As a 50 year old female whose only discovered that I have ADHD, this video is GOLD! Subscribed straight away. Love how you make it so easy to understand.
I’m 60 and have known I have ADHD but haven’t been diagnosed yet. I started on Wellbutrin 4 months ago for depression which has helped with the ADHD a bit but have been curious if Adderall would help even more. This video is very informative, thank you so much.
In my professional experience working with addicts and lived experience, psychiatrists are seeing significant progress and lower rates of relapse by prescribing dexamphetamine/ dextroamphetamine to patients with history of methamphetamine abuse/ addiction because of the similar chemical makeup. Harm reduction works.
levmetamfetamine (the spelling is correct) is the active ingredient in generic inhalers which are still available at Dollar General, Meijer, CVS Pharmacy and Walgreens. Vick's inhalers are now non-medicated. It's levo-methamphetamine, the weaker "left handed" isomer.
The amount of L-meth you’d be exposed to via a nasal inhaler wouldn’t have any effect on you psychologically. It’s just there as a local vasoconstrictor.
Yeah the reaction is just meth driving you wild, I'd punch ciggys and billys to get heart rate up....in addiction just thinking about scoring did the same
l-methamphetamine is barely active as a stimulant. All the activity in that regard is with the dextro isomer. Levomethamphetamine is just there as it is used as a vasoconstrictor the same way that ephedrine isomers are in cold tablets.
My dad had a meth addiction for 20+ years. My mom too. When I was 12 I developed an addiction to amphetamine adderall pills. I didn’t even know what it was or that they were even related until 2 more years in and than finally quitting at 16.
My son was 5 years old when they started giving him those sort of pills I was afraid to take them off of them because I was being watched by CPS because their mother screwed up not cuz I did.. they lived with me a doctor who did not know my son saw him for 1 hour.. well I don't do drugs but one time I know its speed and I went to a Ozzfest I took one of those pills... well on the way we went to my friend's house we were smoking weed and drinking and we got there right before Ozzy came on and I was still so wide awake even after I went home at 3:00 in the morning I still couldn't sleep and they were years old then cuz I took him off of them and I can't even take them ever they are 20 years old I took one a couple summers ago I was awake for a whole day so if it does that to an adult what does it do to your child?? And then later in life Daniel Junior got Adderall back then he started doing crystal meth and I don't think he died from that I think it was the drug dealer but I will never know cuz nobody cared at the Batavia New York Police Department they said they assume he died from drugs.... that's what these drugs can do for your kids and it's not just me my friends kids we're on that kind of medicine and they started going off when they took them off at the age of 18 doing drugs I think it makes you an addict.. I already know I'm an addict but I don't do drugs and when I did the rock it was for one day and I hated myself... and unlike what they tell you it's not exactly wonderful for your sex life either if you're a guy anyway I don't know about women?? If a kid goes in and they're hyperactive or something they get them addicted to this s*** that's where it is f****** garbage excuse my French but I freaking don't like what it did to my son he's gone forever and I hate myself for not being able to save him everyday I called him you got to stop doing that you're going to die and he did.. I have one leg now I called my son Jimmy I said I haven't heard from Daniel can you go check on him while he was dead that's what these drugs can do for you and I'm thinking the Cymbalta to make me happy and the Seroquel to make me sleep and the Vicodin is in helping me either I think cannabis helps me more and gummy bears 50 mg CBD but they don't want you to know it can help people they want you on the f***** up drugs.. I'm 62 years old I drank for 20 years wasted my life away and now I have nothing really and I quit drinking a lot when I was 38 and had children.... well it keeps me from drinking to know I can drink someday but I get in trouble so I Drink Alone just like George Thorogood LOL there's a song I Drink Alone cuz I can only stand to be by myself but the reason I wrote this if it helps anyone it is good...
i can relate to that... be careful out there it's a mad world... idk how old you are now, but that shit leave a trail... it can be hard not to go back in the trail when lost...
its seems that the addition of a methly group to the amphetamine molecule effectively doubles the potency, this is very similar to the what happens with the methylation of morphine to heroin where the addition of the methly group effectively doubles the potency of morphine.
Yep. The Bayer pharmaceutical company used to love adding acetyl groups to stuff. Aspirin is salicylic acid with acetyl groups added. They claimed that this acetyl group made morphine much less addictive, lol
Methamphetamine and amphetamine psychosis is a product of lack of sleep and not due to any inherent properties of the substance. This effect can be seen in patients that deal with insomnia. This should be referred to as sleep deprivation psychosis. The psychosis will subside after regular sleep cycles resume. It takes anywhere from 24 to 72 hours without sleep to start noticing reduced mental function. Cases of insomnia rarely last more than a week but insomnia caused by drug use can go on for weeks or even months with further mental deterioration. People with longer lasting insomnia that is not caused by substance use will also experience similar mental deterioration. There are likely residual effects over time in both cases. This is a case where correlation doesn't equal causation. Failure to acknowledge or study this common link is a disservice to the scientific method.
Decades ago,I took a matched size snort,small amount,went to work 3 days ,ironwork,broke the headboard on my bed with my wife 3 nights,absolute wild man,4th day finally back to normal.
"If I found this video useful"?? Sir I got angry at the end of the video because it was the end and I was enjoying the vivid information you were clarifying
Most people smoke meth, which results in a very rapid onset. Kind of like how crack is more addictive than cocaine, the time to peak blood concentration is what’s responsible for the “rush.”
@@Sniperboy5551 i know its very addictive im glad its not around as much were i live. i instantly liked it smoked a couple of times but im amphetaminefree now thank God
@@carwashadamcooper1538lmao!! THIS is the comment I've been scrolling for ages to find because I said the EXACT same thing!!🤣🤣😂😂😆😆😉😉😳😳👀👀💯💯💀💀🤦♀️🤦♀️👏👏
I have ADHD and they gave me amphetamines. I didn’t realize what it was, they just called it Adderall. So naive as I was, I was shocked when I tested positive on a drug test. As soon as I realized what it was I stopped taking it and have been scared to treat it with Amphetamines. I’m terrified of addiction. I especially saw a quick resistance to Vyvanse which actually worked really well for me at first. I also tried Strattera but had very odd side effects and bupropion I used for a bit but hated the shakiness. Finally decided to live with the ADHD.
I wonder how many of the doctors, chemists or psychiatrists have actually tried both of these drugs. As someone that has taken both on several different occasions, I can tell you that there are no noticeable distinctions between the two highs. They're identical. The only real difference that I may have noticed was that methamphetamine felt a bit dirtier or not as pure as the Adderall or generic brand which was simply labeled as "Amphetamine".
you're not really going to FEEL a difference. most stimulants, still give the "same high" really when it comes down to it. it's like cocaine and meth. they're pretty similar, meth just last much longer and is much cheaper
@@dxxdmxn1010 I disagree. I've done them all including bath salts and I definitely felt differences between them. Although, yes they're all stimulants but they still had slight differences. Crack was a short but powerful rush. Powder cocaine, depending on the quality was shorter acting and less intense. Meth, again depending on purity is intense and LONG lasting but comes with more paranoia and makes the thought of eating nauseating and leaves you feeling very unclean and contaminated. Adderall always gave the same feeling as meth. It took longer to take effect but then it was the same long lasting high that made eating and sleeping impossible. It still left me feeling dirty but maybe the thought of it being "cleaner" was just in my head because I knew it came from a lab rather than some Mexican's bathtub lol
ive done caffine, ritalin, coke, meth, and adderall. basically in my mind ritalin is like super strong caffine or like a shitty coke buzz imo. meth and addy r super simular from what i remember, 2 differences were that meth had more of a rush and horrible psychosis after 8 hours@@dxxdmxn1010
I’ve also taken both on several different occasions and I have to disagree. I do have pretty severe adhd, but I have never experienced a meth level euphoria on adderall.
I've been on adderall since I was 11, this medication helps me so much in my everyday life. I got with someone who liked to abuse it then I made the bad choice if abusing it too. Long story short I've healed and I'm no longer taking them the wrong way anymore. One thing that helped me heal was getting put on presidone. When I was on it for 2 weeks I didn't feel the need to take my adhd medicine like that. It was the reset my body needed. Sharing this info to hopefully help someone else who's struggling to fix their nasal route problem. Also I'm sure there's some some doctors and psychologist on here that read this feed. Please look into this. Maybe it could help others scared to speak up, but want to make the change. ❤
Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
Yes, dr.sporessss I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
Thank you for an exellent video with facts nonstop! Recently a friend and I was discussing how weird it is that MDMA, that is made from Methamphetamine is so risky in Serotonin depleation. I didn't know Methamphetamine itself was like that. But what is it that makes it this way compared to Amphetamine? Is it that S-Amphetamine that is responsible for this too? How? I didn't know there were Isomers and different types of these Amphetamines earlier. I only knew that about Ketamin. Does most subtances have this? I just discovered your channel and will look through your videos. Looking forward to future videos!
@@sn1000k Whoa! Hold on a second! You’re saying the stories my grandfather told about him being so old, he had to ride a dragon to sorcerer’s school are untrue…?!?
Would appreciate more information on the effects of amphetamines on the cardiovascular & pulmonary system. I mean, interesting to learn about the chemical differences between meth and say Adderall, but I think most YT viewers aren’t methamphetamine addicts. More like ADHD users of prescribed stimulants who have concerns & questions about their efficacy, safety, dosage, long-term use & use among different age groups.
I’ve done a video on dexamphetamine vs methylphenidate if that helps. Overall they are safe in the correct doses, and when appropriately prescribed. th-cam.com/video/w44BXLATt5w/w-d-xo.htmlsi=eiKCl_txxPWLj-Sq
As a current meth addict, one part of this video stuck out for me, and that was when you said that methamphetamine caused a ~2000% increase in dopamine transmission. Something that users will all talk about that was not mentioned here or in other videos that I have watched is that both for Heroin and Methamphetamine the very first significant dosage of either drug is unlike any other dose that follows. The intensity and duration of the first significant dose *_CANNOT_* be understated or ignored. It is transformative. Much like the graphic you used with the red liquid almost filling up the human body outline (seen @ 2:38), the first use feels like this, but imagine that instead of red liquid, you are being filled with an absolutely euphoric feeling of joy and happiness. Every fiber of your being is just buzzing, and literally looking at your own hand seems amazing beyond belief. Sex is a joke compared to that feeling, and that is how/why most people get hooked as long term addicts. After that high, your thought is that all the other times you use meth will be like that, (because you'd never done it before) but in reality you only feel, at most, 20% of that same degree of high after that first use, no matter how long of a break you take. This used to be called "Chasing the Dragon" ( the dragon being the first dose high), and as old of an idea as it is, it's worth understanding that it is easily one of the most significant factors that causes people to continue usage after a first dose. If my first dose of heroin or meth had felt like my 3rd or 4th use, then I would have had no problem at all in keeping myself from continuing usage, because I've always had a strong sense of self-discipline and self control, but those first doses just break you. Nothing can prepare you for what I can only imagine is decades of built up, reserve dopamine that is just continuously released like a firehose into your system for hours on end.
Brilliant description! In my next video on this topic I will be covering this ‘chasing the dragon’ from a neurobiological perspective. You describe it really well!
I used to do meth, and holy sheet was is absolutely insane the first time I did it. I got a big fat clear crystal in Vegas for my first time, probably came from a superlab in Mexico. It really is unbelievable just how high you get… It’s scary when you’re still out of your mind high after 6 hours, and your buddy tells you that you still have a few more hours to go. 🫥 I have also been clinically diagnosed with ADHD a few times starting at childhood. Real ADHD, where it can be proven by brain scans and neurological mapping. I can tell you as a matter of fact that the two (methyl-amphetamine and the other amphetamine salts in adderall) are definitely different. I can’t take 20mg of adderall without feeling awful, whereas with meth I could smoke a pipe full and be super euphoric. Pisses me off when someone says they’re the same exact thing. Hopefully you can eventually quit the meth though. It’s fun for a bit, but it ain’t helping you make money… I don’t have access to a big portion of my memory now because of it. What a waste of potential…. 😞
One question from a user of... I thought amphetamine.... The time until it's kicking in..... I prefer to put it into coffee.... And I feel the rushing through my venes after some seconds, it take 1-2 minutes to have the full effect (naturally it's pushing a lot more when I m getting in action by having higher pulse rate by working or cycling for example) but the time it's kicking in by only sitting with a coffee is much faster, than in your explanation........ How is this possible, or what substance could be mixed into speed to have such a fast effect from... (At the end of the day is the question.. :.. what the hell is sold to me ....???).. Do you have an idea maybe??? Thank you!!
@@silvertone1 you have a very good point but unfortunately the social climate in the country I live in means nearly all psychosis turns into paranoia and panic
@@silvertone1that's psychosis dude I used to take all kinds of drugs and I took mdma for awhile and heard voices for awhile when my brain would shut down for sleep, it ended up going away after a year or so, was on herion and every other drug for 15 years been clean like 12 years.
Thank you so much that is the most - actually the only - usefully detailed information on adhd medication rather than just the same ol basic gumph. I have found anywhere, being both detailed and clearly explained.
@@PsychiatrySimplified You are not only more than welcome sir - but I was further impressed by your video when you chose to begin your story using the analogy of Levomethamphetamine in OTC products… I think more people should be aware of these fascinating quirks of chemistry, don’t you? ;)
Methamphetamine is almost like a crack cocaine high that lasts 16+ hours and also meth releases slightly more dopamine than crack cocaine but not by much depending on quality of each drug that is. The dopamine comparison is very close but meth would still be more dominant than the crack.
So here we are largely comparing therapeutic doses of orally administered amphetamine sulphate to excessive, recreational, vaporized doses of n-methylamphetamine hcl (enantiomers aside). Is this a fair comparison?
It was a commonly asked question in comments in the other videos. Also- Desoxyn oral Methamphetamine is prescribed in ADHD in US. Note oral amphetamine when misused can also lead to a similar picture albeit the speed of action and levels are not as high.
@@PsychiatrySimplified Apologies if this comment was interpreted as hostile, and props to you for even making mention of these distinctions. The overwhelming majority of available literature regarding (meth)amphetamine toxicity vs therapeutic efficacy is rife with biased narrative, as I'm sure you are aware. But while I understand it is a delicate matter addressing this information to a general audience, I have witnessed far more harm than good come of perpetuating the narrative that adderall=good, meth=bad
@@myristicinman4566 Agree - And no I didn't think of it as rude. It was a fair comment. Adderall misused o inappropriately prescribed can have detrimental consequences as well.
this is an honest description ive abused both.....they really both screwed me up i want so bad to go back to my time and brain before amphetamine and sometimes meth(crystal)
Thank you so much for covering this topic. As someone who was diagnosed only a few years ago with quite significantly severe ADHD, I'm so fed up with the public's comments such as "ADHD meds are basically meth", your factual explanation will help with this stigma and untruth. I can say first hand my ADHD meds DO NOT cause me any type of euphoria, and have solved my insomnia. I take dexamphetamine 3 x per day and am prone to forgetting to take it, so use a timer and pill counter. Name me an "addict" who forgets to take their drug of choice. I hope your video reaches a lot of people.
yet people in the comments spouting bs like they clearly didn't watch a second of it lol. "i snorted 3 adderals a day in high school and i can tell you that adhd drugs are totally meth" 🤦♀️🙄
If anything this video showed that the main differences are dose and routes of administration... If you compared an oral extended release formulation of methamphetamine at an equivalent dose to oral extended release amphetamine, they would likely be very similar. There are of course less studies on meth because it's illegal.
on 4:12 the subtitles say "biophilic" but i think that is supposed to be "lipophillic". Thank you very much for the subtites! English is not my first language and i appreciate it lots!
There are a couple studies that show that clinical levels of Adderall use (20 to 30mg) lead to a loss of dopamine in the corpus striatum and perhaps elsewhere, as much as 50% after as short as 6 weeks of daily use. Is it possible that this level of Adderall causing lasting brain damage? I have actively avoided continuous use of any stimulant because of this kind of risk.
Worst that happens with Methylphenidate is an increase in reuptake transporters. That will probably reverse over time. It's pretty safe in comparison to Adderall I think. Oddly enough, I wonder if meth is safer because it's so much more powerful at low doses prescribed?
@@PsychiatrySimplified mdma and the mesephetamines witch are often mixed with mdma in pills and can kill easyly naïve consummers. And why people should use only pure mdma rather than pills.
Nicely done. Would enjoy one with their "trippy older brothers" 3-4, methylenedioxyamphetamine(MDA) & 3-4, methylenedioxymethamphetamine(MDMA). What a difference an indole ring makes. Clinically, their effects are just this side of miraculous. And here in Oakland, mushrooms🍄 are legal. (Hell, the speed might as well be, almost impossible to catch a drug felony in CA, illegal white powders)😎🤓 The numbers were fascinating.
Amphetamine (as a racemic mix of D and L stereoisomers) is a mainstay of therapy for ADHD, as described in this video and is also essential for treating those suffering from type 1 or type 2 narcolepsy.
So the pharmaceutical Dex amphetamine also contains levo-amphetamine? I thought that this is the street amphetamine mixture. Speed. Which gives a stronger high than just Dextro amphetamine by itself.
@@nievelsteinmusic612 dextro is the only isomer that gives a good high, levo is basically cut, or equivalent to cut or filler material. So 100% dextro is the best, it's what a user would want
Have there been any studies that look at the long term effects from stimulant medications on the cardiac system? Would love to hear your thoughts on if medications like Adderal and Ritalin are harmful from a cardiac perspective when they are taken as prescribed for conditions such as ADHD. As always love the videos.
“Although stimulants can increase systemic blood pressure and heart rate, no significant associations were found between their use and serious cardiovascular events. Concerns regarding QT effects and attendant sudden cardiac death risks deter clinicians from initiating much-needed ADHD medications in patients with heart disease. This overly cautious approach is potentially depriving low-risk individuals from significant benefits associated with timely ADHD drug treatment” - www.frontiersin.org/articles/10.3389/fnins.2022.1020961/full
@user-bt2su4ob7s not anymore now you get a euphoric rush for about 20 minutes then your just wired for 24 hours and uncomfortable. It used to be 24 hours of rolling balls feeling amazing, now Mexicans cook it terribly
THE only side effect known to check your theory would be higher test scores!!!! Not lower, Just remember they do not let you compete in sporting events while on these substances for a reason & we give them to airplane pilots befor letting a single one go into the air ( Military ) , everyone is dosed! It is a functioning performance enhancer reaction times , & ability to remain focused & remember to execute your training in every & all circumstances. Let RAM Function be. I am RAM. I have been on Amphetamines so long since I was a Small Child I feel a thousand years old if a Day & I Am beginning TO MATURE. People Are Too Dream & Live & Love . Children are to Have newness of Life , God is Good . I choose TO serve Becasue THE light inside us I serve is Christ Jesus THE Lord .
Used to love taking Ecstasy in the late 80s early 90s. We’d get into a club, neck a pill. Then snort half a pill. Then chase a quarter. By the time the chase was over, you’d have come up on the nose and same again for the drop. We were having it from the minute the club opened. Great times dancing all night. I miss Rage every Thursday to this day
One of my best friend snored amphetamine for years. The lack of sleep, often for days (infront of the PC), unfortunately unlocked schizophrenia. He started repeating same phrases over and over again.. can't even start work now cause of low self esteem. life ruined
Sharing my own personal experiences here. I do not have ADHD. I do have other mental disorders that were triggered by past drug usage & childhood trauma. My body does not respond well to heavy stimulants. I experienced psychosis with past meth abuse & I've also experienced psychosis & extreme anxiety from Adderall that was prescribed to me. I was misdiagnosed. My body just doesn't like what I would call extreme stimulants. I can handle a few cups of coffee. Beyond 2 cups I have issues.
I like that this guy looks like he hasn’t slept in 3 days, eyes wide as can be, and that haven’t shaved because of been binging on phetamines for the past 3 days… I like it because it means this guy does his homework, and you can trust he knows what he’s saying. 😹
This was an awesome video! The first many times I snorted methamphetamine, it was in combination with drinking lot of alcohol, so it wasn’t really until I tried it without drinking alcohol that I fully experienced what it could do for me… Since then, I’ve taken A LOT of it! It made me calm, far less aggressive, and more capable of being "present", less clumsy, better at conversations, and also at studying. But it also often ended in taking far more I needed to achieve the benefit, so long periods without sleep, long periods where I made a living of selling it and similar substances, also meant I tended to end up at Monday night parties that had started on a Wednesday…. I also used it a lot while I was in the Army, and it’s freaking wild that I never got caught! The few times I’ve been tested, in sports and in the Army, was always when I hadn’t taken any for a while! Two of the tests in the Army I got told they wanted to test me because I seemed more aggressive, easily distracted, had problems staying on topic when talking, had failed some of my responsibilities, made mistakes I didn’t usually make, forgot things more often than usual, would interrupt/speak out of turn also when addressing people above my rank, I had gotten a couple of stupid traffic tickets by the Military Police (and they had noted my behavior was "suspicious"), and at times they felt I seemed almost erratic…. But both times, it was several weeks since I had taken anything. Long after I left the Army and around a year after I had left "the substance use environment" behind, I had an appointment with a Psychiatrist! I had already been diagnosed with PTSD when I left the Army, and Depression shortly after that! But after a few consultations, he picked a book on the shelf, told me to listen carefully and tell me if anything of what he read out loud sounded familiar - and apparently he had a book that was written about me with the title ADHD! This was in the 00's and I was in my 30's - and he started me up on Ritalin and later on he combined it with Strattera. What a difference that made - it made it much easier for me to study and get an education within the health and healthcare sector. But after years on medicine and psychoeducation, which helped a lot on some of my issues, it was like other symptoms got stronger and then I met this woman who knew a lot about ASD in adults and some of her friends had a lot of insight into this as well - and after having been asked a couple of times about how long ago I had been diagnosed with ASD and telling them that I didn’t have ASD, and on both occasions they had just looked confused at me, and one of them had asked me "are you absolutely sure?", and with the other she had just smiled and then said "you’re definitely autist"! So, I once again ended up at a Psychiatrist, for new evaluation! And it turned out that I have ASD as well - so with the BPH (I probably got from taking the Strattera), and various comorbidities, I got more than enough letters to sustain myself on Alphabet Soup in case SHTF! But my last Psychiatrist replaced my Ritalin and Strattera with Attentin, Aduvanz/Elvanse, and Intuniv! I get fairly high doses, but Blood Tests has shown that the biological half-life (or is it the plasma half-life they measure?), is pretty fast - the same goes for the Duloxetin I take as well, so I wonder if it’s due to the same mechanisms - anyone knows anything about that? I also got very high Dosis of Ritalin when I was on that - so maybe I just burn through it faster? Can this be due to the huge amount of methamphetamine I used to take when I was younger? I’m also a big bastard, Scandinavian, the Thor type you see in God of War Ragnarok, but just more blond, can any of these factors play a role in why I need higher doses for it to have the needed effect? Adderall isn’t approved in my country, but I can’t help wonder if the mix of amphetamine salts in Adderall works better than the combination I get from dexamphetamine and lisdexamphetamine - anyone know anything about that?
Thanks for sharing your interesting story. There is evidence that individuals with substance use especially Meth need higher doses of stimulants - this is mainly due to the changes in dopaminergic pathways with previous use. While IR and XR can be combined it’s important to recognise the targets being treated . Of cognition and activity are targets then before increasing doses it’s important to look at sleep and arousal - addressing this becomes important as it allows for the doses of others to remain lower and can be more effective . Something to look at.
I need that video. Only wanted a few months tops and 7 years later I'm slowly weening off myself and down to 4 MG a day since no clinic wants to lose customers
@@DonHitman-gt9cz....the problem is, none of the MAT drugs (methadone, suboxone, XR morphine) are designed to be used short term really. The ideal treatment course is a minimum of 1 year. Less than that, and like 90% of people end up relapsing Because ya okay you could ween the dope out of your system over a couple months...but the physical dependence is only part of the problem. It’s the mental part that is most difficult to overcome. That’s why the treatment is designed to be long term. Your brain has been wired to search for that fix, and often people abuse drugs for years before seeking treatment.....and you think that you can reverse years of addiction in a couple months? Almost never
Another use for amphetamines is DEPRESSION. If used properly under clinical supervision to treat unipolar depression it can be very effective. They used to use amphetamines to treat depression before the advent of antidepressants as we know them today
The molecules shown at 1:49, labelled S-methamphetamine and R-methamphetamine are not mirror images of each other, let alone having any resemblance to actual methamphetamine.
S and R is that the same compared to S/R ketamine? and another question: my adhd meds kind of stopped working over time. How i could get motivation back because im too tired to make some positive changes.... :) Hope you, or someone else with experience can help me with some advice! Greets
Yes isomers - R and S - left and right in Latin. With ADHD meds when this happens - 1. Identify specific symptoms 2. Sleep ? 3. Usually it’s due to stress increase , sleep worsening , anxiety 4. Rule out medical issues / contributors 5. Rule out presence of other psychiatric issues - depression etc 6. Dose adjustment or augmentation or switch etc are other steps
@@PsychiatrySimplified probably lack of sleep... But Thanks for the comments i made a screenshot ;) I think because my eating habits have gotten worse, no daily routine - because i! between jobs, sleeping at random moments just for 1-2 hours at a time. No rouiine, ... This all combined with mind
….. Um, my sister had 14,000 NG/ML of methamphetamine in her system…. & 120 NG/ML of amphetamine. That is what was stated on my sisters toxicology report. My sister is now dead. My understanding is that once in the bloodstream, the amphetamine metabolizes the methamphetmine (? Is that correct Dr?) which causes the ng/ml of methamphetamine in the blood to gradually decrease (?) & the level of amphetamine to increase (?) I may be wrong about this. But since my sister died I’ve even trying to research & learn all I can about toxicity levels - but I’m having the hardest time getting a ballpark estimate (X) of how much meth ingested (via each individual route) is going to metabolize to (X) ng/ml (taking into account things like weight of person, a& things of that nature. But when it comes to this topic - this is where I struggle. actually the one I’m having the most difficulty with. (Reading up on autopsies, police death scene protocols, blood coagulation, etc.) & medical every aspect of her death along with
We have Vick’s inhalers with levmethamphetamine in the us still they just changed the spelling to levmetamfetamin which was somehow enough to fool everyone lol although you can’t use it like dextromethamphetamine so I don’t understand why it ever even mattered
@@Krisjoverovovejovovichtskilevo is not there to make it work better.....it's the active ingredient, levo is a good decongestant. But it's not good for a high.
I've never understood why people say it takes effect within 5 minutes or something because the effects are almost instantaneous when smoked or injected 💉 in my experience
Great video, as always! I have a question: If someone chronically abuses methamphetamine or amphetamine, leading to issues such as cardiomyopathy or blood circulation problems, are these conditions reversible? Some doctors are afraid to prescribe amphetamines; maybe they are afraid of these conditions developing. I'd appreciate your input, Dr.
Abuse at high doses can result in longer term issues - but this depend on the severity. In terms of reversibility I wouldn't be able to give a definitive answer as such cases would be seen in greater portion by a cardiologist who may have a better idea. Amphetamines in therapeutic doses are safe
Oxidative stress sounds like when you overclock a gaming computer, without the right cooling system, you will fry the cpu (the brain). I hope they find how to restore striatal dopamine transporters for people who don’t have other options and have to take this long term medicinally. I take frequent breaks and raw dog life without my medication but I have so many issues for why I do that, i have to get sleep, the skin dryness is an issue so I hydrate extra and drink extra water, something I find very hard to mitigate even doing those things.
Prof Berk explains oxidative stress further in this video. th-cam.com/video/tvel1kOuUO4/w-d-xo.htmlsi=jPBi2L-U3jrtqZDE re reduction of striatal DA transporters - there is evidence even with Methamphetamine of a recovery of striatal DA transporters after abstinence. ( note Adderall is likely to reduce transporters with misuse or incorrect use) see here 👉th-cam.com/video/5H_tw25HVGA/w-d-xo.htmlsi=elKn5H0PFXhQin_e
I knew people who ate the cotton out of Vick's inhales I used to buy bootleg black beauties a 100 at a time only did Methamphetamine once it was a horrible experience haven't done any booze or dope since Aug. 4 1985.
Modafinil no - we have a video on Ritalin vs Dex. Here is an article on modafinil and armodafinil psychscenehub.com/psychinsights/modafinil-and-armodafinil-mechanism-of-action/
Hi! I wouldn’t recommend combining the two. Adderall contains amphetamine salts directly while Vyvanse uses lisdexamfetamine as a “prodrug,” which gets converted into an active form in the body before it has any effects. Adderall will start taking effect faster because it gets metabolized in the stomach. Vyvanse starts taking effect in your intestines. They are both amphetamines. Just different formulations. Vyvanse is typically “smoother” and lasts longer than adderall. I have taken both for adhd. Anyway talk to your doctor. Don’t take both at the same time because are essentially two sides of the same coin. I can’t imagine any doctor advising you to take both at once. Good luck.
@@ChardeeMacdennis339 I get both dexamphetamine and lisdexamphetamine, and I know others who get both as well - it works perfect together! The dexamphetamine acts faster, but also have a faster half-life, the lisdexamphetamine has a more prolonged effect, but it still burns out so to get the best coverage, I get booth in the early morning, around 0530, and at 1200 I get half the dose of Lisdexamphetamine I got in the morning, and around 1430-1500 I get dexamphetamine again, half the dose I got in the morning. I used to get something similar when I was on Ritalin/Ritalin Uno. And I get fairly high doses in the morning, but it helps me wake up and get the day started! If I only got the Lisdexamphetamine, I would have a very hard time getting up in the morning! I often joke about how my Monster Energy Drink and my Pills are my substitute Coffe! (I don’t like coffe, and as a kid I’ve always been told that when I grew up and became an adult I would learn to love it - so Im a "kid" in my mid fifties….)
@@ChardeeMacdennis339It's been almost ten years since I was prescribed Vyvanse so there may have been new research since then, but when Vyvanse first came out, I was prescribed it. I had been taking only Adderall up to that point, but even with the Vyvanse, I still took Adderall to complement it if I felt the vyvanse was wearing off. I had three more doctors continuing the same prescription until 2013 and i never heard any mention of it being a harmful combination.
I’ve used both of these a few dozen times each and at least subjectively, and comparing their D-isomers, they’re more or less identical. Which one is superior really comes down to what time of day it is and when you need to be asleep. You can highlight minute pharmacological differences and make them sound wildly different if you try, but the reality is that they’re two amphetamines with a single-atom structural difference that effects metabolism and bioavailability more than it does any pharmacological effect. They both work the exact same way at the cellular level, and their subjective feelings reflect that. The dopamine release of either drug is dose-dependent. Adderall can release 10x as much dopamine as meth if you compare 60mg to 5mg. At equal doses, meth is maybe 50% more effective at releasing dopamine, depending which paper you look at. Most societally perceived differences between the two boil down to the fact that meth is sold in very pure crystals for $20 a gram whereas amphetamine is sold in low dosed tablets for $10+ for a single pill) America is flooded with fake adderalls pressed with meth and people using these thinking they’re amphetamine generally don’t have any unique consequences as opposed to legitimate adderalls. They generally have no idea.. The newer drug lisdexamphetamine (vyvanse, elvanse) is basically 100% identical to oral meth. The only subjective difference is the longer onset time. Leaving out that part, I could never differentiate them in a blind test. People usually get mad when you try to point out how similar they are because of their own ignorance. They think meth is “bad” so they need their precious pills (that they definitely “need”) to be far away from it. In reality, they’re extremely similar, and the takeaway isn’t that amphetamine is bad; It’s that meth isn’t bad. Amphetamine isn’t “worse” than you thought, methamphetamine is just not as “bad” as you thought. It’s the most inappropriately maligned drug under the sun minus maybe PCP and “bath salts.”
I hate when people who've never done copious amounts of a drug and lived that lifestyle go ralking about drugs as if some book gives any info about the drug in reality.
Many a doctor, family member, and friend have observed their patients or loved one change over time. Weight loss, malnutrition, skin issues, change in sleep patterns, change in focus, lack of concern for health, work, school, relationships, theft, suicidal ideation, argumentation, and much more. It's often better to learn from other people's mistakes, especially when they come with such life-threatening consequences.
@user-oh1of9qx3s yes absolutely. I agree with that for sure. I just meant when people speak on something as if they REALLY know about it and a book just cannot give intricate details about drugs.
Very informative video! But doesn't comparing adderal xr (extended release with what is basically instant release meth give skewed results if your looking at the amount of the drug in ng/l?
Aim was mainly to compare the two substances. You are correct it’s very different as it’s the phasic DA release that is the issue. Also route of administration which was highlighted.
@@PsychiatrySimplified cheers! Also thank you so much for your video on the neurochemistry of dex & methylphenidate! It was invaluable, especially since most other TH-cam vids I've found on that subject are much more simplified. It'd be super fascinating if you ever get the time to cover the rest of the neuron in the same manner! (even if it's not directly related to adhd)
As a 50 year old female whose only discovered that I have ADHD, this video is GOLD! Subscribed straight away.
Love how you make it so easy to understand.
Thank you 🙏🏻
I’m 60 and have known I have ADHD but haven’t been diagnosed yet. I started on Wellbutrin 4 months ago for depression which has helped with the ADHD a bit but have been curious if Adderall would help even more. This video is very informative, thank you so much.
@@djquinn11 good luck with that tripper
@@djquinn11 ... Wellbutrin is Very addictive and ADDERALL is not ... hope that helps ... plus the side effects with Wellbutrin suck.
@@chipsramek3868 whoaaa there bud. amps are demonstrably high risk to most addictive types. jfc the goofballs on the internet just so weird
In my professional experience working with addicts and lived experience, psychiatrists are seeing significant progress and lower rates of relapse by prescribing dexamphetamine/ dextroamphetamine to patients with history of methamphetamine abuse/ addiction because of the similar chemical makeup. Harm reduction works.
Thanks for sharing. Good point
this is so true i learned the hard way
ii hate everything about meth i have tried it maybe 6 times, only one time was it remotely enjoyable -= stay away!
@@substance9x Amphetamines are great performance enhancers. They are for work, not for joy. Although under the influence you may enjoy the work more.
At small doses, they are absolutely the same, no difference whatsoever.
Okay, that explains why in the 70s,using the Vicks inhalers, made me more alert.
We couldn't afford the name brand Vic's we had to use the green mentholatum jar😂
levmetamfetamine (the spelling is correct) is the active ingredient in generic inhalers which are still available at Dollar General, Meijer, CVS Pharmacy and Walgreens. Vick's inhalers are now non-medicated. It's levo-methamphetamine, the weaker "left handed" isomer.
The amount of L-meth you’d be exposed to via a nasal inhaler wouldn’t have any effect on you psychologically. It’s just there as a local vasoconstrictor.
Yeah the reaction is just meth driving you wild, I'd punch ciggys and billys to get heart rate up....in addiction just thinking about scoring did the same
l-methamphetamine is barely active as a stimulant. All the activity in that regard is with the dextro isomer. Levomethamphetamine is just there as it is used as a vasoconstrictor the same way that ephedrine isomers are in cold tablets.
My dad had a meth addiction for 20+ years. My mom too. When I was 12 I developed an addiction to amphetamine adderall pills. I didn’t even know what it was or that they were even related until 2 more years in and than finally quitting at 16.
My son was 5 years old when they started giving him those sort of pills I was afraid to take them off of them because I was being watched by CPS because their mother screwed up not cuz I did.. they lived with me a doctor who did not know my son saw him for 1 hour.. well I don't do drugs but one time I know its speed and I went to a Ozzfest I took one of those pills... well on the way we went to my friend's house we were smoking weed and drinking and we got there right before Ozzy came on and I was still so wide awake even after I went home at 3:00 in the morning I still couldn't sleep and they were years old then cuz I took him off of them and I can't even take them ever they are 20 years old I took one a couple summers ago I was awake for a whole day so if it does that to an adult what does it do to your child?? And then later in life Daniel Junior got Adderall back then he started doing crystal meth and I don't think he died from that I think it was the drug dealer but I will never know cuz nobody cared at the Batavia New York Police Department they said they assume he died from drugs.... that's what these drugs can do for your kids and it's not just me my friends kids we're on that kind of medicine and they started going off when they took them off at the age of 18 doing drugs I think it makes you an addict.. I already know I'm an addict but I don't do drugs and when I did the rock it was for one day and I hated myself... and unlike what they tell you it's not exactly wonderful for your sex life either if you're a guy anyway I don't know about women?? If a kid goes in and they're hyperactive or something they get them addicted to this s*** that's where it is f****** garbage excuse my French but I freaking don't like what it did to my son he's gone forever and I hate myself for not being able to save him everyday I called him you got to stop doing that you're going to die and he did.. I have one leg now I called my son Jimmy I said I haven't heard from Daniel can you go check on him while he was dead that's what these drugs can do for you and I'm thinking the Cymbalta to make me happy and the Seroquel to make me sleep and the Vicodin is in helping me either I think cannabis helps me more and gummy bears 50 mg CBD but they don't want you to know it can help people they want you on the f***** up drugs.. I'm 62 years old I drank for 20 years wasted my life away and now I have nothing really and I quit drinking a lot when I was 38 and had children.... well it keeps me from drinking to know I can drink someday but I get in trouble so I Drink Alone just like George Thorogood LOL there's a song I Drink Alone cuz I can only stand to be by myself but the reason I wrote this if it helps anyone it is good...
i can relate to that... be careful out there it's a mad world... idk how old you are now, but that shit leave a trail...
it can be hard not to go back in the trail when lost...
Nice Try ... Do You work for MOSSAD/CIA/MI6/GIP or the UN ? ADDERALL is NOT Addictive.
@chipsramek3868... yeah ok... by how much sense you make, that gives the idea...
Adderall is not addictive? Bullshit I don't buy that for a second. Anything done in excess for extended period is addictive@@chipsramek3868
its seems that the addition of a methly group to the amphetamine molecule effectively doubles the potency, this is very similar to the what happens with the methylation of morphine to heroin where the addition of the methly group effectively doubles the potency of morphine.
Morphine is acetylated to heroin.
Methyl morphine is codeine which is orders of magnitude weaker than morphine, whereas diacetylmorphine is heroin and approximately 6x stronger.
@@antitheziz717diacetyl-morphine yup!!
Yep. The Bayer pharmaceutical company used to love adding acetyl groups to stuff. Aspirin is salicylic acid with acetyl groups added. They claimed that this acetyl group made morphine much less addictive, lol
It increases the speed across the blood brain barrier
Methamphetamine and amphetamine psychosis is a product of lack of sleep and not due to any inherent properties of the substance. This effect can be seen in patients that deal with insomnia. This should be referred to as sleep deprivation psychosis. The psychosis will subside after regular sleep cycles resume. It takes anywhere from 24 to 72 hours without sleep to start noticing reduced mental function. Cases of insomnia rarely last more than a week but insomnia caused by drug use can go on for weeks or even months with further mental deterioration. People with longer lasting insomnia that is not caused by substance use will also experience similar mental deterioration. There are likely residual effects over time in both cases. This is a case where correlation doesn't equal causation. Failure to acknowledge or study this common link is a disservice to the scientific method.
Decades ago,I took a matched size snort,small amount,went to work 3 days ,ironwork,broke the headboard on my bed with my wife 3 nights,absolute wild man,4th day finally back to normal.
yup, doesnt take alot at first, but after 20 years of use....
You talking about a Benny? Benzadrine inhaler
Lol😅
It was that good dextro rotary speed made by reductive amination of pseudoephedrine with red phosphorous in hydriodic acid. 👌
Meth makes me an animal in the bedroom rivaling John Holmes
"If I found this video useful"?? Sir I got angry at the end of the video because it was the end and I was enjoying the vivid information you were clarifying
Sorry! 😀. We have a range of other videos and more coming up that you should find useful. But can’t guarantee you won’t feel angry at the end ☺️
If snorted, the on set time of both meth and amphetamine are very close to each other if not exactly the same, same goes with intravascular use.
yup its intravenous by the way
Most people smoke meth, which results in a very rapid onset. Kind of like how crack is more addictive than cocaine, the time to peak blood concentration is what’s responsible for the “rush.”
@@Sniperboy5551 i know its very addictive im glad its not around as much were i live. i instantly liked it smoked a couple of times but im amphetaminefree now thank God
Back in the day IV was the ONLY way to for meth or crank.
@@dant.3505 the flash ;)
This just popped up but. Dude. You have the right look for a video of this type
🤣
Yup.
Those eyes say a whole lot!
@@carwashadamcooper1538lmao!! THIS is the comment I've been scrolling for ages to find because I said the EXACT same thing!!🤣🤣😂😂😆😆😉😉😳😳👀👀💯💯💀💀🤦♀️🤦♀️👏👏
The right look.... Just lol because that's obviously the credentials required to make videos, right ?
You can look like that if slam liquid courage all the time as well. It's all lack of sleep
I have ADHD and they gave me amphetamines. I didn’t realize what it was, they just called it Adderall. So naive as I was, I was shocked when I tested positive on a drug test. As soon as I realized what it was I stopped taking it and have been scared to treat it with Amphetamines. I’m terrified of addiction. I especially saw a quick resistance to Vyvanse which actually worked really well for me at first. I also tried Strattera but had very odd side effects and bupropion I used for a bit but hated the shakiness. Finally decided to live with the ADHD.
lol
I wonder how many of the doctors, chemists or psychiatrists have actually tried both of these drugs.
As someone that has taken both on several different occasions, I can tell you that there are no noticeable distinctions between the two highs. They're identical. The only real difference that I may have noticed was that methamphetamine felt a bit dirtier or not as pure as the Adderall or generic brand which was simply labeled as "Amphetamine".
Bullshit. Meth is like a thousand time stronger. Also used both.
you're not really going to FEEL a difference. most stimulants, still give the "same high" really when it comes down to it. it's like cocaine and meth. they're pretty similar, meth just last much longer and is much cheaper
@@dxxdmxn1010 I disagree. I've done them all including bath salts and I definitely felt differences between them. Although, yes they're all stimulants but they still had slight differences. Crack was a short but powerful rush. Powder cocaine, depending on the quality was shorter acting and less intense. Meth, again depending on purity is intense and LONG lasting but comes with more paranoia and makes the thought of eating nauseating and leaves you feeling very unclean and contaminated. Adderall always gave the same feeling as meth. It took longer to take effect but then it was the same long lasting high that made eating and sleeping impossible. It still left me feeling dirty but maybe the thought of it being "cleaner" was just in my head because I knew it came from a lab rather than some Mexican's bathtub lol
ive done caffine, ritalin, coke, meth, and adderall. basically in my mind ritalin is like super strong caffine or like a shitty coke buzz imo. meth and addy r super simular from what i remember, 2 differences were that meth had more of a rush and horrible psychosis after 8 hours@@dxxdmxn1010
I’ve also taken both on several different occasions and I have to disagree. I do have pretty severe adhd, but I have never experienced a meth level euphoria on adderall.
I've been on adderall since I was 11, this medication helps me so much in my everyday life. I got with someone who liked to abuse it then I made the bad choice if abusing it too. Long story short I've healed and I'm no longer taking them the wrong way anymore. One thing that helped me heal was getting put on presidone. When I was on it for 2 weeks I didn't feel the need to take my adhd medicine like that. It was the reset my body needed. Sharing this info to hopefully help someone else who's struggling to fix their nasal route problem. Also I'm sure there's some some doctors and psychologist on here that read this feed. Please look into this. Maybe it could help others scared to speak up, but want to make the change. ❤
Which medication were you put on? Thanks for sharing
@@PsychiatrySimplified Sorry, I misspelled Prednisone.
@@PsychiatrySimplified Prednisone orally Q.D. for 2 weeks.
@@syzygy4365 Prednisone will make you fat, really fat.
youll be braindead soon
Vicks inhalers still contain levomethamphetamine. It’s just labeled as levmetamfetamine.
yep
Yes, but it doesn’t get you high. It just makes you jittery.
@@Sniperboy5551 because its in its purest form
@@sotiify9221 because its in its purest form
- On the contrary, it is pure L-enantiomer, with all R-meth being removed.
A gram of amphetamine, some lsd and a vix stick got a lot of over 40 year olds through many a night of dancing..
Thumbs up'd and subscribed. Your delivery when explaining complex material is perfection. Thank you for this.
Thank you for your feedback 🙏🏼
Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.
Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Australia. Really need!
Yes, dr.sporessss I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
Is he on instagram?
Yes he is. dr.sporessss
Microdosing helped me get out of the pit of my worst depressive episode, a three year long episode, enough to start working on my mental health.
Thank you for an exellent video with facts nonstop! Recently a friend and I was discussing how weird it is that MDMA, that is made from Methamphetamine is so risky in Serotonin depleation. I didn't know Methamphetamine itself was like that. But what is it that makes it this way compared to Amphetamine? Is it that S-Amphetamine that is responsible for this too? How?
I didn't know there were Isomers and different types of these Amphetamines earlier. I only knew that about Ketamin. Does most subtances have this?
I just discovered your channel and will look through your videos. Looking forward to future videos!
Greatly enjoy learning things I did not expect to learn. I’m 54 and now understand why my grandfather always had a tube of Vick’s Inhaler with him.
I don't think Vicks is psychoactive. Benzedrine inhalers were different.
@@sn1000k Whoa! Hold on a second! You’re saying the stories my grandfather told about him being so old, he had to ride a dragon to sorcerer’s school are untrue…?!?
Would appreciate more information on the effects of amphetamines on the cardiovascular & pulmonary system.
I mean, interesting to learn about the chemical differences between meth and say Adderall, but I think most YT viewers aren’t methamphetamine addicts. More like ADHD users of prescribed stimulants who have concerns & questions about their efficacy, safety, dosage, long-term use & use among different age groups.
I’ve done a video on dexamphetamine vs methylphenidate if that helps. Overall they are safe in the correct doses, and when appropriately prescribed. th-cam.com/video/w44BXLATt5w/w-d-xo.htmlsi=eiKCl_txxPWLj-Sq
And we’ve also done a clondine vs Guanfacine video - which provides an understanding of the key aims in ADHD management.
As a current meth addict, one part of this video stuck out for me, and that was when you said that methamphetamine caused a ~2000% increase in dopamine transmission. Something that users will all talk about that was not mentioned here or in other videos that I have watched is that both for Heroin and Methamphetamine the very first significant dosage of either drug is unlike any other dose that follows. The intensity and duration of the first significant dose *_CANNOT_* be understated or ignored. It is transformative. Much like the graphic you used with the red liquid almost filling up the human body outline (seen @ 2:38), the first use feels like this, but imagine that instead of red liquid, you are being filled with an absolutely euphoric feeling of joy and happiness. Every fiber of your being is just buzzing, and literally looking at your own hand seems amazing beyond belief. Sex is a joke compared to that feeling, and that is how/why most people get hooked as long term addicts. After that high, your thought is that all the other times you use meth will be like that, (because you'd never done it before) but in reality you only feel, at most, 20% of that same degree of high after that first use, no matter how long of a break you take. This used to be called "Chasing the Dragon" ( the dragon being the first dose high), and as old of an idea as it is, it's worth understanding that it is easily one of the most significant factors that causes people to continue usage after a first dose. If my first dose of heroin or meth had felt like my 3rd or 4th use, then I would have had no problem at all in keeping myself from continuing usage, because I've always had a strong sense of self-discipline and self control, but those first doses just break you. Nothing can prepare you for what I can only imagine is decades of built up, reserve dopamine that is just continuously released like a firehose into your system for hours on end.
Brilliant description! In my next video on this topic I will be covering this ‘chasing the dragon’ from a neurobiological perspective. You describe it really well!
Very similar thing happened when I first tried high purity Cocaine Hydrochloride.
Were you on meth when you wrote this?
I used to do meth, and holy sheet was is absolutely insane the first time I did it. I got a big fat clear crystal in Vegas for my first time, probably came from a superlab in Mexico. It really is unbelievable just how high you get… It’s scary when you’re still out of your mind high after 6 hours, and your buddy tells you that you still have a few more hours to go. 🫥
I have also been clinically diagnosed with ADHD a few times starting at childhood. Real ADHD, where it can be proven by brain scans and neurological mapping. I can tell you as a matter of fact that the two (methyl-amphetamine and the other amphetamine salts in adderall) are definitely different. I can’t take 20mg of adderall without feeling awful, whereas with meth I could smoke a pipe full and be super euphoric. Pisses me off when someone says they’re the same exact thing.
Hopefully you can eventually quit the meth though. It’s fun for a bit, but it ain’t helping you make money… I don’t have access to a big portion of my memory now because of it. What a waste of potential…. 😞
One question from a user of... I thought amphetamine.... The time until it's kicking in..... I prefer to put it into coffee.... And I feel the rushing through my venes after some seconds, it take 1-2 minutes to have the full effect (naturally it's pushing a lot more when I m getting in action by having higher pulse rate by working or cycling for example) but the time it's kicking in by only sitting with a coffee is much faster, than in your explanation........ How is this possible, or what substance could be mixed into speed to have such a fast effect from... (At the end of the day is the question.. :.. what the hell is sold to me ....???).. Do you have an idea maybe??? Thank you!!
As someone involved with this stuff, psychosis I’ve seen has nearly always been triggered by a lack of sleep.
yep lol got to sleep and eat or you get into trouble
Exactly lack of sleep is like taking drugs on its own.
You guys can't trell me hearing voices isn't cool. I get this deep robotic voice issuing non-stop comnands but I can't make out what its saying.
@@silvertone1 you have a very good point but unfortunately the social climate in the country I live in means nearly all psychosis turns into paranoia and panic
@@silvertone1that's psychosis dude I used to take all kinds of drugs and I took mdma for awhile and heard voices for awhile when my brain would shut down for sleep, it ended up going away after a year or so, was on herion and every other drug for 15 years been clean like 12 years.
Thank you so much that is the most - actually the only - usefully detailed information on adhd medication rather than just the same ol basic gumph. I have found anywhere, being both detailed and clearly explained.
Thank you 🙏🏻
For whatever it’s worth I subscribed at 0:32
Very impressed already
Thank you for this ❤🎉
Thank you 🙏🏻
@@PsychiatrySimplified You are not only more than welcome sir - but I was further impressed by your video when you chose to begin your story using the analogy of Levomethamphetamine in OTC products… I think more people should be aware of these fascinating quirks of chemistry, don’t you? ;)
Good analogy with the train! Yes astounding when we think of the role of mETH in society
Methamphetamine is almost like a crack cocaine high that lasts 16+ hours and also meth releases slightly more dopamine than crack cocaine but not by much depending on quality of each drug that is. The dopamine comparison is very close but meth would still be more dominant than the crack.
Crack tastes wayyy better than meth
@@DoctorDriftTheWhip I'm going to agree with DoctorDrift here.
Are you speaking from experience
I love meth way to much but I'm 2 years clean
which ever one is currently present is the better tasting i would argue
So here we are largely comparing therapeutic doses of orally administered amphetamine sulphate to excessive, recreational, vaporized doses of n-methylamphetamine hcl (enantiomers aside).
Is this a fair comparison?
It was a commonly asked question in comments in the other videos. Also- Desoxyn oral Methamphetamine is prescribed in ADHD in US. Note oral amphetamine when misused can also lead to a similar picture albeit the speed of action and levels are not as high.
@@PsychiatrySimplified Apologies if this comment was interpreted as hostile, and props to you for even making mention of these distinctions.
The overwhelming majority of available literature regarding (meth)amphetamine toxicity vs therapeutic efficacy is rife with biased narrative, as I'm sure you are aware. But while I understand it is a delicate matter addressing this information to a general audience, I have witnessed far more harm than good come of perpetuating the narrative that adderall=good, meth=bad
@@myristicinman4566 Agree - And no I didn't think of it as rude. It was a fair comment. Adderall misused o inappropriately prescribed can have detrimental consequences as well.
this is an honest description ive abused both.....they really both screwed me up i want so bad to go back to my time and brain before amphetamine and sometimes meth(crystal)
Thank you so much for covering this topic. As someone who was diagnosed only a few years ago with quite significantly severe ADHD, I'm so fed up with the public's comments such as "ADHD meds are basically meth", your factual explanation will help with this stigma and untruth. I can say first hand my ADHD meds DO NOT cause me any type of euphoria, and have solved my insomnia. I take dexamphetamine 3 x per day and am prone to forgetting to take it, so use a timer and pill counter. Name me an "addict" who forgets to take their drug of choice. I hope your video reaches a lot of people.
Thank you for your feedback and I am glad you found it useful
As a 25 yr heroin and meth addict all I got to say to u is try to go 3 days without it. That is the ultimate addiction test bro
depends on how much you ingest tho i would assume? the mg etc
yet people in the comments spouting bs like they clearly didn't watch a second of it lol. "i snorted 3 adderals a day in high school and i can tell you that adhd drugs are totally meth" 🤦♀️🙄
If anything this video showed that the main differences are dose and routes of administration... If you compared an oral extended release formulation of methamphetamine at an equivalent dose to oral extended release amphetamine, they would likely be very similar. There are of course less studies on meth because it's illegal.
on 4:12 the subtitles say "biophilic" but i think that is supposed to be "lipophillic".
Thank you very much for the subtites! English is not my first language and i appreciate it lots!
Simple answer is that Methamphetamine is orders of magnitude more powerful than the Amphetamines.
There are a couple studies that show that clinical levels of Adderall use (20 to 30mg) lead to a loss of dopamine in the corpus striatum and perhaps elsewhere, as much as 50% after as short as 6 weeks of daily use. Is it possible that this level of Adderall causing lasting brain damage? I have actively avoided continuous use of any stimulant because of this kind of risk.
Was that study done on people who were diagnosed with ADHD or with non-ADHD controls?
apparently amphetamines can be neurotoxic while methlyphenidate is not neurotoxic
Worst that happens with Methylphenidate is an increase in reuptake transporters. That will probably reverse over time. It's pretty safe in comparison to Adderall I think. Oddly enough, I wonder if meth is safer because it's so much more powerful at low doses prescribed?
@@MontezumasViper u mean amphetamines? Yea i dont know the newer doctors seem to prescribe adderall while the old ones do ritalin first
@@MontezumasViper my doc put me on ritalin first because she said adderall is too strong
Super informative!! 😁 Thanks for all the insight.. Could you please do an episode on MDMA next. Thanks 🙏🏻
I will keep it on the list.
@@PsychiatrySimplified mdma and the mesephetamines witch are often mixed with mdma in pills and can kill easyly naïve consummers.
And why people should use only pure mdma rather than pills.
Nicely done.
Would enjoy one with their "trippy older brothers" 3-4, methylenedioxyamphetamine(MDA) & 3-4, methylenedioxymethamphetamine(MDMA). What a difference an indole ring makes. Clinically, their effects are just this side of miraculous. And here in Oakland, mushrooms🍄 are legal. (Hell, the speed might as well be, almost impossible to catch a drug felony in CA, illegal white powders)😎🤓
The numbers were fascinating.
indole is the wrong nomenclature. The methylene dioxy functionality is chemically akin to an ether.
Amphetamine (as a racemic mix of D and L stereoisomers) is a mainstay of therapy for ADHD, as described in this video and is also essential for treating those suffering from type 1 or type 2 narcolepsy.
Yes true. Methylphenidate can also be used
I thought most formulations was 75/25,...25% levo?
So the pharmaceutical Dex amphetamine also contains levo-amphetamine? I thought that this is the street amphetamine mixture. Speed. Which gives a stronger high than just Dextro amphetamine by itself.
@@nievelsteinmusic612 dextro is the only isomer that gives a good high, levo is basically cut, or equivalent to cut or filler material. So 100% dextro is the best, it's what a user would want
@@nievelsteinmusic612 of course some formulations have both, for example, Adderall has some levo in it, as others have stated
I never knew those Vicks inhalers I used as a kid had meth in them.
Have there been any studies that look at the long term effects from stimulant medications on the cardiac system? Would love to hear your thoughts on if medications like Adderal and Ritalin are harmful from a cardiac perspective when they are taken as prescribed for conditions such as ADHD. As always love the videos.
“Although stimulants can increase systemic blood pressure and heart rate, no significant associations were found between their use and serious cardiovascular events. Concerns regarding QT effects and attendant sudden cardiac death risks deter clinicians from initiating much-needed ADHD medications in patients with heart disease. This overly cautious approach is potentially depriving low-risk individuals from significant benefits associated with timely ADHD drug treatment” - www.frontiersin.org/articles/10.3389/fnins.2022.1020961/full
There’s no way it doesn’t affect your heart. It puts your heart in overdrive. 🫡🇺🇸🏴
Yes, modern stimulant medication is nearly a century old.
Caffeine is worse
Don't even try it.
too good?
Ima try It
@user-bt2su4ob7s not anymore now you get a euphoric rush for about 20 minutes then your just wired for 24 hours and uncomfortable. It used to be 24 hours of rolling balls feeling amazing, now Mexicans cook it terribly
one more thing in your mind thst stays forever..😮😅
I’ve got ADHD though so it helps me so much to take adderall or vyvanse
I do remember people hooked on the vics inhaler thingys... makes sense now...😊
I had a stage as a kid where was obsessed with it
F*** no wonder my friends in primary school always gets high and fail their exams. They kept snorting that damn Vicks Inhaller in the 90s.
Is that right? Wow I didn't know people used this for exams.
they dont the levo part is not very psychoactive
THE only side effect known to check your theory would be higher test scores!!!! Not lower, Just remember they do not let you compete in sporting events while on these substances for a reason & we give them to airplane pilots befor letting a single one go into the air ( Military ) , everyone is dosed! It is a functioning performance enhancer reaction times , & ability to remain focused & remember to execute your training in every & all circumstances. Let RAM Function be. I am RAM. I have been on Amphetamines so long since I was a Small Child I feel a thousand years old if a Day & I Am beginning TO MATURE. People Are Too Dream & Live & Love . Children are to Have newness of Life , God is Good . I choose TO serve Becasue THE light inside us I serve is Christ Jesus THE Lord .
Stimulants can’t make idiots any smarter 😂
Used to love taking Ecstasy in the late 80s early 90s. We’d get into a club, neck a pill. Then snort half a pill. Then chase a quarter. By the time the chase was over, you’d have come up on the nose and same again for the drop. We were having it from the minute the club opened. Great times dancing all night. I miss Rage every Thursday to this day
One of my best friend snored amphetamine for years.
The lack of sleep, often for days (infront of the PC), unfortunately unlocked schizophrenia.
He started repeating same phrases over and over again.. can't even start work now cause of low self esteem.
life ruined
You did a great job explaining this so that it is easy to understand.
Excellent presentation. Do you have one of these for MDMA?
Not yet. On the list
Pretty sure this guy tried them all for this video. Look at the man's eyes. Sleep my man
typically you find dangerous propaganda and disinformation about this topic. instead you're serving the community with good information. thank you.
Sharing my own personal experiences here. I do not have ADHD. I do have other mental disorders that were triggered by past drug usage & childhood trauma. My body does not respond well to heavy stimulants. I experienced psychosis with past meth abuse & I've also experienced psychosis & extreme anxiety from Adderall that was prescribed to me. I was misdiagnosed. My body just doesn't like what I would call extreme stimulants. I can handle a few cups of coffee. Beyond 2 cups I have issues.
Try GABA, its calming
I don't recommend it but wouldn't valium be given to you just incase?
Weakling
@@aidenfielding1348 so funny
@@Krisjoverovovejovovichtski i wasnt talking to you
@@aidenfielding1348 ok well let's keep the name calling to people who say it to you not people with mental health issues
Would like to see a video on the connection between narcicism and psychopathy. I got a relative whose screwed up. 😢
Thanks for the suggestion. Will add to list
I like that this guy looks like he hasn’t slept in 3 days, eyes wide as can be, and that haven’t shaved because of been binging on phetamines for the past 3 days… I like it because it means this guy does his homework, and you can trust he knows what he’s saying. 😹
😂
@@PsychiatrySimplifiedVideo on Ritalin vs Cocaine next?
Came here to say this!
This was an awesome video!
The first many times I snorted methamphetamine, it was in combination with drinking lot of alcohol, so it wasn’t really until I tried it without drinking alcohol that I fully experienced what it could do for me…
Since then, I’ve taken A LOT of it!
It made me calm, far less aggressive, and more capable of being "present", less clumsy, better at conversations, and also at studying.
But it also often ended in taking far more I needed to achieve the benefit, so long periods without sleep, long periods where I made a living of selling it and similar substances, also meant I tended to end up at Monday night parties that had started on a Wednesday….
I also used it a lot while I was in the Army, and it’s freaking wild that I never got caught!
The few times I’ve been tested, in sports and in the Army, was always when I hadn’t taken any for a while!
Two of the tests in the Army I got told they wanted to test me because I seemed more aggressive, easily distracted, had problems staying on topic when talking, had failed some of my responsibilities, made mistakes I didn’t usually make, forgot things more often than usual, would interrupt/speak out of turn also when addressing people above my rank, I had gotten a couple of stupid traffic tickets by the Military Police (and they had noted my behavior was "suspicious"), and at times they felt I seemed almost erratic….
But both times, it was several weeks since I had taken anything.
Long after I left the Army and around a year after I had left "the substance use environment" behind, I had an appointment with a Psychiatrist!
I had already been diagnosed with PTSD when I left the Army, and Depression shortly after that!
But after a few consultations, he picked a book on the shelf, told me to listen carefully and tell me if anything of what he read out loud sounded familiar - and apparently he had a book that was written about me with the title ADHD!
This was in the 00's and I was in my 30's - and he started me up on Ritalin and later on he combined it with Strattera.
What a difference that made - it made it much easier for me to study and get an education within the health and healthcare sector.
But after years on medicine and psychoeducation, which helped a lot on some of my issues, it was like other symptoms got stronger and then I met this woman who knew a lot about ASD in adults and some of her friends had a lot of insight into this as well - and after having been asked a couple of times about how long ago I had been diagnosed with ASD and telling them that I didn’t have ASD, and on both occasions they had just looked confused at me, and one of them had asked me "are you absolutely sure?", and with the other she had just smiled and then said "you’re definitely autist"!
So, I once again ended up at a Psychiatrist, for new evaluation!
And it turned out that I have ASD as well - so with the BPH (I probably got from taking the Strattera), and various comorbidities, I got more than enough letters to sustain myself on Alphabet Soup in case SHTF!
But my last Psychiatrist replaced my Ritalin and Strattera with Attentin, Aduvanz/Elvanse, and Intuniv!
I get fairly high doses, but Blood Tests has shown that the biological half-life (or is it the plasma half-life they measure?), is pretty fast - the same goes for the Duloxetin I take as well, so I wonder if it’s due to the same mechanisms - anyone knows anything about that?
I also got very high Dosis of Ritalin when I was on that - so maybe I just burn through it faster?
Can this be due to the huge amount of methamphetamine I used to take when I was younger?
I’m also a big bastard, Scandinavian, the Thor type you see in God of War Ragnarok, but just more blond, can any of these factors play a role in why I need higher doses for it to have the needed effect?
Adderall isn’t approved in my country, but I can’t help wonder if the mix of amphetamine salts in Adderall works better than the combination I get from dexamphetamine and lisdexamphetamine - anyone know anything about that?
Thanks for sharing your interesting story. There is evidence that individuals with substance use especially Meth need higher doses of stimulants - this is mainly due to the changes in dopaminergic pathways with previous use. While IR and XR can be combined it’s important to recognise the targets being treated . Of cognition and activity are targets then before increasing doses it’s important to look at sleep and arousal - addressing this becomes important as it allows for the doses of others to remain lower and can be more effective . Something to look at.
Looks like he tested them all before the video. Ha
@pjsavagejr His BIG eyes.
Will you do this on long effects of Buprenorphine(Suboxone)?
Will come in due course
I need that video. Only wanted a few months tops and 7 years later I'm slowly weening off myself and down to 4 MG a day since no clinic wants to lose customers
@@DonHitman-gt9cz....the problem is, none of the MAT drugs (methadone, suboxone, XR morphine) are designed to be used short term really. The ideal treatment course is a minimum of 1 year. Less than that, and like 90% of people end up relapsing
Because ya okay you could ween the dope out of your system over a couple months...but the physical dependence is only part of the problem. It’s the mental part that is most difficult to overcome. That’s why the treatment is designed to be long term. Your brain has been wired to search for that fix, and often people abuse drugs for years before seeking treatment.....and you think that you can reverse years of addiction in a couple months? Almost never
@@DonHitman-gt9czwell done don keep it up. I got down to 1mg a day without any w/d. The rest of the way was a little rocky but I'm sub free now.
Another use for amphetamines is DEPRESSION. If used properly under clinical supervision to treat unipolar depression it can be very effective. They used to use amphetamines to treat depression before the advent of antidepressants as we know them today
That's correct. Dopaminergic agents are very effective in the treatment of depresssion
From what I have gathered, they can be especially useful with seasonal affective disorder. Or 'the winter blues'.
Yeah. I was prescribed it for short term depression. Until I had access to better methods
Lol drugs cause depression
Heck yeah
I just found your channel, uou should have a million subscribers!!! I liked, subscribed and forwarded this video.
I appreciate your feedback 🙏🏼. Thank you for sharing
The molecules shown at 1:49, labelled S-methamphetamine and R-methamphetamine are not mirror images of each other, let alone having any resemblance to actual methamphetamine.
That’s the structure of blue meth
Yup, not the chili meth anymore
thoses illustrations are far from being accurate
S and R is that the same compared to S/R ketamine?
and another question: my adhd meds kind of stopped working over time. How i could get motivation back because im too tired to make some positive changes.... :)
Hope you, or someone else with experience can help me with some advice! Greets
Yes isomers - R and S - left and right in Latin. With ADHD meds when this happens - 1. Identify specific symptoms 2. Sleep ? 3. Usually it’s due to stress increase , sleep worsening , anxiety 4. Rule out medical issues / contributors 5. Rule out presence of other psychiatric issues - depression etc 6. Dose adjustment or augmentation or switch etc are other steps
@@PsychiatrySimplified probably lack of sleep... But Thanks for the comments i made a screenshot ;)
I think because my eating habits have gotten worse, no daily routine - because i! between jobs, sleeping at random moments just for 1-2 hours at a time. No rouiine, ...
This all combined with mind
Sleep 1-2 hrs? It’s really important to address that.
whoever had 1600 NG/ML in their blood must have been in turbo tweak mode.
….. Um, my sister had 14,000 NG/ML of methamphetamine in her system…. & 120 NG/ML of amphetamine.
That is what was stated on my sisters toxicology report. My sister is now dead.
My understanding is that once in the bloodstream, the amphetamine metabolizes the methamphetmine (? Is that correct Dr?) which causes the ng/ml of methamphetamine in the blood to gradually decrease (?) & the level of amphetamine to increase (?) I may be wrong about this.
But since my sister died I’ve even trying to research & learn all I can about toxicity levels - but I’m having the hardest time getting a ballpark estimate (X) of how much meth ingested (via each individual route) is going to metabolize to (X) ng/ml (taking into account things like weight of person, a& things of that nature. But when it comes to this topic - this is where I struggle. actually the one I’m having the most difficulty with. (Reading up on autopsies, police death scene protocols, blood coagulation, etc.) & medical every aspect of her death along with
We have Vick’s inhalers with levmethamphetamine in the us still they just changed the spelling to levmetamfetamin which was somehow enough to fool everyone lol although you can’t use it like dextromethamphetamine so I don’t understand why it ever even mattered
So
. Its just a buffer ingredient to make the vix work better?
Kinda like cocoa in cocoa powder is just chocolate and nothing to do with cocoa leaves?
@@Krisjoverovovejovovichtskilevo is not there to make it work better.....it's the active ingredient, levo is a good decongestant. But it's not good for a high.
@@KrisjoverovovejovovichtskiChocolate is made from the cocoa plant, but not the leaves, it's the seeds of the plant.
@@ShannonDove-sy7ye i see
A catalyst of sorts, like the cold is one thing, but its the wind that helps it work.
Wind chill factor
@@ShannonDove-sy7ye what? So how come Belgium is the chocolate capital of the world not Columbia
I've never understood why people say it takes effect within 5 minutes or something because the effects are almost instantaneous when smoked or injected 💉 in my experience
Great video, as always! I have a question: If someone chronically abuses methamphetamine or amphetamine, leading to issues such as cardiomyopathy or blood circulation problems, are these conditions reversible? Some doctors are afraid to prescribe amphetamines; maybe they are afraid of these conditions developing. I'd appreciate your input, Dr.
Abuse at high doses can result in longer term issues - but this depend on the severity. In terms of reversibility I wouldn't be able to give a definitive answer as such cases would be seen in greater portion by a cardiologist who may have a better idea. Amphetamines in therapeutic doses are safe
Thanks for the swift reply!
@@PsychiatrySimplified
Oxidative stress sounds like when you overclock a gaming computer, without the right cooling system, you will fry the cpu (the brain). I hope they find how to restore striatal dopamine transporters for people who don’t have other options and have to take this long term medicinally. I take frequent breaks and raw dog life without my medication but I have so many issues for why I do that, i have to get sleep, the skin dryness is an issue so I hydrate extra and drink extra water, something I find very hard to mitigate even doing those things.
Prof Berk explains oxidative stress further in this video. th-cam.com/video/tvel1kOuUO4/w-d-xo.htmlsi=jPBi2L-U3jrtqZDE re reduction of striatal DA transporters - there is evidence even with Methamphetamine of a recovery of striatal DA transporters after abstinence. ( note Adderall is likely to reduce transporters with misuse or incorrect use) see here 👉th-cam.com/video/5H_tw25HVGA/w-d-xo.htmlsi=elKn5H0PFXhQin_e
mam this sounds sweet to have my dopamine levels back to pre amphetamine days
but wouldn't reduced DAT in stratium reduce akathisia (in patient who was responsive to Mirtazapine for akathisia) ? @@PsychiatrySimplified
I knew people who ate the cotton out of Vick's inhales I used to buy bootleg black beauties a 100 at a time only did Methamphetamine once it was a horrible experience haven't done any booze or dope since Aug. 4 1985.
Great Video mate :) I subscribed to your channel because you offer brave, honest, polished insights. I appreciate your work. ✊💛🌟
Thanks for the sub!
brave? lol you sir are bot
This is really very educational ❤❤
Thank you 🙏🏼
One is bad, the other is really really really bad
Can you do a video comparing Adderall vs Ritalin vs Modafinil? And particularly Modafinil for depression, is that done?
Modafinil no - we have a video on Ritalin vs Dex. Here is an article on modafinil and armodafinil psychscenehub.com/psychinsights/modafinil-and-armodafinil-mechanism-of-action/
Adderall is called the devils dandruff for a reason 🫡🇺🇸🏴 I’ve been off ADHD meds 15 months now…so healthy, life is so much better.
Hi Dr. Rege, can you also make a video explaining differents between adderall vs vyvanse and also can we combine adderall with vyvanse? Thank you
Hi! I wouldn’t recommend combining the two. Adderall contains amphetamine salts directly while Vyvanse uses lisdexamfetamine as a “prodrug,” which gets converted into an active form in the body before it has any effects. Adderall will start taking effect faster because it gets metabolized in the stomach. Vyvanse starts taking effect in your intestines. They are both amphetamines. Just different formulations. Vyvanse is typically “smoother” and lasts longer than adderall. I have taken both for adhd. Anyway talk to your doctor. Don’t take both at the same time because are essentially two sides of the same coin. I can’t imagine any doctor advising you to take both at once. Good luck.
Vyvanse is just dexamphetamine only in a pro drug release form. it's a better vehicle for an XR effect
@@ChardeeMacdennis339
I get both dexamphetamine and lisdexamphetamine, and I know others who get both as well - it works perfect together!
The dexamphetamine acts faster, but also have a faster half-life, the lisdexamphetamine has a more prolonged effect, but it still burns out so to get the best coverage, I get booth in the early morning, around 0530, and at 1200 I get half the dose of Lisdexamphetamine I got in the morning, and around 1430-1500 I get dexamphetamine again, half the dose I got in the morning.
I used to get something similar when I was on Ritalin/Ritalin Uno.
And I get fairly high doses in the morning, but it helps me wake up and get the day started!
If I only got the Lisdexamphetamine, I would have a very hard time getting up in the morning!
I often joke about how my Monster Energy Drink and my Pills are my substitute Coffe!
(I don’t like coffe, and as a kid I’ve always been told that when I grew up and became an adult I would learn to love it - so Im a "kid" in my mid fifties….)
@@ChardeeMacdennis339It's been almost ten years since I was prescribed Vyvanse so there may have been new research since then, but when Vyvanse first came out, I was prescribed it. I had been taking only Adderall up to that point, but even with the Vyvanse, I still took Adderall to complement it if I felt the vyvanse was wearing off. I had three more doctors continuing the same prescription until 2013 and i never heard any mention of it being a harmful combination.
I’ve used both of these a few dozen times each and at least subjectively, and comparing their D-isomers, they’re more or less identical. Which one is superior really comes down to what time of day it is and when you need to be asleep.
You can highlight minute pharmacological differences and make them sound wildly different if you try, but the reality is that they’re two amphetamines with a single-atom structural difference that effects metabolism and bioavailability more than it does any pharmacological effect. They both work the exact same way at the cellular level, and their subjective feelings reflect that.
The dopamine release of either drug is dose-dependent. Adderall can release 10x as much dopamine as meth if you compare 60mg to 5mg.
At equal doses, meth is maybe 50% more effective at releasing dopamine, depending which paper you look at.
Most societally perceived differences between the two boil down to the fact that meth is sold in very pure crystals for $20 a gram whereas amphetamine is sold in low dosed tablets for $10+ for a single pill)
America is flooded with fake adderalls pressed with meth and people using these thinking they’re amphetamine generally don’t have any unique consequences as opposed to legitimate adderalls. They generally have no idea..
The newer drug lisdexamphetamine (vyvanse, elvanse) is basically 100% identical to oral meth. The only subjective difference is the longer onset time. Leaving out that part, I could never differentiate them in a blind test.
People usually get mad when you try to point out how similar they are because of their own ignorance. They think meth is “bad” so they need their precious pills (that they definitely “need”) to be far away from it.
In reality, they’re extremely similar, and the takeaway isn’t that amphetamine is bad; It’s that meth isn’t bad. Amphetamine isn’t “worse” than you thought, methamphetamine is just not as “bad” as you thought. It’s the most inappropriately maligned drug under the sun minus maybe PCP and “bath salts.”
Good post
I hate when people who've never done copious amounts of a drug and lived that lifestyle go ralking about drugs as if some book gives any info about the drug in reality.
Many a doctor, family member, and friend have observed their patients or loved one change over time. Weight loss, malnutrition, skin issues, change in sleep patterns, change in focus, lack of concern for health, work, school, relationships, theft, suicidal ideation, argumentation, and much more. It's often better to learn from other people's mistakes, especially when they come with such life-threatening consequences.
@user-oh1of9qx3s yes absolutely. I agree with that for sure. I just meant when people speak on something as if they REALLY know about it and a book just cannot give intricate details about drugs.
Very informative video!
But doesn't comparing adderal xr (extended release with what is basically instant release meth give skewed results if your looking at the amount of the drug in ng/l?
Aim was mainly to compare the two substances. You are correct it’s very different as it’s the phasic DA release that is the issue. Also route of administration which was highlighted.
@@PsychiatrySimplified cheers! Also thank you so much for your video on the neurochemistry of dex & methylphenidate! It was invaluable, especially since most other TH-cam vids I've found on that subject are much more simplified.
It'd be super fascinating if you ever get the time to cover the rest of the neuron in the same manner! (even if it's not directly related to adhd)
@@Wintermute909 hopefully yes 👍. Thanks for the feedback
It's good to have balance ...take both😂😂