Collagen Types, Collagen synthesis, Collagen disorders
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- เผยแพร่เมื่อ 7 ก.พ. 2025
- 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash
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Types of Collagen, Collagen synthesis, Collagen disorders
Collagen is the most common type of fiber found in the ECM. There are at least 25 subtypes (don’t worry, we only need to know about four of those!), which vary in the specific amino acid sequences.
Type I collagen is the most common among the collagen subtypes and makes up 90% of all the collagen in our body! It is found in bone, skin, tendons, ligaments, organ capsules, dermis, and even the dentin and cementum in our teeth. Its key function is to resist tension, which makes sense, right? You want the bones in your body, which are made of type I collagen, to be able to resist tension; otherwise you’d always be getting broken bones.
In this transmission electron micrograph (TEM) image of collagen, we can see that the collagen fibers are very straight and not branched. Their “stripy” appearance is due to a complex, staggered arrangement of smaller molecules called tropocollagen.
Type II collagen fibers are found primarily in hyaline cartilage matrix, but they are also present in the nucleus pulposus of vertebral discs and the vitreous body of the eye. Their primary function is to resist pressure. These fibers are very thin and not easily seen with hematoxylin and eosin (H&E) staining. In the hyaline cartilage in (high magnification), the matrix components-type II collagen fibers and glycosaminoglycans (GAGs)-blend together to give the matrix a smooth, glassy appearance.
Type III collagen fibers are extremely fine and delicate. They form web-like networks that provide structural support inside hematopoietic organs like the bone marrow, spleen, and lymph nodes. They are also called reticulin (or reticular) fibers, derived from the Latin reticulum, meaning network. These fibers are invisible on regular H&E stains-but fortunately, they are argyrophilic (silver-loving), as you can see in this silver stain of hematopoietic tissue.
Ehlers-Danlos syndrome (EDS) is a genetic disorder of connective tissues. Thirteen subtypes have been described. Vascular EDS is due to a genetic defect in transcribing or translating DNA or messenger RNA, respectively, which encodes type III collagen. Signs and symptoms of EDS include thin, easily bruised, fragile skin that can sometimes be excessively “stretchy” as well as hyperflexible joints that may be dislocated. It’s important to diagnose these patients before medical emergencies like rupture of the bowel or large arteries occur; type III collagen fibers surround smooth muscle cells of these tissues.
Type IV collagen forms a meshwork of fibers and is found in the basal lamina of basement membranes. Its function is to support and anchor epithelial cells, as well as to aid filtration and act as a scaffold for cell migration.
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Triple helix formation is after hydroxylation and glycosylation
EDS is so much more than just hypermobility of the joints! Even you stated that EDS effects EVERY type of collagen and collagen is found is EVERY part of the body! Not only is it extremely painful when we do our “party tricks” but every day life is painful as we are prone to constant injuries even without sustaining trauma, like the time I dislocated three ribs from a single sneeze. It also effects every aspect and function of the body from digestion and nutrient absorption, autonomic system functionality (commonly resulting in dysautonomia which a common comorbidity associated with EDS) vascular function, cardiac function, immune system response - or over-response if you also have MCAS as a result, not to mention daily issues such as malnutrition because your jaw dislocates every time you eat, which is painful so you just simply stop eating because you can’t deal with any more additional pain right now.
I have so much more to say but I’m currently in a lot of pain and I’m exhausted which is why this post is so chaotic, but my bottom line is this…. Ehlers-Danlos Syndrome isn’t just stretchy joints. Did you know that at the age of 32 I developed pressure injuries (previously known as ‘bed sores’) on both my heels after being in a hospital bed for LESS than 24 hours?!? That is definitely not normal (I know, I’m a Wound Specialist!) but it happened because having defective collagen doesn’t just result in hyper elastic joints. Please learn more about this condition. It is far more extensive than anyone realises. I am slowly educating people in this area as I teach Wound Management as a specialist (don’t worry, I’m far more articulate when I’m teaching) but there is so much more to it that still needs to be identified and formally recognized and we desperately need medical professionals to actually know and understand the harsh reality of EDS.
A few comorbidities that are very commonly associated with EDS, which I also have that you might like to look into include Postural Orthostatic Tachycardia Syndrome, Mast Cell Activation Syndrome and Raynaud’s Syndrome.
Very amazing lecture sir. Please we need more lectures on biochemistry
best video on collagen
rectify pls lenticonus is not corneal disease , its lens disorder
What a great lecture Sir,very helpful.now my concept clear thanks sir be happy and healthy forever.keep it up sir
Superb lecture sir ;looking forward to hear much more topics
very good, you simplify it 👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻
Mind blowing 😊
You made it supper easy ,i want you in my colg😢
Thank you so much 😀
BEST BEST BEST MAY ALLAH BLESS U ❤
U got a new subscriber ❤😉
Amazing lecture ❤
Glad you liked it
Sir I think LENTICONUS is change in shape of lens but not cornea, that's keratoconus
Yea. Keratoconus is the cornea, Lenticonus is the lens
Sometimes mistakes can happen while speaking....
But the whole lecture was really nice ...😊
Perfect sir 👍
Are these steps in order ?
excellent sir
Thanks and welcome
You are doing God's work.
Highly appreciated
Tysm
Thank you soooooo much sir 😊
Most welcome
Thanks a great video!!
You're welcome!
Usefull sir
Thank u sir ❤❤❤
So nice of you
which book???
I looked for the notes on telegram but can't find them. can you please help me? thank you
Is their any app to see sirs biochem lecture
great video, thank you
Thank u ❤
You're welcome 😊
Good
So nice
Thank you so much for this video Sir ☺️This is my seminar topic...I didn't know what to do...Now I understand very well.❤️❤️❤️💗
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within 1st Minute of upload
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