Thank you sir. You have taught me something which is not routinely written in text books. I have one doubt, you said the more lipid solubility, the less reabsorotion into the blood stream. If that is the case, lignocaine should have longer duration of action than bupivacaine as at physiological pH, lignocaine will have more unionic fraction which will make it more lipid soluble?
We meet again…I think you confused pKa with lipid solubility. The pKa will determine the speed of onset hence why lignocaine with a pKa of 7.8 will start working faster than bupivacaine (8.1); the lipid solubility (ie the partition coefficient) will determine the duration of action and the potency.
Superb resource
Thank you Doc
Succinctly well explained😊
Excellent presentation
wonderful presentation
EXCELLENT LECTURE THANKS
Well explained prof thanks so soooo much❤
I wish I had a mentor like you..
Nice sir
Thank you for this information. I found the explanation helpful.
Thank you sir. You have taught me something which is not routinely written in text books.
I have one doubt, you said the more lipid solubility, the less reabsorotion into the blood stream. If that is the case, lignocaine should have longer duration of action than bupivacaine as at physiological pH, lignocaine will have more unionic fraction which will make it more lipid soluble?
We meet again…I think you confused pKa with lipid solubility. The pKa will determine the speed of onset hence why lignocaine with a pKa of 7.8 will start working faster than bupivacaine (8.1); the lipid solubility (ie the partition coefficient) will determine the duration of action and the potency.
It was my mistake in understanding. Thank you so much for clarification.