Medicinal chemistry 6th semester important questions। B Pharm। Short & long Questions। Part-1।

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Today In this video I provide Medicinal chemistry B Pharm 6th semester important questions : Short & long questions with solution pdf. (Part-1)
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#medicinalchemistry
#pharmacognosy
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#pharmaceutics
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#importantquestions
#bpharmacy
#6thsemester
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#exam
Unit-I 10 Hours
Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity
relationship, Chemical degradation classification and important products of the
following classes.
β-Lactam antibiotics: Penicillin, Cephalosporin, β-Lactamase inhibitors,
Monobactams.
Aminoglycosides: Streptomycin, Neomycin, Kanamycin.
Tetracycline: Tetracycline, Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline.
Unit-II
Antibiotics: Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the
following classes.
Macrolide: Erythromycin Clarithromycin, Azithromycin.
Miscellaneous: Chloramphenicol*, Clindamycin.
Prodrugs: Basic concepts and application of prodrugs design.
Antimalarial: Etiology of malaria.
Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine.
Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil.
Miscellaneous: Pyrimethamine, Artesunate, Artemether, Atovaquone.
Unit-III
Anti-tubercular Agents:
Synthetic anti tubercular agents: Isoniazid*, Ethionamide, Ethambutol, Pyrazinamide,
Para amino salicylic acid.*
Ant-tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine, Streptomycin,
Capreomycin sulphate.
Urinary tract anti-infective agents:
Quinolones: SAR of quinolones, Nalidixic Acid, Norfloxacin, Enoxacin, Ciprofloxacin*,
Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin.
Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine.
Antiviral agents: Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine
trifluoride, Acyclovir*, Ganciclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine,
Loviride, Delavirdine, Ribavirin, Saquinavir, Indinavir, Ritonavir.
Unit-IV
Antifungal agents:
Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin.
Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole
Tioconazole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole,
Naftifine hydrochloride, Tolnaftate.*
Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine.
Anthelmintic: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole,
Niclosamide, Oxamniquine, Praziquantel, Ivermectin.
Sulphonamides and Sulfones: Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*,
Sulphapyridine, Sulfamethoxazole*, Sulphadiazine, Mefenide acetate, Sulfasalazine.
Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole.
Sulfones: Dapsone*.

Unit-V
Introduction to Drug Design
Various approaches used in drug design.
Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammett’s electronic parameter, Taft’s steric parameter and
Hansch analysis.
Pharmacophore modeling and docking techniques.
Combinatorial Chemistry: Concept and applications of combinatorial Chemistry: Solid phase and solution phase synthesis.

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