A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Thanks very much for this wonderful video! I just met a tenosynovial giant cell tumor without any giant cells, but the presence of foamy cells and the collagenization of the stroma helped me a lot to achieve this diagnosis. Thanks for your teaching video a lot!
My pleasure. A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Super helpful review, as usual. Especially topical for me given a sclerosed GCT on my desk this week from finger, which threw me a little to start with as very scant on the actual giant cells. But thanks to your rules, am happy!
What a great presentation! I like the clues at the bottom. Thanks for all your teaching. It's helping me as a histopathology trainee in the UK (looking for ladybirds).
Thanks for the amazing concepts, comparisons and the ever lucid way of explaining Sir..Feel all the more in love with this subject after seeing your videos!
Can you also do a video about differentiating ddx for the hyaline deposits! Like EPp vs lipoid proteinosis vs colloid millium vs nodular amyloid. The more I look it up and try to learn it.. the more confused I get! Thanks in advance
Haha you’re not alone! I think they look nearly identical as well and I have to look them up every time I am considering them. Maybe that’s a good reason to make a video though...
Common? My understanding was it is a rare disease... I also had a large nodule (Giant cell tumor) in my knee-It pressed on my ACL and I couldn’t straighten my leg. In addition, I had a lot of diffuse growth. Both types returned less than one year after the resection and synovectomy. Waiting for the new chemotherapy. I certainly hope that they keep on top of it because if someone misdiagnoses it non-malignant in error, this is a very deadly sarcomatous type cancer if it does in fact become malignant!
Thank you for your presentation. My query is about prominent angiomatous proliferation of capillary endothelial cells in addition to plenty of haemosiderin loaded histiocytes.
I don’t understand. Are you asking if these things can be present in tenosynovial giant cell tumors? Abundant hemosiderin is a common feature. But I don’t recall seeing prominent proliferation of capillaries in this tumor before.
Thank you! No I haven’t done one on malignant transformation in these because it’s incredibly rare. I’ve only see one or two (back in fellowship) and not sure if I even have recuts of those.
@@JMGardnerMD Thank you so much. A few days ago, we received a case of a malignant transformation of GCT of tendon sheath, in our department. I will do my best to send you some histological slides, in case they might be useful to you to make a video about this rare and infrequent type of tumor.
I did surgery for giant cell tumor of tendonsheath nearly two years back in my right ring finger.biopsy confirmed diffuse gctts and it is benign.Now I had a pain in my joints (tumor site)without any swelling. What can I do for this?.I met a orthopedic surgeon for my previous surgeries.
It is probably a good idea for you to visit your orthopedic surgeon again and have them do a work up to see if they think the pain is related to a recurrence of your tumor or something else. Best wishes for a quick healing.
I wad diagnosed with Giant cell tumor of the tendon sheet on my 5 finger of my left hand. Now I am showing the same symptoms on the 4 finger of the left hand. Is it posible to get it on multiple areas? What should I do? I have visited 3 different surgeons and the don’t know what to do.
I can’t recall seeing a patient with this in 2 different places but I think it is possible. Did your surgeons do an MRI of the left hand to see if there is a mass present? Did they do a biopsy or surgery on the left hand? A hand surgeon or an orthopedic oncologist (a specialized Orthopedic surgeon that deals not only with malignant but also benign tumors of bone and soft tissue)...they are familiar with this type of tumor. Most other doctors would not be very familiar with it. Please be sure to talk with your surgeon, ask them to explain what they think is going on and what the options are for dealing with the issue. Best wishes for good health.
Jerad Gardner, MD thanks for your response I am from Puerto Rico here we only have 2 specialists in hands and they decided not to take my case. Yes they did an MRI and it shows soft tissue. It keeps growing and it gets so painful, they only inject me for the inflammation and that’s it. I don’t know what else I can do. Really appreciate your suggestions
I was diagnosed with gct of tendon sheath in my right hand thumb . fnac test confirmed gct. And yesterday I went through excision biopsy. My Doctor once again asked for biopsy of removed tumor. Is this going to worrying .I have this tumor since last 5. To 6years painless. But slowly its size grew up.
They are benign tumors but most of the time they are removed surgically. However if yours is not causing you any symptoms and you don’t want another surgery, then you can discuss with your doctor the risks vs benefits of choosing to watch and wait rather than remove the tumor now. If it were my own thumb, I would probably personally choose to have it removed just to avoid having a mass there if nothing else. But as you are not my patient and I am not your doctor I can’t give you official personal medical advice. Discuss with your own doctor so you can make the best decision for you. Best wishes.
@@JMGardnerMD thanks Sir but please tell me one more thing is fnac test is accurate and I already had removed gct on my thumb . now what is reoccurring rate
No, Far from it! I’m just a pathologist trying to share the small area of pathology that I know about with others so they can better help their patients. But thank you for the kind sentiment. 😊
I cannot recall ever seeing a siderophage that looks like these in a DF. But regardless, the other features discussed here would easily differentiate tenosynovial giant cell tumor from DF. And these tumors rarely involve the dermis which is where most DFs are located.
That just looks terribly pathological and one might even auspect Rheumatoid Arthritis among all the neoplasia. It is highly plausible that an idiopathic autoimmune disease is conducive to many other disorder, neoplasia amongst many others.
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Hye Dr Jerad, do you have videos on Giant Cell granuloma, and how does it differ from usual giant cell tumor
Thanks very much for this wonderful video! I just met a tenosynovial giant cell tumor without any giant cells, but the presence of foamy cells and the collagenization of the stroma helped me a lot to achieve this diagnosis. Thanks for your teaching video a lot!
Those haloes and swimming pools are just so sweet! Amazing lesson, sir!
I like your videos because you illustrate so many features not usually given in books.
Thank u Guruji
An absolutely enlightening presentation. Many-many thanks, Prof.
My pleasure. A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Thank you so much for the comprehensive information you provide in your videos!!
Very Educational and you explain step by step to reach the final diagnosis. Very much appreciated, Prof.
Super helpful review, as usual. Especially topical for me given a sclerosed GCT on my desk this week from finger, which threw me a little to start with as very scant on the actual giant cells. But thanks to your rules, am happy!
Thank you very much Sir, this is highly educational !!
A resident in Pathology from France.
Amazing as usual Dr. Gardner. Thank you for the hard work!!
Great video! Thank you so much.
What a great presentation! I like the clues at the bottom. Thanks for all your teaching. It's helping me as a histopathology trainee in the UK (looking for ladybirds).
Thanks for the amazing concepts, comparisons and the ever lucid way of explaining Sir..Feel all the more in love with this subject after seeing your videos!
Thank you Sir for another great video, but then we expect nothing less from you. 😊
Thank you very much i am from egypt and i benefit from you a lot, God bless you, thank you sir
I had GCT in my right wrist(distal radius). Extended cutterage was done along with fibular bone graft. Hope it doesn’t recur.
Can you also do a video about differentiating ddx for the hyaline deposits! Like EPp vs lipoid proteinosis vs colloid millium vs nodular amyloid. The more I look it up and try to learn it.. the more confused I get! Thanks in advance
Haha you’re not alone! I think they look nearly identical as well and I have to look them up every time I am considering them. Maybe that’s a good reason to make a video though...
Thank you for this amazing video
I have focal pvns in my hip and I was wondering if you knew any stretches I could try to relieve the pain? Also interesting video!
Common? My understanding was it is a rare disease...
I also had a large nodule (Giant cell tumor) in my knee-It pressed on my ACL and I couldn’t straighten my leg. In addition, I had a lot of diffuse growth. Both types returned less than one year after the resection and synovectomy. Waiting for the new chemotherapy. I certainly hope that they keep on top of it because if someone misdiagnoses it non-malignant in error, this is a very deadly sarcomatous type cancer if it does in fact become malignant!
Very good, thank you very much!!!!!
thank you, it is very helpfull
Thank you Sir.🌿
Thank you for your presentation. My query is about prominent angiomatous proliferation of capillary endothelial cells in addition to plenty of haemosiderin loaded histiocytes.
I don’t understand. Are you asking if these things can be present in tenosynovial giant cell tumors? Abundant hemosiderin is a common feature. But I don’t recall seeing prominent proliferation of capillaries in this tumor before.
Thank you Jerad, for another masterfully explained case.
Have you done some video related with the malignant form of Tenosynovial giant cell tumors?
Thank you! No I haven’t done one on malignant transformation in these because it’s incredibly rare. I’ve only see one or two (back in fellowship) and not sure if I even have recuts of those.
@@JMGardnerMD Thank you so much.
A few days ago, we received a case of a malignant transformation of GCT of tendon sheath, in our department. I will do my best to send you some histological slides, in case they might be useful to you to make a video about this rare and infrequent type of tumor.
Thank you for excellent explanation sir🙏
Thank you sir , for such a nice presentation.
very informative. Thanks
can we have spindling of the histiocytic cells in a case of GCT?
Usually not a lot of spindling. If there is a lot of spindle cells I would think of other entities including giant cell tumor of soft parts.
Thank you Sir so much, amazing guidance.
Amazing thank you very much
Thank you sir for useful discussion.
I did surgery for giant cell tumor of tendonsheath nearly two years back in my right ring finger.biopsy confirmed diffuse gctts and it is benign.Now I had a pain in my joints (tumor site)without any swelling. What can I do for this?.I met a orthopedic surgeon for my previous surgeries.
It is probably a good idea for you to visit your orthopedic surgeon again and have them do a work up to see if they think the pain is related to a recurrence of your tumor or something else. Best wishes for a quick healing.
@@JMGardnerMD Thank you sir
I wad diagnosed with Giant cell tumor of the tendon sheet on my 5 finger of my left hand. Now I am showing the same symptoms on the 4 finger of the left hand. Is it posible to get it on multiple areas? What should I do? I have visited 3 different surgeons and the don’t know what to do.
I can’t recall seeing a patient with this in 2 different places but I think it is possible. Did your surgeons do an MRI of the left hand to see if there is a mass present? Did they do a biopsy or surgery on the left hand? A hand surgeon or an orthopedic oncologist (a specialized Orthopedic surgeon that deals not only with malignant but also benign tumors of bone and soft tissue)...they are familiar with this type of tumor. Most other doctors would not be very familiar with it. Please be sure to talk with your surgeon, ask them to explain what they think is going on and what the options are for dealing with the issue. Best wishes for good health.
Jerad Gardner, MD thanks for your response I am from Puerto Rico here we only have 2 specialists in hands and they decided not to take my case. Yes they did an MRI and it shows soft tissue. It keeps growing and it gets so painful, they only inject me for the inflammation and that’s it. I don’t know what else I can do. Really appreciate your suggestions
What about inflammatory cells inbetween neoplastic cells
I was diagnosed with gct of tendon sheath in my right hand thumb . fnac test confirmed gct. And yesterday I went through excision biopsy. My Doctor once again asked for biopsy of removed tumor. Is this going to worrying .I have this tumor since last 5. To 6years painless. But slowly its size grew up.
They are benign tumors but most of the time they are removed surgically. However if yours is not causing you any symptoms and you don’t want another surgery, then you can discuss with your doctor the risks vs benefits of choosing to watch and wait rather than remove the tumor now. If it were my own thumb, I would probably personally choose to have it removed just to avoid having a mass there if nothing else. But as you are not my patient and I am not your doctor I can’t give you official personal medical advice. Discuss with your own doctor so you can make the best decision for you. Best wishes.
@@JMGardnerMD thanks Sir but please tell me one more thing is fnac test is accurate and I already had removed gct on my thumb . now what is reoccurring rate
It is very rare for a doctor to ask for a biopsy again. Take a second opinion. which city are you based in?
Thank you so much for sharing 🤩
I just recently had surgery to my ankle with pvns. Can I still drink red wine with pvns
Please ask your doctor for advice about this.
Thank you very much sir
You are god of pathology
No, Far from it! I’m just a pathologist trying to share the small area of pathology that I know about with others so they can better help their patients. But thank you for the kind sentiment. 😊
This slide is available on the pathpresenter platform ?
Not currently but I can scan a few and upload them and add links to video description. Great Idea!
How would you differentiate from ringed siderophages seen in DF?
I cannot recall ever seeing a siderophage that looks like these in a DF. But regardless, the other features discussed here would easily differentiate tenosynovial giant cell tumor from DF. And these tumors rarely involve the dermis which is where most DFs are located.
thank you
Any treatment?if recurrence possible
These are usually treated with surgery to remove the mass. If it recurs, it is usually surgically removed again.
Thanks a lot....
thank you sir
That just looks terribly pathological and one might even auspect Rheumatoid Arthritis among all the neoplasia. It is highly plausible that an idiopathic autoimmune disease is conducive to many other disorder, neoplasia amongst many others.