i could not understand that upregulate and downregulate part of dimerization, which is at the end of the lecture. like when you said in the downregulation the monomer would not be available in the cell and in upregulation lots of dimer are present to dimerise, aren't both the dimer present in a same protein?? please explain
Where one monomer has a constitutive expression while the other one has a variable expression, the availabilty or abundace and unavailability or scarcity of one of the two monomers ( the one with variable expression) will control the transcriptional activity as lesser number of these monomers will result in lesser number of dimers being formed leading to decreased activity of this particular TF, while a higher number of the variable monomer will have an opposite impact.
Excellent, thank you.
My pleasure sir 🙂
i could not understand that upregulate and downregulate part of dimerization, which is at the end of the lecture. like when you said in the downregulation the monomer would not be available in the cell and in upregulation lots of dimer are present to dimerise, aren't both the dimer present in a same protein?? please explain
Where one monomer has a constitutive expression while the other one has a variable expression, the availabilty or abundace and unavailability or scarcity of one of the two monomers ( the one with variable expression) will control the transcriptional activity as lesser number of these monomers will result in lesser number of dimers being formed leading to decreased activity of this particular TF, while a higher number of the variable monomer will have an opposite impact.