He sounds very confident and convincing to a layperson, but he doesn't actually know what he's talking about on most things, and doesn't really understand how to read study literature.
I take curcumin supplements regularly to lower my inflammation. I have ankylosing spondilitis, so I get flare ups often. It really helps a lot and I have managed to keep my autoimmune disease under control without biologics. Just using supplements, anti inflammatory diet (avoiding sugar and other triggers) and exercise. Thanks for this video. Im a big fan of your work. Thank you!
I hadn't realized that curcumin helps with blood sugar issues. It would be interesting to learn if its anti-inflammatory properties are truly helpful for cardiac concerns.
@@mindfulmomentswithColmYes, definitely. Lots of vegetables and the occasional bit of fruit will do a lot for you to reduce inflammation and many other aspects of the Mediterranean diet will help you greatly. For one thing, stay away from processed food as much as you can and avoid alcohol as well.
Garry Small ( UCLA, I think,) did a trial to measure the benefits of Theracurmin, a nanoparticle form of curcumin. It was relatively successful in reducing cognitive decline. Granted it was as a small study, but it has found its way into AD prevention protocols.
I've never heard of "inflammation genes", that seems interesting. For what it's worth, I've noticed turmeric supplements seem to settle my ibs symptoms, but never did enough experimentation to know for sure. This video doesn't exactly explain that, but I was told I have pre-diabetes around the same time that my ibs symptoms started kicking up...maybe some sort of pancreas/liver/insulin/sugar connection? Really don't know, I just take shots in the dark until I find things that work but videos like these help inspire me and give me ideas on what things to try more or less of. Gonna go back and do more experiments with turmeric now. Ty!
I suffer from myalgic encephalomyelitis (ME) - a multi-system autoimmune disease. Among the many physical malfunctions ME encompass, neuroinflammation is one of them. I experience great improvement by taking 1 teaspoon of curcumin mixed with a teaspoon of freshly grined pepper, and a teaspoon olive oil - all disolved in juice, tea, coffee, or yoghurt naturel. Curcumin does NOT taste good, but it certainly helps on my headaches, fatigue, and cognitive problems. Thanks for a great science channel ❤🙏❤
My doctor recommended curcumin to help with some medication side effects. I have suffered with migraine since late childhood, although it could be weeks between attacks, they tended to be in clusters leaving me low for a few days without early use of my medication for whenever I had an attack. After taking curcumin with success for many months, I noticed that my migraine medication (which I carried in my wallet) was out of date. I then couldn't remember when I last had an attack. I have now been free from debilitating migraines for over a decade. Interestingly, the only other period that I was migraine free was while I was on steroid treatment, so I am suspecting that my migraine was, to a degree, related to inflammation.
Hello again. I had been taking osteo biflex (Glucosamine/Chondroitin) for joint pain (side note: our yellow had unbelievable help when we gave it to her). However, my finger joints started to give me some pain (guitar player, not good). My primary physician (from India) suggested Curcumin. I got some and in a very short amount of time ... no more finger joint pain. I've been taking for several years now ... still no finger joint pain. Btw ... "Normal blood sugar numbers" before starting curcumin. Started Low Carb/Mediterranean ... really good blood sugar number (checking fasting insulin and A1c in addition to the standard fasting glucose number).
Just LOVE ALL your stuff Nic! you are my favorite "physionic" YT channel! You present in an intelligent, concise and digestable (pun intended) fashion and are never pretentious! You sir, are a genuine teacher and seeker of the truth! I've been a subscriber for some months and look forward to all your new content! Thanks and Kudos "professor!"
I was pre diabetic prior to starting Carnivore (actually Lion “diet”…hate that word, really it’s a lifestyle). It’s been 2.5 months no longer pre diabetic. My CRP is low, but I would like it lower. I already have plenty Curcumin in a powder form with absorption agent, so I will start it again. I’m a chronic pain suffer, so anything to keep my inflammation low is a good thing. Apart from not being prediabetic I no longer have high blood pressure, sleep apnea. Love your videos. I’m a new Sub.
Guys, dont forget to check your lead levels using hair mineral analysis ( i think the name is metalogram). Currently Im treating lead in my body since it was the main responsible for my kidneys stones and the fact I took turmeric powder for years contributed for this I believe
My vendor for such a test allows to use finger and toe nails too. I have heard, that a hair analysis can be affected by hair conditioners, shampoo etc. So could taking nails be better? How do you treat your lead level?
@@thomasmuller1850 There are some easy procedures to do in order to perform such tests like use neutral shampoos for some time before taking the hair samples. I used Dmsa following the schedule of Acc protocol to remove lead. Im not producing anymore the kidney stones after the treatment. I had to take magnesium with every meal in order to avoid them before
Nic- your channel and insights are incredible. Forever grateful. I could literally sit and watch all your videos all day long. Perhaps I am a nerd, too? Thanks man!
Nice video. I think we need to start acknowledging though an inconvenient gap between what the studies say and what happens in clinical practice. Curcumin is often touted as this magic anti-inflammatory, and yet we still have people with autoimmune diseases having to go through strong immunosupressants. As an alternative therapy, I'd be much more interested in seeing the mechanism of Low Dose Naltrexone (LDN) than Curcumin, which has been gaining a lot of traction, in special now with the Long Covid RCTs. In general, people that seek LDN prescriptions have already tried things like Curcumin and other supposedly anti-inflammatory supplements. This leads me to believe that Curcumin is great in paper, but not so much in practice.
It doesn't work on any illnesses that people anecdotally claim to have helped them. I've tried using it for arthritis and heart disease for many months with no improvement.
It has helped with my IBS tremendously and I take 20,000mg capsules twice a day. Though from experimentation even 10,000 2x a day would be sufficient. I like the extra protection it offers to my gut pain.
I routinely test on the high side of normal for fasting blood sugar (95-105 typically). Type II diabetes runs in my family. I get a lot of exercise and my blood sugar hasn't gotten any worse in five years. Nonetheless, I still am mildly concerned. So I did some checking on curcumin. What I've found is that I can routinely see my morning fasting glucose drop by about 10 mg/dL about an hour after taking curcumin and some black pepper. Yes, I just grind some up fresh and take it with the pill. An hour later, my glucose will be about 10 units lower. I've also tested an hour later multiple times with no curcumin and see no similar pattern of blood sugar dropping. There has been, however, one exception out of about 7 tests so far where my blood sugar did not drop after taking curcumin. Given that Metformin has real side effects (maybe reduces some of the beneficial effects of exercise and inhibit skeletal muscle gains) I'd like to avoid the medication. So maybe @Physionic is on the right track. This may very well be a good supplement for borderline/borderline people like myself.
I just started curcumin since studies have shown it can help with inflammation and muscle recovery. I will know soon weather that works on me or not. Dr Stanfield is more interested in life extension, not muscle recovery. It's nice to know curcumin can also help with blood sugar.
I don't really bother with supplements. I simply add generous amounts of real turmeric and pepper to my foods - usually steamed veggies or ground beef.
Excellent, informative presentation! As for the argument for not needing to take Curcumin, I simply ask, is there such a person living on this planet? The world in general, is moving towards less and less healthy eating....so I think wisdom would suggest that, yes, everyone should consider supplementing with Curcumin.
This is very cool indeed . i am a big advocate for turmeric supplementing , i discovered the benefits in fast recovery form colds and any infections, then started researching the anti-inflammatory properties , didn't look into blood sugar effects for some reason it was always being dismissed by Drs :) I wander why 😇. Thank you for sharing .
IBS sufferer here. Hands down the best natural remedy I came across in my journey towards health is curcumin. I have been taking 20,000mg twice a day for the last 3-4 years and I can safely say, that it has no adverse effects (not that I am aware at least) and it has definitely helped with my gut inflammation issues. Thank God I came across this substance a few years ago because aging does not help with IBS (not to mention other auto-immune disorders).
@@KiIlAllMen The same. I have also found butyric acid to be very helpful as well. So curcumin and butyric acid are the best out there (for my type of IBS at least).
@@joelsombroek it is the chemical equivalent, it is only 2 pills per day every 12 hours, with both having enough curcumin corresponding to 40 grams of turmeric. I've been doing this successfully for 6-7 years at least. So any concern anyone raises about a potential toxicity of this natural remedy, I would simply disregard it or take it with a big pinch of salt. This substance is truly the most potent non-chemical non-drug anti-inflammatory I have known, the next best is Mesulid, but that is a proper drug which I take in special/difficult circumstances regarding my IBS flare-ups. BTW, after so many years with this problem I find that the biggest culprit is not carbs, not sugar but definitely crappy oils like rancid vegetable oils (sunflower, safflower, canola, etc) and especially palm oil. Palm oil is hands down the most pro inflammatory vegetable oil out there and the food industry has it literally on every piece of junk processed food out there. People read the labels!
The reason I'm personally steering clear of Curcumin as a supplement is that it inhibits P-glycoprotein activity. The same reason applies to piperine, quercetin, and vitamin K2.
This paper appears to suggest that P-Glycoprotein is a cause of cancer Multidrug resistance. www.ncbi.nlm.nih.gov/pmc/articles/PMC5198046/#:~:text=Curcumin%20as%20Modulator%20of%20P,models%20%5B21%2C33%5D.
@@xXxXxCGPBxXxXx P-gp protects the body from harmful substances by pulling it from the liver and kidneys into the urine and bile. It also helps maintain the blood-brain barrier. Since P-gp molecules are present in many organs like BBB, kidney proximal tubule, and bile ductule, their inhibition can potentially improve not only the absorption, but also the distribution, metabolism, and elimination of their substrates. this is google search so I can't translate. Looks like it has potential positive and negative effects.
Hindus who have been traditionally non-meat-eaters, have used turmeric dietarily in their daily curries and counteracted the diabetes their more carbaceous diets otherwise would have produced. They also got plenty of MK7 (K2’s calcium-directing form) from their many fermented pickle varieties🎉 I doubt many turned down curry or chutney because of P-glycoprotein worries.
If you're already healthy, then have turmeric in food as a prophylactic. There's a favorite Filipino dish of mine called potchero that doesn't usually contain turmeric, but my wife accidentally added some turmeric root to it and it was fantastic.
I had years lasting inflammations as result from heavy bruxism. Once in a while I had to use antibiotics, the inflammations lasted at least 20 years. Until the moments I started pressing my own 1000mg caps Kurkuma+pepper in 10:1..20:1 ratio, used 3000mg daily for half a year or so, in just 1 week the inflammations were gone and never returned. My dentist could not understand why it worked but it DID
I started taking Curcumin 5 years ago. I was having problems with short term memory and a young man I knew said that his dad, who was the head of psychiatry at a big university hospital, was involved in a study of curcumin for short term memory that was showing good results. I started taking it and within 2 weeks my short term memory was noticeably better and still is. I'm not going to talk about the effect on my erections so - don't ask.
All participants were instructed to take three capsules with blinded labels of either curcumin or placebo twice a day (total of six capsules per day) for 9 months continuously. Each curcumin capsule has curcuminoid content of 250 mg.
Thanks! I guess as a type 1 diabetic I should keep taking my tumeric supplements. Is it important to take it with pepper? I remember that you mentioned in another video that pipian (not sure if that’s the right term) from pepper increases the absorption of curcumin substantially.
Yep! But along with “piperine”which makes many substances (including my anti-seizure med carbamazepine) more bioavailable, fats help too. That’s why a warm & definitely fatty peppered “golden milk” is so powerful💪 (For Keto I make it with Milkadamia, MCT, pepper, turmeric, ginger, Ceylon cinnamon & cardamom, usually sweetened with Allulose. Yum! Coconut milk would work very well too, but has higher carbs to count.)
I'd love to see a study on people who had pre-diabetic levels of blood sugar who also took a reasonable amount of berberine. It seems that if the effects were additive, then the combination could extend a lot of lives. High A1C levels are directly related to CVD complications such as heart attacks, strokes, and CHF
I'm considering doing an extended water fast. I'm first going to go speak with my doctor & start documenting and posting about the results & how I feel. It would be great to watch videos you make on how things progress for me. The extra layer of accountability from another TH-cam would definitely aid in motivation!
My husband paid no mind to my efforts to manage my insulin resistance until his arthritic thumbs were killing him and I suggested he try it. He seemed sheepish as he acknowledged it worked
I hurt my back years ago due to a herniated disc and I am currently going through a flare-up. I am doing a number of things to get better, but I've been taking a curcumin (with piperine!) supplement daily to reduce inflammation in my sciatic nerve. I don't think it has made a dent in pain levels, but I'll continue going through the whole bottle in case the anti-inflammatory effects compound and help me get back to a pain-free state quicker. Diabetes also runs in my family though, so as I get older, I'll definitely keep a close eye on this one. Hopefully by the time I'm getting into late middle age these supplements are cheaper!
If curcumin increases insulin sensitivity then it should reduce C peptide meaning less stress from insulin production and possibly weight loss and reducing the risk of diabetes further in so-called healthy people. In other words, consider the impact of curcumin on the HOMA IR score before you conclude that healthy people see no benefit.
Im not pre diabetic and decently healthy, and i can get 90 caps (3 months worth) of curcumin for about 7-8 dollars. Just for the reduction of inflammation it seems like a good deal
I believe curcumin is a substance that deserves further investigation. Online there are several studies attesting to its benefits for relieving arthritis symptoms, going so far as to equate its results with the use of nonsteroidal anti-inflammatory drugs. For example, my wife started taking curcumin 3 months ago and her pains have reduced considerably. Unfortunately, there is not much money to do research on curcumin, I'm afraid the patents have expired.... 😅😅 Thank you for your science education work.
I am still trying to wrap my head around what inflammation is at the cellular and molecular level. My solid idea for inflammation is still "i banged a part of my body somewhere" or "certain of my glands are infected" and some parts of body is swollen beyond normal.
It also stimulates glucose transporters in beta cells forcing increased secretion of insulin, the kind noted in sulphonylureas. Damaging to the beta cells.
You didn’t mention if those pre-diabetics that had 0% progression to Diabetes also had to take pepper with their curcumin. Since you had another vid on the pepper connection it seemed a huge blind site.
Pat, extended fasting will also waste muscle, though 16:8 is generally too short. Muscle “building” requires weights & higher protein. The intermittent fasting, itself, only protects muscle in comparison to other weight loss methods.
I’ve got ankylosing spondylitis and I want to know why coffee and black tea help alleviate my back pain? I’ve read about how caffeine is bad and good in various ways, and how some people avoid it. I find it actually helps me, every time I drink it. I’m not sure what’s happening on the cellular level. I know COX-2, TNF, IL17, IL22 are involved in the inflammation. I also notice that cherry juice helps. I don’t know what’s going on there. Placebo? Anthyocyanins? No idea. I take Meloxicam sometimes in the evening if the pain persists, but I prefer a daily coffee in the morning, as the meloxicam has side effects like upset stomach and diarrhoea.
I've been diagnosed with ME/CFS and have been taking Turmeric (with Piperine) to help curb the chronic inflammation that this condition tends to generate. My question is ... would Turmeric (with Piperine) be as effective as Curcumin - in this particular scenario? And ... Does Curcumin require Piperine for absorption - as well?
Elevated blood sugar is not the problem, persistent elevated blood insulin levels is the problem and so it would be interesting to know how curcumin affects the release of insulin and what is the mechanism.
Thanks for a very interesting and thought-provoking video. Question: Is curcumin the only beneficial compound in turmeric? In addition to it's anti inflammatory and and anti diabetic properties, I've also read that turmeric has some neuro-protective and anti-cancer ones as well. Is there any truth to this and if so, can they all be attributed to curcumin alone or are there other compounds in turmeric that could be responsible?
It's the main compound, but it's still possible other compounds could also be of benefit. I would probably focus on curcumin, however. I haven't looked into those areas myself, yet, but I can tell you that I've read similar claims in the scientific reviews.
@@dailyoccasions9539 Any healthy anti-inflammatory will help you. But please research how high HORMONE D LEVELS can put MS into remission!!! Other necessary treatments are also combined. There’s an original Brazilian high D protocol & some in the US have been very successful, too (sorry I cannot remember their names, but should come up in a search💔)
I suffer from Carpal Tunnel syndrome, and have had it for 3 years now. I was considering consuming a tea that consists of Turmeric & Black Pepper. Since I’ve heard it can heal damaged nerves. Would this be the proper route for healing?
The conclusion made me curious. Has there ever been a nutrient/supplement shown to be a good alternative to medication, actually ? I can't think of any whatsoever.
I know I'm not answering your question strictly speaking (like a 1 for 1 swap of curcumin for metformin), but there are examples where meds might be eliminated in lieu of non-phamaceuticals. Exercise has tremendous anti-depressant effects over many drug treatments. Or changing what you eat reversing some metabolic disease when the meds are only managing symptoms. (I'm not against meds, but they aren't the only answer... Though sometimes they may be). I'd rather take turmeric instead of ibuprofen. But if the pain is bad enough, I'll take it or acetaminophen.
Your previous video touched on how curcumin isn't absorbed into the blood stream or is inactivated by the liver. The conclusion of that video was that curcumin needs to be taken with pepperine. Is that combo what was given to the subjects in these studies? Something doesn't match if curcumin isn't absorbed into the blood but it does have an effect on insulin resistance and diabetes.
You are so funny. And cute. But even more attractive is your presentation of information that you have researched so I don’t have to. Thank you. Now, how much pepper and what is a protocol I can follow? Please.
A 5-10% drop in total blood sugar is a very large percentage drop in the extra blood sugar a diabetic has. Say your fasting blood sugar is 110, meaning you are glucose impaired before you take curcumin. After curcumin, your blood sugar is 100. Congratulations, you are now in the healthy range! Even if you are diabetic at 125, you're 40% closer to a healthy glucose level. That is massive?
What do you think about turmeric/curcumin causing liver toxicity? I feel like you would have to take an excessive amount to do that. Maybe 10,000 mg plus ?
I don't take as a supplement but I do use it quite a bit in cooking, My Dna says I am insulin resistant, but I have no signs of diabetes. My mother and her mother were both diabetics, not due to being over weight, insulin users. Should I take as a supplement, or am I getting sufficient in my diet (BM 20)
Eating patterns are inherited far more than diabetes, itself. Diabetes can take decades to develop from its low D/Insulin Resistance beginnings, so if you eat like they do, turmeric could be a very potent protective!
@@eliseville As they both followed a diabetic diet and were the main cooks then my diet if inherited should be good. I do have an healthy diet, no package, fast food, processed food, all fresh , no alcohol and never smoked just like them, but they still had diabetes and non of us is/was overweight. Diet may help but I think genetics takes precedence.
Thx so much for sharing with all of us your work and your down->top view. By the way... could you consider to do some videos about more "popular" supplements on "cancer" scenarios? ... yes .. I know... it´s a complex scenario to dive on, but... it coud be so interesting to see that under your "analitic" point of view.
@@Physionic I´m pretty sure that there will be a lot of people thrilled to watch that... A realistic (not necessarily good or bad) point of view is always necessary. Thank you... once again.
It would be great to understand the implications of the different forms in which curcumin is available (Meriva, Long Vida, Novasol, or basic molecule plus pepper) which all have different levels of absorption. Is more absorption always good? Or is there an optimum after which there are diminishing returns?
Wow very interesting information. I read that IL-6 is (for a big part) responsible for the feeling of fatigue while having for example the flu. Should turmeric/curcumin therefore help for people with CFS ? Very curious, thanks an best to you from the Netherlands…
Cumulative study of 17 cur cumin studies--each courtesy of the Indian Curcumin Growers Assn--concludes that curcumin has health benefits despite none of it being absorbed.
It's very good when you are hangover, uhm...a friend told me that, i know alcohol is bad for you. Do you know what the normal dose should be and if more is better?
If you take pills, it depends on the formula, as some are more absorbable than others. Generally speaking, you're looking at one or two capsules per day.
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You are definitely the best nutritional podcaster I have encountered so far.
He sounds very confident and convincing to a layperson, but he doesn't actually know what he's talking about on most things, and doesn't really understand how to read study literature.
I take curcumin supplements regularly to lower my inflammation. I have ankylosing spondilitis, so I get flare ups often. It really helps a lot and I have managed to keep my autoimmune disease under control without biologics. Just using supplements, anti inflammatory diet (avoiding sugar and other triggers) and exercise. Thanks for this video. Im a big fan of your work. Thank you!
Would you mind sharing your supplement stack for helping with AS and inflammation?
I hadn't realized that curcumin helps with blood sugar issues. It would be interesting to learn if its anti-inflammatory properties are truly helpful for cardiac concerns.
Curcumin also has anti-carcinogen and anti inflammatory properties for musculature and tendons as well, these are the subjects of several studies.
As someone with multiple inflammatory conditions (fibre, EDS, arthritis) this is what I am interested in when it comes to curcumin.
@@Maazzzo if you change your diet you can overcome arthritis and inflammation.
@@mindfulmomentswithColmYes, definitely. Lots of vegetables and the occasional bit of fruit will do a lot for you to reduce inflammation and many other aspects of the Mediterranean diet will help you greatly. For one thing, stay away from processed food as much as you can and avoid alcohol as well.
If you’re such an expert, start your own TH-cam channel instead of poaching others.
My athlete son swears by turmeric during multiple-day tournaments. Helps with muscle recovery.
And boy do you sleep like a baby when you take it.
I read this at first as Circumcision: Some should use it, some should not!"
Garry Small ( UCLA, I think,) did a trial to measure the benefits of Theracurmin, a nanoparticle form of curcumin. It was relatively successful in reducing cognitive decline. Granted it was as a small study, but it has found its way into AD prevention protocols.
I've never heard of "inflammation genes", that seems interesting. For what it's worth, I've noticed turmeric supplements seem to settle my ibs symptoms, but never did enough experimentation to know for sure. This video doesn't exactly explain that, but I was told I have pre-diabetes around the same time that my ibs symptoms started kicking up...maybe some sort of pancreas/liver/insulin/sugar connection? Really don't know, I just take shots in the dark until I find things that work but videos like these help inspire me and give me ideas on what things to try more or less of. Gonna go back and do more experiments with turmeric now. Ty!
I suffer from myalgic encephalomyelitis (ME) - a multi-system autoimmune disease. Among the many physical malfunctions ME encompass, neuroinflammation is one of them.
I experience great improvement by taking 1 teaspoon of curcumin mixed with a teaspoon of freshly grined pepper, and a teaspoon olive oil - all disolved in juice, tea, coffee, or yoghurt naturel. Curcumin does NOT taste good, but it certainly helps on my headaches, fatigue, and cognitive problems.
Thanks for a great science channel ❤🙏❤
take the curcumin pills I have talked about, just read my comments :)
My doctor recommended curcumin to help with some medication side effects.
I have suffered with migraine since late childhood, although it could be weeks between attacks, they tended to be in clusters leaving me low for a few days without early use of my medication for whenever I had an attack.
After taking curcumin with success for many months, I noticed that my migraine medication (which I carried in my wallet) was out of date. I then couldn't remember when I last had an attack. I have now been free from debilitating migraines for over a decade.
Interestingly, the only other period that I was migraine free was while I was on steroid treatment, so I am suspecting that my migraine was, to a degree, related to inflammation.
Dr. Stanfield actually does recommend for people with osteoarthritis. Lucky me, I have that and t2d...
Good morning Nic, I love your videos! They are very informative, and so easy to understand. Keep up the good work!
Thank you, Joy. :)
@@Physionic Late I know...Does Curcumin and Peperine good for the Liver or reduce inflammation of liver?
Hello again. I had been taking osteo biflex (Glucosamine/Chondroitin) for joint pain (side note: our yellow had unbelievable help when we gave it to her). However, my finger joints started to give me some pain (guitar player, not good). My primary physician (from India) suggested Curcumin. I got some and in a very short amount of time ... no more finger joint pain. I've been taking for several years now ... still no finger joint pain. Btw ... "Normal blood sugar numbers" before starting curcumin. Started Low Carb/Mediterranean ... really good blood sugar number (checking fasting insulin and A1c in addition to the standard fasting glucose number).
Whats the curcumin dose you take? I have ankylosing spondylitis and want to try this
Just LOVE ALL your stuff Nic! you are my favorite "physionic" YT channel! You present in an intelligent, concise and digestable (pun intended) fashion and are never pretentious! You sir, are a genuine teacher and seeker of the truth! I've been a subscriber for some months and look forward to all your new content! Thanks and Kudos "professor!"
Thanks so much, Marco!
I was pre diabetic prior to starting Carnivore (actually Lion “diet”…hate that word, really it’s a lifestyle). It’s been 2.5 months no longer pre diabetic. My CRP is low, but I would like it lower. I already have plenty Curcumin in a powder form with absorption agent, so I will start it again.
I’m a chronic pain suffer, so anything to keep my inflammation low is a good thing.
Apart from not being prediabetic I no longer have high blood pressure, sleep apnea.
Love your videos. I’m a new Sub.
Thanks for sharing!
Excellent videos. Extremely informative, pleasantly explained, you've found your calling son.
Thanks, SB. I’ve seen a few of your comments around. Thanks for watching.
Guys, dont forget to check your lead levels using hair mineral analysis ( i think the name is metalogram). Currently Im treating lead in my body since it was the main responsible for my kidneys stones and the fact I took turmeric powder for years contributed for this I believe
My vendor for such a test allows to use finger and toe nails too. I have heard, that a hair analysis can be affected by hair conditioners, shampoo etc. So could taking nails be better?
How do you treat your lead level?
@@thomasmuller1850 There are some easy procedures to do in order to perform such tests like use neutral shampoos for some time before taking the hair samples. I used Dmsa following the schedule of Acc protocol to remove lead. Im not producing anymore the kidney stones after the treatment. I had to take magnesium with every meal in order to avoid them before
I wonder if curcumin extract has the same lead contamination problem as the 1:1 root powder.
Nic- your channel and insights are incredible. Forever grateful. I could literally sit and watch all your videos all day long. Perhaps I am a nerd, too? Thanks man!
Just discovered your channel, been binge watching. Fantastic content thank you
Nice video. I think we need to start acknowledging though an inconvenient gap between what the studies say and what happens in clinical practice.
Curcumin is often touted as this magic anti-inflammatory, and yet we still have people with autoimmune diseases having to go through strong immunosupressants.
As an alternative therapy, I'd be much more interested in seeing the mechanism of Low Dose Naltrexone (LDN) than Curcumin, which has been gaining a lot of traction, in special now with the Long Covid RCTs. In general, people that seek LDN prescriptions have already tried things like Curcumin and other supposedly anti-inflammatory supplements. This leads me to believe that Curcumin is great in paper, but not so much in practice.
It doesn't work on any illnesses that people anecdotally claim to have helped them. I've tried using it for arthritis and heart disease for many months with no improvement.
It has helped with my IBS tremendously and I take 20,000mg capsules twice a day. Though from experimentation even 10,000 2x a day would be sufficient. I like the extra protection it offers to my gut pain.
Hope you do another video on curcumin as a painkiller / cox-2 inhibitor
I routinely test on the high side of normal for fasting blood sugar (95-105 typically). Type II diabetes runs in my family. I get a lot of exercise and my blood sugar hasn't gotten any worse in five years. Nonetheless, I still am mildly concerned. So I did some checking on curcumin. What I've found is that I can routinely see my morning fasting glucose drop by about 10 mg/dL about an hour after taking curcumin and some black pepper. Yes, I just grind some up fresh and take it with the pill. An hour later, my glucose will be about 10 units lower. I've also tested an hour later multiple times with no curcumin and see no similar pattern of blood sugar dropping. There has been, however, one exception out of about 7 tests so far where my blood sugar did not drop after taking curcumin.
Given that Metformin has real side effects (maybe reduces some of the beneficial effects of exercise and inhibit skeletal muscle gains) I'd like to avoid the medication. So maybe @Physionic is on the right track. This may very well be a good supplement for borderline/borderline people like myself.
Thanks for sharing!
I just started curcumin since studies have shown it can help with inflammation and muscle recovery. I will know soon weather that works on me or not. Dr Stanfield is more interested in life extension, not muscle recovery. It's nice to know curcumin can also help with blood sugar.
I don't really bother with supplements. I simply add generous amounts of real turmeric and pepper to my foods - usually steamed veggies or ground beef.
Excellent, informative presentation! As for the argument for not needing to take Curcumin, I simply ask, is there such a person living on this planet? The world in general, is moving towards less and less healthy eating....so I think wisdom would suggest that, yes, everyone should consider supplementing with Curcumin.
This is very cool indeed . i am a big advocate for turmeric supplementing , i discovered the benefits in fast recovery form colds and any infections, then started researching the anti-inflammatory properties , didn't look into blood sugar effects for some reason it was always being dismissed by Drs :) I wander why 😇. Thank you for sharing .
Thanks a lot for this very interesting free review ! Great video in a smart format 😊
I really enjoy your information and your helpful way of presenting including your wit, quite refreshing!
Thank you for all your efforts sir!!!
Great video!
Do you recommend supplementing, or just eating a bunch of spice? Add fat for increased absorption?
IBS sufferer here. Hands down the best natural remedy I came across in my journey towards health is curcumin. I have been taking 20,000mg twice a day for the last 3-4 years and I can safely say, that it has no adverse effects (not that I am aware at least) and it has definitely helped with my gut inflammation issues. Thank God I came across this substance a few years ago because aging does not help with IBS (not to mention other auto-immune disorders).
Which formulation are you taking now?
@@KiIlAllMen The same. I have also found butyric acid to be very helpful as well. So curcumin and butyric acid are the best out there (for my type of IBS at least).
40 grams a day ???
@@joelsombroek it is the chemical equivalent, it is only 2 pills per day every 12 hours, with both having enough curcumin corresponding to 40 grams of turmeric. I've been doing this successfully for 6-7 years at least. So any concern anyone raises about a potential toxicity of this natural remedy, I would simply disregard it or take it with a big pinch of salt. This substance is truly the most potent non-chemical non-drug anti-inflammatory I have known, the next best is Mesulid, but that is a proper drug which I take in special/difficult circumstances regarding my IBS flare-ups. BTW, after so many years with this problem I find that the biggest culprit is not carbs, not sugar but definitely crappy oils like rancid vegetable oils (sunflower, safflower, canola, etc) and especially palm oil. Palm oil is hands down the most pro inflammatory vegetable oil out there and the food industry has it literally on every piece of junk processed food out there. People read the labels!
Thanks for the information you present.
Thank you!
How cool (and informative) is this video? Wow, kudos. Great explanation of how curcumen works
The reason I'm personally steering clear of Curcumin as a supplement is that it inhibits P-glycoprotein activity. The same reason applies to piperine, quercetin, and vitamin K2.
What does this mean in lay terms? I tried to find the answer but didn’t exactly get a sufficient answer. Interested…
This paper appears to suggest that P-Glycoprotein is a cause of cancer Multidrug resistance. www.ncbi.nlm.nih.gov/pmc/articles/PMC5198046/#:~:text=Curcumin%20as%20Modulator%20of%20P,models%20%5B21%2C33%5D.
@@xXxXxCGPBxXxXx P-gp protects the body from harmful substances by pulling it from the liver and kidneys into the urine and bile. It also helps maintain the blood-brain barrier. Since P-gp molecules are present in many organs like BBB, kidney proximal tubule, and bile ductule, their inhibition can potentially improve not only the absorption, but also the distribution, metabolism, and elimination of their substrates. this is google search so I can't translate. Looks like it has potential positive and negative effects.
Hindus who have been traditionally non-meat-eaters, have used turmeric dietarily in their daily curries and counteracted the diabetes their more carbaceous diets otherwise would have produced.
They also got plenty of MK7 (K2’s calcium-directing form) from their many fermented pickle varieties🎉
I doubt many turned down curry or chutney because of P-glycoprotein worries.
Vitamin K2? So Eggs?
If you're already healthy, then have turmeric in food as a prophylactic. There's a favorite Filipino dish of mine called potchero that doesn't usually contain turmeric, but my wife accidentally added some turmeric root to it and it was fantastic.
Apart from NFkB, curcumin also suppresses microglial and glutamate excitotoxixcity, very relevant in chronic pain.
I had years lasting inflammations as result from heavy bruxism. Once in a while I had to use antibiotics, the inflammations lasted at least 20 years. Until the moments I started pressing my own 1000mg caps Kurkuma+pepper in 10:1..20:1 ratio, used 3000mg daily for half a year or so, in just 1 week the inflammations were gone and never returned.
My dentist could not understand why it worked but it DID
Eagerly looking forward to your carnivore eval video to drop 🔥
I started taking Curcumin 5 years ago. I was having problems with short term memory and a young man I knew said that his dad, who was the head of psychiatry at a big university hospital, was involved in a study of curcumin for short term memory that was showing good results. I started taking it and within 2 weeks my short term memory was noticeably better and still is. I'm not going to talk about the effect on my erections so - don't ask.
All participants were instructed to take three capsules with blinded labels of either curcumin or placebo twice a day (total of six capsules per day) for 9 months continuously. Each curcumin capsule has curcuminoid content of 250 mg.
Thanks! I guess as a type 1 diabetic I should keep taking my tumeric supplements. Is it important to take it with pepper? I remember that you mentioned in another video that pipian (not sure if that’s the right term) from pepper increases the absorption of curcumin substantially.
Yes, Peter - good memory!
Yep! But along with “piperine”which makes many substances (including my anti-seizure med carbamazepine) more bioavailable, fats help too. That’s why a warm & definitely fatty peppered “golden milk” is so powerful💪
(For Keto I make it with Milkadamia, MCT, pepper, turmeric, ginger, Ceylon cinnamon & cardamom, usually sweetened with Allulose. Yum! Coconut milk would work very well too, but has higher carbs to count.)
I'd love to see a study on people who had pre-diabetic levels of blood sugar who also took a reasonable amount of berberine. It seems that if the effects were additive, then the combination could extend a lot of lives. High A1C levels are directly related to CVD complications such as heart attacks, strokes, and CHF
Thank you. Always appreciate your research based info.
I'm considering doing an extended water fast. I'm first going to go speak with my doctor & start documenting and posting about the results & how I feel. It would be great to watch videos you make on how things progress for me. The extra layer of accountability from another TH-cam would definitely aid in motivation!
I think non-scientist “nutritional science guru” Tom DeLauer covers a study showing curcumin powerfully instigating early autophagy.💪
Did you see the 31st July video on water fasting?
Good luck (maybe you have already done it by now).
Your doctor will crap on the idea, guaranteed.
So happy to have found your You tubeI I liked and hit the bell,I was happy to hear about your info on curcumin
My husband paid no mind to my efforts to manage my insulin resistance until his arthritic thumbs were killing him and I suggested he try it. He seemed sheepish as he acknowledged it worked
I hurt my back years ago due to a herniated disc and I am currently going through a flare-up. I am doing a number of things to get better, but I've been taking a curcumin (with piperine!) supplement daily to reduce inflammation in my sciatic nerve. I don't think it has made a dent in pain levels, but I'll continue going through the whole bottle in case the anti-inflammatory effects compound and help me get back to a pain-free state quicker. Diabetes also runs in my family though, so as I get older, I'll definitely keep a close eye on this one. Hopefully by the time I'm getting into late middle age these supplements are cheaper!
Thanks but you could also mention the interaction with warfarin ('some should not' or only in moderation).
You are awesome thanks so much
If curcumin increases insulin sensitivity then it should reduce C peptide meaning less stress from insulin production and possibly weight loss and reducing the risk of diabetes further in so-called healthy people. In other words, consider the impact of curcumin on the HOMA IR score before you conclude that healthy people see no benefit.
Can you get the effect by taking powdered curcumin or is it better to take it fresh?
Im not pre diabetic and decently healthy, and i can get 90 caps (3 months worth) of curcumin for about 7-8 dollars. Just for the reduction of inflammation it seems like a good deal
If it prevents the diabetes we are ALL being pushed towards, it is the very best investment!
I believe curcumin is a substance that deserves further investigation. Online there are several studies attesting to its benefits for relieving arthritis symptoms, going so far as to equate its results with the use of nonsteroidal anti-inflammatory drugs.
For example, my wife started taking curcumin 3 months ago and her pains have reduced considerably.
Unfortunately, there is not much money to do research on curcumin, I'm afraid the patents have expired.... 😅😅
Thank you for your science education work.
I am still trying to wrap my head around what inflammation is at the cellular and molecular level. My solid idea for inflammation is still "i banged a part of my body somewhere" or "certain of my glands are infected" and some parts of body is swollen beyond normal.
It also stimulates glucose transporters in beta cells forcing increased secretion of insulin, the kind noted in sulphonylureas. Damaging to the beta cells.
This is one of THE best scientific breakdown / bio hacking channels out there imho.
You didn’t mention if those pre-diabetics that had 0% progression to Diabetes also had to take pepper with their curcumin. Since you had another vid on the pepper connection it seemed a huge blind site.
Great video! Now I feel even better taking Curcumin (Turmeric)
great channel, I'm glad I found it. 😎
Thanks, Jake! I didn't see your other comment.
Great video, no hyperbole, many thanks
Thank you, Keith!
Do you worry about the oxalate amount?
Can you maximize muscle growth with 16:8 intermittent fasting? Sorry it's not in line on what you are talking about today
Pat, extended fasting will also waste muscle, though 16:8 is generally too short. Muscle “building” requires weights & higher protein. The intermittent fasting, itself, only protects muscle in comparison to other weight loss methods.
Is there any study comparing cooked tumeric vs. powder vs. supplements?
Great job! 👍🏼
Thank you!
I’ve got ankylosing spondylitis and I want to know why coffee and black tea help alleviate my back pain?
I’ve read about how caffeine is bad and good in various ways, and how some people avoid it. I find it actually helps me, every time I drink it. I’m not sure what’s happening on the cellular level.
I know COX-2, TNF, IL17, IL22 are involved in the inflammation.
I also notice that cherry juice helps. I don’t know what’s going on there. Placebo? Anthyocyanins? No idea.
I take Meloxicam sometimes in the evening if the pain persists, but I prefer a daily coffee in the morning, as the meloxicam has side effects like upset stomach and diarrhoea.
كنت استيقظ لتبول ليلا لكن بعد شرب مشروب الكركم كل ليلة لا استيقظ الا مع الصباح واذان الفجر أنه رائعا حقا
I've been diagnosed with ME/CFS and have been taking Turmeric (with Piperine) to help curb the chronic inflammation that this condition tends to generate.
My question is ... would Turmeric (with Piperine) be as effective as Curcumin - in this particular scenario?
And ... Does Curcumin require Piperine for absorption - as well?
Thanks!
Thank you!
😂😂😂 Love it. Thanks. ❤
Elevated blood sugar is not the problem, persistent elevated blood insulin levels is the problem and so it would be interesting to know how curcumin affects the release of insulin and what is the mechanism.
Much cooler than 900% man my hopes plummeted, wiz guy hay 😅😂
Thanks
Thanks for a very interesting and thought-provoking video. Question: Is curcumin the only beneficial compound in turmeric? In addition to it's anti inflammatory and and anti diabetic properties, I've also read that turmeric has some neuro-protective and anti-cancer ones as well. Is there any truth to this and if so, can they all be attributed to curcumin alone or are there other compounds in turmeric that could be responsible?
It's the main compound, but it's still possible other compounds could also be of benefit. I would probably focus on curcumin, however. I haven't looked into those areas myself, yet, but I can tell you that I've read similar claims in the scientific reviews.
So can you please look into brain inflammation.
Will it help with Multiple Sclerosis?
@Anne 😮 Lately, it seems everyone's brain is inflamed !,
@@dailyoccasions9539 Any healthy anti-inflammatory will help you. But please research how high HORMONE D LEVELS can put MS into remission!!! Other necessary treatments are also combined. There’s an original Brazilian high D protocol & some in the US have been very successful, too (sorry I cannot remember their names, but should come up in a search💔)
Take with black pepper 😊👌
Driving me crazy trying to figure out who this young man reminds me of. Hazard of old age--everybody looks familiar.
Great content.
3brown1blue?
A young Clark Kent
He looks like my nephew. I'm 67 years-old and have this problem as well. Everybody looks familiar.
I suffer from Carpal Tunnel syndrome, and have had it for 3 years now. I was considering consuming a tea that consists of Turmeric & Black Pepper. Since I’ve heard it can heal damaged nerves. Would this be the proper route for healing?
Hey guy how about a show on B1 especially Benphotamine (sp?) and the new products made from garlic that are both fat soluble and water soluble
And what brand of turmeric/ curcumin do you recommend.
The conclusion made me curious. Has there ever been a nutrient/supplement shown to be a good alternative to medication, actually ? I can't think of any whatsoever.
I know I'm not answering your question strictly speaking (like a 1 for 1 swap of curcumin for metformin), but there are examples where meds might be eliminated in lieu of non-phamaceuticals. Exercise has tremendous anti-depressant effects over many drug treatments. Or changing what you eat reversing some metabolic disease when the meds are only managing symptoms. (I'm not against meds, but they aren't the only answer... Though sometimes they may be). I'd rather take turmeric instead of ibuprofen. But if the pain is bad enough, I'll take it or acetaminophen.
So what’s the difference between curcumin and turmeric??
I use it and love it.
I also like
Glucosamine and MSM at 4gms daily which works best for me. What are your thoughts?
Your previous video touched on how curcumin isn't absorbed into the blood stream or is inactivated by the liver. The conclusion of that video was that curcumin needs to be taken with pepperine. Is that combo what was given to the subjects in these studies? Something doesn't match if curcumin isn't absorbed into the blood but it does have an effect on insulin resistance and diabetes.
Yea
You are so funny. And cute. But even more attractive is your presentation of information that you have researched so I don’t have to. Thank you.
Now, how much pepper and what is a protocol I can follow? Please.
I've heard that curcumin is one of PAINS (pan-assay interference compound) and IMPs (invalid metabolic panaceas)...
A 5-10% drop in total blood sugar is a very large percentage drop in the extra blood sugar a diabetic has. Say your fasting blood sugar is 110, meaning you are glucose impaired before you take curcumin. After curcumin, your blood sugar is 100. Congratulations, you are now in the healthy range! Even if you are diabetic at 125, you're 40% closer to a healthy glucose level.
That is massive?
Dank music at the end, btw. Question: Could this inhibit beneficial inflammation?
Great question, and yes, Darren. It can.
But it should still provide antinflammatory and antioxidant benefits for all people correct?
What do you think about turmeric/curcumin causing liver toxicity? I feel like you would have to take an excessive amount to do that. Maybe 10,000 mg plus ?
What about all the other information you said that it does for health benefits besides what you're talking about now?
Do you think pepper and curcumin could be a good treatment for fibromyalgia?
I don't take as a supplement but I do use it quite a bit in cooking, My Dna says I am insulin resistant, but I have no signs of diabetes. My mother and her mother were both diabetics, not due to being over weight, insulin users. Should I take as a supplement, or am I getting sufficient in my diet (BM 20)
Eating patterns are inherited far more than diabetes, itself. Diabetes can take decades to develop from its low D/Insulin Resistance beginnings, so if you eat like they do, turmeric could be a very potent protective!
@@eliseville As they both followed a diabetic diet and were the main cooks then my diet if inherited should be good. I do have an healthy diet, no package, fast food, processed food, all fresh , no alcohol and never smoked just like them, but they still had diabetes and non of us is/was overweight. Diet may help but I think genetics takes precedence.
Thx so much for sharing with all of us your work and your down->top view. By the way... could you consider to do some videos about more "popular" supplements on "cancer" scenarios? ... yes .. I know... it´s a complex scenario to dive on, but... it coud be so interesting to see that under your "analitic" point of view.
I'm thrilled to do it!
@@Physionic I´m pretty sure that there will be a lot of people thrilled to watch that... A realistic (not necessarily good or bad) point of view is always necessary. Thank you... once again.
Can we avoid costs and just take Turmeric with black pepper ?
I eat a lot of spicy foods and turmeric gets thrown in, it would seem incorrect not to do so. I dont think i need any more.
I wonder if there is a synergistic effect of having the curcumin in the wholefood turmeric form rather than isolated curcumin?
Turmeric has multiple constituents. Curcumin gets most of the cred, but I also believe the total complex is more helpful.
It would be great to understand the implications of the different forms in which curcumin is available (Meriva, Long Vida, Novasol, or basic molecule plus pepper) which all have different levels of absorption. Is more absorption always good? Or is there an optimum after which there are diminishing returns?
Wow very interesting information. I read that IL-6 is (for a big part) responsible for the feeling of fatigue while having for example the flu. Should turmeric/curcumin therefore help for people with CFS ? Very curious, thanks an best to you from the Netherlands…
Ive had kidney stones. I know tumeric is high oxilate. Is curcumin suppliment high? I can't find any info.
Does Curcumin have benefits for longevity (regardless of diabetes improvements)?
Cumulative study of 17 cur cumin studies--each courtesy of the Indian Curcumin Growers Assn--concludes that curcumin has health benefits despite none of it being absorbed.
It's very good when you are hangover, uhm...a friend told me that, i know alcohol is bad for you. Do you know what the normal dose should be and if more is better?
Can't remember where but found study saying raw is best, along with black pepper and something fatty like a bit of oil
is it recommended to take pills or better powder with food? and how much intake? thank you
If you take pills, it depends on the formula, as some are more absorbable than others. Generally speaking, you're looking at one or two capsules per day.