Ketone is called a prochiral centre as it is achiral (trigonal planar geometry), but it can become chiral after undergoing reaction like nucleophilic addition.
Nice question! 🙂.... When we used LiAlH4, we got racemic mixture. So to get one particular enantiomer as major product, we use chiral ligand to increase enantiomeric excess. You can read this paper for more information: Reference: S. Yamaguchi and H. S. Mosher, J. Org. Chem., 1973, 38, 1870-1877 doi.org/10.1021/jo00950a020
Thank you for making this video. It's helped me in my science seminar class. That I have to talk about this topic.
Thanks! You study in which class?
Thank you so much your video was very helpful
Thanks..Happy to know that!😊
So in this case what group is a ketone under in terms of stereochemistry
Ketone is called a prochiral centre as it is achiral (trigonal planar geometry), but it can become chiral after undergoing reaction like nucleophilic addition.
Thank you ❤
You're welcome! 🙂
Why you used L*-chiral ligand in enantioselective reaction
Nice question! 🙂.... When we used LiAlH4, we got racemic mixture. So to get one particular enantiomer as major product, we use chiral ligand to increase enantiomeric excess. You can read this paper for more information:
Reference: S. Yamaguchi and H. S. Mosher, J. Org. Chem., 1973, 38, 1870-1877 doi.org/10.1021/jo00950a020
Thanks
Welcome