Imaging of Pheochromocytoma
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- เผยแพร่เมื่อ 27 พ.ค. 2024
- In this video lecture, we discuss the diagnosis and imaging appearance of pheochromocytoma on ultrasound, CT, MRI, and nuclear medicine studies.
Key points include:
1) Pheochromocytoma is a biochemical diagnosis.
2) Symptoms are variable, and patients may present with headache, palpitations, sweating, hypertension or be asymptomatic.
3) Most cases are sporadic with mean age of presentation in the 40s.
4) Hereditary pheochromocytoma can be seen in the setting of Von Hippel-Lindau disease, multiple endocrine neoplasia (MEN) type II, neurofibromatosis type I, and pheochromocytoma-paraganglioma syndromes associated with succinate dehydrogenase gene mutations.
5) Pheochromocytoma is the “10%” tumor, as approximately 10% are bilateral, extra-adrenal, contain calcification, occur in children, or are malignant.
6) Most pheochromocytomas are solid, but they can also appear as mixed cystic and solid with varying degrees of complexity.
7) The ultrasound appearance is nonspecific, and tumors may contain echogenic hemorrhage or be hypervascular on Doppler imaging.
8) Any mass that enhances to a density greater than 110 HU on an arterial phase CT scan should raise suspicion for pheochromocytoma.
9) On CT, most pheochromocytomas will have noncontrast density greater than 10 HU and absolute washout less than 60%, findings similar to adrenal metastases and adrenocortical carcinoma.
10) However, pheochromocytoma can rarely have noncontrast density less than 10 HU and absolute washout greater than 60%, thus mimicking adrenal adenoma.
11) Studies have shown that pheochromocytoma is not a contraindication to modern nonionic IV contrast media.
12) On MRI, the “light bulb” T2 bright appearance classically associated with pheochromocytoma may or may not be present.
13) If intratumoral hemorrhage is present, pheochromocytomas may show T1 hyperintensity or susceptibility artifact on T1-weighted in-phase images depending on the age of blood.
14) Pheochromocytomas usually do not show signal dropout on T1-weighted opposed-phase images but rarely do and can mimic adrenal adenomas.
15) MIBG scans have nearly 100% specificity for pheochromocytoma and are useful to confirm clinically suspected pheochromocytoma and for detection of metastatic disease.
16) Extra-adrenal pheochromocytomas (paragangliomas) usually occur in abdomen, typically at the organ of Zuckerkandl or in the retroperitoneum.
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All of my residents are required to watch these lectures when rotating through abdomen... Thank you!
That is magnificent to hear! Thank you :)
ONE OF EXCELLENT VIDEO I HAVE SEEN.GREAT PRESENTATION AND TO THE POINT AND CONSOLIDATED
Thank you kindly Ramesh!
This content is top notch. Brilliant. Please do more videos :)
Thank you so much, very kind, and will do!
Another great video
Thanks alot ..great presentation
Glad you liked it!
Excellent teacher
Thank you! 😃
Thanks
Welcome
simply brilliant !!!!!
Wow, thank you shariq shah!
What software do you use to visualize scan in colors?
Great video! Do you have any experience with Ga-68 DOTATATE scan?
Thank you! We've been increasingly using Ga-68 DOTATATE to assess for metastatic pheochromocytoma, as studies have shown it has a higher uptake intensity compared to F-18 FDG (cancerimagingjournal.biomedcentral.com/articles/10.1186/s40644-016-0084-2) and may have improved sensitivity & accuracy compared to both F-18 FDG and I-131 MIGB (www.ncbi.nlm.nih.gov/pmc/articles/PMC4463879/).
@@Radquarters Do you use it also to find primary pheo/para or only for metastatic tumors?
@@kocho4242 Also to localize tumors, but only if a biochemical diagnosis of pheo/para has already been made.
Thanks
You're welcome, and thank you for watching.