GDNF and fast walking self-challenge (Parkinson’s Disease)

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  • เผยแพร่เมื่อ 25 ม.ค. 2025

ความคิดเห็น • 37

  • @ElenaManoli-os5kn
    @ElenaManoli-os5kn 2 วันที่ผ่านมา +1

    Hi, David
    From the first minute I saw your video, i saw that you were calmer, with a lot less dyskinrsia.
    My mom walks for 5 days now und she already saw improvement in her left leg.
    ❤❤❤

    • @LifewithParkinsons
      @LifewithParkinsons  2 วันที่ผ่านมา

      Hi Elena, thank you for sharing this positive feedback. Your comment made my day😊😁😃

  • @BlackButterFlyTongue
    @BlackButterFlyTongue 4 หลายเดือนก่อน +2

    A very important presence on TH-cam, excellent content.🌞

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      Thank you for your very kind and encouraging words and for supporting this channel ❤️😃😄😊

  • @jezfish1
    @jezfish1 4 หลายเดือนก่อน +6

    Hi David, great video , thanks. I read somewhere of a study done by pwp getting noticeably better results by 'forced' cycling, ie riding on a tandem bicycle with a non-pwp. The results were very positive. I am not able to find a tandem or a partner to ride with so decided to look for what I thought was the next best thing, a treadmill. I tried it out at a gym first and I enjoyed it. I found a well priced 2nd hand one and I now do fast walking every second day for 30 to 40 minutes. It is stable, I am not dependant on the weather, and I can walk faster on the treadmill for extended periods than I would if I was walking outside. I do between 3 and 4,5km every second day. It definitely helps suppress the PD symptoms, gets the joints moving, gets the heart pumping and lungs working. Cheers Jez

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +4

      Hi Jez, thanks for the memory prompt. I remember reading about forced cycling as well. I found the treadmill good also, especially in the winter. The only negative was that the surface of the treadmill never changed, so certain muscles rarely got used, like you might use while walking around a lake in a park where there are uneven surfaces. 😊😁😀

  • @stevyfire6556
    @stevyfire6556 4 หลายเดือนก่อน +3

    I’m sooo glad you saw the John Pepper video. I too have Parkinson’s (since 2013) and was shocked when watching how it made a lot of sense but that I had never heard of GDNF before. I asked my movement disorder doc and she knew of its benefits but said there had not been success at creating a delivery method that effectively crossed the blood brain barrier. In other words a medical delivery method had not been effectively solved but John Peppers point was that the body itself can create its own excess from the walking that properly gets it where it needs to go without having to replicate it a different way. I’m doing the walking too and also liking the results so far. I like my doc but the docs I find mainly discuss meds and not specifics of exercise as you mention. I truly think there’s something good here and try to share with Parkinson’s friends but many only want to listen to a doc and can’t trust a new idea on a video that may be buried in the vastness of You Tube. Wish you continued success here and happy to discuss more.

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      Hi Stevy, the John Pepper video was amazing, and very welcomes. I have been trying for a while to find that SPECIFIC exercise that benefits PWP's the most. Was excited when I learned fast walking was tied to increased GDNF. At least now there is some proof about a SPECIFIC activity. Thanks for your comment.😊😁😃

  • @IOSARBX
    @IOSARBX 4 หลายเดือนก่อน +2

    Life with Parkinson’s, nice video keep it up

  • @keithmcneil1286
    @keithmcneil1286 4 หลายเดือนก่อน +2

    Thank you. I appreciate your encouraging and informative video. Best wishes.

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      Hi Keith, glad it was helpful! Thank you for supporting the channel.😊😁😀

  • @Recordesk
    @Recordesk 4 หลายเดือนก่อน +2

    Cool! I will check out your blog page and follow along. ;)

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +2

      Thanks Nancy. Just started the blog page yesterday when I woke up and re-wrote the entire episode lol. This is much better, but I need to stop doing that!😊😁😀

  • @elainedrake4309
    @elainedrake4309 4 หลายเดือนก่อน +2

    I look forward to your next post!

  • @dparker3185
    @dparker3185 35 นาทีที่ผ่านมา

    So it took 8years to come off his medication. He makes it seem he was on a whole lot of meds. He was only on selegiline, he stopped l dopa after 3 months as it did nothing for him. He told me no one had been able to reverse their PD as he had. You will find all the people he mentions as having good results are early in the disease process.

  • @stevenrein3118
    @stevenrein3118 4 หลายเดือนก่อน +2

    I heard Emory in Atlanta has had a 12-year program using Argentina Tango to help movement

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน

      If you see the results please let me know 😃😊😀

  • @petergranstrom3699
    @petergranstrom3699 4 หลายเดือนก่อน +2

    It's good to do all sorts of exercise i think. There is something called Interval walking training that is a form of hiit that you can do while you walking. You can look it up, it originated from Japan.

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      Hi Peter, that sounds like the run/walk run/walk etc.. that I did for a while. I will check it out thanks.😊😁😃

  • @rosered9029
    @rosered9029 4 หลายเดือนก่อน +3

    You are notably looking fabulously healthful today!
    Moments are notably unique...and everchangingly unchanging. Sometimes we need to rest, sometimes we need to suckerpunch that punchingbag, and sometimes we need to embrace our sassypant side and shove that ol' bootie in the air an' swing it all around!!❤❤😅😂😊❤❤

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      Thanks Rose, been feeling well lately. There's a time for everything, even feeling good when you have PD. Thanks for the reminder.😁😊😀

  • @JeremyMcdonald
    @JeremyMcdonald 4 หลายเดือนก่อน +2

    Sounds promising!

  • @BlackButterFlyTongue
    @BlackButterFlyTongue 4 หลายเดือนก่อน +3

    Please consider a carnivore diet. ❤

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +2

      Thank you for supporting this channel. I have tried to eat more protein but it keeps interfering with my medication but I am trying 😃😄😊

    • @BlackButterFlyTongue
      @BlackButterFlyTongue 4 หลายเดือนก่อน +3

      @@LifewithParkinsons Excellent to hear. Eliminating all carbohydrates, sugar and seed oils is a start and introducing natural animal fats. High fat and protein to rebuild. You're in my prayers. 🌸

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      @@BlackButterFlyTongue that is exactly what I have done I have eliminated almost all carbs except from fruit and vegetables. Thank you for your prayers. 😄😃😊

  • @GoProGoalieUzi
    @GoProGoalieUzi 4 หลายเดือนก่อน +3

    Hey buddy great job ❤ in
    My opinion any high intensity exercise is good and slows the progression of pd. Number 1: boxing!! High intensity and volume with moving around the heavy bag, and running on the spot while throwing straight punches. Gets the heart pumping as well lifting weights. Walking and running, sure..baby steps until you can push yourself to the maximum. I recommend while “on” you can see sonw of my boxing workout on my channel ❤❤❤❤

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      Thanks GoPro, yes any hi intensity exercise is good to do! Love your videos on your channel and recommend them to everyone!😊😁😀

  • @xcicilyx
    @xcicilyx 4 หลายเดือนก่อน +3

    how fast is "fast"?

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +3

      I love this question. "Fast" is your top speed that you can maintain for 1hr straight.😊😁😀

  • @heikohinrichsen5542
    @heikohinrichsen5542 4 หลายเดือนก่อน +2

    Hallo David, ab welcher Geschwindigkeit und nach welchem Zeitraum fängt der Körper beim Laufen GDNF zu produzieren? Liebe Grüße aus Hamburg

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน

      I am not sure, but here is an observation from one of the studies.
      "Higher intensity exercise (>30 m/min) can increase glial cell line‐derived neurotrophic factor (GDNF) protein content in fast‐twitch myofibers as well as induce changes in the neuromuscular junction (NMJ) morphology. These findings help to inform exercise prescription to preserve the integrity of the neuromuscular system through aging and disease."
      Here are the links to the resources I used:
      John Pepper video - th-cam.com/video/YkCN5COXjbY/w-d-xo.htmlsi=hBEOOeeAkhhTd3wP
      Parkinson's UK Study - www.parkinsons.org.uk/news/gdnf-clinical-trial-offers-hope-restoring-brain-cells-damaged-parkinsons
      www.parkinsons.org.uk/research/research-blog/research-explained/gdnf-and-other-growth-factors
      GDNF rat study - www.ncbi.nlm.nih.gov/pmc/articles/PMC3966253/#:~:text=Higher%20intensity%20exercise%20(%3E30%20m/min)%20can%20increase%20glial,of%20the%20neuromuscular%20system%20through%20aging%20and%20disease.
      www.nature.com/articles/s41582-019-0180-6
      healthunlocked.com/cure-parkinsons/posts/138242010/have-you-tried-fast-walking-yet-if-so-has-it-helped-you
      th-cam.com/video/pfMeAxENq8c/w-d-xo.html
      th-cam.com/video/NGgqr_gu9lc/w-d-xo.html

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน

      Hello, I am not sure. Here is a good observation from one of the studies.
      "
      Higher intensity exercise (>30 m/min) can increase glial cell line‐derived neurotrophic factor (GDNF) protein content in fast‐twitch myofibers as well as induce changes in the neuromuscular junction (NMJ) morphology. These findings help to inform exercise prescription to preserve the integrity of the neuromuscular system through aging and disease."
      Here are links to all of the resources I used.
      John Pepper video - th-cam.com/video/YkCN5COXjbY/w-d-xo.htmlsi=hBEOOeeAkhhTd3wP
      Parkinson's UK Study - www.parkinsons.org.uk/news/gdnf-clinical-trial-offers-hope-restoring-brain-cells-damaged-parkinsons
      www.parkinsons.org.uk/research/research-blog/research-explained/gdnf-and-other-growth-factors
      GDNF rat study - www.ncbi.nlm.nih.gov/pmc/articles/PMC3966253/#:~:text=Higher%20intensity%20exercise%20(%3E30%20m/min)%20can%20increase%20glial,of%20the%20neuromuscular%20system%20through%20aging%20and%20disease.
      www.nature.com/articles/s41582-019-0180-6
      healthunlocked.com/cure-parkinsons/posts/138242010/have-you-tried-fast-walking-yet-if-so-has-it-helped-you
      th-cam.com/video/pfMeAxENq8c/w-d-xo.html
      th-cam.com/video/NGgqr_gu9lc/w-d-xo.html

    • @LifewithParkinsons
      @LifewithParkinsons  4 หลายเดือนก่อน +1

      I am not sure, but here is a good observation from one of the studies.
      "Higher intensity exercise (>30 m/min) can increase glial cell line‐derived neurotrophic factor (GDNF) protein content in fast‐twitch myofibers as well as induce changes in the neuromuscular junction (NMJ) morphology. These findings help to inform exercise prescription to preserve the integrity of the neuromuscular system through aging and disease."
      Please check the video description for all the links to the resources I used.😊😁😀