Nutraceutical 3 in CVD September 2024

Role of Nutraceuticals in
Cardiovascular Diseases
The Nutraceutical Triple-Play in CVD
Sterols, Stanols, Phenols & Flavones
Plant-derived sterols and stanols compete with cholesterol to form micelles with bile salts. This reduces cholesterol’s absorption into the bloodstream.
A unique commercial form of sterols is Microphyte.
"Microphyte is produced by a patented milling technology called vortex milling, allowing us to produce a small phytosterol particle with higher dispersibility in liquids and spreads," said David Charles Fondots the President at at Extracts-Unlimited LLC, Chester, New Jersey, United States Ltd, producer of Microphyte.
Phenols have been shown to reduce cholesterol levels and LDL oxidation.
Polyphenolic catechin which is present in Green tea (Camellia sinensis) reduces the CVD by enhancing antioxidant activity by improving endothelial dysfunction, preventing cardiac hypertrophy and protects mitochondria.
Oxyphyte is now a days available products of polyphenolic extracts of green tea, apple, pomegranate and red grape.
Super Fibers
Dietary fiber found in plant foods ( fruits, vegetables and whole grains) and is essential to maintain healthy digestive system.
Two types of fiber i.e. soluble fiber (gums & pectins) which can dissolve in water which helps to lower blood fat and maintain blood sugar. E.g. beans, fruit such as strawberry & banana and oat products, barley,
Insoluble fibers can’t dissolve in water, so directly passes through the digestive tract and helps to trap cholesterol, toxins etc. that are then expelled through feces. E.g. cellulose, hemicelluloses in bran, leafy vegetables.
What is VLDL cholesterol? Can it be harmful?
Very-low-density lipoprotein (VLDL) cholesterol is produced in the liver and released into the bloodstream to supply body tissues with a type of fat (triglycerides).
Fats for Vascular Health
The cardiovascular benefits of omega 3 oils.
Sources : Marine plants, algae sources such as
Alpha linolenic acid (ALA), Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA)
Vegetable oil such as soyabean, sunflower and nut like Peanuts and Almonds
Omega 3 consumption appears to reduce the risk of LDL-c oxidation by reducing diacylglycerol acyltransferase (DGAT) activity in the liver.
Diets high in saturated fats, trans-fats and fried foods tend to increase VLDL-c and LDL-c levels.
This is not necessarily applicable to dairy, however. Dairy is high in conjugated linoleic acid (CLA). As it significantly lowered VLDL-c and triglycerides.
Furthermore, dairy tripeptides such as valine-prolyl-proline (VPP) and isoleucine-prolyl-proline (IPP) from cultured dairy products have been shown to be vascular-healthy.
Tocotrienols
Tocotrienols are members of a subgroup of the vitamin E family, which includes tocopherols. Both tocotrienols and tocopherols are antioxidants, but only tocotrienols have been shown to reduce cholesterol, inhibit certain cancers and manage diabetes.
High levels of VLDL cholesterol have been associated with the development of plaque deposits on artery walls, which narrow the passage and restrict blood flow.
There's no simple, direct way to measure VLDL cholesterol, which is why it's normally not mentioned during a routine cholesterol screening. VLDL cholesterol is usually estimated as a percentage of your triglyceride value. An elevated VLDL cholesterol level is more than 30 milligrams per deciliter (0.77 millimole/liter).
The best way to lower your VLDL cholesterol is to lower your triglycerides. Losing weight and exercising regularly are key, and you might also want to avoid sugary food and alcohol in particular. Medications also can help.