need to know genetic relationship between the dogs and initial coefficient of inbreeding. This was just example that with each round of inbreeding loss of heterozygosity would be 50% .
@@GeneticsLessons thank you, but we select it trait by trait with selection and culling until we produced the homzygous domnt. is inbreeding in dogs highly risky that can produced undesirable traits? thanks
@@calvinmateo1646 Inbreeding of almost any animals is bad for productivity, those some tolerate it pretty well, for example mice.
I have some questions?
What is your question?
Hello, I'm in a situation where (even as a breeder I know these basics) I have now bought 3 female dogs of great importance in a specific breed ( basically closest to the source, time of breed creation ) but due to that I one of them even have unknown (no data) dogs or even cross breed dogs from before it even became a breed close as 4. 5. generation back... But one of them is a direct daughter of the oldest dog of the one of the first bloodlines that's still alive on the planet... And I have frozen semen of that dog, but only for one time use. Now, I have access to her sibling brother for breeding also, and because their mother is the best bitch from serious kennel who breeds for working, health, performance...etc that mother side of pedigree have hips elbows eyes..etc checked and info about that many generations back... But the old blood dog has an immense amount of courage, defense and fight drives ( new blood (mother side is protection work competition dogs but it's based on prey drive) now I would like to inbred and create a bloodline of HD-A hips and etc .. but with mindset and inborn instincts of old time tuff dogs that lived hard life in hard times serving to humans risking their lives for real not just playing on competitions.... So, because these females and that sperm are priceless. I will need to hire someone with a degree and book knowledge in genetics to guide me through this process... Are you interested in something like this and if so, please just give me a personal email to show you the details and online pedigree data base
So you want to breed for appearance or for fight and protection (behavior) traits?
@@GeneticsLessons "behavior"
No.1 most important is the mindset, the will. there is no use in dog being able to do something if he don't want to.
No.2 Health
No.3 Comes the body (don't know if that is what you consider by "appearance") they do need to be heavy enough for man stopping, yet not short, heavy boned, wide chest and wide short muzzle head (impressive bodybuilder appearance). But longer legs, deeper chest, thinner but longer neck, lighter head with longer muzzle...etc ( that means, faster running, deep chest more lung capacity, longer neck is like longer arms in boxing-reach, better breathing when holding the bite with longer muzzle) higher ass than shoulders, tail starting lower the better, back legs proportion of lower and upper bone (sorry English is not my first language) how much opened angles of back legs, paws longer or shorter fingers... That's all appearance but for purpose of practical and performance benefits...
If you meant by "appearance" on will dog be black or white, blue or yellow eyes... That I don't care about 😁
Is it better to have a dog that is not able to protect you, a chihuahua for example, but wants so much that he dies trying.. German shepherd who is strong and able, but because he is hungry, tired, wounded... Now he wants to eat, pain to stop hurting him and to go sleep, so he stops fighting and simply just quit
Or huge, scary looking, fearless mastiff 150 pounds of muscle laying on your porch but have hip dysplasia so can't get up
@@GeneticsLessons just type in TH-cam search "pitbul dog' you'll see the new blood based on appearance only, then type 'pitbul grand champions of history' and you'll see ugly, skinny but immensely athletic healthy dogs with personality of battle heroes warriors..
Mine breed is perro de presa canario... But same thing happening (cross breeding with mastiffs to get larger more intimidating looking dogs, but calming temper so pups can be sold to inexperienced people and kids... All because of the damn money
Watch my new video : Brahmins' closest relatives outside of India th-cam.com/users/shortsL-9dfYWGvFE
How many dogs are needed to make a new bloodline???
Minimum two. Some breeds are interbreeds.
so what happens after that .. ? can u plz explain more
Do you have specific questions?
Nikolay's Genetics Lessons yes , after dog6 are created those would be considered pure? how do i keep that line bredding
First of all, inbreeding is not a goal (it can be a goal in lab rats though) . Pure line when phenotypic traits are stable in a progeny. Inbreeding is a bad thing due to "inbreeding depression" and if possible you should avoid it.
Let say by chance you got a dog with blue fur- none of the puppets of this dog have this trait (cause it is recessive and all puppet are heterozygous) - you need to cross this dog to all the progeny of the opposite sex (aaxAa) - and 1/2 of the progeny will have this trait as homozygous recessive (aa) - you got pure line for this trait only after one cross.
Meaning if you will cross dogs with blue fur with blue fur = 100% of the progeny of such a cross will have blue fur. It is a pure line for this trait.
What about breadind dog 4? Is that pushing it
You can not inbreed for long - dogs are not mice - and you will see inbreeding depression in them.
Dogs would be sick and will have many genetic problems. Next step would be to cross with another inbred line to increase heterozygosity - and health.
this means we can breed so the bees also ? with this whay we keep pure line ? right
Specially for you I will make a video in which I will explain how to breed bees.
Nikolay's Genetics Lessons woww that is perfect you are king if you can example 5 generations it will be Good, if you can also write i can give you email also dadiplavi84@gmail.com thanks thanks king
Here is the video that should help you to understand artificial selection methods: th-cam.com/video/GwvTfZCYCkE/w-d-xo.html
Here is additional information for you: The queen naturally mates with up to 20 drones, making the colony a collection of many subfamilies (half sisters with the same mother, but different fathers).
My greetings sir. Please am into rabbits.
So I have this one male 🐇 and two females 🐇 that i believe are all crossed breeds. So I need to build a better rabbits from them. Please how do I program my breeding
You need couple hundreds to begin with ;-)
@@GeneticsLessons please I don't understand your reply
You need to start not with 3 rabbits but with much more and rabbits have to be genetically diverce. What is your breeding goal?
@@GeneticsLessons my goal is to produce a fast growing and good feed to meat conversation rabbits.
The male is a cross of chinchilla and hyla, the females are Dutch and chinchilla crossed
OK, and what is your breeding plan?
ohh wow
But these 2 examples are the simplest and need only 2-3 inbreeding crosses to fix the trait. In most cases traits are under the control of many genes - in those cases more inbreeding crosses needed to fix many genes (loci). Could be 3-4-5-6-7 close relative crosses.
If dog 6 has sister or a brother if u breed them then u have pure breed also?
In a purebred strain or breed, the goal is that the organism will "breed true" for the breed-relevant traits. The sooner you get such characteristics the better, no need to inbreed more - this may cause inbreeding depression.
@@GeneticsLessons i myself would breed back too dog 3
you need to review genetics, your talking on bloodcoeficient, genes always pass 50% to its offspring and in the law of independent segregation offsprings of the same litter possess different genes depends on the genotype of their parent. imposible to have 75%genes
I'm MS in genetics. You are wrong. Google "inbreeding".
@@GeneticsLessons ah
So a bunch of dogs fucking ? jaja im kiding but i am not agree with the breeding of the same race of gens . the croos breeding with unspected strains is always better for the progenie.
Watch my new video: Why Jews look so different? th-cam.com/users/shortsI28WoDsoh7Q
Largest fault of this theory is that the successive breed lost immunity in every step , so best way is to mix inbreed and outbreed ....that is why always thumbs down for this pure line breeding theory....
Watch my new video " How to develop super memory" th-cam.com/video/9k2sM_jcZUQ/w-d-xo.html
Are you considering Dog 2 100% heterozygous?
Watch my new video " How to develop super memory" th-cam.com/video/9k2sM_jcZUQ/w-d-xo.html
Top my friend
Thank you 👍