Mpox: New mRNA Vaccine Versus Traditional Live Virus in Animal Series
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- เผยแพร่เมื่อ 16 ก.ย. 2024
- Roger Seheult, MD of MedCram examines the new mRNA vaccine and how it compares to the traditional live virus in monkeys. See all Dr. Seheult's videos at: www.medcram.com/
(This video was recorded on September 8th, 2024)
Roger Seheult, MD is the co-founder and lead professor at www.medcram.com/
He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.
LINKS / REFERENCES:
First doses of mpox vaccines arrive at the heart of Africa's outbreak. What took so long? (NPR) | www.npr.org/se...
About Mpox (CDC) | www.cdc.gov/po...
ACAM2000 (Smallpox Vaccine) Questions and Answers (FDA) | www.fda.gov/va...
Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates (Cell) | www.cell.com/c...
Moderna’s First mRNA Mpox Vaccine Beats Licensed Rival Shots In Early Testing (Forbes) | www.forbes.com...
Visit MedCram.com for more updates on pox virus infectious disease details including monkeypox uk, monkeypox virus diagnosis, and more.
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#monkeypox #mpox #monkeypoxcases
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We need more pox to make mRNA great again.
Thank you, Doc. I was severely vacc!ine injured the last round and almost died. Never ever again. Further, I am based in Rwanda, next door to Congo. The official government site of Rwanda is stating as of today Sept 9, a total of 4 cases of mpox with 2 recovered and that has not changed in 2 weeks! KENYA 3 cases with the first identified in late July, UGANDA another 4-5 cases over the last weeks. People, wake up and stay safe!
Thank you for speaking out & giving a voice to all the vacc1ne injured! My 59 yo healthy slim boyfriend was injured as well. He had 4 in Vegas & had a bad heart attack in October and needed to get a pacemaker. Then the cardiologist told him to go get another one and a flu shot two weeks after he got out of the hospital!!! This is insanity!
What do current numbers have to do with potential numbers in the future? Do you think covid went from 3 cases to 1 million in a week?
@@444brandy Insanity how exactly? Unvaccinated end up in coffins, some vaccinated end up with rare side-effects. Which one you would rather be?
Unlikely due to vaccine. And you not wanting to use them in future shows your bias.
I’m so sorry. So many are in your same shoes. 😔 I hope you get better.
Here's a helpful list of when you should trust pharmaceutical companies:
Never
ever!
So if you get major surgery, can we assume you'll forgo anaesthesia and just tell them to put a belt between your teeth?
😂❤
Leave the macaques alone!
Hope they finish it soon. Can't wait to not take it.
Good luck at the Darwin awards.
@@cyberfunk3793 ? Literally the only thing you need to do to not get MPox is don't put a diversity hire front rod in your bonus hole. And thats it, you safe.
You sound like a rainbow school teacher.
@@yuricopperhooves
It’s so good to see people with some common sense here. I won’t be getting it either!
@@PeaceIsYeshuaSense. Ahahahahah
Safe and effective
Thank you for putting together and sharing this helpful update!
Excellent MedCram update video about Mpox that I am sending off to my cousin (M.D.) for viewing. Thanks for keeping us informed Doc! 👍👍
You just know how much doctors love to be the recipient of forwarded posts on medical news. So you’re an ofta specialized for uvetitis? Now look at this stem cell blurb i heard on a pdcast 😂
Based on the data they provide . . . Thanks for the warning. Hope you all lerned something from the last time.
Sadly, many people here still haven’t learned and are still ridiculing people who didn’t get it. 🤷🏻♀️
@@PeaceIsYeshuathe ones who got it are the smart ones. Not the antivaxxers.
@@xiphoid2011 In the UK the ONS have shown that the risk of the unvaccinated dying from COVID-19 was 4 times that of the vaccinated for the whole of the pandemic. The ratio of the unvaccinated to vaccinated peaked at 10.7 in Dec 2021.
So ist stops transmission?@@xiphoid2011
Excellent Video. Thank you for producing all of these.
Thank you for the excellent video and information. Good luck.
As usual you nailed it
Thank you once again for your education.
My pleasure!
Nice to see some clear science.
Thank you!
My understanding is that the Covid mRNA vaccines caused injury in some people because the mRNA, which was supposed to stay localized in the injection area, instead traveled to many other body parts. Do we know if that has been corrected in this newer MPox vaccine or any of the newer Covid boosters? We don’t want the harms to outweigh the benefits in either case, and we need to do right by patients who have been injured.
Must strict intramuscular inject.
Must not use injected muscle some hours after,to mitigate risk of blood spread of liposomes with mRNA.
@@traianliviudanciu8665Interesting.. This won’t be easy for All People to do.. No exertion.. post Injection.
let's try :) said big pharma
Most of the vaccine remains in the deltoid muscle where it is take-up by these cells. Some will be distributed by the blood system to other parts of the body. This very small portion will be quickly taken up by other cells and the remainder degraded.
This mechanism will be the same for all mRNA vaccines.
@@christopherrobinson7541 and If accidentaly are intravesel inject theoretically can transfect even vesel endothelial cells
Safe and effective 🤣
Almost completely stopped the excess deaths. Excess deaths continued more in republican areas with lower vaccination rates. Hope this helps.
"Safe and effective... once we remove the adults/children who died and were injured from the official count." -- Researchers, probably
@@dkiresearch4423 no u
@@edz1624 you TENETeers are exhausting 😉
@@Robubbabub actually, excess deaths are higher in modern, westernised countries that had more widespread access to the mRNA vaccines.
But don't let the truth get in the way of your lame "Republican areas" BS story.
No thanks as most of the population will never require it. Give it to those at high risk due to their lifestyles or lack of hygeine.
Likely it will not be recommended to the general public where there is not a threat, like the many other vaccines the United states does not require… small pox just to name one.
That is exactly what they said about HIV. They called it a gay disease. How did that work out.
please grow up and pick your nose elsewhere
Sure....when hell freezes over! Never letting more of that stuff get pushed into my body!
please grow up and pick your nose elsewhere
Perhaps Eric Weinstein's perceptions are worthy of consideration. Humanity is treated with contempt by the manipulative narcissists who dictate terms to humanity. No wonder trust in medical science has become questionable when commercial constraints dictate policy rather than a desire for a healthy & FREE society. God bless the truthsayers 🙏💜✨
Safe and effective
Unexpected and suddenly
Questions nobody seems to be asking. Why did they change the name from monkeypox? Is this a cousin of smallpox rebranded? Could it be bio weapon which mutates as it moves through people?
Are people with low immunity more susceptible?
It never really had anything to do with monkeys. It was first identified in a colony of research monkeys in 1958 but they are not the normal source or reservoir of the virus.
It's in the same family of viruses as variola ie smallpox, but it is not a direct ancestor. The central region of mpox's genome is mostly identical to that of smallpox, but there are significant differences in the end regions that code for virulence factors. While it can mutate and cause serious illness, it's not likely to acquire the true capabilities of smallpox to spread and cause death.
'According to best practices, new disease names should be given with the aim to minimize unnecessary negative impact of names on trade, travel, tourism or animal welfare, and avoid causing offence to any cultural, social, national, regional, professional or ethnic groups.'
Ref: WHO recommends new name for monkeypox disease
I am sure that a few people here will join in with this nonsense. The northern part will pay for these “safe products” for the south.
please grow up and pick your nose elsewhere
China has also developed its own vaccinia-based mpox vaccine (mva by Sinopharm) going into clinical trials this week, avoiding any vaccine racism and nationalism by the US imperialists, and giving African countries another option
More options and supply is always better. I think people are quite naive if they think that China doesn't also have imperial objectives in Africa and the rest of the developing world.
Lol. And you don't think China is imperialist? 😄
Appreciate the knowledge.
Can you please do a video on how a traditional vaccine can bring on myocarditis? It should stay in the deltoid muscle, not go round the system making a nuisance of itself.
It’s for the fact that it’s your whole body‘s immune system that is responding. It is the response of your immune system that causes the inflammation around the heart.
@@Medcram One of the trickiest arts of vaccine development seems to be learning to kick the hornet's nest just hard enough....
No thanks
This is a TH-cam channel for those who would like to get medically educated not for conspiracy theories. This is something that is relevant for the medical community. This is something relevant to the world. However, this is not something to get your panties in a bunch about because we don’t have an active threat of monkeypox in the United States and being that that is the case, we will likely not be recommended the vaccine, just like the case for smallpox just like the case for Ebola just like the case for the hundreds of other vaccines that are available worldwide and approved and we don’t get inoculated with. so relax if you don’t like this information click away but if you want to learn something then by all means listen and learn with an open mind.
People are people, and systemic damage from mRNA is NOT a theory. Myocardial damage has been documented and is a smoking gun elucidated almost definitively by detailed autopsies in Europe on unexplained deaths.
Diffuse myocardial damage that is not appreciable macroscopically was demonstrated with special stains that showed that the foci of inflammation were staining positive for spike protein. These types of myocardial insults have been shown to produce conduction abnormalities that result in rhythm disturbances.
@@iceangel587 Only bad scientists don't question results as presented; censorship brought us Zuckerberg and Taibbi among others exposing unscientific government intrusion that brought us unwarranted deaths and a repressive government intrusion to suppress information and subversive plots to undermine First Amendment rights.
we just hope that you will take mRNA when ever you have chance
Ironically, out of the three vaccines covered in this video, the one that has the highest risk of myopericarditis is actually the oldest one.
@@mdh00000 take mrna wheb i get a chance? You do know we have all sorts of natural and viral mrna in our bodies living day to day?
Can you do a video on the mortality data available by the paper published on the WHO?
WHO and mNRA....hell no to both!!
I think the odds are that you know very close to nothing at all about either subject.
Who ? 😂😂
Not sure if it was specified here, but in this study was MVA given SC or under the new intradermal protocol using the 1/5th dose?
If it is the latter, we might not be seeing a true test of MVA's capability vs the new mRNA candidate. Is the lower performance of MVA due to the inherent immunogenicity of the modified virus preparation or due to a sub-optimal dosing? I seem to recall that the intradermal EUA was driven more by necessity and vaccine shortage than any great volume of data that established it's equivalence.
Intradermal can be a very efficient vaccine route with all of the antigen producing cells in the dermal layers, but any confounding factors always leave us with an asterisk in reading head to head comparisons.
Likely SQ.
@@Medcram Now that I think about it, I wouldn't want to be the one to try to get a macaque to sit still long enough to try an intradermal!🤣
Just shaving the bugger's forearm enough to do that would be an ordeal!
How is mpox primarily spread?
So what's about individuals vaccinated with the "old" vaccine? Any tests when you take one of the new ones additional (BN /moderna)?
Thanks for keeping us informed Doc.
No
I'm probably at low risk for mpox, but I'd kind of like to get the vaccine just in case smallpox is ever used as a bioweapon. Would the mRNA version be just as effective for that?
Based on the description in the paper, it seems as though these proteins are highly conserved across that family, so yes.
@@Medcram Thanks!
please take it
That's part of the reason I opted to get the vaccine a couple years ago. I was born just after they stopped vaccinating for smallpox in the U.S. I think the chance of a smallpox re-introduction to the world are small, yet far from impossible. When the Soviet Union fell apart, control of military and other deadly state assets went up for grabs. That was scary. There were things like weapons-grade plutonium sitting around in unguarded places which were little more than a storage shed with a padlock.
Even today, when all smallpox samples are supposed to be in the CDC or one highly secure facility in Russia, viable samples sometimes are discovered in old FDA or other labs. It's also estimated that a relatively modest lab with the right specialists and about $100,000 could re-assemble the virus more or less from scratch.
I would prefer to take my chances with monkey pox thanks. 😊
So, back in the day, I took the Smallpox inoculation as a kid. I did develop a pox that resolved. Can I reasonably assume immunity from the "Pox" family?
My question as well.
Anecdotally yes. But I don’t believe they’ve actually put that to a rigorous study.
Can that immunity be titred?
The smallpox vaccine was a form of live virus,( a conventional vaccine)., however mRNA innoculation is a form of gene therapy & there is a profound distinction. m - for messenger or MODIFIED ⁉️
@@rowanedwards235. If they aren’t using the pseudo uridine it stands for Messenger, if they are using it , look out.
Great explanation, thank you.
Well we knew it would happen....
Yes we did, because outbreaks of communicable diseases have been happening to humans for many thousands of years.
For all that, we have it better than 99% of people who ever lived.
this is clearly going to take off like a lead balloon. :|
No thanks. I don't need it
Most don't, but it's damn nice to have for those who do.
Could introducing the virus in the blood give mRNA an advantage? Or put another way, is the mRNA disadvantaged if the virus is contracted by normal means? Maybe because it has fewer proteins?
That’s a good question. I’m not sure, but if there is a difference, it would raise questions about the methodology.
The mRNA vaccines have no protein. That comes in when our own ribosomes translate that RNA (or in this case the macaques ribosomes). What seems to matter is whether the mRNA can be delivered efficiently enough and whether the target proteins it codes for are the right ones to elicit an effective immune response. It seems promising on that score.
It's hard to know how all of this translates to infection by the normal routes. These viruses evolved to infect by skin and mucosal routes and to overwhelm the immune response in those locations versus the circulatory and other systems.
Still, for a first time at bat for this vaccine design, it turned an almost universally fatal challenge into a zero fatality situation and yielded some very impressive results in morbidity and viral burden. Not ready for prime time certainly, but good enough to show the mRNA approach is fruitful for further development.
Ward Cove
My dude, your channel is big enough that you don't need to lower yourself with click-bait
We are a medical education channel. We post things for health care providers. Not click bait.
You're not on TikTok! This is a channel for people who are serious about medicine and want to further educate themselves. If that's not for you, it's okay, just stay away!!
@@Medcraminject yourself with mRNA and get myocarditis, it would be an epic prank 😝
Confusing thumbnail.. "MRNA vaccine for monkey pox? Results in monekys"
So, does the vaccine cause people to become monkeys? 😂
Forget it. I'll use Sarracenia purpurea which is what the Native Americans used for smallpox back in the day. It's also good for shingles or ANY other "pox".
Shingles is human herpes virus, and not a Ortho pox virus
If treatments like that were truly effective, we would not have seen the horrible slaughter that smallpox caused among native populations. From the middle 1500s to the mid 1800s, its estimated that smallpox alone killed some 3 million natives in the West Indies and the Americas.
This and other pathogens introduced by Europeans wiped out between two thirds and 95% of these populations. These were almost extinction events for these peoples.
That's not to say this plant is useless. I've seen one in-vitro study that found some specific and fairly robust anti-pox virus inhibition, but it's a long way from in-vitro to safe and effective treatment, and only about 1 in 5,000 candidate molecules successfully navigate that entire route to approval. There are anecdotal 19th century reports of this treatment reducing symptoms, but there is far less data to support efficacy or even basic safety for S. purpurea than there is for the mRNA vaccines so many people distrust.
It's probably worth further exploration, but all things equal, it's always best to prevent a viral infection from taking hold than trying to chase it down with anti-viral compounds once symptoms present.
@@Medcram To the extent it's been tested, this plant medicine's antiviral properties seem to be fairly specific to viruses of the poxviridae family. I don't think the in vitro assay checked against zoster, but it didn't do much against four or five non-pox viruses they tested it against.
scary how the antivaxx bots are early to these videos.
Bots? Considering all the real people who are against it, I’m pretty sure it’s real people-maybe one is the 3 million following Dr. John Campbell.
Scary how many people just unthinkingly do what the government tells them to do.
@@tfrazie
Exactly. 👍🏻
When a strawman is too obvious, it's not worth attempting
@@tfrazie I don’t do that. I’m able to look up the research from peer reviewed journals and make my own decisions. That’s why I get vaccinated. You do the same thing when you get your information from Facebook.
The development of a new mRNA vaccine for Mpox represents a significant advancement in vaccine technology, contrasting with traditional live virus vaccines that have been used for many years. mRNA vaccines offer several potential advantages, such as quicker development times and the ability to rapidly adapt to new variants. However, traditional live virus vaccines have a long history of effectiveness and safety in various infectious diseases. Comparing these two approaches in animal studies is crucial to understanding their relative efficacy and safety profiles. How do the new mRNA vaccines for Mpox perform in terms of immunity and long-term protection compared to traditional live virus vaccines, and what might be the implications for future vaccine strategies and public health?
There is a Phase (I/II) that is being conducted by Bristol University, UK. This will address issues such as the safety profile.
It should take years with longterm studies...
Hope the WHO isn't found sleeping again this time like it did during Covid
The WHO was wide awake. It was our own government officials and medical professionals that were sleeping.
Vaccination against small pox used scarification.
Maybe using intradermic way , liposomes with mRNA did not blood spread.
Is vaccinia cowpox? The non-replicating vaccines sound better then.
Yes, vaccinia is the cowpox virus. ACAM 2000 is the non-replicating version.
It would be beneficial if they could regulate the dose of antigen that an mRNA injectible will cause the subject to produce. That would likely eliminate a significant percentage of adverse reactions.
They haven’t got it figured out yet but don’t worry too much, you will have a fair chance of surviving the experiment. Especially since they aren’t rolling it out in the west just yet.
Studies have been conducted to investigate the titer of antibodies produced and the incidence of adverse events, which show that the correlation is very weak, suggesting that the amount of antigen produce is not related to the number of adverse events.
Thanks a lot for this video! Quite impressive the mRNA tech...
Except on the tentacles on the side of the body, there is no other observed side effect.
If they are prehensile and useful, it will be in great demand amongst data entry clerks....
🤣🤣🤣🤣🤣
@@RICDirector Or cyborgs😁
Maybe strict intramuscular injection can mitigate risk of blood spread of liposomes with mRNA.
And after vaccination, injected muscle must not be used some hours, before mRNA transfect only cells at injected site.
Maybe after rapid insert of needle,can soft aspirate to be sure that needle are not in a vesel,and If are not, injection can be lent not rapid
Aspirate was not used in vaccinology, historicaly because was used a siringue with many doses, changing only needles after each inoculation.,and risk of contamination of siringue with blood was high.
After mRNA vaccination,I suport sustain forearm like after shoulder trauma, three hours,and deltoid muscle did not contract.
And general secondary effects did not occur
Look up Onpattro. An RNA/LNP product orders of magnitude higher dose given every three weeks IV.
@@Medcram can liposomes with mRNA also transfect vesel endothelial cells ?
@@traianliviudanciu8665. Yes.