Thank you Doc for the wonderful lecture. Well, that explains why we as healthcare professionals should not sedate heavily or paralyze these COVID pts. Because when you sedate a vented patient, the blood pressure drops. And the traditional response is give more fluids. And the result is a viscous cycle of sedate, bp drops, then more fluids given and those fluids will go to the lungs. Thus needing more peep and oxygen requirements. As a respiratory therapist, we need to find the happy medium of ventilator settings and some sedation just to keep them comfortable. Thank you.
Thanks so much for taking the time to post this. I have a layman interest in virology which is to say I don't have a medical background but to have viral interaction with body cells explained so clearly is really interesting especially in explaining why fluid in the lungs is generated and the mechanics behind that. I had no idea it was breakdown of the blood vessels and leaking plasma. Thank you, especially as I grew up hearing old folks in my Welsh village speak about fluid on the lungs and too much coughing leading to scaring. Until your post I didn't understand what was behind this.
It is unknown yet. They know there is a strong relationship between thrombosis and inflammation and that those two processes reinforce each other. But that's about it. I will leave you a link of an article of the COVID-19 and haemostasis: a position paper from Italian Society on Thrombosis and Haemostasis (SISET). www.sah.org.ar/pdf/covid-19/083-20_pre-publishing.pdf
Ngl I originally clicked because I thought you were shirtless in the thumbnail and I was intrigued by the thought of chaotic science man, but then I stayed for the engaging and informative presentation and overall I was absolutely not disappointed
Hi Dr. Mike! Thank you, this is the best coronavirus video so far. I’ve been watching your videos for my A&P class, you make it so easy to understand. You helped me a lot 😀
I was waiting for macrophages to come in earlier but the scenario didn’t go as I planned in my head! You’re explaining in such a great way that I remember the joy of studying when I was studying biology in university. Thank you :)
nice information but can you make a concept map of virus that how it links to varioussymptoms , risk factors , diagnosis and treatment please. waiting for this video
Hey! Just wanted to say I was watching your videos when I was reviewing for the licensure exams, and now i’m a registered medical lab scientist! So great to have watched this, as always, so easy to follow 😊
Thank you Doc, I t gave me a good understanding. I really appreciate you having done. I buried so many during the AIDS crisis and feeling like were are in the medical storm of a lifetime once again.
Hey I have a question. During when the Spike proteins of the virus inhibit the ACE2 receptors, what will happen to Angiotensin I? Is it correct they are converted to Angiotensin II by ACE1 receptor. Since ACE1 has more activity it will cause more binding of Angiotensin II to type 1 Angiotensin II receptor and thus creating more pulmonary vascular permeability?
This is excellent information, not too technical for the lay-person (me), and very clearly explained. One thing I've not seen discussed, probably because no one knows, is the infectious dose necessary to start an an infection. My understanding is that different viruses vary widely in that regard. With HIV, for instance, I'm told that a huge dose is necessary, and that with norovirus, as few as a dozen individual viruses can be enough to start an infection and make you sick.
You are correct that viral infection is not a binary thing as a certain threshold has to be met. Data on this virus is not clear yet; however, healthcare practitioners who are exposed more often have been found to have higher viral loads and worse outcomes, but a study out of China found asymptomatic and symptomatic people to have similar viral loads, so overall the the data is not clear on specifics with this virus. Also there are other confounding variables in regards to who becomes symptomatic and who does not, lots questions still left.
Awesome video, been trying to get my head around the whole coronavirus thing and watching this video really helped clear the gaps and understand it so much better. Great explanation cheers!
Thanks Dr. Mike this video was really helpful. One thing that I didn't quite understand is, how does the virus inhibit the anti-inflammatory effects of AT 1-7? Does it use up the ACE2 proteins on the type 2 cells thereby reducing their availability or is their another mechanism I'm not understanding?
Thanks doc! I just lost my step dad to covid on the 17th. It happened very suddenly. He started out delirious with a fever then two days later it went into his lungs and they inserted a ventilator. A day later they took it out and he died immediately. He was also a heavy drinker and had kidney failure and heart failure. We are heartbroken. He was only 61.
![COVID-19 made simple [Pathophysiology and Symptoms]](http://i.ytimg.com/vi/m87EyS8-UmE/mqdefault.jpg)
“When you take a breath in...”
*takes deep breath automatically, oddly proud of my lungs for doing such a great job*
It's all because of grace of God.
@@anonvlogs281 i can’t tell if you’re sarcastic or not
Thank you Doc for the wonderful lecture. Well, that explains why we as healthcare professionals should not sedate heavily or paralyze these COVID pts. Because when you sedate a vented patient, the blood pressure drops. And the traditional response is give more fluids. And the result is a viscous cycle of sedate, bp drops, then more fluids given and those fluids will go to the lungs. Thus needing more peep and oxygen requirements. As a respiratory therapist, we need to find the happy medium of ventilator settings and some sedation just to keep them comfortable. Thank you.
this guy explained it so well. haven't been this interested in a science lesson in a long time
The simpler way you explain the pathophysiology is fantastic. Anybody can understand. Thank you.
Thanks so much for taking the time to post this. I have a layman interest in virology which is to say I don't have a medical background but to have viral interaction with body cells explained so clearly is really interesting especially in explaining why fluid in the lungs is generated and the mechanics behind that. I had no idea it was breakdown of the blood vessels and leaking plasma. Thank you, especially as I grew up hearing old folks in my Welsh village speak about fluid on the lungs and too much coughing leading to scaring. Until your post I didn't understand what was behind this.
One of the best COVID tutorials I've seen!
The only one I’ve seen
Would you be kind enough to review how the virus in its relation to Cytokine Storm causes issues with coagulopathy? Thank you!
It is unknown yet. They know there is a strong relationship between thrombosis and inflammation and that those two processes reinforce each other. But that's about it. I will leave you a link of an article of the COVID-19 and haemostasis: a position paper from Italian Society on Thrombosis and Haemostasis (SISET). www.sah.org.ar/pdf/covid-19/083-20_pre-publishing.pdf
Ngl I originally clicked because I thought you were shirtless in the thumbnail and I was intrigued by the thought of chaotic science man, but then I stayed for the engaging and informative presentation and overall I was absolutely not disappointed
What does your fitness routine look like? You get a gold star for health good sir!
Brilliant!!!
I'm an RRT boning up on ARDS, and this is the most informative video i've found yet!
It would help plenty to have links to research articles in the description or in the comment section, as references or for further reading
sir, that was mind-blowing. tomorrow i have an exam, and this helped me much♥️
I love people like you sharing important information for free
Excellent explanation as usual, but somehow you are very underrated
Needs to have better sound, seems to be a youtube thing.
Adam Webb sound is too low
#agreed
Your accent inhibits your pronunciation rendering misunderstandings of your explanation. Try losing the accent. God bless you and your house.
@@sokmkim5057 Einstein was an extremelly high educated man he never spoke that bad. Listen to Zack he will lead you to better pronunciation.
Hi Dr. Mike! Thank you, this is the best coronavirus video so far. I’ve been watching your videos for my A&P class, you make it so easy to understand. You helped me a lot 😀
Amazing video. The audio could have been louder though😅
Superb presentation... well done
Pathophysiology: I learned a new word.
A Big THANK YOU for making this video, it was asked in my VIVA examination.
saving me minutes before my pathology exam
Thanks Doc Mike.. wonderful lecture..Now I understand the concepts very well..You are a great teacher ☺️👍🏻
amazing video really good explanation but the only thing I could focus on was his biceps and triceps :) XD
you explained it amazingly, thank you so much for all the effort, you are helping a lot of students.
Excellent. Thank you. Clear and concise.
well done doctor💜
Great Information Thanks
Very good, clear explanation.
Thanks a lot, you make it so easy to understand. I don't even know much about medicine.
he's so quirky and cute. like the awkward moment at the start and end where he just smiles lol
Realistically video, thank you so much, Doc
Great teaching!
this is excellent. Great job
Very nice lecture
Brilliant explanation Mike
Thanks for the explanation. Its very helpful.
You may experience difficulties in handling your nursing assignments please check on me for help. musumbujoseph@yahoo.com
Thank you.
Thanks for explaining it the way you did! Great video
You're amazing please make a video about dialysis hemo and peritoneal
I was waiting for macrophages to come in earlier but the scenario didn’t go as I planned in my head! You’re explaining in such a great way that I remember the joy of studying when I was studying biology in university. Thank you :)
Thanks for the video ! Ur a genius for simplifyiing medicine in sucha manner !
wow, your explanation on what surfactant does was really helpful, finally get it now thank you heaps
Awesome description, great understanding about pathophysiology of COVID 19
very thorough !!
Very very informative
Great job dr mike🎉
I really understand the pathogenesis of the virus. Thanks very much.
Great explanation! Thanks from NZ
Oh god , you are amazing 🤩
Keep uploading such lectures
Great lecture! Thank you!
Outstanding presentation!
Thank you. Your video is very helpful and it's also easy to understand.
Thank you so much for your such elaborated video. It helps to clear my concepts.
Amazing expansion 😊
nice information but can you make a concept map of virus that how it links to varioussymptoms , risk factors , diagnosis and treatment please. waiting for this video
Beautifully explained!
Thanx..
Very good
this is sooo good! pls keep making videos 😊
You may experience difficulties in handling your nursing assignments please check on me for help. musumbujoseph@yahoo.com
Thank you.
Great summary!
Very great video ! easily to understand and memorize!
Nice explaination 👍
Hey! Just wanted to say I was watching your videos when I was reviewing for the licensure exams, and now i’m a registered medical lab scientist! So great to have watched this, as always, so easy to follow 😊
Wonderful lecture
Great presentation.
Great explanation. Cheers!
Excellent and very clear Dr
i took good notes and learned more about sars-cov-2 virus.thanks #stayhome #alertnotanxious
Thanks a lot from me in Germany! Very clear information.
Incredible! Thank you for this explanation. You inspired me
Excellent info! Very clear. Well done and thank you.
Very helpful.. Thank you so much!
Thank you Doc, I t gave me a good understanding. I really appreciate you having done. I buried so many during the AIDS crisis and feeling like were are in the medical storm of a lifetime once again.
Amazing explanation. Thank you a lot ❤🙏🏻
Thanku for this.....👏👏👏
Can you do a video on the microvascular thrombotic properties of COVID-19
Thank you very much👍👍👍
Amazing video. Appreciate the time and effort!
Good explanation, thank you.
Nicely explained..thanks
Loved this video - made it all very easy to understand!
Informative indeed.
great info mate...
Hey I have a question. During when the Spike proteins of the virus inhibit the ACE2 receptors, what will happen to Angiotensin I? Is it correct they are converted to Angiotensin II by ACE1 receptor. Since ACE1 has more activity it will cause more binding of Angiotensin II to type 1 Angiotensin II receptor and thus creating more pulmonary vascular permeability?
Nicely explained. but audio shoulde be more loud and clear!🎉
Nicely explained. Thank you.
u are the best,sir
Amazing explanation!!! Thank you Doc. 😆🙌🙌🙌
Thanks sir 😍😍
This is excellent information, not too technical for the lay-person (me), and very clearly explained. One thing I've not seen discussed, probably because no one knows, is the infectious dose necessary to start an an infection. My understanding is that different viruses vary widely in that regard. With HIV, for instance, I'm told that a huge dose is necessary, and that with norovirus, as few as a dozen individual viruses can be enough to start an infection and make you sick.
You are correct that viral infection is not a binary thing as a certain threshold has to be met. Data on this virus is not clear yet; however, healthcare practitioners who are exposed more often have been found to have higher viral loads and worse outcomes, but a study out of China found asymptomatic and symptomatic people to have similar viral loads, so overall the the data is not clear on specifics with this virus. Also there are other confounding variables in regards to who becomes symptomatic and who does not, lots questions still left.
Excellent as usual sir.. I have learned so much from you....
Awesome video, been trying to get my head around the whole coronavirus thing and watching this video really helped clear the gaps and understand it so much better. Great explanation cheers!
Great video
good and clear , easy to understand. thanks
Thank you very much, useful video
Nice presentation
It was very good presentation. Thanks for explaining so nicely. But you didn't explain the fecal oral transmission.
Thanks Dr. Mike this video was really helpful. One thing that I didn't quite understand is, how does the virus inhibit the anti-inflammatory effects of AT 1-7? Does it use up the ACE2 proteins on the type 2 cells thereby reducing their availability or is their another mechanism I'm not understanding?
Thanks doc...great explanations
good work
Thanks doc! I just lost my step dad to covid on the 17th. It happened very suddenly. He started out delirious with a fever then two days later it went into his lungs and they inserted a ventilator. A day later they took it out and he died immediately. He was also a heavy drinker and had kidney failure and heart failure. We are heartbroken. He was only 61.
Please make vedio about bone disorders like cervical spondylitis etc
How would I cite this lecture? Is there a print version that approximates to this lecture?