She even mentions other scientists of the past whose works all added to the mountain of info and understanding on the whole issue in her book ‘A Crack in Creation’, great book on explaining the technology in layman’s terms and what’s it like to be on the very edge of a momentous discovery that will directly or indirectly impact all humans going into the future. Considered by many to be the greatest accomplishment in the history of biology. Imagine it to be a simple to use tool like a word processor on DNA, add/change/delete any single letter or sequence of letters in the DNA (A,C,G,T) nucleotides. I hope sickle cell anemia, a genetic disease , can be forever eliminated in the not too distant future, as I recollect it’s caused by a wrong single letter in the DNA. Incredible and awesome.
you guys do realize that there is an on-going patent dispute with the Broad Institute right? just because she won the Nobel prize for this, doesn't mean she holds all the key patents of CRISPR.
@@charmander777 You do realize that she and a female co-creator, Charpentier are the only one's credited with this discovery? They did it first in a test tube, and then this guy came along and copied their process into a human....These women are the sole Creators of Crispr...
Not at all.... They are actually rock stars of their field and quite renowned and celebrated in their circle. Yes, that circle might be smaller but the people there are quite enthusiastic and passionate about things they do. Popularity, if you are not actor/politician can become useless in many fields. It sucks away the focus.
@@shrgai8821 the circle being small is what the OG comment meant. Its unfortunate that our society as a whole pay more attention to celebs such as actors, actress, singers etc. compared to scientist.
Jennifer, thanks to you, I finished my Law School thesis on the need for CRISPR-CAS9 and Ethics to go hand in hand when it comes to the area of Biolaw in Brazil. I was honored to receive top marks and recognition from the evaluators. Thank you for that. Congratulations, for your work and the effort of your team. Award more than deserved.
What really blew me away is that she grew up in my hometown of Hilo, Hawaii and graduated from the same Hilo High school I went to, just 21 years later than me. I’m still in awe and shock. Go Vikings!
It’s crazy when you think about how these mechanisms have been evolving over billions of years, and how people have figured it out! As scary as it sounds to me, it’s quite a monumental achievement.
I just watched Her co-laureate, Emmanuelle Charpentier present her work. Now seeing Jennifer Doudna talk about her complementary work, it feels like watching a miraculous chemical event that has evolved over millions of years being displayed by the work of these two wonderful scientists and all the people who worked with them and before them. This does raise ethical issues re:all living things. And excitement about the explosion of discovery.
I am so happy for both Doudna and Charpentier, inspiring the next generation of scientists, have been following CRISPR Cas-9, from grade 8, now I am in college, someday will be pushing the frontline of science someday along with them
Hope you can someday make a contribution however small, it is that mountain of accumulated knowledge that helped Doudna and Charpentier reach their momentous accomplishment. As have other great scientists.
I remember hearing a talk by you at my grad school Prof. Doudna :). I was taking a course on bio informatics and genomics and I asked you a question about crispr :). Even though my question was naive and silly you still answered my question with a lot of enthusiasm :). I was so inspired my project for that course was about predicting crispr locations and cutting frequency using machine learning. I am so stoked you got this success. Congratulations :)
No question I love everything about you. Now reading Isaacson’s fabulous book about you. I’m so sorry this entire field in chemistry was not known to me in my younger days. I’m 73 now. You are perfect for our times to help avert and stop the destroyers in our days. Love you.
As a layperson, I found her lecture very accessible and interesting!! I too respect the credit and thanks she extends to her colleagues and, in particular, to her graduate students. Well done!!!
Genius work Jeniffer and Emmanuelle. God has really blessed you. Giving great concern to the ethical and social outcome of applying this technology is really another important issue to be dealt with.
It's really wonderful to hear such a clear and compelling lecture. Excited to see Crispr used in ethical ways to solve big problems facing humanity. Also impressive is how everyone she worked with was mentioned by name
@ 13:00 this is extremely easy to understand "layman terms" on what is happening within the cell when CRISPR is introduced. What an amazing woman. Let's hope going forward technologies such as these will be used in constructive means to advance all living systems.
A comprehensive thought by Prof Jennifer, so nicely presented the technology and its immense potential and possibilities in present and future applications including covid19. The technology appears to be a magical wand. Its always the experience which comes to the forefront in justifying the thoughts judiciously. Thanks Jennifer for such sincere effortI that is going to change the future of humankind in a silent way. Dr. Gyanesh Kumar Satpute, Senior Scientist, ICAR - Indian Institute of Soybean Research, Indore India 🇮🇳
Congratulations. Genius work by Jennifer and Emmanuelle. No doubt that the Noble minds produce Nobel prize winning scientists. That in turn helps the humanity to move forward. Hope this new invention will soon replace from the present medicine system for treating sickness to the Bio tech system.
We knew about CRISPR in the 1970s or early 80s in Masbate, Masbate, Philippines. I was scanning live the process using a lensing technique and monitoring it using perhaps a "crisp" hologram. In the 1980s, they went to me again about CRISPR and we knew then Doudna and Charpentier will win the Nobel Prize for this.
Some consider it the greatest accomplishment in the history of biology. I think so too, being able to edit a single nucleotide or letter in the DNA sequence is incredible. Like a word processor of DNA, add delete change any single letter or sequence of letters. Changing the very essence of an organism’s attributes. In here book she mentions others creating mini-pigs the size of a small dog, changing the patterns in a butterfly’s wings, some day bringing back extinct creatures. I recently read about experiments where a portion of a poisononous spider’s DNA was put into the DNA of a fungus. This made the fungus have spider toxin that was deadly to malaria carrying mosquitos. Incredible stuff.
It would be very interesting to know how the Nobel committee decided the awardees given the ongoing disputes over the intellectual property rights for crispr-cas9.
This is profoundly Groovetastic 💝😎🔬💊💉🧫🧪 I'm so Exponentially excited about what Dr.Doudna's discovery will deliver to the advancement of mankind from medicine to biotech. CRISPR-CAS9 will transform human life. It's truly the most important discovery in decades.
Considered by some to be the greatest accomplishment in the history of biology. And you can see why it is an incredible tool for future scientists. DNA manipulation to the smallest degree, a single (or chain) nucleotide can be edited. Resultant change will be carried forward into future generations of the organism. Incredible.
If any size biopsy were collected could the cancer cells mitochondrial DNA be sequenced? If so could the cancer specific mtDNA be scrambled so the cancer cells starve?
Seems like that's coming from the conformational change of CAS-9 which in turn comes from random thermal motion. I'm not sure though, I didn't look through details, but apparently it doesn't need ATP. Still don't feel shy to correct me.
I am so amazed by how naive people are. This research comes with so many dangers attached to it and with such huge risks for the very existence of humanity, but nobody seems to realise it. In her talk she mentions in passing the ethical issues raised by this research, doesn't mention any risks or unknowns, but focuses on the carrot at the end of the tunnel. That clearly shows where the biggest effort is made. It should be exactly the opposite. This research opens a Pandora's box. The damage caused by Alfred Nobel's invention is a drop in the ocean of what the application of this research will cause.
When already there were gene editing techniques like TALEN & ZFN which are also very specific to the sequence of our interest, so why CRISPR-Cas9 is presented as something very novel ? I mean, I still cannot understand that why the world is talking about CRISPR when there are already gene editing techniques existing ?
I note that in announcing the Nobel prize winner, the committee only gives out the name but leaves out any indication of background, the associated university or company, city, country, and continent. They might as well leave out the planet too .
can we cas9 the damaged cells 'dna' in a mechanically damaged cervical disk and replace with an injection of healthy cells from another disc thus fixing the disc ???
She credits EVERY scientist she worked with. Respect Jennifer!!! Great delivery
She even mentions other scientists of the past whose works all added to the mountain of info and understanding on the whole issue in her book ‘A Crack in Creation’, great book on explaining the technology in layman’s terms and what’s it like to be on the very edge of a momentous discovery that will directly or indirectly impact all humans going into the future. Considered by many to be the greatest accomplishment in the history of biology. Imagine it to be a simple to use tool like a word processor on DNA, add/change/delete any single letter or sequence of letters in the DNA (A,C,G,T) nucleotides. I hope sickle cell anemia, a genetic disease , can be forever eliminated in the not too distant future, as I recollect it’s caused by a wrong single letter in the DNA. Incredible and awesome.
I agree! so much respect for her and admire her contribution to the discipline.
Such a humble leader and expert.
you guys do realize that there is an on-going patent dispute with the Broad Institute right? just because she won the Nobel prize for this, doesn't mean she holds all the key patents of CRISPR.
@@charmander777 You do realize that she and a female co-creator, Charpentier are the only one's credited with this discovery? They did it first in a test tube, and then this guy came along and copied their process into a human....These women are the sole Creators of Crispr...
Isn't it sad how such bright minds get so little attention or appreciation from us?
And there are so many that do not believe in scientific facts and evidence. Sad but true.
Jennifer Doudna got a lot of recognition, I mean CRISPR have totally blown up in recent years.
Not at all.... They are actually rock stars of their field and quite renowned and celebrated in their circle. Yes, that circle might be smaller but the people there are quite enthusiastic and passionate about things they do. Popularity, if you are not actor/politician can become useless in many fields. It sucks away the focus.
@@shrgai8821 the circle being small is what the OG comment meant. Its unfortunate that our society as a whole pay more attention to celebs such as actors, actress, singers etc. compared to scientist.
Jennifer, thanks to you, I finished my Law School thesis on the need for CRISPR-CAS9 and Ethics to go hand in hand when it comes to the area of Biolaw in Brazil. I was honored to receive top marks and recognition from the evaluators. Thank you for that.
Congratulations, for your work and the effort of your team. Award more than deserved.
What really blew me away is that she grew up in my hometown of Hilo, Hawaii and graduated from the same Hilo High school I went to, just 21 years later than me. I’m still in awe and shock. Go Vikings!
It’s crazy when you think about how these mechanisms have been evolving over billions of years, and how people have figured it out! As scary as it sounds to me, it’s quite a monumental achievement.
I just watched Her co-laureate, Emmanuelle Charpentier present her work. Now seeing Jennifer Doudna talk about her complementary work, it feels like watching a miraculous chemical event that has evolved over millions of years being displayed by the work of these two wonderful scientists and all the people who worked with them and before them.
This does raise ethical issues re:all living things. And excitement about the explosion of discovery.
I had good and excellent teachers in my history, but to be able to get the lesson straight from the source is a privilege I credit the internet.
It's like a big complex chemistry (we humans) explaining and manipulating a little chemistry.
I agree ! I think it's time, I checked out your TH-cam Channel !
I am so happy for both Doudna and Charpentier, inspiring the next generation of scientists, have been following CRISPR Cas-9, from grade 8, now I am in college, someday will be pushing the frontline of science someday along with them
Go on Kiddo.
Hope you can someday make a contribution however small, it is that mountain of accumulated knowledge that helped Doudna and Charpentier reach their momentous accomplishment. As have other great scientists.
I remember hearing a talk by you at my grad school Prof. Doudna :). I was taking a course on bio informatics and genomics and I asked you a question about crispr :). Even though my question was naive and silly you still answered my question with a lot of enthusiasm :). I was so inspired my project for that course was about predicting crispr locations and cutting frequency using machine learning. I am so stoked you got this success. Congratulations :)
🎉
No question I love everything about you. Now reading Isaacson’s fabulous book about you. I’m so sorry this entire field in chemistry was not known to me in my younger days. I’m 73 now. You are perfect for our times to help avert and stop the destroyers in our days. Love you.
As a layperson, I found her lecture very accessible and interesting!! I too respect the credit and thanks she extends to her colleagues and, in particular, to her graduate students. Well done!!!
Genius work Jeniffer and Emmanuelle. God has really blessed you.
Giving great concern to the ethical and social outcome of applying this technology is really another important issue to be dealt with.
Missed out on taking her class this semester but I’m so glad to be taught be another Nobel Laureate, Randy Schekman! 😁
It's really wonderful to hear such a clear and compelling lecture. Excited to see Crispr used in ethical ways to solve big problems facing humanity. Also impressive is how everyone she worked with was mentioned by name
Congratulations and thank you for this important work.
this are the type of people who move humanity forward.
Thank you Noble Prize for putting this video. This is very kind of you. God Bless you all.
@ 13:00 this is extremely easy to understand "layman terms" on what is happening within the cell when CRISPR is introduced. What an amazing woman. Let's hope going forward technologies such as these will be used in constructive means to advance all living systems.
One thing I love about American, they are clear, respectful and to the point. Thank you so much for this lecture.
D.r Jennifer ❤ i love you ❤love your soul ❤🎉🎉🎉
A comprehensive thought by Prof Jennifer, so nicely presented the technology and its immense potential and possibilities in present and future applications including covid19. The technology appears to be a magical wand. Its always the experience which comes to the forefront in justifying the thoughts judiciously. Thanks Jennifer for such sincere effortI that is going to change the future of humankind in a silent way. Dr. Gyanesh Kumar Satpute, Senior Scientist, ICAR - Indian Institute of Soybean Research, Indore India 🇮🇳
I am so happy that you got what you deserved... Love you ma'am
Hats off to both of you. Really inspiring. Many congratulations
Noble prize is a my goal 👈💪
another milestone in history of genetic engineering
Congratulations on a great find! I imagine locating and isolating the CRISPR-Cas9 was tedious to say the least. Much respect from a random person
Glad this important innovation was jointly founded by women, shows the growth of the modern world towards women!
The infinite multiplication of cancer cell is a wonder for me!
Congratulation Jennifer Dudna.
You are is the best.
Congratulations. Genius work by Jennifer and Emmanuelle. No doubt that the Noble minds produce Nobel prize winning scientists. That in turn helps the humanity to move forward. Hope this new invention will soon replace from the present medicine system for treating sickness to the Bio tech system.
Sounds like poetry to me! 🧬 Beautiful what capable and well funded scientists can achieve!
DouDNA 🧬 is amazing
This makes me so happy ohmygod I am so proud of her
Great to see two women get the Prize. Should be very inspirational to girls worldwide.
Congratulations, Dr. Doudna. Mad respect!!!!!!
We knew about CRISPR in the 1970s or early 80s in Masbate, Masbate, Philippines. I was scanning live the process using a lensing technique and monitoring it using perhaps a "crisp" hologram. In the 1980s, they went to me again about CRISPR and we knew then Doudna and Charpentier will win the Nobel Prize for this.
"Thank you for the wonderful lecture. I bet it will save a bunch of people's lives." - my daughter Augusta
Congratulation Prof. Jennifer Doudna for your great contribution to science.
Some consider it the greatest accomplishment in the history of biology. I think so too, being able to edit a single nucleotide or letter in the DNA sequence is incredible. Like a word processor of DNA, add delete change any single letter or sequence of letters. Changing the very essence of an organism’s attributes. In here book she mentions others creating mini-pigs the size of a small dog, changing the patterns in a butterfly’s wings, some day bringing back extinct creatures. I recently read about experiments where a portion of a poisononous spider’s DNA was put into the DNA of a fungus. This made the fungus have spider toxin that was deadly to malaria carrying mosquitos. Incredible stuff.
Came here after Code Breaker. Amazing and incredible scientists… big congratulations.
God bless U and thank U
It's very clear explanation great speech .Thank you so much.wish and prayers for all work and your wish will be success.
Phenomenal accomplishment Jennifer...congratulations!
Thank you Jennifer😍Congratulation🌍
Cell-resistot intellegence -response
Congrats!!!!! I truly believe that it is our bright future with very careful use of the technology and projection of such an amazing research!!! 🌺🌺🌺
This is much better then reality shows ....
I'm reading her book now, The Code Breaker. It is a great read, exciting and fascinating.
Congrats Jennifer, you are amazing. Thank you for your contribution to society. I’m joining the revolution and buying CRSP stock
Thank you for your incredible efforts, fascinating.
Great lecture, credited every scientist she work with. 👍
What to be like her!
Bravo! What a great lecture, marvelous teacher. Seems all so magical to me, and I have a science background. Worthy of a Nobel Prize.
Jennifer Doudna
Great work...congratulations
Congratulations for great work
Great talk!
Beware; for I am fearless, and therefore powerful.”She could have been Frankenstein's daughter. I'm in love with you.Jennifer rockstar overnight!
It would be very interesting to know how the Nobel committee decided the awardees given the ongoing disputes over the intellectual property rights for crispr-cas9.
Much Respect. A very approachable lecture.
Reads her name as Do U DNA.
Brilliant performance! Thank you
This is profoundly Groovetastic 💝😎🔬💊💉🧫🧪 I'm so Exponentially excited about what Dr.Doudna's discovery will deliver to the advancement of mankind from medicine to biotech. CRISPR-CAS9 will transform human life. It's truly the most important discovery in decades.
OMG!! Yes this is so exciting.
Considered by some to be the greatest accomplishment in the history of biology. And you can see why it is an incredible tool for future scientists. DNA manipulation to the smallest degree, a single (or chain) nucleotide can be edited. Resultant change will be carried forward into future generations of the organism. Incredible.
What a lesson...
Amazing DNA and RNA CRISPR!
What is her routine? How is it possible that she was doing her PhD when I was born?
Merci
Thank you for your life work
Informative information, thanks, congrats on this endeavors.
Amazing work! Congratulations! Big fan!
If any size biopsy were collected could the cancer cells mitochondrial DNA be sequenced? If so could the cancer specific mtDNA be scrambled so the cancer cells starve?
amazing update. Worked. Towards value education. 👌 fun!
Are the colours shown significant in the operation
MBraithwaite Yorkshire Viking
Where does the energy come from to accomplish these functions? Asking for a friend
Seems like that's coming from the conformational change of CAS-9 which in turn comes from random thermal motion. I'm not sure though, I didn't look through details, but apparently it doesn't need ATP. Still don't feel shy to correct me.
One source I've heard from her is from the conformational change of the Cas9 complex, you can watch it from her video on CRISPR basics
I am so amazed by how naive people are. This research comes with so many dangers attached to it and with such huge risks for the very existence of humanity, but nobody seems to realise it. In her talk she mentions in passing the ethical issues raised by this research, doesn't mention any risks or unknowns, but focuses on the carrot at the end of the tunnel. That clearly shows where the biggest effort is made. It should be exactly the opposite. This research opens a Pandora's box. The damage caused by Alfred Nobel's invention is a drop in the ocean of what the application of this research will cause.
Very nice👍👏👏
👏👏👏... wonderful tho hear
Please, credits for Francis Mojica too... :(
In her co-authored book she gives ample credit to many contributors over the years, including Mojica. Too many to mention in a lecture like this.
When already there were gene editing techniques like TALEN & ZFN which are also very specific to the sequence of our interest, so why CRISPR-Cas9 is presented as something very novel ?
I mean, I still cannot understand that why the world is talking about CRISPR when there are already gene editing techniques existing ?
She and her partner have developed an easy to use and inexpensive technique for gene editing, other ways are difficult and not precise.
because this is like a giant leap to make this more precise, dynamic and inexpensive, a real breakthrough.
Thanks
Amazing!!!!!!!!!!
Wonderful
Thanks mam....
I note that in announcing the Nobel prize winner, the committee only gives out the name but leaves out any indication of background, the associated university or company, city, country, and continent. They might as well leave out the planet too .
why is that relevant?
You inspired me!
Congratulations for her revolution ized discovery -CRISPER theory
Congratulations
Incredible!
Congrats!!!!!
Impressive!
Very nice..
amazing
I am here from Code Breaker by Walter Issacson
can we cas9 the damaged cells 'dna' in a mechanically damaged cervical disk and replace with an injection of healthy cells from another disc thus fixing the disc ???
Wao😍
Congratulations 🎉. How about you make a Nobel in Biology? Every biologist contribution goes either to chemistry or medicine.
Awesome
So your cutting Dna, and introducing New RNA. Genius. This is the invention of the mechanism.
❤️❤️❤️
Its the only future
👏👏👏
So many hopes, so many fears..Will humans be able to harness such a wonderful and fearful inventions?
Great person!