How to decide the concentration for the sample and standard in related substances?
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- เผยแพร่เมื่อ 28 ก.ย. 2024
- How to set the concentration for the sample and standard in related substances?
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1. Assay method validation mastery
» Everything you need to know to perform assay validation
» Preparation of conc. matrix, protocol, calculations, report wrt global requirements
2. Dissolution method validation mastery
» Everything you need to know to perform dissolution validation
» Preparation of conc. matrix, protocol, calculations, report wrt global requirements
3. Related substances method validation mastery
» Everything you need to know to perform RS validation
» Preparation of conc. matrix, protocol, calculations, report wrt global requirements
4. Residual Solvents method validation mastery
» Everything you need to know to perform Res sol. validation
» Preparation of conc. matrix, protocol, calculations, report wrt global requirements
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» Specification for unknown impurity
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19. Concentration matrix design mastery
» Concentration matrix for method validation
» Confirmation on selected weighing and dilution details
» Mapping expected concentrations for API/Impurities
20. Calculation formula design mastery
» Reporting and rounding of analytical results
» Basic calculation functions in excel
» Basic calculation formulas in Analytical chemistry
» Preparation of automated calculation sheet
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» Conc. Optimization for assay, RS, Dissolution, Residual solvent
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Sir, your all vedios are knowledgeable and helpful 🙏🙏
So nice of you
where 1ppm come from and how did find SN 10. please not clear
Plz make video on "How to develop method from a given molecular structure"
very good explaination sir
Sir why prepared std concentration in unknown level? And why must be our reporting threshold with inthe
I am hapy to you,thank you very much sir,your vedio was very useful for whom studying drug analysis by HPLC
Sir i need to how to calculate for LOD and LOQ in both sample and standard drug and formulation using HPLC with perfectly
Thank you sir
sir I need to know use of buffer compostion and its pH? WITH SOLVENT
Thank you so much sir
Sir, Can you elaborate how 1ppm = 0.025 percentage
I think that is 25 ppm right
There is very simple calculation,
Impurity LOQ in % /100 × Sample Concentration in ppm = Impurity in ppm
0.025/100× 4000= 1ppm,
Note: above calculation I used 100 because your Impurity LOQ in %, hence
Example:
Assay in % : mg per mL / Labled Amount × 100 = content in %
Very good
Thanks
Sir, What is chart purity?
Thank u sir
Can somebody tell me how 1ppm equals to 0.025%
Sir plz translate in hindi
Sir you can't explain proper
😂😂😂😂😂😂😂
Hi Bhaskar sir, this is the first ever channel which is providing enormous knowledge to our pharma professionals. God bless you and your family 👌❤
Thanks a lot
My standard is 0.00146 mg/ml and test is 0.0146 in method. How to disregard 0.05% ??calculation
Dear sir, First of all thanks for helping me to improve the knowledge. In this class I have one small doubt sir, I am not understand to set the concentration of standard clearly sir
Standard concentration is set according to the specifications of the highest unknown specifications impurity for eg. Unknown impurity specifications are 0.2% and sample concentration is 1000ppm simply cross multiplication we will get standard concentration.
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How decide sample conc in assay?
yours videos are highly appreciable and useful...thank you lot
Sir how to fix limit for dissolution of tablets or capsules dosage forms???
Pls mk vdo on how to rectify process and degrade impurity if possible. Thnk you!!
thank you , it is very helpful
Very helpful
Sir why taken standard concentration higher unknown impurity %
Easy understanding
RS sple concentration in API afyer method set
Thanks Sir, it's new for me. Thanks for upgrading....
Pl make different video of method development Related Substance..
Very worthable vedio to me. Tq sir.. Please educate like this way with more vedios
Cleary understood ....how to set standard and sample concertration... Thank you.........
Thank you very much sir for such support
Thank you for describe
Sir thanku for ur valuable information
Thank you sir it's nice vedeo
ur explanation is very good thanks sir
Thanks sir very good keep it up work
informative
It's nice explaination..
Thank you sir
Thank you
Good video
Please make video on RS qualifications techniques
Rs quantification techniques
Perfect
Good videos sir..
Nice
Great
Very well explained
Glad it was helpful!
@@pharmagrowthhub3083sir.... requesting you to make vedio on Analytical method development
Reply sir
Excellent sir
Sir Plese make video on how to start analytical method development for new molecule
So nice of you
Sir, please take lecture on isolation of impurities by Preparative HPLC and it's profile topic.