Imprinting and Uniparental Disomy for the USMLE Step 1

[@telatti]

the best video on uniparental disomy i've found! thank you so much :)

[@physeo-USMLE]

Thanks for the support! We're glad you like it!

[@telatti]

@@physeo-USMLE thank you for helping me learn :)
struggling med student from czech republic

[@physeo-USMLE]

@@telatti You've got this!

[@faiziiiiii]

love you, just in the first 2 minutes you explained what I've been trying to understand for years. I am beyond greatful for this! Thank you again!

[@vineshmanohar2060]

Can’t get any clearer than this. Thank u so much :)

[@physeo-USMLE]

❤😎

[@pawandeepkour544]

Best video on Imprinting and Uniparental disomy I have come across.👌🏼

[@Alexandra-sd4yy]

My colleagues need to know about this channel! Thank you for the beautiful teaching!

[@ashozy1003]

Excellent video which is underrated.. I'm not a native speaker or from US, but sir I loved your video it's very helpful. Thank you !

[@opoppo6413]

the best I found on TH-cam I think

[@saul3965]

Spectacular, Im reading over this for my medical genetics and the book did not make it easier.

[@amiramadhi2074]

Best video on uniparental disomy thank u so much 🌸

[@pallaviguha9354]

Thank you so much! I was having such a hard time understanding uniparental disomy😭!

[@riflemusket]

OK. For proper cytogenetic nomenclature, 15q11 is read as "Fifteen-Q-One-One", not "Fifteen-Q-Eleven". Same with 15q13 -> Fifteen-Q-One-Three.

[@saadsohail9379]

cant thanks enough........ May Allah blessed u

[@batol5361]

You are such a legend. Thank you helped a lot truly! Keep up the good work!🥰

[@workation6663]

thank you so much)))) u helped a lot

[@abijeyarajan2173]

Very clear explanation on imprinting. Thank you 😊

[@sadmanchowdhury9823]

Incredible well explained. God bless you!!

[@DazeOpYT]

In your question about Prader Willi Syndrome, it's also likely that the father underwent a mutation in the imprinting gene which causes the methylation of the paternal PWS-gene and thus the wrong imprinting pattern. Just a side note, your video explains it very well :D

[@chocolatecharley99]

Is everyone's paternal gene silenced because of imprinting in that section of chromosome 15 that causes angelman syndrome? (I'm asking if every typical person has this imprinting for angelman syndrome and vice versa maternally for PWS) I'm getting confused while writing a report

[@DazeOpYT]

@@chocolatecharley99 Not necessarely, there can also be a misstep in the meiotic splicing of the cell which causes the child having to maternal copies.

[@chocolatecharley99]

@@DazeOpYT But the reason these maternal copies don't do anything and causes Prader-willie syndrome is because it is imprinted (silenced) and there is no gene expression, right?

[@chocolatecharley99]

@@DazeOpYT I'm wondering if you and I both have our maternal genes imprinted on PWS on chromosome 15

[@jared394]

Killed it!

[@maryamhani7725]

Nice presentation

[@lotfiadj5896]

much love from algeria

[@mandyads]

5:47 for heterodisomy vs. isodisomy

[@cakuh8900]

in Germany we dont say "good video" we say: "geiles Video Bruder, du bist ein geisteskranker Ehrenmann", and i think thats beautiful.

[@umerkhan7545]

Very nicely done

[@nesrinech3967]

you made it so easy to understand , thanks a lot.

[@juliaaysenurturkozeaston]

Thank you so much 😊

[@divyeshkhatri2538]

Excellent explanation 😋😋😋😋

[@Salopovpaz]

Thank you very much. God bless you 🙏

[@studiesaura]

This is lit 🔥 Thank you so much.

[@ivangrishin8547]

Perfect explanation

[@markmegaly1626]

Awesome Content! Keep it up. Thank you

[@arzofaqiri-aksoy6857]

thanks a lot, best explanation ever

[@crichighlights2612]

Nice explanation bro! Couldn’t understand the concept in other channel videos.✌️

[@namrtasharma335]

best video, appreciate ur work

[@Sparrow6_]

That’s a very good explanation 🤝🤝

[@cubba20]

amazing video

[@revanthsurapaneni6258]

Thank you man!

[@Robertson284]

awesome. thanks a lot

[@faizanshahzad8598]

Awesome vid with a clear explanation, Kudos 2 u :)))

[@azadbharath7444]

In a RFLP related question -boy has symptoms of praderw ,means paternal deletion,means at the time of fertilitzn incompatible trisomy caused by incoming spem,so incoming paternal gene chr deleted,is that so is only possible by maternal disomy by nondisjunction M-1#opt-a???&M-2,means is aspermatogenes view na ,so paternal disomy -un compatible trisomy by incoming maternal ova.

[@mellowdoctor9029]

Boss of the bosses

[@iknowiamwrong.butstill...2073]

amazing

[@drswekcharanjan7481]

Really good

[@muntehakhatun7783]

Thanks👍

[@iw16n17]

thank you so much

[@femidaelettil1002]

Thanks a lot

[@ahlamal-bloshi9656]

THANK YOU

[@ishanisingh862]

Thank you 😊

[@burns1606]

great video!

[@salehFayoumi]

thanks a ton , many many thanks

[@physeo-USMLE]

❤

[@manuelgoncalves9753]

great video

[@ibraheemalma]

beautiful
thank you sir

[@GermanHeul]

Amazing thx 💗

[@jrh1677]

Wow

[@phantasmalphasmidzoo8280]

So if an embryo has a deletion of the pws gene of the male side, can you avoid Prader Willi by demethylating the pws gene on the female side??

[@benjaminazumah9833]

No because unlike histone methylation, DNA (cystine) methylation is almost always irreversible.

[@DoctorKlenk]

4:35 B is just as likely

[@oviyagnanasekaran2756]

How exactly does the cell loose a chromosome during fertilisation?

[@mellowdoctor9029]

❤️

[@jesiraj2448]

It is a clear explanation, but please do not say q eleven instead it is q one- one ...

[@samarthchauhan6289]

what about monosomy rescue? can't this mean PWS can occur following nondisjunction in sperm

[@arnebshaikh]

😍😍👍🏻👍🏻

[@Alexandra-sd4yy]

so is it a problem if it is heterodisomy? the cromosomes are different, one from grandpa and one from grandma, right???

[@zainab_abd3776]

مرحبا
ممكن أعرف اذا كنت بدرس دروس خصوصية لمواد المجموعة الطبية
؟؟؟

[@jenniferjdaidani1397]

THANK YOU

[@rawanaimat2367]

thanks a lot