Mechanisms and Classification of Antibiotics (Antibiotics - Lecture 3)

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  • เผยแพร่เมื่อ 11 ม.ค. 2025

ความคิดเห็น • 160

  • @StrongMed
    @StrongMed  5 ปีที่แล้ว +41

    Errata:
    @9:00 Aminopenicillins are NOT penicillinase-resistant penicillins.
    @15:52 As pointed out by a viewer, there should be a negative sign next to MSSA (at least here in the United States) due to the high rates of penicillinase production in Staph aureus. For example, MSSA is ~20% sensitive to PCN among patients at both Stanford and San Francisco General, which is definitely low enough to be considered inadequate. This may be different in other parts of the world.

    • @Thevince92
      @Thevince92 5 ปีที่แล้ว +1

      Thank You

    • @黃紹閔
      @黃紹閔 3 ปีที่แล้ว

      ps. in 14:40 MSSA is resistant to natural PCN

  • @ysk249
    @ysk249 4 ปีที่แล้ว +20

    I've discovered this video in 2013 during the residency and I still believe this is the best lecture on antibiotics on TH-cam to this date. The picture at 07:50 is very helpful for organizing different classes of antibiotics.

  • @antoniopeixotoii9865
    @antoniopeixotoii9865 5 ปีที่แล้ว +10

    I've never seen such a concise and effective approach to antibiotics, congratulations for your content sir!

  • @chau-kuenchan4730
    @chau-kuenchan4730 9 ปีที่แล้ว +64

    Hi! [I'm referring to 9:00/24:20.] Indeed, Aminopenicillins are NOT referred to as the penicillinase-resistant penicillins. They DO NOT resist beta-lactamases.
    I'm sorry to point it out, but some viewers may get the wrong message, which can be a serious issue. Apart from this, the lecture is good! Concise and clear!

    • @StrongMed
      @StrongMed  9 ปีที่แล้ว +62

      +Chau-kuen Chan Ugh. I can't believe that mistake has been there for almost 3 years... thanks for pointing it out. I've added an annotation correcting it.

  • @N2CAGE
    @N2CAGE 6 ปีที่แล้ว +6

    I’m a pharmacist and your lecture has done a good reversion....,excellent 👏🏼

  • @pattyphelps2188
    @pattyphelps2188 9 ปีที่แล้ว +10

    I am a first year nursing student and this has helped more than you can know thank you so much

  • @allthewaynatural6695
    @allthewaynatural6695 5 ปีที่แล้ว +9

    This is helping me prepare for an interview I have coming up this week as a Supervisor in a Microbiology lab testing CRE INFECTIONS AND N. Gonorrhoeae surveillance project. Thank you for breaking it down in a clear way that is understandable. I found this to be a very helpful video to refer to.

    • @doctor9963
      @doctor9963 4 ปีที่แล้ว

      Carry on... Love from indian doctor

  • @drarpitsaha9697
    @drarpitsaha9697 9 ปีที่แล้ว +5

    I am resident of ICU from India...Sir,ur lectures of antibiotics really helps me lot..i n one word sir, u r awesome...thank u very much...thnx a lot for ur video

  • @genieocay612
    @genieocay612 10 ปีที่แล้ว +3

    You are a very good teacher & doctor. You have exponentially help a lot of people over the world with your very clear and simplified lectures.

  • @lamerebill
    @lamerebill 4 ปีที่แล้ว +3

    Thank you for your lectures and for including photos of the three scientists who won the Nobel Prize for antibiotics here, especially Chain. His kind, averted eyes seem so humble. I am glad he came to UK in 1933 and did not die in the camps like his mother and sister and undoubtedly like so many brilliant minds whose innovations we will never know.

  • @StrongMed
    @StrongMed  12 ปีที่แล้ว +2

    Hari, I'm glad you are enjoying them. Regarding organizing the lectures into systems, do you mean the antibiotic lectures specifically, or all of them? If the former, I'm going to post some more videos in the next couple of days organized by type of pathogen (e.g. gram positives, negatives, anaerobes, etc...), and have a few supplemental lectures at the end of the antibiotic series on high-frequency sites of infection (e.g. lung, skin/soft tissue, GU tract, etc...)

  • @StrongMed
    @StrongMed  12 ปีที่แล้ว +4

    Sounds good. Thanks for the feedback. After more videos get posted, I'll create some playlists for specific organ systems.

  • @FabianRWhite
    @FabianRWhite 5 ปีที่แล้ว +3

    Incredible lecture. Possibly the best one I've seen on antibiotics. Thank you.

  • @maudeisabelle1182
    @maudeisabelle1182 4 ปีที่แล้ว +3

    Thanks so much! This series of lectures is so helpful. I was really looking for a good approach to learn antibiotics and have finally found it!

  • @StrongMed
    @StrongMed  11 ปีที่แล้ว +5

    It's true that beta lactam antibiotics are generally bactericidal. They not only inhibit new cell wall formation, they also trigger autodigestion of previously formed peptidoglycans in the cell wall, which eventually leads to cell lysis. There are a couple of unsual circumstances when they act more bacteriostatic, but these are rare exceptions.

  • @nishatanwar1590
    @nishatanwar1590 6 ปีที่แล้ว

    uitimate lecture ,everything is presented in a concise and crystal clear manner. It is easy to understand and all the important pont is covered without any excess.I give it 5 star.

  • @afarmboy76
    @afarmboy76 11 ปีที่แล้ว +1

    Thanks so much for these amazingly clear & succinct vids! I'm in the PA program at Stanford right now and can't thank you enough... really.

  • @c3811273
    @c3811273 7 ปีที่แล้ว +1

    Excellent presentation, well delivered, straight to the point, good voice and enthusiastic. Thank you

  • @joliescoldbeans29
    @joliescoldbeans29 10 ปีที่แล้ว +5

    This was fantastic, thank you for making it.
    Coming to the end of 4th med school year, approaching exams, I've realised that I don't really understand how antibiotics relate to each other, and I therefore have trouble remembering when to use them.
    This was very useful for helping me organise all the names I keep hearing, thank you so much!

    • @StrongMed
      @StrongMed  10 ปีที่แล้ว

      Jolie Miller Glad you found it helpful. Loved the cover of I See Fire!

    • @mauritiandoc2584
      @mauritiandoc2584 6 ปีที่แล้ว

      Omgggggggggggggggg that's THE REASOn why am here

  • @zeezeebo
    @zeezeebo 9 ปีที่แล้ว

    I'm becoming a better nurse by watching your videos. Pl keep uploading them. Thank you!!!

  • @itsLannoh
    @itsLannoh 3 หลายเดือนก่อน +1

    enjoying the lecture 11 years later😆Thanks alot

  • @diveshpatel915
    @diveshpatel915 8 หลายเดือนก่อน +1

    This course is very important for me I appreciate your hard work sir keep it up sir thaku

  • @bn9891
    @bn9891 8 ปีที่แล้ว +1

    Thank you so much for these truly wonderful videos sir. Id really like to appreciate the immense effort you have taken to research and put together this data along with the great slides and animations

  • @okothamsonwokorach9
    @okothamsonwokorach9 4 ปีที่แล้ว

    THANKS for educating the world. Personally I have benefitted a lot.

  • @Testango
    @Testango 6 ปีที่แล้ว +1

    i have no words to express my gratitude for You, Professor Strong!

  • @rahisadik6345
    @rahisadik6345 ปีที่แล้ว +1

    ❤ very concised lecture.. Thanks a lot

  • @jonnyunited
    @jonnyunited 2 ปีที่แล้ว +1

    Thanks!

  • @dvmsharifi
    @dvmsharifi 12 ปีที่แล้ว

    Dear Dr.Drericstrong Thanks a lot from your helpful video you have download it to TH-cam and share it to all that the student can used it. I am A student bacteriology and this kind of video can help me a lot i am from Afghanistan but because in Afghanistan we dont have the master degree i have to continue in Iran so this can help me. thanks

  • @HariKishore87
    @HariKishore87 12 ปีที่แล้ว +1

    i appreciate ur efforts to help the medical students all over the world .......good work ..DrErck.
    it would be more useful if the lectures are system wise organised(like cvs , cns.. etc)

  • @tiffanyhyman5227
    @tiffanyhyman5227 5 ปีที่แล้ว

    Great Video, which helps me in my understanding of Antibiotics.

  • @othoncezar
    @othoncezar 9 ปีที่แล้ว +1

    Thanx for the video, it helped me to present my individual work in the Uni about antibiotics

    • @Rhodah_Musonda
      @Rhodah_Musonda 4 ปีที่แล้ว

      I'm doing my presentation on antibiotics this wednesday,fingures crossed and I'm so glad i came upon this video cause I've been having trouble remembering them all (classes and mechanism of action and what note

  • @LD-tc4jp
    @LD-tc4jp 3 ปีที่แล้ว +1

    thanks for the concise & helpful review!

  • @shashikantreddy9376
    @shashikantreddy9376 3 ปีที่แล้ว +1

    Amazing sir..thank you so much for nice tables

  • @ajeminadouglas6400
    @ajeminadouglas6400 9 ปีที่แล้ว

    This video really helped me to prepare for my microbiology quiz...........thanks alot

  • @بلالغانم-ز6ز
    @بلالغانم-ز6ز 4 ปีที่แล้ว +1

    Thanks broooo i'd liked your style in learning&explication

  • @noornaushu4546
    @noornaushu4546 10 ปีที่แล้ว +1

    so very thankful to you sir. enjoyed watching. please upload more videos of different types of drug classifications like antivirals, anticancer, etc

  • @zkiller67
    @zkiller67 11 ปีที่แล้ว

    Awesome Lecture! I spent time looking for videos and luckily I found this one. Thanks!

  • @StrongMed
    @StrongMed  11 ปีที่แล้ว

    afarmboy76, I'm glad you've found them helpful. It's always great to hear from a fellow member of the Stanford community on here!

  • @pratishsharma
    @pratishsharma 9 ปีที่แล้ว +2

    very nice presentation...thanks for such informative videos.

  • @vishnuviswaroopan3693
    @vishnuviswaroopan3693 4 ปีที่แล้ว +1

    thank you ................incredible teaching

  • @HafizahHoshni
    @HafizahHoshni 5 ปีที่แล้ว +3

    Awesomely informative and perfectly explained! Thank you so much! 😊😊 17/3/2019

  • @brianmi2380
    @brianmi2380 11 ปีที่แล้ว

    Thank you! That helped clear it up very well! Your videos have helped me a lot in my research.

  • @danypetrix
    @danypetrix 11 ปีที่แล้ว

    I love you videos !!!! easy to understand, thorough explanation !!! you made my day :) keep it up!!

  • @StrongMed
    @StrongMed  12 ปีที่แล้ว

    If it's the later, there are a couple of playlists on the main channel (e.g. antibiotics, EKGs, ABGs, cardiac auscultation, etc...). Hopefully, the playlists will seem more robust once I have posted more videos.

  • @D007user
    @D007user 5 ปีที่แล้ว

    Very nice information & It is the best review

  • @lehu8529
    @lehu8529 4 ปีที่แล้ว +1

    22:35 What's the mechanism of synergy when using aminoglycosides in combination with beta-lactams or vancomycin?

  • @alyssachevalier1988
    @alyssachevalier1988 8 ปีที่แล้ว +14

    I am currently watching all of your lectures as part of my FNP coursework. They are excellent and very easy to follow! I am wondering if there is a link to just the powerpoints so I can download those for the useful tables and images. Thank you so much!

    • @StrongMed
      @StrongMed  8 ปีที่แล้ว +1

      th-cam.com/video/iJiUBFsvdtg/w-d-xo.html

  • @ravipandey9215
    @ravipandey9215 5 ปีที่แล้ว

    Thanx sir for your lectures...may god bless you...once again thanx

  • @aymanelsamany9829
    @aymanelsamany9829 12 ปีที่แล้ว

    thanks dr eric , i cant wait ti finish the series

  • @tessatharakan3568
    @tessatharakan3568 9 ปีที่แล้ว

    Superb..clear and concise...It would be very helpful if you have antiviral,antifungal,antiparasitic drug presentations too

    • @StrongMed
      @StrongMed  9 ปีที่แล้ว

      Thanks. An antifungal video is already in the works and hopefully will be posted soon. Antivirals and antiparasitic drugs will be a bit further down the road.

  • @howtomedicalvideos6597
    @howtomedicalvideos6597 3 ปีที่แล้ว +1

    Great video, thank you

  • @rhcorr
    @rhcorr 9 ปีที่แล้ว

    This was actually very good

  • @nemodot
    @nemodot 9 ปีที่แล้ว

    Great review on the main antimicrobials. Thanks a lot.

  • @geoffreykibuga7028
    @geoffreykibuga7028 5 ปีที่แล้ว

    An excellent presentation

  • @clemencetshinga-mabudi4311
    @clemencetshinga-mabudi4311 8 ปีที่แล้ว

    I like the subject I just learned It, this week very good.

  • @shelleyaurand4779
    @shelleyaurand4779 10 ปีที่แล้ว

    This is sooooo extremely helpful! Thank you so much!!!

  • @brianmi2380
    @brianmi2380 11 ปีที่แล้ว +1

    I have other sources saying beta-lactam antibiotics are bactericidal agents. Though they do interfere with cell wall synthesis and inhibit peptidoglycan polymerization, it is said the pressure differential and the weakened cell walls cause the bacteria to explode. So I am confused whether beta-lactam antibiotics are bacteriostatic or bactericidal.

  • @aswanikumar24
    @aswanikumar24 11 ปีที่แล้ว +9

    very useful,,,GOD BLESS U SIR...

  • @AnitaKumari-sc2dc
    @AnitaKumari-sc2dc 7 ปีที่แล้ว

    very comprehensive n useful ...thank u ....

  • @MrTiwarygunda
    @MrTiwarygunda 4 ปีที่แล้ว +1

    Faropenem available in oral form .
    What are its coverage that make it different from rest 3 of the..

  • @mandmaq
    @mandmaq 6 ปีที่แล้ว

    Great lecture. Thanks doc!

  • @HariKishore87
    @HariKishore87 12 ปีที่แล้ว

    thank u for the reply .. a system at one place for example cvs playlist with content of some imp topics like ekg, heart failure,hypertension ...etc i know its not a one day work ...it would take some time to get in to shape as u already said...but i wanted to share my views as Ur subscriber..thank u doc !!

  • @mukeshsuthar5207
    @mukeshsuthar5207 5 ปีที่แล้ว

    Awesome sir great information

  • @nellyhoffman6194
    @nellyhoffman6194 8 ปีที่แล้ว

    Amazing lecture ! God blesss you !

  • @realmedicine9972
    @realmedicine9972 7 ปีที่แล้ว

    Great lecture.find it really helpful .Antibiotic no doubt are miracle and life saving drugs but because we doctor sometime miss used over used and abused them bugs are becoming resistant.i am an antibiotic steward and i hope all of you are too.please upload a lecture on selection of appropriate antibiotic treatment with system based guideline it will be very helpful thanks in antecepation

  • @StrongMed
    @StrongMed  11 ปีที่แล้ว +1

    Thanks! I hope u r enjoying the videos! For the most part, my slides are created in Powerpoint. Simple diagrams/illustrations are drawn right in Powerpoint, while I use Adobe Creative Suite for the most complicated stuff. Slides are exported from Powerpoint as jpgs & imported into Adobe Premiere, where it is synched with narration that I've recorded in Audacity. There are certainly quicker workflows that can produce something superficially similar, but I find this one affords more control.

  • @MAlMahrous
    @MAlMahrous 10 ปีที่แล้ว

    Thank you Eric. very useful talk.

  • @hema11901
    @hema11901 4 ปีที่แล้ว +2

    اللهم علمنا ما ينفعنا وانفعنا بما علمتنا وذدنا علما يا كريم اللهم امين

  • @lilitbabajanyan7783
    @lilitbabajanyan7783 6 ปีที่แล้ว

    Thank you! A very good lecture!

  • @avgjoeyd
    @avgjoeyd 11 ปีที่แล้ว +1

    Thank you! Very helpful presentation.

  • @mutelarsorhougbe4606
    @mutelarsorhougbe4606 11 หลายเดือนก่อน +1

    So good, thank you!

  • @ATNye
    @ATNye 9 ปีที่แล้ว

    Thank you for the great lectures.

  • @xoxobeauty4341
    @xoxobeauty4341 6 ปีที่แล้ว

    Thanks it helped with primary school project

  • @houzhienyong239
    @houzhienyong239 8 ปีที่แล้ว

    Thank you for the wonderful video!

  • @isabellagracacamara8650
    @isabellagracacamara8650 11 ปีที่แล้ว

    Thank you! The video was very helpful!

  • @rajeshghanta99
    @rajeshghanta99 11 ปีที่แล้ว

    I missed this information all these days!!!!!!!!

  • @tariqhassan7306
    @tariqhassan7306 7 ปีที่แล้ว

    This is just fentastic..

  • @mohammedaltamimi4315
    @mohammedaltamimi4315 ปีที่แล้ว +1

    Very Good

  • @KaraManning
    @KaraManning 11 ปีที่แล้ว

    this video is fantastic thank you!

  • @GAURAVKUMAR-mq9vl
    @GAURAVKUMAR-mq9vl 10 ปีที่แล้ว +1

    thanx man. u r just f***in genius. upload more videos nd abt antibiotic resistance

    • @StrongMed
      @StrongMed  10 ปีที่แล้ว

      Thanks for watching and for the feedback! Lecture 9 from this series is all about antibiotic resistance.

  • @victoriaaginova3198
    @victoriaaginova3198 10 ปีที่แล้ว +4

    Dear Eric! I like yours lectures very much. There are very clear and easy. Pictures and tables are great. I'm teacher of medicine microbiology from Russia. What books do you use? I would like to get links, if it possible. Thank you so much for these videos. It's really helpful for me. I would hope to cooperate with you. There are you from?
    With respect,
    Victoria

    • @StrongMed
      @StrongMed  10 ปีที่แล้ว +4

      Victoria, thanks for your feedback. I always love to hear from other educators! One of the reasons I chose to cover antibiotics relatively early in the life of this TH-cam channel is because I was dissatisfied with the options already available that students had to learn the material. Existing textbooks or other videos were either not clinically relevant enough, or were too superficial. The resource for these videos was largely a combination of UpToDate (www.uptodate.com - paid subscription required), primary literature, guidelines from the Infectious Diseases Society of America (www.idsociety.org/IDSA_Practice_Guidelines/) and informal consultation with several ID docs here at Stanford University. I also referred to the Sanford Guide to Antimicrobial Therapy (www.sanfordguide.com/) for organism-specific or disease-specific antibiotic recommendations.

  • @shriswamiramanand
    @shriswamiramanand 10 ปีที่แล้ว

    veyr helpful..thank you.. espcially from 14:30..

  • @Drhazaa
    @Drhazaa 11 ปีที่แล้ว +1

    thank you for this ppt. video

  • @ierax29
    @ierax29 6 ปีที่แล้ว +1

    I'm quite curious to know why a large share of people never mention membrane-disrupting antibiotics, is there any particular reason for this ?

  • @jittu2009
    @jittu2009 12 ปีที่แล้ว

    great work keep it up

  • @rehammahmoud3027
    @rehammahmoud3027 9 ปีที่แล้ว

    very useful video thanks alot

  • @abousetita
    @abousetita 6 ปีที่แล้ว

    Wonderful presentation
    How can l get handout of this lectures?

  • @ВікаСабадош
    @ВікаСабадош 9 หลายเดือนก่อน

    Excuse, but in video you say that cephalosporines do not influence enterococcus, but in Pharm. Encyclopedia we have the contrary...

  • @sunitadantare4443
    @sunitadantare4443 ปีที่แล้ว +8

    Lecture 1and 2,where i will get these?

  • @fairuzastevenson9896
    @fairuzastevenson9896 ปีที่แล้ว +2

    Thank you

  • @icefirexd
    @icefirexd 8 ปีที่แล้ว

    Really helped me a lot

  • @mickhaelagill7691
    @mickhaelagill7691 6 ปีที่แล้ว

    Hi! I'm currently in medical school and I love your video lectures. I just was wondering like an appropriate site you would suggest to do practice questions from. Your suggestion would truly be appreciated.

    • @StrongMed
      @StrongMed  6 ปีที่แล้ว

      I don't know where you are from, but here in the US, most students use a service called USMLE World (a.k.a. "uworld") for practice questions. Unfortunately, it's a subscription service and not cheap.

  • @noornoor440
    @noornoor440 11 ปีที่แล้ว

    Do u use powerpoint program to create ur slides
    They are awesome ^_^

  • @RicardoPerez-vt1sq
    @RicardoPerez-vt1sq 8 ปีที่แล้ว

    Does the glycopeptide antibiotics as the vancomycin enter the group of the inhibitors of the cell wall??

  • @poop6719
    @poop6719 9 ปีที่แล้ว +1

    Thank you ,,really u help me more

  • @claireplymouth3326
    @claireplymouth3326 8 ปีที่แล้ว

    Hi. What's your reference for the generations of Cephalosporins?

  • @snoberfozia2857
    @snoberfozia2857 8 ปีที่แล้ว

    thanks it really helped me

  • @voladripavanreddy2376
    @voladripavanreddy2376 10 ปีที่แล้ว +1

    really good sir

  • @Wowhondor
    @Wowhondor 7 ปีที่แล้ว

    I am confused by aminoglycosides. In my book they are refereed to as bactericidal, yet they are said to inhibit protein synthesis. Can they be both? Also, I was told by my teacher that vancomycins are NOT aminoglycosides even though everywhere I look says that they are. Any idea?

  • @babyytt69
    @babyytt69 12 ปีที่แล้ว

    Good work