compared to Mirikizumab (anti IL-23 p19), or Ustekinumab (IL-12 and IL23), what is your opinion regarding the safety of the treatment for the patient? Does the treatment with IL2 (mutein Fc fusion) have any positive particularity? Thank you!✌️
I wouldn't have allowed myself to ask, but I followed with interest the studies related to IL 2 and it can be seen from afar that you understand its functionality extremely well. My profession is a doctor, but my specialty is surgical, and I honestly don't have such well-structured information. I personally suffer from UC and unfortunately I have to take the step towards an innovative treatment, all the others have exhausted their effectiveness. I studied Anti TNF@, JAK inhibitors, IL12, IL23 but honestly I kept taking my time hoping for a more precise study. There is now a study started by those from AMGEN, who are targeting efavaleukin alfa Fc fusion and we wanted your opinion. Thank you very much!🤝
Unlikely. Therapeutically administered IL-2 will act on pro-inflammatory T cells ( CD4 and CD8) along with regulatory T cells ( Tregs), increasing the risk of worsening preexisting inflammation.
@@geluduprii2675anti IL-23 seems like a better option for UC. IMHO, antagonists ( blocking or neutralizing drugs) are a better strategy for treating autoimmunity than agonists, like IL-2.
Really nice talk, thank you!
Do you think the efavalukin alfa( part of IL2) , mutein Fc fusion can be a good treatment for ulcerative colitis?
compared to Mirikizumab (anti IL-23 p19), or Ustekinumab (IL-12 and IL23), what is your opinion regarding the safety of the treatment for the patient? Does the treatment with IL2 (mutein Fc fusion) have any positive particularity? Thank you!✌️
I wouldn't have allowed myself to ask, but I followed with interest the studies related to IL 2 and it can be seen from afar that you understand its functionality extremely well. My profession is a doctor, but my specialty is surgical, and I honestly don't have such well-structured information. I personally suffer from UC and unfortunately I have to take the step towards an innovative treatment, all the others have exhausted their effectiveness. I studied Anti TNF@, JAK inhibitors, IL12, IL23 but honestly I kept taking my time hoping for a more precise study. There is now a study started by those from AMGEN, who are targeting efavaleukin alfa Fc fusion and we wanted your opinion. Thank you very much!🤝
Unlikely. Therapeutically administered IL-2 will act on pro-inflammatory T cells ( CD4 and CD8) along with regulatory T cells ( Tregs), increasing the risk of worsening preexisting inflammation.
@@geluduprii2675anti IL-23 seems like a better option for UC. IMHO, antagonists ( blocking or neutralizing drugs) are a better strategy for treating autoimmunity than agonists, like IL-2.
Great research, great presentation