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- เผยแพร่เมื่อ 30 ก.ย. 2024
- This video is a small part of a larger course, go to big-bio.org to see the full course.
In part 2 of the Inheritance and Linkage Disequilibrium module, Rob describes the concept of linkage disequilibrium (LD) and how it relates to recombination.
I found the explanation of the student about equilibrium really intelligent
My teacher explained it using Mendelian laws of inheritance, stating that unrelated alleles that followed Mendelian Inheritance will be in equilibrium. I.e. they wouldn't be linked. However, disequilibrium (Positive or negative) demonstrates linking. I think it is a similar point of view, and this girl really got it!! Not many people speak up in class like that kudos to her.
linkage disequilibrium is a kind of misnomer and is extant due to its historicity , however simple way to think about it, two snps are in LD when they are co-inherited together. the randomness for eg in Hardy Weinberg principle seems shortchanged here , we see linkage rather than independent outcomes outta randomness ( like 25% each)
Very well explained!!! Now I finally get LD
Excellent video just one question for me, the statistically inept: at 2:59 it is said, "80% this is a T and only a 20% chance this is a C". How was this math computed? Thank you in advance!!
Thank you for your really helpful video!! I still have one question and that is: Does LD mean that certain combinations of gene markers occur together more often than one would expect under Mendel's 3rd Law... or does it mean that certain genes occur together both more often and less often than one would expect under Linkage Equilibrium?
Thank you for uploading these types of videos, I'm studying the subject and I would like to know what references you recommend me for more information.
Based on allele frequency whether we can calculate haplotype frequency??
No. Calculating haplotype frequency requires knowledge of linkage disequilibrium in the population. If you have different linkage patterns in a population a given haplotype may be less frequent or nonexistent.
Just out of curiosity , who are the students you are teaching to I mean are they undergrads or masters?
This video was taught to several undergraduate students with computational backgrounds. In future videos we won't have an audience since it slowed things down.