A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
thank you very much dr gardner, i like the way you discuss cases and how to rule out other differential diagnoses ... very educated video.. God bless you.. Algeria
On core biopsy, I usually say something like this: “myxoid sarcoma, consistent with myxofibrosarcoma, grade 1 on this biopsy”. comment: the findings are consistent with myxofibrosarcoma, but other pleomorphic sarcomas with myxoid change (myxofibrosarcoma-like features) can have an identical microscopic appearance. Unsampled higher grade areas cannot be excluded. This biopsy may not be representative of the whole mass. Correlation with resection specimen is needed for final grading and subclassification of this sarcoma.
I’m about 2 weeks out from a mastectomy on my left breast. I was diagnosed with High-grade Myxofibrosarcoma. My surgeon was amazing but due to a small margin at my chest wall, recommended 28 rounds of radiation to make sure it doesn’t come back. This cancer is so aggressive! It went from a grape to 8CM in a month and a half.
Thank you! I just use glass slides at the microscope and then record video and Audio using a mounted SLR camera (this setup: bit.ly/2HWY9pN). I Edit in iMovie.
@@JMGardnerMD thank you, Dear Dr. Gardner, just in case, you might want to use Debut video capture program with or without Amcap video capture program. With the first one you can record your screen and slide at the same time even it can record your voice. Thank you for your beautiful case and presentation again!
Thanks so much for these great videos! Also highly appreciated by pathology residents in Germany. Just a quick question regarding your explanation of the grading. Is that in addition/independent of the FNCLCC Grading?
@@JMGardnerMD Thanks so much for the quick reply, just had a case with a biopsy of probable Myxofibrosarcoma so could use your tips from the video right away!
It can be quite difficult. I discuss MIFS in this video kikoxp.com/posts/5306 (case 4). Also, A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). You San always search those pages to see if I have a video about a specific entity.
Yes it can have a mixture of low and high grade in same tumor. Curvilinear Vessels may be present in low or high grade areas but not always present. They are easiest to see in low grade tumors.
Gardners syndrome FAP dercums, and Ht6 mutations epilthemilol hyperlasia with sarcocotoid blemishes, pleomophic angioplasty with atypical low grade, tT9 chromosomes with dorsal dominant aplastic syndrome with big round cell chramasia if tFt112 through to the curvle y petitiones and irregular blastoma point 4 genes??? Any comments?
Grading of myxofibrosarcoma doesn't fit perfectly into FNCLCC in my opinion. Here's my basic approach: If all hypocellular but has scattered large atypical cells = grade 1. If that plus more cellular zones, cells aggregated around vessels = grade 2. If solid sheetlike areas resembling UPS = grade 3. If partial sample and I'm giving a grade less than 3, I say "myxofibrosarcoma, at least grade 1 (or 2)" with comment that this biopsy may not be representative and correlation with wide local excision is needed. I often see myxofibrosarcoma removed piecemeal as treating physicina suspected it would be a cyst clinically.
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Im path resident and I love soft tissue pathology because of you and these videos! Thank you so much for making ST so interesting
The way you describe things, like the floating driftwood analogy, is so great. Thanks once again.
lol I forgot that I even said that. But I’m glad you liked it!
thank you very much dr gardner, i like the way you discuss cases and how to rule out other differential diagnoses ... very educated video.. God bless you.. Algeria
Excelent! Thanks a lot for free-pathology-teaching around the globe!!
Great. Thank you very much from Morocco 🇲🇦
Amazing work...Thank you so much for sharing it ..
How would we report a lesion with features of myxofibrosarcoma on core biopsy?
On core biopsy, I usually say something like this: “myxoid sarcoma, consistent with myxofibrosarcoma, grade 1 on this biopsy”. comment: the findings are consistent with myxofibrosarcoma, but other pleomorphic sarcomas with myxoid change (myxofibrosarcoma-like features) can have an identical microscopic appearance. Unsampled higher grade areas cannot be excluded. This biopsy may not be representative of the whole mass. Correlation with resection specimen is needed for final grading and subclassification of this sarcoma.
I’m about 2 weeks out from a mastectomy on my left breast. I was diagnosed with High-grade Myxofibrosarcoma. My surgeon was amazing but due to a small margin at my chest wall, recommended 28 rounds of radiation to make sure it doesn’t come back. This cancer is so aggressive! It went from a grape to 8CM in a month and a half.
Thanks, Jerad. Excellent lecture 👍
great lecture, so educational
Thank you very much ..clear and simple ...what about myxofibrosarcoma like tumors of retroperitoneum ...the differential diagnosis
If it looks like myxofibrosarcoma in retroperitoneum, it is dedifferentiated liposarcoma until proven otherwise.
@@JMGardnerMD ...thank you ..
Thank you for sharing.
beautiful! thanks a lot, Jerad.. lipoblast vs pseudolipoblast was good!
Here’s another video focused just on Lipoblasts vs pseudolipoblasts: kikoxp.com/posts/3787
Dear Dr Gardner, which software did you use for the casting. Thanks your great presentations!
Thank you! I just use glass slides at the microscope and then record video and Audio using a mounted SLR camera (this setup: bit.ly/2HWY9pN). I Edit in iMovie.
@@JMGardnerMD thank you, Dear Dr. Gardner, just in case, you might want to use Debut video capture program with or without Amcap video capture program. With the first one you can record your screen and slide at the same time even it can record your voice. Thank you for your beautiful case and presentation again!
Thanks so much for these great videos! Also highly appreciated by pathology residents in Germany. Just a quick question regarding your explanation of the grading. Is that in addition/independent of the FNCLCC Grading?
Yes Technically you should still do FNCLCC for these. But those different patterns of cellularity usually seem to match pretty well with FNCLCC.
@@JMGardnerMD Thanks so much for the quick reply, just had a case with a biopsy of probable Myxofibrosarcoma so could use your tips from the video right away!
Greetings from India sir .How to differentiate myxoinflammatory fibroblastic sarcoma ? Can you take a future video on MIFS
It can be quite difficult. I discuss MIFS in this video kikoxp.com/posts/5306 (case 4). Also, A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). You San always search those pages to see if I have a video about a specific entity.
Hi. Does myxofibrosarcoma has low and high grade areas. Are curvilinear vessels present in high grade areas also
Yes it can have a mixture of low and high grade in same tumor. Curvilinear Vessels may be present in low or high grade areas but not always present. They are easiest to see in low grade tumors.
Gardners syndrome FAP dercums, and Ht6 mutations epilthemilol hyperlasia with sarcocotoid blemishes, pleomophic angioplasty with atypical low grade, tT9 chromosomes with dorsal dominant aplastic syndrome with big round cell chramasia if tFt112 through to the curvle y petitiones and irregular blastoma point 4 genes??? Any comments?
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Wich grading system do you use FNCLCC ?
Grading of myxofibrosarcoma doesn't fit perfectly into FNCLCC in my opinion. Here's my basic approach: If all hypocellular but has scattered large atypical cells = grade 1. If that plus more cellular zones, cells aggregated around vessels = grade 2. If solid sheetlike areas resembling UPS = grade 3. If partial sample and I'm giving a grade less than 3, I say "myxofibrosarcoma, at least grade 1 (or 2)" with comment that this biopsy may not be representative and correlation with wide local excision is needed. I often see myxofibrosarcoma removed piecemeal as treating physicina suspected it would be a cyst clinically.
@@JMGardnerMD Great explanation..thank you very much Dr. Gardner .. much appreciated
@@JMGardnerMD is myxofibrosarcoma curable?
Is it very dangerous or life threatening
Check out this myxoid tumor review article by Dr. Nicole Riddle & me (free fulltext): bit.ly/myxoidtumors
J
Thanks sir