#Epidermal growth factor (EGF) plays an important role in cell proliferation of a variety of cells types by binding to the EGF receptor (EGFR), which stimulates several signal transduction pathways leading to the transcriptional activation of a number of growth-related genes and transcription factors including c-fos, c-jun, and Ets. This signaling pathway activation also plays an important role in the development of many solid tumors. -Creative BioMart
Impressive. Is this 12th grade biology that you are teaching? I have to say that this is highly advanced for that level of education. We, as oncologists, routinely use agents that bind to these receptors and observe certain lung cancers with egfr +ve mutations regress dramatically and prolonging overall and progression free survival of patients. Very impressed to see that such valuable information is being imparted to 12th grade students.
Good job but one suggestion. EGF binding just doesn't phosphorylate the protein, it's a complicated process so please make sure you at least explain that EGF makes the receptor dimerize (a canonical model although not completely true as EGFR mostly multimerize) and activates only one of the two kinases (the receiver kinase) and that kinase then phosphorylates both the tails and activates the pathway you talked about. Simultaneously, it also activates PI3K pathway for the similar purpose.
thanks for a great explanation, I am studying skin, I still don't understand the difference between epidermal growth factor and fibroblasts. maybe you can explain! thanks
thanks for a great explanation, I am studying skin, I still don't understand the difference between epidermal growth factor and fibroblasts. maybe you can explain! thanks
thanks for a great explanation, I am studying skin, I still don't understand the difference between epidermal growth factor and fibroblasts. maybe you can explain!
I AM A TOTAL FAN OF THIS YOUNG MAN - he is amazing
and has such a talent for imparting knowledge
Thank you
THANK YOU. i have a presentation and this video was extremely helpful
That was the EASIEST way to understand this.
Hello Sir! My friend Shalvi is a big fan of you and your videos!
Glad to hear that you are getting benefit from the videos
#Epidermal growth factor (EGF) plays an important role in cell proliferation of a variety of cells types by binding to the EGF receptor (EGFR), which stimulates several signal transduction pathways leading to the transcriptional activation of a number of growth-related genes and transcription factors including c-fos, c-jun, and Ets. This signaling pathway activation also plays an important role in the development of many solid tumors. -Creative BioMart
Very nice my friend 🧡
Wish you the best😊
Thank you so much for appreciating my efforts
Thank you Sir, your explanation made this so easy.
Man that video was awesome! Thank's very much!
Impressive. Is this 12th grade biology that you are teaching? I have to say that this is highly advanced for that level of education. We, as oncologists, routinely use agents that bind to these receptors and observe certain lung cancers with egfr +ve mutations regress dramatically and prolonging overall and progression free survival of patients. Very impressed to see that such valuable information is being imparted to 12th grade students.
+Harsh Parmar no its definitely not for 12 grade students. It's for graduation
this man is a gem 😍 respect from 🇵🇰 keep it up ☺️ amazing explanation
Thank you so much for appreciating my efforts
❤️
Thank u for good explanation
You're welcome
Good job but one suggestion. EGF binding just doesn't phosphorylate the protein, it's a complicated process so please make sure you at least explain that EGF makes the receptor dimerize (a canonical model although not completely true as EGFR mostly multimerize) and activates only one of the two kinases (the receiver kinase) and that kinase then phosphorylates both the tails and activates the pathway you talked about. Simultaneously, it also activates PI3K pathway for the similar purpose.
thanks for a great explanation, I am studying skin, I still don't understand the difference between epidermal growth factor and fibroblasts. maybe you can explain! thanks
Thank you, this helps out a lot!
You're welcome
Thank you very much for the explanation 👍 👍👍👍👏👏👏👏🙋🏻♂️🙋🏻♂️🙋🏻♂️🇩🇪🇩🇪🇩🇪
You're welcome
Wow Great explanation! Do you have any idea What to eat or avoid to decrease Ras?
It's not related like that in a simple relationship
Really very helpful
You're welcome
You are the best.🔥
Thank you so much for appreciating my efforts
I love all of your videos!! Thx
You are simply amazing!
+Raisa Catunda you're welcome
so nice explanation , excellent
You're welcome
Very useful ♥️
Thank you
amazing videos...thank you so much..
Good! Well done and thank you!
Thank you
You're welcome
Understood..Thank You.
How long after expire date on the bottle is it still effective?
Can u please upload a video on pharmacogenomic as soon as possible.
Please sir.
Plss sir rpy
Plsss sir its really very urgent..can u please help me out..by providing video lectures related to biotechnology..
@@poojadubey8540 You crazy g
Thank you!
Bio just got real !
Still amazing!!!!
+Eugen Mollaknoil you're welcome
i love u (: , that was insane
Thank you
Thank you so much !
thank you sir.
You're welcome
great!
Is this considered autoimmune disease?
Are bioactive growth factors good to take?
Sir will u pls make a video on nerve growth factor
hope to explain MSC stem cell growth factors
why nerve growth factor cannot pas through lipid membrane
take my love, thanks a lot
You're welcome
Does ras has any full form
So is the Ras-GDP phosphorylated or exchanged for GTP?
TheQueenaby because there was no mention of a GTP exchange factor, just kinases.....
and what aboout MAPKK? thanks x
As I read it is exchanged for GTP.
👍
Thank you
i m nt able to find production of growth factors can anyone suggest from which book I can find that?
P53 pathway please
Later
Yes please 🙃
thanks for a great explanation, I am studying skin, I still don't understand the difference between epidermal growth factor and fibroblasts. maybe you can explain! thanks
Thank you
You're welcome
Thank you sir
You're welcome. Glad to hear that you're getting benefit from my lectures
thanks for a great explanation, I am studying skin, I still don't understand the difference between epidermal growth factor and fibroblasts. maybe you can explain!