7 Life Extension Technologies That Could Help You Live To 150 | Answers With Joe

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  • เผยแพร่เมื่อ 28 ก.ย. 2024
  • Billions of dollars are going into age research, and many experts believe that we're on the cusp of beating aging. Here are 7 technologies and strategies to look out for.
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    =====================
    LINKS LINKS LINKS:
    Durham University nanobots
    www.weforum.or...
    Studies on Antioxidant Supplementation
    www.rice.edu/~j...
    Calorie restriction
    www.scientific...
    SENS Research Foundation
    www.sens.org/re...
    Theories on why we age
    www.verywell.c...
    Why we still have a ways to go
    www.scientific...
    Silicon valley immortalists
    www.newyorker....
    An interesting infographic
    immortality-roa...
    TA-65 Study
    www.ncbi.nlm.n...
    The evolution of oxidative energy
    www.ncbi.nlm.n...
    =================
    TRANSCRIPT (Partial):
    Caloric restriction or dietary restriction is a diet that decreases your calorie consumption by at least 30%. People on caloric restriction eat very little food along with a regimen of vitamins to make sure they get all the nutrients they need. They say it lowers your body’s metabolism by putting your body into a fasting state.
    The theory is that when your body is in a fasting state, it focuses its energy on tissue repair, which means less tissue damage and a longer lifespan.
    Experiments with caloric restriction in mice showed up to a 45% increase in life span, and similar results were found in experiments with rhesus monkeys.
    But studies have started showing similar results from intermittent fasting.
    There are different types of intermittent fasting, one involves fasting every day, basically not eating until late in the afternoon. This is actually advocated by the actor Terry Crewes.
    This has some noted benefits but the type of fasting that’s of interest to age research involves going for 5 days a month without eating.
    Studies tend to show that this puts your body into extreme tissue repair and is even helps prevent cancer.
    One of the things that causes the most metabolic wear and tear on your cells is oxidative stress.
    Luckily there are antioxidants that bind to the free radicals and prevents them from damaging the cells. Just in case you ever wondered what the whole antioxidant thing was all about.
    Now antioxidant supplementation has shown a lot of promise in preventing different types of cancers, but it hasn’t shown to really affect the aging process.
    A lot of research in the last couple decades has focused on telomeres.
    Well scientists discovered that these telomeres get shorter every time your cell and chromosomes divide and the theory is that over time throughout your life, this leads to the chromosomes and the DNA becoming frayed, which leads to cells becoming damaged and thus, stop reproducing.
    This is a point known as the Hayflick limit.
    But, they discovered an enzyme that’s created in cells that reproduce often like skin cells and more so in stem cells called telomerase that actually lengthens and prevents the shortening of telomeres, meaning the cells and tissues survive much longer before hitting the Hayflick limit.
    This was a big deal, and won the Nobel Prize for Physiology and Medicine in 2009.
    But the drug that’s really got everyone talking these days is metformin.
    Metformin is a drug that’s been used since the 1950s to treat diabetes, so it’s nothing new. But researchers started noticing something over the decades.
    Patients who took metformin tended to live longer and suffer from fewer age-related illnesses. One study found that diabetics on metformin not only lived longer than diabetics who aren’t on metformin, they lived longer than non-diabetic people as well.
    You really can’t talk about aging research without talking about Aubrey De Grey. He’s the founder and head scientist at the SENS Research Foundation and the SENS foundation has pinpointed 7 different categories of cellular damage that leads to aging and has set about fixing them one by one.
    But of course the ultimate option is nanobots.
    Swarms of blood-cell size robots that can be programmed to repair tissues, destroy tumors, clean blockages in our arteries and physically connect neurons are the ultimate life expander.

ความคิดเห็น • 1.7K

  • @innocentferret2365
    @innocentferret2365 4 ปีที่แล้ว +298

    My only problem with living 10 lifespans is the sheer amount of Christmas presents I'd have to buy with nearly 800 years worth of descendants.

    • @zombiasnow15
      @zombiasnow15 4 ปีที่แล้ว +3

      ACK!!

    • @barquerojuancarlos7253
      @barquerojuancarlos7253 3 ปีที่แล้ว +3

      4:30 "... and birthrate has been dropping for decades." And, there is no reason to believe it won't continue to drop long into the future. So, forget the problems of wrapping tons of Christmas pkgs

    • @curranfrank2854
      @curranfrank2854 3 ปีที่แล้ว +12

      @@barquerojuancarlos7253 Yeah if we are going to live that long, many people will probably have kids at like 100 or 200 or not even have kids at all

    • @XEN-ZOMBIE
      @XEN-ZOMBIE 3 ปีที่แล้ว +2

      Just don't do it.

    • @andyreznick
      @andyreznick 3 ปีที่แล้ว +12

      Once a descendant passes 100 it's time they grow up and stop expecting presents. Tough love.

  • @peterdavila3045
    @peterdavila3045 6 ปีที่แล้ว +13

    I do 2 36-hour fasts each week. I find that I have a lot of energy and don't seem to ever get sick. Yep, I want to live long enough to live forever.

    • @ronschlorff7089
      @ronschlorff7089 5 ปีที่แล้ว +1

      May you "live long and prosper", Peter Davila : )

    • @r6bunny
      @r6bunny 5 ปีที่แล้ว

      You don’t don’t eat only once a week you spastic

    • @vcvbrrory2269
      @vcvbrrory2269 4 ปีที่แล้ว

      r6bunny can you add spaztic

  • @noahway13
    @noahway13 7 ปีที่แล้ว +916

    They will figure out immortality the day after I die.

    • @SailorBarsoom
      @SailorBarsoom 7 ปีที่แล้ว +43

      For the past decade I've assumed that immortality will come too late to save me (I'm fifty-one), but that some of the precursors will allow me to have a more enjoyable old age. In my fiction I assume that I die in my sleep at one hundred twenty-seven.

    • @RationalAnimations
      @RationalAnimations 7 ปีที่แล้ว +23

      The only way to avoid this is to donate to research (to non profits like SENS or LEAF), advocate or be a scientist working on aging yourself.

    • @IntarwebUser
      @IntarwebUser 7 ปีที่แล้ว +14

      I'm hoping these technologies come in time for my grandma. She's in her 90's.

    • @SailorBarsoom
      @SailorBarsoom 7 ปีที่แล้ว +5

      I hope they do. It's possible that some will come along in time to help her in some way, even if the full-on agelessness does not.

    • @RobCFlame
      @RobCFlame 6 ปีที่แล้ว +8

      The funny thing is that will actually be the case for thousands of people

  • @pythonl0rd584
    @pythonl0rd584 3 ปีที่แล้ว +61

    My only fear is I’ll be “too old” when they discover a true way to extend life, even though I’m currently 15

    • @Michael-gi5th
      @Michael-gi5th 3 ปีที่แล้ว +2

      Lucky I'm 27

    • @SeanKula
      @SeanKula 2 ปีที่แล้ว +4

      @@Michael-gi5th 26, let's go!

    • @Michael-gi5th
      @Michael-gi5th 2 ปีที่แล้ว +4

      @@SeanKula nice, now I'm 28 🤣

    • @blueveins295
      @blueveins295 2 ปีที่แล้ว

      @@Michael-gi5th I'll sing your eulogy

    • @gerardanderson9665
      @gerardanderson9665 2 ปีที่แล้ว

      I'm too also 15

  • @Robert-wz7jw
    @Robert-wz7jw 4 ปีที่แล้ว +44

    ok, it's been 2 years ....time for an update on this subject, imo.

  • @MrCoffis
    @MrCoffis 7 ปีที่แล้ว +150

    We see life through the eyes of a human, once we see life through the eyes of the universe you realise that extending our lives is what we have to do in order to be able to survive and explore this vastness of space...in this ferry tale like world we are living in. "Nature" did not select for longevity, for different evolutionary reasons, but no one said that, that selection process is over. Live as if its your last day, plan as if you are going to live for ever!

    • @lorenzonorthern1749
      @lorenzonorthern1749 6 ปีที่แล้ว +1

      Our exploration is limited by the speed of light. We might travel everywhere, but we cannot observe everything. But there are other interesting things besides that. We might upload(safe) our consciousness and load ourselves into a new body(mechanical, biological etc.) every time we die, thus reaching real immorality. Leading to the question, what is consciousness? Why am I born in this body and not another one? Or why am I „there“ at all(not that I would complain)

    • @James-jc4xn
      @James-jc4xn 6 ปีที่แล้ว

      MrCoffis i agree with you my friend :)

    • @matthewnelson325
      @matthewnelson325 5 ปีที่แล้ว +3

      @ @@lorenzonorthern1749 - What you just described would be a copy of you ... It wouldn't be you, it would be a copy of you ! : (

    • @lorenzonorthern1749
      @lorenzonorthern1749 5 ปีที่แล้ว

      Matthew Nelson
      It would be you without your body. Might solve that problem as well in the future if you have an indefinite lifespan

    • @jameshumphrey9939
      @jameshumphrey9939 5 ปีที่แล้ว +1

      life evolved into its many species for the gene we live for only the gene to survive as it created us in all its wonders as it is the one thing that sees through the eyes of the universe . as you said human beings are not meant for longevity and I might add live a very limited existence in the realm of understanding yet we cannot live in the now without embracing the past and future simultaneously

  • @lisamurphy9136
    @lisamurphy9136 3 ปีที่แล้ว +1

    Hi Joe from Australia. Love your vids. Im 59yo and on a waiting list for double complete knee replacement. Recently my doctor recommended PRP (Platelet Rich Plasma). I went ahead and got it injected into both my knees. Instantly I could walk with absolute no pain, something I have put up for years. 2 weeks down the track, I'm jogging, no bone rubbing and movement like a young person. 1000% recommend it!!!

  • @Axioanarchist
    @Axioanarchist 7 ปีที่แล้ว +139

    Are you SURE he's not Rasputin? That guy is already famous for being hard to kill....

    • @Axioanarchist
      @Axioanarchist 7 ปีที่แล้ว +9

      Sean Moonshine yes I know that is part of the joke

    • @IntarwebUser
      @IntarwebUser 7 ปีที่แล้ว +6

      How does it show him to be a monster? Just makes me think, wow, what a tough cookie! Someone who's that hard to off certainly deserves some respect!

    • @Axioanarchist
      @Axioanarchist 7 ปีที่แล้ว +4

      IntarwebUser early 1900s religious fundamentalists

    • @RODERICKMOLASAR
      @RODERICKMOLASAR 6 ปีที่แล้ว +1

      Axioanarchist He looks like Rasputin.

    • @krashd
      @krashd 5 ปีที่แล้ว +3

      To be fair, if you really want to kill someone you should not wrap them in a thick hemp carpet before firing small calibre pistols at them, that's less likely to kill them and more likely to just make them grumpy and bleeding.

  • @chagew8966
    @chagew8966 6 ปีที่แล้ว +116

    I just want to live long enough to see myself become the villian.

    • @Citizen_JQP
      @Citizen_JQP 5 ปีที่แล้ว +3

      @ chagew8966~I can't believe that doesn't have more thumbs up.
      Brilliant movie line application 👍

    • @squamish4244
      @squamish4244 4 ปีที่แล้ว +2

      Crossed that bridge 13 years ago. So I guess I will refuse the magic pills.

    • @hata6290
      @hata6290 4 ปีที่แล้ว

      valar what bridge

    • @efisgpr
      @efisgpr 4 ปีที่แล้ว

      Villain*

    • @doubledownpleasegosubtotte4274
      @doubledownpleasegosubtotte4274 3 ปีที่แล้ว

      @@efisgpr super humans when

  • @blackfish4147
    @blackfish4147 4 ปีที่แล้ว +9

    Just by making these videos you've moved your second death more than you'll ever realize. You've inspired countless viewers to pursue topics that they may have otherwise ignored. They could make incredible breakthroughs and would owe it all to you. Hmmmm

  • @hangoutwithme346
    @hangoutwithme346 5 ปีที่แล้ว +1

    Totally agree with you about people who say they don't want to live longer or forever. Like dude, do you know how many books, music, people, food, experiences there are out there? If you took away the pressure to have to choose and be selective within your lifetime about which activities you were going to partake in and simply got to just try things out as they came with no thought of 'Am I wasting my time with this or that?', it would be pure joy.

  • @SlavElenkov
    @SlavElenkov 7 ปีที่แล้ว +8

    "oxygen, cant live with it, cant live without it" i laughed pretty hard

  • @foxpup
    @foxpup 7 ปีที่แล้ว +37

    Rant is absolutely appropriate. :-)

  • @scubasteve1802
    @scubasteve1802 7 ปีที่แล้ว +30

    Phineas and Ferb made a whole episode on the aglet. There's even a song!!

    • @youtubetrash3196
      @youtubetrash3196 5 ปีที่แล้ว +1

      Yes

    • @razvancisma4154
      @razvancisma4154 4 ปีที่แล้ว

      that is where i know the name from....even after 10 years......

  • @hiredsword
    @hiredsword 7 ปีที่แล้ว +26

    Loved the rant cam, need me some Nano Bots pronto.

  • @TheAzazzExperience
    @TheAzazzExperience 3 ปีที่แล้ว

    This topic deserves to be revisited in 2021. A lot has progressed since then.

  • @BenSullinsOfficial
    @BenSullinsOfficial 7 ปีที่แล้ว +57

    Yes to IF (Intermittent Fasting)! Big fan, although hanger does occur around 11am

    • @XEN-ZOMBIE
      @XEN-ZOMBIE 3 ปีที่แล้ว +17

      I fast by simply being poor.

    • @hulCAWmanianUniverse
      @hulCAWmanianUniverse 3 ปีที่แล้ว +1

      yes to Jason Fung =D

    • @doubledownpleasegosubtotte4274
      @doubledownpleasegosubtotte4274 3 ปีที่แล้ว

      We must reach the singularity

    • @ulrikahaggard9923
      @ulrikahaggard9923 3 ปีที่แล้ว +4

      @@Trixtoxia that's not intermittent fasting that's killing yourself

    • @willbedford8381
      @willbedford8381 3 ปีที่แล้ว +1

      I love IF but same as Xen Anon said I pretty much do it because I'm poor. I do target the foods I do eat too be healthy so that is intentional. I actually found the great health benefits of fasting to be incredibly true. From 21 to about 25 I lived an incredibly stressful and unhealthy life. I started seeing grey hairs, wasn't in great shape etc. But when I started fasting I obviously got into better shape but most amazing was that my hair turned back. I still don't have any grey hairs left to this day and now I'm 32 an age when you might start to expect to see them

  • @MrBlues113
    @MrBlues113 5 ปีที่แล้ว +5

    We are approaching the true philosophers stone. Scientist are now starting to look exactly where they should. Ancient alchemists living through the modern scientists.

  • @arthshukla762
    @arthshukla762 7 ปีที่แล้ว +71

    I don't want to die.

    • @roodlyfbuts8006
      @roodlyfbuts8006 6 ปีที่แล้ว

      Haha

    • @earshotmedia7629
      @earshotmedia7629 6 ปีที่แล้ว +9

      Arth Shukla
      Join the club.

    • @ronschlorff7089
      @ronschlorff7089 5 ปีที่แล้ว +3

      Sad but true, no one gets off this rock alive, unless maybe you go to Mars with Elon Musk, and die there, or on the way. Burial in deep space is sort of, shall we say, a "romantic" notion! You see a lot of it in sci fi movies and I always say to myself, "not a bad way to end, floating in space forever". An "immortality of sorts" I guess.

    • @AntonioMontana_7.5
      @AntonioMontana_7.5 5 ปีที่แล้ว +7

      Dying is inevitable, even the universe will cease to exist. But, prolonging our lifespan to a few hundreds of years is the key.

    • @MarkHarrierT99Music
      @MarkHarrierT99Music 5 ปีที่แล้ว

      @Papaya Tasty True, but I try to not think that way.

  • @elizabethshaw734
    @elizabethshaw734 5 ปีที่แล้ว

    I lived in Durham and went to the University of Durham in England and they are doing some mighty good stuff when it comes to sickness and age and death.

  • @UnknownXV
    @UnknownXV 7 ปีที่แล้ว +5

    I respect your rant at the beginning. I never understood how anyone expects to be bored of life. There is SO much to do it would take thousands upon thousands of years to do it all. Not to mention the simple pleasures that are always pleasant, like eating good food.

    • @rustymustard7798
      @rustymustard7798 7 ปีที่แล้ว

      UnknownXV boredom is being stuck in your body for that long, without some sort of transhumanisn what would be the point? There will be less and less novel experiences available until they all become a mundane chore.

  • @Michigander269
    @Michigander269 6 ปีที่แล้ว +2

    I've been intermittent fasting on a ketogenic diet for almost a year and personally speaking I've had nothing but great results!

  • @AndDiracisHisProphet
    @AndDiracisHisProphet 7 ปีที่แล้ว +136

    Gandalf De Grey

  • @ャンティオカ
    @ャンティオカ 5 ปีที่แล้ว +2

    I just love your channel man.

  • @chrisgarcia6098
    @chrisgarcia6098 7 ปีที่แล้ว +444

    I need immortality, I won't be complete until I see how the universe ends. I need immortality to be cracked.

    • @OleKristianElns
      @OleKristianElns 7 ปีที่แล้ว +69

      I wanna live until the end of the universe, then die with it

    • @niveshproag8660
      @niveshproag8660 7 ปีที่แล้ว +44

      you could go to the restaurant at the end of the universe

    • @nygeriunprence
      @nygeriunprence 7 ปีที่แล้ว +16

      O. K. E. Same. Fucking same.

    • @michaelfarrell4824
      @michaelfarrell4824 7 ปีที่แล้ว +8

      How do you know you aren't?

    • @joshuatraffanstedt2695
      @joshuatraffanstedt2695 7 ปีที่แล้ว +4

      Chris Garcia #relationshipgoals LMAO

  • @illya_od_ua
    @illya_od_ua 6 ปีที่แล้ว +3

    Thank you, Joe. Very interesting video. Could you, please, update this topic?
    I'd love to see people, including myself, live longer and healthier. 120-140 years at least, up to 200.

  • @nickmurphy7177
    @nickmurphy7177 7 ปีที่แล้ว +58

    Fasting is not that bad, try it before commenting. Also reduces fat and saves food money. Win, win, win

    • @oldtoby4062
      @oldtoby4062 6 ปีที่แล้ว +16

      Yep, fasting has a whole host of benefits and is arguably a more natural state than the food abundance that we enjoy today.

    • @RODERICKMOLASAR
      @RODERICKMOLASAR 6 ปีที่แล้ว +1

      Nick Murphy My body runs on slow.

    • @roodlyfbuts8006
      @roodlyfbuts8006 6 ปีที่แล้ว +4

      A scientist praised it once! Saying it makes him think clear. Which is true when you make it a few days. I think it was the father of medicine, hypocracies or something. It repairs cells and flushes toxins. It also humbles you.

    • @earshotmedia7629
      @earshotmedia7629 6 ปีที่แล้ว +2

      Nick Murphy
      Sometimes toxic substances can be sequestered in your fat. Forcing ketosis and releasing those toxins once a month could intermittently stress your liver and kidneys. Also, depending on the substance sequestered and the amount released all at once, it could kill you.

    • @waynethegreat23
      @waynethegreat23 6 ปีที่แล้ว +2

      Lowers happiness

  • @raikupwns243
    @raikupwns243 4 ปีที่แล้ว +1

    The more I learn about where technology is going, the more I want to live to see it. I want to live to see space travel, cures for the incurable, to see all the solutions and problems facing us in the future. I guess I want to see where humanity goes, and I can't be guaranteed that if I die.

  • @jessicasettle1843
    @jessicasettle1843 7 ปีที่แล้ว +6

    These videos make my Mondays! Thanks!

  • @sandragoodman2227
    @sandragoodman2227 4 ปีที่แล้ว +4

    You have convinced me to try intermittent fasting. All these other methods of life extension are in the future (aside from metformin, which requires a prescription), but fasting I can do right now.

  • @Poey12
    @Poey12 7 ปีที่แล้ว +4

    So much food for thought I am definitely shortening my lifespan digesting all of this.

  • @davidcurtis3119
    @davidcurtis3119 5 ปีที่แล้ว +2

    Great video. But must mention David Sinclair in this list. He’s one of the foremost authorities out of Harvard and his work with NMN is showing great progress.

  • @Ineffablered
    @Ineffablered 7 ปีที่แล้ว +8

    At 9:26 you say free radicals are ions... they are not. A free radical is just a molecule with an unpaired valence electron, it doesn't have a charge like a ion does. Sorry if I'm being pedantic, it's still a great video : )

    • @klaus29a
      @klaus29a 7 ปีที่แล้ว

      Ineffable Red to be more accurate, radicals may or may not have charge. It is wrobg to say that radical is an ion, but it is equally wrong to say that radical cannot have charge. Radical-anions or radical-cations are still radicals.

    • @Ineffablered
      @Ineffablered 7 ปีที่แล้ว

      This is true but radical ions are not the "free radicals" talked about in regards to human health which he is referring to in this video. But I take you point, I should have been more clear.

    • @joescott
      @joescott  7 ปีที่แล้ว +4

      +Ineffable Red True story: as I was editing this I realized I said the word ions and thought to myself, "I don't know if that's technically accurate or not. I'm sure someone's going to call me out on it..."
      So you get the gold star. 😉

  • @thorbergilofth9053
    @thorbergilofth9053 4 ปีที่แล้ว

    And we love you ! Greatest channel ever ! Comedy, Science, and a little bit of everything else going on in the world just to shake things up, it’s never boring. Call me an ass kisser but you are by far the best TH-camr I’ve ever watched and I’ve been watching TH-cam since about two years after it came out. Love your content ! TH-cam was starting to bore me before I found this channel. I’ll end this nearly stalking comment with thanks for all your hard work ! I’ll support then channel when I can fit it in to my finances. Thanks again.

  • @LilGreenKitty
    @LilGreenKitty 6 ปีที่แล้ว +2

    Borg nanobots are always the answer. Resistance is futile. You will be assimilated.

  • @johnwang9914
    @johnwang9914 6 ปีที่แล้ว +7

    If we"re in a simulated universe, dying and starting a new player character might not be a bad idea.

  • @zirokl
    @zirokl 5 ปีที่แล้ว +1

    Thanks for the great episode

  • @bubbakushii
    @bubbakushii 4 ปีที่แล้ว +1

    I’m never bored , I wanna live forever . Life is a lot better then no life , I chose life

  • @BobaGabe1
    @BobaGabe1 7 ปีที่แล้ว +4

    Time restricted eating really isn't hard at all. I stop eating at 7:00 pm and I don't start eating until 10:00 am the next day. Postponing my coffee until 10 took some getting used to but it really isn't that big of a change especially when you consider the benefits.

    • @yes0r787
      @yes0r787 3 ปีที่แล้ว

      It's been years since I was really hungry in the evening. Most days I eat from 10 or 11 a.m. to 2 or 3 p.m. When I feel like it I eat in the morning or evening off hours, I don't like to be too strict. But I definitely feel better mood and healthier when I eat less.

  • @Devillunar
    @Devillunar ปีที่แล้ว

    I come 5 years late to this discussion (and hadn't even started back then to do this) but I do regular fasting. Here are some things I can add onto this:
    - Fasting gets much easier when your body turns into the ketosis state. Normally it does not start in a normal rate when there is still glucose in your body left. Low glucose means low blood sugar, so it is not the best state to be in. So, the first 2-3 days are the worst. The difficult part can be skipped or shortened if the body is already in ketosis when starting fasting, which is done by ketogenic diet. Eating low carb before fasting can shorten the worst part as well.
    - During fasting always make sure to drink enough water and to take enough electrolytes. Electrolytes can be as a type of supplement or even adding some type of salt to your drink (The pink himalayan salt is very good for this).
    - Practice makes the master. Don't jump into 5-6 day fasts without doing 24 hour, 2 days, 3 days fast etc. Make sure you are comfortable with shorter fasts first, know and prepare for the difficulties that will await you in longer fasts.

  • @Bradlee297
    @Bradlee297 5 ปีที่แล้ว +14

    I think Queen Elizabeth already found the secret. That woman Is so strong and sharp at her age

    • @youtubetrash3196
      @youtubetrash3196 5 ปีที่แล้ว

      Bradlee297 agreed

    • @squamish4244
      @squamish4244 4 ปีที่แล้ว

      Between her and Philip, Charles will live to be 150.

    • @Prophezora
      @Prophezora 4 ปีที่แล้ว +3

      She is part of a satanic clergy...so...

  • @MFimian
    @MFimian 5 ปีที่แล้ว +1

    Great show, Joe! Thanks...

  • @arniesardena4586
    @arniesardena4586 6 ปีที่แล้ว +2

    I love when some parts of your video gets dark 😂😂

  • @PhillLOL
    @PhillLOL 6 ปีที่แล้ว

    Thinking death is inevitable is like going to war and mentally accepting defeat before you even see your enemy.

  • @nygeriunprence
    @nygeriunprence 7 ปีที่แล้ว +18

    What about CRISPR

    • @marymary49
      @marymary49 4 ปีที่แล้ว

      Not in our life time.

  • @devonjamesj
    @devonjamesj 3 ปีที่แล้ว

    I know this is years late but my great aunt is 94 in 2021. She still drives, she lives alone, she volunteers with seniors helping them do their taxes and manage their affairs, I swear she is immortal already.

  • @Fishrokk
    @Fishrokk 5 ปีที่แล้ว +1

    This would be a good one to revisit with what we've learned about aging in the last couple of years.

    • @Fishrokk
      @Fishrokk 4 ปีที่แล้ว

      @John Barber LOL! The fit of pique that led to this name was years ago, and directed at TH-cam. Sorry for the collateral damage!

  • @alexfoxleigh9443
    @alexfoxleigh9443 ปีที่แล้ว +2

    @joescott congratulations on avoiding that bus for 5 years and counting!

  • @secretpanda64
    @secretpanda64 3 ปีที่แล้ว

    Okay the whole fasting is a great point. I started a schedule where I have a 4hr period that I can eat a day. I started it so it would be easier to maintain a regular body weight easier but a fun side effect is Im now in my 30's and people mistake me for being 20-25 on a daily basis. It's rough the first bit but your body adjusts and you don't feel hungry throughout the day after a while.

  • @tomasotreasaigh111
    @tomasotreasaigh111 5 ปีที่แล้ว +3

    I dont understand this fascination with living forever, I just want to go quick.

  • @thomasrebotier1741
    @thomasrebotier1741 4 ปีที่แล้ว +1

    You left out David Sinclair, MTOR, limb regeneration (including electric gradients à la Bob Becker), etc. Still, I loved this video. And the sarcasms on social impact are spot on :)

  • @Ohhelmno
    @Ohhelmno 3 ปีที่แล้ว +1

    The one question I have about things like uploading your consciousness or whatever is that like... how would you know it’s YOU. Like, I know that I’m me because I perceive everything that I do, essentially, but how would we make sure that it wasn’t just a copy of us but our actual core of perception, our actual consciousness. Like, that’s the worry I have here, like yeah, a version of me could live forever, but if I’m not perceiving it what good does that do me?

  • @RLReagan
    @RLReagan 7 ปีที่แล้ว

    I follow this pretty closely. Right now the hottest treatments - and are available - are NAD infusion (google NAD), stem cell banking and of course, Metformin. Telomere lengthening and genetic alteration(s) will be soon (relatively).

  • @robertbloom3078
    @robertbloom3078 6 ปีที่แล้ว

    Thanks so much for being as entertaining as you are about science topics and other "geeky" stuff. I've seen everything you've made and turned on a bunch of other people to your site (I'm a high school teacher). I talked my med. provider into giving me metformain for a year plus even though I'm not diabetic (or pre) when I saw the data. I'm a long distance runner who eats healthy to a T. I'm always interested in any studies and/or your humorous take on anything having to do with health/life extension. Yea, I completely want to be hiking the Colorado Trail when I'm 110 just like you. Being alive today is incredibly awesome!

  • @veritablepixel6904
    @veritablepixel6904 5 ปีที่แล้ว +1

    First post - Love it man. Nanobots. Stemcells, for sure. I want to live forever too and agree with your perspective about people who think they would get bored if they lived forever. Sooo much to see and learn! If I lived forever I would build a giant comma out in space and explore the galaxy with it. Anyways , Thanks for sharing!

  • @angelosasso1653
    @angelosasso1653 7 ปีที่แล้ว +6

    Ketosis also can get triggered by just eating fats and protein and nearly no carbs at all. It takes a little bit of time for your body to adapt. Bodybuilders use it a lot, also it can help loose some weight. It also gets used in order to help epileptic people.
    Yet it´s still a very interesting subject a lot of research has to be done on.
    Regarding living longer, maybe try freeze your body after death, it´s not that expensive and also this service is available in your country. Otherwise, preserving your dna somewhere in hope somebody could clone you in a few thousand years or so is a neat thing, if you then have the possibility to upload your memory or your "soul" to google or whoever, you can respawn with 100 % health in the future. If Google would offer me to upload my mind and my dna in somewhere to restore me somewhen I wouldn´t hesitate a second...

    • @hypnocilicdreams
      @hypnocilicdreams 6 ปีที่แล้ว

      I@ve been told I have a fast metabolism by many people, I'm skinny & never gain weight no matter how much I eat. In this video Joe said high metabolism is associated with dying sooner. I'm worried. I wonder if this true & I will die sooner than I would if my metabolism was slow

    • @angelosasso1653
      @angelosasso1653 6 ปีที่แล้ว

      I wouldn´t be worried about that one, since:
      A faster metabolism can be normal when in puberty
      Metabolism can be changed, by the amount of food you consume
      Metabolism is also affected by how much you do sports.
      Metabolism is linked to several medical conditions (which I hope you don´t have)
      Often people with a fast metabolism overestimate the amount of food they are really eating (Tracking your food for a week can be a enlighting moment :D)
      and so on and so on, it´s a little bit more complicated as you see...

    • @brunosco
      @brunosco 5 ปีที่แล้ว

      hypnocilicdreams Paradoxically, if you *worry* about dying sooner (for fast metabolism or any reason, and about any other thing), you will probably die sooner, since worrying is harmful. Instead, let the worry go and enjoy your life with joy, while keeping a cooler eye on your metabolism. By the way, I also seem to have a fast metabolism, being lean while eating a lot (apparently, see comment above) and I look significantly younger than my 43 years (touch wood), despite being a bit of a couch potato (working on changing that, I’m also aiming at passing the 150 bar-no matter how realistic or not).

    • @carlwessels2671
      @carlwessels2671 4 ปีที่แล้ว

      Bodybuilders are the last ones to look to ror longevity

    • @carlwessels2671
      @carlwessels2671 4 ปีที่แล้ว

      For

  • @kokomanation
    @kokomanation 6 ปีที่แล้ว +1

    with 234 k subscribers you will be remembered don't be afraid

  • @JLHunter61
    @JLHunter61 5 ปีที่แล้ว +4

    Spider-Man: "I don't want to go!"
    Doctor Who: "I don't want to go!"
    Me: "Screw that! I REFUSE to go!"

  • @II-ux5oh
    @II-ux5oh 6 ปีที่แล้ว

    The nanobots repairing us is basically the premise of the Lynsay Sands Argeneau Family series.

  • @jamesboaz4787
    @jamesboaz4787 6 ปีที่แล้ว

    Dude I love you bro, in a bromantic way no homo. When a person openly talks about there fear of death it's good to put it lightly. And you just have this way of reporting and not sounding like a no it all douch bag. I've bin a subscriber for a while now and if things pan out on my end I'm fully prepared (mentally) to start $ supporting your channel and keep this ride a rollin. Until then, keep it up, keep it right up.

  • @dubstep.maximus7391
    @dubstep.maximus7391 7 ปีที่แล้ว +3

    @joescott you forgot to talk about blood transfusions from younger blood to older blood. Plasma being the key ingredient. Great talk!

    • @joescott
      @joescott  7 ปีที่แล้ว +3

      Got cut for time. Really wanted to talk about it because of the Silicon Valley reference.

  • @differenttakethanmost
    @differenttakethanmost 4 ปีที่แล้ว

    Dogs ARE the BEST company. Period. Dogs are the most amazing gifts. Perfect examples of grace and beauty and art...

  • @TheCgOrion
    @TheCgOrion 4 ปีที่แล้ว

    I've done a five day water fast. It wasn't too bad, because I already don' eat grains (seeds of grasses), or sugar. So there wasn't a grain flu and terrible glucose plummet. I already drink only water and actually like it. I did take in a small amount of Himalayan salt during those days. I did notice a slight tired feeling in the early third day, but felt great by day four. I would imagine it can be rough, but it's going to depend on where you're starting from. Metformin would stop being cheap the moment it was being marketed as an anti aging medication. Slap a new label on it, and mark it up 10,000%.

  • @dandhiari7144
    @dandhiari7144 4 ปีที่แล้ว

    2:45 hagrid says, you are a wizard, Joe

  • @michaelgarbett4088
    @michaelgarbett4088 2 ปีที่แล้ว

    Here is a quote from my favorite TV show, Community:
    "Life is only worth a damn because it’s short. It’s designed to be consumed, used, spent, lived, felt. We’re supposed to fill it with every mistake and miracle we can manage. And then we’re supposed to let go. "

  • @camgamgee7036
    @camgamgee7036 5 ปีที่แล้ว

    I'm with you Joe! also I could never grow bored as long as there were new Answers with Joe to watch!

  • @luciengrondin5802
    @luciengrondin5802 7 ปีที่แล้ว +4

    17:44 "but more than that, I want to be able to live without fear of dying"
    Well, you don't have to be immortal for that. Just stop being afraid.

  • @terryjones2467
    @terryjones2467 4 ปีที่แล้ว

    I usually dont get very hungry until about 9pm. And I get up at 6am so that isnt after sleeping all day. Past few years I might have a snack throughout the day and then pig out on one big meal before bed.
    I dont know if it's good or bad for me. But the intermediate fasting thing got me thinking about it

  • @johnstjohn4705
    @johnstjohn4705 3 ปีที่แล้ว

    Your best and most important video. Well done.

  • @zerotolerance5581
    @zerotolerance5581 5 ปีที่แล้ว +5

    If we're going to be able to double typical life spans, then at some point we're going to have to address the matter of world population control. Because even as it stands right now with an 80 year old lifespan, the population is only ever going up. While the resources available are not.
    Personally I think we should be addressing world population control even without life-extension technology.

    • @carlwessels2671
      @carlwessels2671 4 ปีที่แล้ว

      We should have already done much more than we have. The planet is finite, growth is not

  • @CrystalClearSQL
    @CrystalClearSQL 4 ปีที่แล้ว

    Phineas and Ferb taught us all about the Aglet... amazing what you can learn from cartoons.

  • @nixl3518
    @nixl3518 4 ปีที่แล้ว

    Love your channel… But that shirt is just to “godly“ for me, if you know what I mean, which you should. Your channel is perhaps the most informative channel I have ever experienced and I don’t mean only through TH-cam. You answer questions that have lingered in my mind that require so much research, I just can’t take the time. You are an encyclopedia (if you remember what that was) that I don’t have to search through, because every page has the answers to my questions. Thanks Joe and I expect in due time to become another Patron.

  • @WillBoothe3
    @WillBoothe3 5 ปีที่แล้ว

    Can’t believe this was published 2 years ago.. I remember when I subscribed Joe only had like 10k subscribers. Love the channel

  • @TheMilwaukeeProtocol
    @TheMilwaukeeProtocol 7 ปีที่แล้ว +7

    Joe, they're bored with life because they're stupid.
    Love you
    Love your videos

  • @drakedbz
    @drakedbz 6 ปีที่แล้ว

    creating a clone for organs was also from house of the scorpion, a book by Nancy Farmer written in 2002

  • @kamieaston3016
    @kamieaston3016 5 ปีที่แล้ว +3

    *Sigh*
    We need a sugar daddy to invest money into nanotechnology...

    • @PinataOblongata
      @PinataOblongata 5 ปีที่แล้ว +1

      Or you could vote for governments who fund basic science and convince your friends and family to do the same.

  • @_on_earth_
    @_on_earth_ 4 ปีที่แล้ว +1

    I encountered this article once in my genetics class. It discussed how aging is not evolutionary in nature because it is outside the bounds of selection, and how aging turns out to be very much connected with gene expression, wherein which of our genes turned "on" and which are turned "off" change as we age.
    Check it out: "Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres" by Song and Johnson (2018).

    • @_on_earth_
      @_on_earth_ 4 ปีที่แล้ว

      I just noticed your vid was from 2017 and the article was from 2018 so I hope my comment would be useful. I hope you find the fountain of youth. Cheers

  • @gmanon1181
    @gmanon1181 3 ปีที่แล้ว +2

    That means you will have more time to persut your dreams, find your soulmate, achieve fame and fortune.
    You might even discover solutions to overpopulation.

  • @susancorgi
    @susancorgi 4 ปีที่แล้ว +2

    I don't think i can take life more then 80 years time. I'm already sick of everything at 45.

  • @garyhoward4064
    @garyhoward4064 5 ปีที่แล้ว

    Should mention also NMN, NAD+, etc

  • @HeleneLouise
    @HeleneLouise 5 ปีที่แล้ว

    I just listened to several minutes of Aubrey de Grey hashing over the criticisms of anti aging. It's like hearing someone tell me for the millionth time that telomeres are shoelaces. Now almost six minutes into this and I'm still waiting to hear thoughts on anti aging.

  • @MegaEvoluzione
    @MegaEvoluzione 4 ปีที่แล้ว +3

    When you're worry-free you can live 1000 years.

  • @supervastgut1568
    @supervastgut1568 6 ปีที่แล้ว +1

    do a video about the ketogenic diet and its actual benefits

  • @amphibiousone7972
    @amphibiousone7972 6 ปีที่แล้ว +1

    Thanks Joe, very thought provoking. Seems like you have invested a bunch of thought into this subject.....long before this video. Yes life is awesome! I want to know about everything! Keep up the great work.👍👊👏

  • @kylorenkardashian5518
    @kylorenkardashian5518 5 ปีที่แล้ว +3

    not so fun fact: life expectancy is decreasing

  • @stonedsnakestudios
    @stonedsnakestudios 6 ปีที่แล้ว

    Dude I love your shit. Very diverse and humorous

  • @LeighJFP
    @LeighJFP 4 ปีที่แล้ว +1

    If the future we can be cyborg we can make parts of Brian robotic, memory chips, the stuff that transmit data and gives information to other parts of the body with transmitters.

  • @martinjohnson2549
    @martinjohnson2549 4 ปีที่แล้ว

    I do fast from time to time, feels great.

  • @josemontes5313
    @josemontes5313 6 ปีที่แล้ว +1

    Really likes this video

  • @amysidders8802
    @amysidders8802 3 ปีที่แล้ว +1

    Berberine and cinnamon do the exact same thing as metformin without all the stomach issues.

  • @ThirtytwoJ
    @ThirtytwoJ 4 ปีที่แล้ว

    So from age 26 to now, ive been in miserable agony and slowly dying. At times i begged for death and could easily see myself doin it again. Granted i wasted and didnt appreciate a lot of my life and youth but things change. I got sick, at the same time i found out i would be a father.. so my sons entire life ive been sick and outside the picture several years now. With no college education ive now proven wrong dozens of doctors, figured out the puzzle of my condition, and am trying to get surgery done to start correcting the problems literally so i wont have to take the risks of doing it myself but will if i run out of options. Point being, sometimes you dont discover a meaning til later and then youll walk through any hell to continue on. Youve probably never known pain and strife like i have or ever will, physical or emotional. The ones that have clawed their way back from hell will understand, if youre okay with dying then youre either doing life wrong or delusional about an afterlife. Its not the pain or the boredom thats the worst in life, its loneliness. Imagining death could be anything like my last 6 years alone.. pain or not, no... Id rather not find out. Youve never known irony til you find yourself responding to the news they missed the problem so long you probably have developed cancer by saying "good, now maybe I'll actually get taken seriously enough a surgeon will do the work and to have a fighting chance fixing the problems the graft caused" and i hope you never do except in the sense youll appreciate life far more once youve nearly lost it. Id probably be a great candidate to go into deep space now though, already done years of isolation ..so provided im not goin alone i could probably handle that mentally. Dont kid yourself, the worst thing in life is finding out how truly alone you are and how quickly the people you love will sweep you under the rug when you need support the most. You can be alive and already be forgotten. "Go not ye gentle into that good night. Rage, rage against the dying of the light"

  • @kwitseo
    @kwitseo 3 ปีที่แล้ว

    Stem cell research sounds lovely. I need to replace my damaged eyes and improve my ability to hear. Living a 1000 years or is a bonus.

  • @Immad1337
    @Immad1337 5 ปีที่แล้ว

    Phineas and Ferb would have never mad an episode about the aglet if it wasn’t first mentioned in Zach and Cody years before. 👍🏽 👌🏾

  • @CRASS2047
    @CRASS2047 4 ปีที่แล้ว +1

    Limit families to 1 or two kids based on current population. Living to be 200 or more is exactly what I want. Imagine getting to have fun until 50, then study until 75, start a career, have kids around 100, retire at 200 and die at 300.

  • @SilverFan21k
    @SilverFan21k 5 ปีที่แล้ว +1

    Thank you for making his video! I personally am an activist in the Healthspan movement and appreciate your efforts! +1

  • @waldoayala74
    @waldoayala74 6 ปีที่แล้ว +1

    I wanna live forever, I am also afraid to the idea of dying... I want to go where no man has ever gone before!!!!

  • @edwardrobertson2958
    @edwardrobertson2958 2 ปีที่แล้ว

    The last comment was over a year ago, but if someone comes across this...Here goes (I'll try to be brief):
    Chelation-therapy: taking the calcium out of the hardening arteries and deposits it into the deteriorating bones.
    Another one had it that a tumor put out a substance that kept micro-tumors from growing. Remove a cancer and others will develop in surprising places. Right? Studies were looking pretty good about this not cure, but keep it in the benign stage treatment.
    Does anyone talk about these things anymore?

  • @johndugmore713
    @johndugmore713 7 ปีที่แล้ว

    Awesome video. Thanks Joe. Been following you for a while. This one made me press the subscribe button

  • @darrenhenderson6921
    @darrenhenderson6921 5 ปีที่แล้ว

    There are about 20 totally different techniques that can stop aging altogether or reverse it to the genetic prime, even at 100 years old, once administered, just a matter of healing.

  • @mrsalshammari2377
    @mrsalshammari2377 6 ปีที่แล้ว

    What ever helps us to get a healthy life and longer it’s a fantastic experience