All 13 studies referenced in the video are linked in the video's description 💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin For extra insights + a free health checklist, sign up here 👉 drstanfield.com/pages/sign-up
@@DrBradStanfield What you have is fine except you should check all reported bad side effects before presenting Ozempic as something to take. Do you really not tell your patients about these other issues?
I still think you should discuss the natural fiber -> glp-1 pathway for satiation signaling so that people know why they don't naturally produce enough glp-1.
With respect to gallstones, they’re also more likely to form during periods of rapid weight loss, so it’s hard to tell whether GLP-1 agonists are primarily or secondarily responsible for their increased incidence. To really find out, you would need to compare gallstone rates in people using GLP-1 agonists against gallstones rates in people achieving similar rates of weight loss without GLP-1 agonists. It could turn out that there is no difference.
I guess the argument could be that rate of weight loss is far less likely without GLP-1 agonists and/or GIP. Maybe a better study would be both groups on GLP-1 but gallstone rates of fast vs moderate weight loss groups?
@@DigiDriftZone I agree that most people would not be able to lose weight at the same rate as they would on a GLP-1 agonist, but it would be difficult to study either way due to the various challenges associated with dietary studies in humans. That said, there might already be some research related to gallstone formation and weight loss that we could infer from. If it could somehow be demonstrated with a reasonable degree of confidence that it is a secondary effect, we would at least be able to employ the same mitigating strategies we use to prevent gallstones in unmedicated weight loss.
My BMI was 54 and I was using 240 units of insulin each day. I've gone from A1c of 6.9 to to 5.6, lost 80 pounds, and now use 0 to 6 units of insulin a day. For me it was a huge health benefit.
So cool! I’ve had many patients be able to fully come off insulin, thanks to GLP-1 meds. They lose weight, have more energy, and we can often stop their blood pressure meds as well
Thank You for this. I do have nausea issues but it's worth it. My relationship with food has totally changed. I will never eat the way I used to. I was raised to believe I needed so much food I just don't need.
Muscle mass loss is higher in older folks that can't move around as much. My mother was on ozempic for over 2 years after which she stopped treatment and now she's even less mobile than she was prior to being prescribed ozempic.
@@ColinHeddle doctors really need to stress the importance of protein per kg and resistance training before prescribing. If you take it without a plan you are indeed likely to lose as much if not more muscle than fat.
100% Unfortunately they have no problem prescribing it to elderly folks that already have limited mobility and muscular atrophy. In my mother's case she's gone from bad to worse. She was already experiencing limited mobility, and now she's unable to safely navigate stairs.
@@ColinHeddle that’s horrible :( sorry to hear. Might be worth encouraging her to eat more protein, I’m doing this with my elderly parents and bought them a treadmill too so they try to walk while watching their TH-cam.
It's been hard to watch the decline from the other side of the country. Been trying to get her to increase protein intake and (unfortunately) she's taking Boost daily. I'm in the process of selling my property so I can move back to be closer so I can have more influence and support. Ultimately I'm hoping to get her into ketovore/carnivore to mitigate inflammation etc and help her get moving again.
What Brad doesn't mention is the broadening application of these medications. Semaglutide has already been approved for cardiac protection in known atherosclerotic disease. Tirzepatide now approved as the only medication to treat sleep apnea. Tirzepatide also recently demonstrated a 99% efficacy in preventing progression from prediabetes to diabetes. GLP-1 drugs (and not just the fancy long-acting new ones but also the older ones that needed daily injection) have shown a 40% reduction in overdose deaths in opioid users and a 50% reduction in positive alcohol screenings in alcoholics. These drugs are also being used for fertility in men and women, in PCOS... they're associated with drastic reductions in the occurence of alzheimer's disease... I could go on and on. I love this TH-cam channel, and. I suppose on TH-cam this just comes with the medium, but I feel like it's concern trolling or at least sensational to decry GLP-1 telehealth practices. People who have been trying to lose weight heir entire lives should not be told to spend another 3-6 months doing lifestyle mod-that's just silly. Obesity kills people through cancer, heart disease, misery, etc. The cure should be embraced. The people should have the remedy.
66yo, very fit, got injured went from 175 to 220. Dieted the hard way and went down to 155, was told I looked sick. So weight went to 175. I wanted to drop 10lb - so I got some mounjaro from a buddy (2 x 5ml). took the doses (5ml/week) on the 2 weeks I was skiing - didn't eat b/fast , I small sandwich for lunch, small dinner .. didn't feel hungry and was burning around 1200 exercise calories .. abs now clearly visible .. If I had to lose a lot of weight - I'd definitely use the drugs and not "tough it out" (again). I have not weighed myself but using my jeans as a measure - I'd guess Im down 6 - 8 lb. I'm sure a lot of that water weight .. I was peeing every hour for the first 3 days. jeans went from "snug" to "I can get a fist between by stomach and the jeans". One hears a lot about fasting and MTOR - and how fasting is all kind of "good" .. well, I've been on a 600kcal/day for 14 days ... so - more goodness. I also did dry January .. WAY THE HELL easier with the mounjaro ... didn't want to eat and didn't want to drink.
You missed one indication for glp-1 prescription beyond the BMI of 30 you did mention: GLP-1 agonists are prescribed for people with a BMI of 30 or higher, or a BMI of 27 or higher with obesity-related conditions (high bp etc.)
Yes, correct. It’s tricky to strike a balance between what information to put in these videos and what to leave out. Could talk for a couple of hours about GLP-1 meds haha
@DrBradStanfield For sure! Don't want to nitpick an otherwise excellent video. But I do think it is important to not potentially steer people away from a good therapy if they think they are not a candidate while they do qualify.
I am very curious about individuals who don’t have a very high BMI (or waist circumference, meaning they aren’t very overweight), but who struggle with sticking to healthy eating or overeating and forming binge eating habits. Ozempic quiets down food noise that a lot of people like that suffer with. I know someone who is on it who struggled with their weight and made a big effort to keep a healthy weight (and went up and down 10/15kg) and now that’s he’s on it, he just eats in a regular balanced way without ever binging or thinking about food constantly. He’s lost some weight and has remained consistent.
In the USA, the FDA approved use of these drugs to treat obstructive sleep apnea in obese patients. The patients would have been able to take the drugs for being obese to begin with, but because insurance companies don't typically cover obesity drugs, but do cover sleep apnea treatments, more people get insurance coverage for taking them. There's a huge push for an oral form to be "over the counter" medication one day.
Please discuss the rampant use of antidepressants as well, even though studies show talk therapy is just as effective, and sometimes more effective long term.
Not saying anything negative about this modality, just a question. Why not just take the base peptide by itself and forego the other ingredients in Ozempic? The base peptide is off patent whereas the other is patented due to the manufacturing process. Being a lay person, I'm trying to understand what the non peptide ingredients do. The bare peptides seem to have extremely low side effects which is why I'm questioning this. Thank you Doctor
@@babaluto Yes I know but you make it sound that ozempic is a "Base peptide" plus other ingredients. Hence me saying what base peptides are you talking about that you want to isolate? Ozempic is just semaglutide - a single peptide.
@pvw337 I think I'm confused about GLP-1 as a naturally occurring hormone/peptide in the body and how it is interchangeably used with Ozempic/semaglutide. Where the Ozempic is manufactured/cultured or whatever, it does contain the preservative phenol and the side effect warnings of the drug. I've read about GLP-1 l.a ong before hearing about Ozempic. The info available looks at diets that increase satiety and blood sugar regulation. As with nearly all type 2 diabetes, the management is truly a lifestyle choice. Rather than saying, "other ingredients", maybe it is the process of the manufacture that I'm looking at. If Ozempic is a pure peptide analog and is supposed to be identical to the GLP-1 that occurs in the body, why is it unsafe for type 1 diabetics and is taxing on renal and liver functions. Looking at the MSDS for Ozempic, there is some indication that there is some manipulation of the peptide in the manufacturing process. Not saying it is a bad or good thing. In order to patent the product the makers have to change something in the process from the previous off patent methods. So yeah, I have questions, maybe stupid, maybe not. Cheers!
I have a friend who has been prescribed Ozempic for over a year, but she hasn't made any significant lifestyle changes. She continues binge eating and avoids exercise. I haven't noticed any improvements in her health, and she's also taking some tablets, but I’m not sure what they are. As far as I know, she has type 2 diabetes. I've advised her to change her lifestyle to maximize the benefits of the medication, but it feels pointless now. Are there any complications if she continues like this? I'm not sure if she's being honest with her doctor during check-ups or if the doctor isn't paying much attention.
The problem is that GLP1 agonists are being used as a injectable discipline. Individuals with poor pre-treatment diet and exercise habits will just reduce food intake while maintaining unhealthy food choices. This extreme calorie restriction can further decrease exercise motivation and negatively impact NEAT. Lack of exercise and likely low nutrient dense diet will exacerbate muscle and bone wasting.
How do researchers perform double blinded placebo controlled studies of stuff like Semaglutide? If every participant has to believe they're taking the medication, even the placebo needs to be labeled as containing a GLP-1 agonist, which causes in some degree a placebo effect, too.
I don’t doubt that these things you charge could be true. But how do you know that they’re true? How do you know what most doctors do? How do you know that they’re not telling patients about the need for long-term use? Where do you get this information?
I was prescribed Ozempic to control my A1c. It has dropped from 7.4 to 6.4. Additionally, I have lost 25 pounds. The biggest problem I have is being nauseous most days. On a scale of 0 to 10 (zero being non-nauseous) I am consistently at a 1 or 2, with occasional 0s and, if I'm careful, few actual vomiting events.
The glp-1 chemical pathway is closely related to one of the natural pathways in the body for satiation. The normal pathway involves eating fiber, which is processed by a healthy gut biome to trigger glp-1 release into the bloodstream. Fiber (and phytates) also delay(s) processing of nutrients so that the microbiome near the end of your digestive track have better nutrition. The most important way to build your gut biome is to have a variety of different fibers with no fiber skip-days.
Currently 22 years old male, and using 15mg tirzepatide. Drop weight from 82 to 59kg in 6 months. No sides effects, just amazing benefits. Liver enzymes are the best I ever had, no more hyperphagia. These drugs are a revolution
My BMI is 23 but I want to get it to 20 as I like to compete in running events. I guess they won't let me use it? They might let me use statins to optimise ldl so why not ozempic.
These drugs have a very good chance to reduce your desire to exercise . Has been shown in mice. So more data needed in humans. This will be hard to work out - as many overweight have little motivation , so as weight less have more energy to do more,. But at your BMI is it worth the risk. Wait to more data I say. Better to try and do it naturally
As an amateur athlete, it was completely game changing for me. I would recommend exploring it and they are not strict with online prescriptions if you happen to mistype your weight or height. Personally I used the 2.5mg mounjaro (starting dose) only for a cut (2 months) and stretched it to every 10 days instead of 7. This is not medical advice, check you don’t have pancreas problems before considering this. I’ve never been this lean in my life with a defined six pack and I have more energy and motivation without the food noise and cravings. My training has never been this consistent in my life (I’m 38). Before I would say to myself I’m too hungry to go to the gym, now I eat after. I also have a sustained energy level the whole day, life changing stuff.
@@robertusga You're right- access and lack of coverage is an issue. I'm referring to having very expensive drugs being over-prescribed for very common conditions/ indications. This is a problem, even for public healthcare systems that can aggressively negotiate down the price of drugs.
I tried ZepBound but sadly it gave me severe diarrhea. I stuck it out for two and half months hoping it would go away but it didn't appear to be letting up so I stopped. I did lose 20 lbs which is a lot in two months. It has been six months since I've stopped and I haven't gained any weight back but I'm no longer getting leaner. Having difficulty reducing my calories to the necessary level. Can't really increase exercise. I ride my bike 60 miles three to four days a week.
Since microdosing Tirz to help with joint inflammation (very successfully I must add) I’ve noticed that it’s also helped with food noise, making it easier to stick to an animal based diet. I also noticed, now that you mention gallbladder, that I no longer have any discomfort with my GB like I was before. I think people who have side effects are dosing too high.
I’m definitely using this off label, I struggled to get under 18% body weight since 2018 (life/travel/work gets in the way). I took a 2.5mg Mounjaro pen (the starting dose) and stretched the doses to every 10 days. I’ve smashed past the plateau, down to 15% body fat, visible six pack, large muscle gain (I targeted 1.8g of protein per kg of body weight) and I’m off it now. It’s miraculous this stuff. I now plan to take a half dose only when I travel to avoid putting on weight and being miserable and hungry when I can’t meal prep.
Hi Doc, thanks for this information. I have a quick question, the “Weight loss outcomes with FDA-approved medications” graphic presented toward the end of the video…. I could not find the graph in the referenced links, but would guess that it was produced with the information from the Obesity Reviews article from Wiley Online … would that be correct? Thanks
A competent Doctor that already has a long term relationship with a patient may not need to do all the 5 steps at the start. He/she may already have most of that information. I'm not disagreeing with Dr Brad. Just highlighting the importance of a strong Dr Patient relationship. Going to a random Doctor that doesn't know your history for weight loss medication may not be a good idea. Many people (Docs and patients) are eager to give or get a quick fix. You can see how things can go poorly so easily. Slow weight loss is the healthiest weight loss. You don't want to lose muscle by rushing it. The longer term effects of muscle loss are devastating, especially around mid life and beyond. Be patient, play it smart and do resistance training as described in the video. In time you'll be stronger, leaner and glad you did it that way.
When i was a kid up to like 19, i ate a third the volume of food i do now and was obese, now i am lean at 54. Telling people that are eating not enough volume to eat less and giving them drugs to curb appetite, appears morally wrong to me
Mounjaro is not a new medication, its been widely used for 14 months already. Those doctors who haven't informed patients about it are not professionals. Also, I don't like when doctors justify taking GLP1 agonists forever by showing that chart of 66% gaining weight back that NN clearly created for that particular purpose of creating a fear of stopping. If you don't have a plan when your patient stops taking a medication and stabilizes weight significantly lower, it means you have no plan at all.
The medical industry is just that, an industry. A machine to make money, not to prioritize health and well being. Not saying it can't change for the better but profiteering is currently its main purpose. At least here in the US.
I wish Americans would stop assuming the whole world is the same as their hell-hole. Other countries with state health care are far more likely to prioritize health and well being as its cheaper for the system as a whole.
I am a bit confused, because all this time, I thought Ozempic should be taken by diabetics, and in the last two years I have been hearing that it is wrong that celebrities and other wealthy people use Ozempic to lose weight and inflate the price of the drugs, so it is not available for every diabetic. So I thought it is not intended to be used by every overweight person, but mainly by diabetics, and not every diabetic is overweight. But if I understand from your video, if overweight people cannot lose weight through lifestyle changes, it is OK to prescribe them GLP? So, since >30 BMI people are at higher risk of death, the critique against celebrities is not actually justified. Of course, they want lose weight to look better, but it also heals them and lowers their risk of dying.
hearing doctors talk about malpractice that didn't point out malpractice with the thing from 2021 always makes me laugh. the medical industry is such a joke.
I've already tried to loose weight by changing my diet and exercising more (my BMI is stuck at 28.5). Dietary changes and exercise that worked for me 10 years ago to lose weight no longer work for me. Therefore, I need a doctor to prescribe a GLP-1 medication. I don't need to beat around the bush by waiting ANOTHER 3 - 6 months. If a doctor pulls that crap on me, I'll be looking for another doctor.
@@suncat9 I agree, I think the doctor should be advising and warning but not making the ultimate decision on the behalf of the patient. It’s useful to stress the importance of protein intake and the danger of losing critical muscle mass if you don’t watch your macros or exercise, but as long as you do that you can actually gain muscle too. Also dangers if you have pancreas problems.
The influencers are probably better educated on this than doctors, generally speaking. But neither are qualified to get information on this. Who is though
You couldn't be more off base on this topic. Doctors have been telling patients to lose weight for decades, the result: Americans got fat. GLP-1 antagonists have a remarkable impact on their weight, improving health outcomes. GLP-1 antagonists work. Jawboning does not. It is that simple.
@ham9187 you must have been watching a different video bud. He is VERY much on base and knocks it out of the park. He uses outcome data from RCTs, gold standard in science.
For mice on these drugs they lose weight but exercise much less. So maybe reducing desire to eat , reduces desire to exercise. So it will help it obese will do more when lose weight as more able. But best to wean yourself off or lower amount and have great diet and exercise. Use it to get better , not as a be all end all. Same as people with depression drugs help to motivate you out of your house . But surely you need to address underlying issues. Anyway you are in charge of your own bodies , though as the good Dr says a 2 fold path is best if not more Maybe start will redefining your taste buds , learn that ultra sweet things actually don't taste that good as you think they do . Eat high sugar melted ice cream and it's yucky and way too sweet - the cold hides that yucky sweetness
@@nimblegoat If you believe people can just decide to eat less while off the drug you must also believe that theycan just decide to exercise more while on the drug.
@@nimblegoat my personal experience is before I would say to myself I’m far too hungry, I’ll skip the gym, now I don’t. But I used it to get from 18 to 15% body fat so I’m not the target group of this message I guess :) I do feel I would crash in the afternoon, now I have sustained energy and will power all day, it’s been life changing for me.
@volos_olympus Not exactly what I'm saying - you could reduce amount you inject to find a happy medium . Plus there are the vicious and virtuous circles, ie they worse you feel the less you want to do exercise, the better you feel the more energy you have to want to do more . Ie if I needed to take this, I would use it as a path to other improvements, and hope to reduce dependency . Most watching here are seeking to better our health so just wouldn't rely on bottom of the cliff insulin , heart surgeries, BP drugs etc . Also these drugs reduce the desire and endless thoughts to eat for those with unhealthy relationships to food . So WHY NOT define better relationships when you are not craving junk endlessly. Many people under 30 BMI could get great benefits just eating more fiber, veggies, good sources of protein , oil , fats , fruits, nuts and no added sugar etc - they may not become slim but they will improve BMI and not get worse . I'm lucky no depression , can lose weight easily , never felt need to eat in middle of night . But I know many struggle and it's FN hard - they have tried 50 diets etc - so not for want of trying
@@DigiDriftZone Think my BF% is now as low as want to go ( sub 15% for sure ) . I find strength training does not make me too hungry . An extra piece of afternoon fruit ( 2 instead of one ) , a glass of cocnut water for electrolytes . Though after a big session will feel hungrier at 10pm - but don't eat late at night so doesn't matter - again I'm not target audience
I don't blame you for feeling this way, For myself: as long as only the title is clickbait, but the content is legit, I can overlook the title. But I don't like it either.
The fact that the weight bounces back up is a real problem. I lost 55 lbs in 5 months with no side effects, but my insurance would only cover about 5 doses a year, so I could not afford to stay on it, and my weight bounced up 35 lbs in 8 months even with me changing my diet. Now I am back on it (with better insurance) but I am having the side effects I have heard others have had: Nausea, gastric acid reflux, and lots of gas. I have cut my dose way down, but it is taking a while to figure out what is an effective dose without excessive side effects.
@@macrumpton what do you mean "real problem"? Obesity is a chronic disease requiring chronic treatment. What do you think happens to blood pressure and cholesterol if you stop meds?
Could you make a video about the withdrawal process from these medications? I believe they can be an effective tool but in no way should you continue taking it for the rest of your life.
BMI is a joke. I have weight trained all my life and have been lean all my life but my BMI has always indicated that I was obese. This was suggested again by a new doctor during a routine check. I am 6ft 2in with a 32in waist. I stood up and asked him to identify the area on my body from, which in his opinion, I should be losing weight. No answer. Red face.
@@BarryGee-pm6rv For every person like you there are 10000 people with a bmi of 24.5 but a fat % of 35%. BMI isn‘t perfect but not for the reasons you are thinking of.
@volos_olympus Exactly...BMI is so imprecise as to be virtually useless. Looking in the mirror works fine most of the time. If it looks good, it usually is...:)
@@BarryGee-pm6rv BMI is a rough measurement that works pretty well for a large amount of people such as study participants. Imo most everyone would benefit from taking GLP1 except those who are visibly underweight.
All 13 studies referenced in the video are linked in the video's description
💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin
For extra insights + a free health checklist, sign up here 👉 drstanfield.com/pages/sign-up
You should take a look at Michael Gregers Ozempic series. He has a lot of interesting research
Great video! What about kidney issues and gastroparesis frequencies?
@@DrBradStanfield What you have is fine except you should check all reported bad side effects before presenting Ozempic as something to take. Do you really not tell your patients about these other issues?
I still think you should discuss the natural fiber -> glp-1 pathway for satiation signaling so that people know why they don't naturally produce enough glp-1.
With respect to gallstones, they’re also more likely to form during periods of rapid weight loss, so it’s hard to tell whether GLP-1 agonists are primarily or secondarily responsible for their increased incidence. To really find out, you would need to compare gallstone rates in people using GLP-1 agonists against gallstones rates in people achieving similar rates of weight loss without GLP-1 agonists. It could turn out that there is no difference.
I guess the argument could be that rate of weight loss is far less likely without GLP-1 agonists and/or GIP. Maybe a better study would be both groups on GLP-1 but gallstone rates of fast vs moderate weight loss groups?
@@DigiDriftZone I agree that most people would not be able to lose weight at the same rate as they would on a GLP-1 agonist, but it would be difficult to study either way due to the various challenges associated with dietary studies in humans. That said, there might already be some research related to gallstone formation and weight loss that we could infer from. If it could somehow be demonstrated with a reasonable degree of confidence that it is a secondary effect, we would at least be able to employ the same mitigating strategies we use to prevent gallstones in unmedicated weight loss.
My BMI was 54 and I was using 240 units of insulin each day. I've gone from A1c of 6.9 to to 5.6, lost 80 pounds, and now use 0 to 6 units of insulin a day.
For me it was a huge health benefit.
So cool! I’ve had many patients be able to fully come off insulin, thanks to GLP-1 meds. They lose weight, have more energy, and we can often stop their blood pressure meds as well
Thank You for this. I do have nausea issues but it's worth it. My relationship with food has totally changed. I will never eat the way I used to. I was raised to believe I needed so much food I just don't need.
Wonderful to hear that you are on a better health path now
I was prescribed pantoprozle to deal with the nausea/heartburn does the trick
Muscle mass loss is higher in older folks that can't move around as much. My mother was on ozempic for over 2 years after which she stopped treatment and now she's even less mobile than she was prior to being prescribed ozempic.
@@ColinHeddle doctors really need to stress the importance of protein per kg and resistance training before prescribing. If you take it without a plan you are indeed likely to lose as much if not more muscle than fat.
100%
Unfortunately they have no problem prescribing it to elderly folks that already have limited mobility and muscular atrophy. In my mother's case she's gone from bad to worse. She was already experiencing limited mobility, and now she's unable to safely navigate stairs.
@@ColinHeddle that’s horrible :( sorry to hear. Might be worth encouraging her to eat more protein, I’m doing this with my elderly parents and bought them a treadmill too so they try to walk while watching their TH-cam.
It's been hard to watch the decline from the other side of the country. Been trying to get her to increase protein intake and (unfortunately) she's taking Boost daily.
I'm in the process of selling my property so I can move back to be closer so I can have more influence and support. Ultimately I'm hoping to get her into ketovore/carnivore to mitigate inflammation etc and help her get moving again.
@@ColinHeddle you’re a good son, that sounds like a great strategy!
What Brad doesn't mention is the broadening application of these medications. Semaglutide has already been approved for cardiac protection in known atherosclerotic disease. Tirzepatide now approved as the only medication to treat sleep apnea. Tirzepatide also recently demonstrated a 99% efficacy in preventing progression from prediabetes to diabetes. GLP-1 drugs (and not just the fancy long-acting new ones but also the older ones that needed daily injection) have shown a 40% reduction in overdose deaths in opioid users and a 50% reduction in positive alcohol screenings in alcoholics. These drugs are also being used for fertility in men and women, in PCOS... they're associated with drastic reductions in the occurence of alzheimer's disease... I could go on and on. I love this TH-cam channel, and. I suppose on TH-cam this just comes with the medium, but I feel like it's concern trolling or at least sensational to decry GLP-1 telehealth practices. People who have been trying to lose weight heir entire lives should not be told to spend another 3-6 months doing lifestyle mod-that's just silly. Obesity kills people through cancer, heart disease, misery, etc. The cure should be embraced. The people should have the remedy.
66yo, very fit, got injured went from 175 to 220. Dieted the hard way and went down to 155, was told I looked sick. So weight went to 175. I wanted to drop 10lb - so I got some mounjaro from a buddy (2 x 5ml). took the doses (5ml/week) on the 2 weeks I was skiing - didn't eat b/fast , I small sandwich for lunch, small dinner .. didn't feel hungry and was burning around 1200 exercise calories .. abs now clearly visible .. If I had to lose a lot of weight - I'd definitely use the drugs and not "tough it out" (again). I have not weighed myself but using my jeans as a measure - I'd guess Im down 6 - 8 lb. I'm sure a lot of that water weight .. I was peeing every hour for the first 3 days. jeans went from "snug" to "I can get a fist between by stomach and the jeans".
One hears a lot about fasting and MTOR - and how fasting is all kind of "good" .. well, I've been on a 600kcal/day for 14 days ... so - more goodness.
I also did dry January .. WAY THE HELL easier with the mounjaro ... didn't want to eat and didn't want to drink.
Thanks!
Thanks again Keith
You missed one indication for glp-1 prescription beyond the BMI of 30 you did mention: GLP-1 agonists are prescribed for people with a BMI of 30 or higher, or a BMI of 27 or higher with obesity-related conditions (high bp etc.)
Yes, correct. It’s tricky to strike a balance between what information to put in these videos and what to leave out. Could talk for a couple of hours about GLP-1 meds haha
@DrBradStanfield For sure! Don't want to nitpick an otherwise excellent video. But I do think it is important to not potentially steer people away from a good therapy if they think they are not a candidate while they do qualify.
@Dr Yes, but it’s fair to say that that’s a rather important piece of information. ✅
Excellent Brad...good work.
Thank you!
I am very curious about individuals who don’t have a very high BMI (or waist circumference, meaning they aren’t very overweight), but who struggle with sticking to healthy eating or overeating and forming binge eating habits. Ozempic quiets down food noise that a lot of people like that suffer with. I know someone who is on it who struggled with their weight and made a big effort to keep a healthy weight (and went up and down 10/15kg) and now that’s he’s on it, he just eats in a regular balanced way without ever binging or thinking about food constantly. He’s lost some weight and has remained consistent.
In the USA, the FDA approved use of these drugs to treat obstructive sleep apnea in obese patients. The patients would have been able to take the drugs for being obese to begin with, but because insurance companies don't typically cover obesity drugs, but do cover sleep apnea treatments, more people get insurance coverage for taking them. There's a huge push for an oral form to be "over the counter" medication one day.
“That is not medicine, that is drug dealing.” Great line, Dr Brad.
Please discuss the rampant use of antidepressants as well, even though studies show talk therapy is just as effective, and sometimes more effective long term.
Some people say if you take Berberine, magnesium, B1, cinnamon and turmeric it increases natural Glp-1. Is this true?
Not saying anything negative about this modality, just a question. Why not just take the base peptide by itself and forego the other ingredients in Ozempic? The base peptide is off patent whereas the other is patented due to the manufacturing process.
Being a lay person, I'm trying to understand what the non peptide ingredients do. The bare peptides seem to have extremely low side effects which is why I'm questioning this.
Thank you Doctor
What do you mean base peptides? Ozempic is just semaglutide
@tiptoptanktop GLP = glucagon-like peptide
@@babaluto Yes I know but you make it sound that ozempic is a "Base peptide" plus other ingredients. Hence me saying what base peptides are you talking about that you want to isolate? Ozempic is just semaglutide - a single peptide.
@pvw337 I think I'm confused about GLP-1 as a naturally occurring hormone/peptide in the body and how it is interchangeably used with Ozempic/semaglutide. Where the Ozempic is manufactured/cultured or whatever, it does contain the preservative phenol and the side effect warnings of the drug. I've read about GLP-1 l.a ong before hearing about Ozempic. The info available looks at diets that increase satiety and blood sugar regulation. As with nearly all type 2 diabetes, the management is truly a lifestyle choice. Rather than saying, "other ingredients", maybe it is the process of the manufacture that I'm looking at. If Ozempic is a pure peptide analog and is supposed to be identical to the GLP-1 that occurs in the body, why is it unsafe for type 1 diabetics and is taxing on renal and liver functions. Looking at the MSDS for Ozempic, there is some indication that there is some manipulation of the peptide in the manufacturing process. Not saying it is a bad or good thing. In order to patent the product the makers have to change something in the process from the previous off patent methods.
So yeah, I have questions, maybe stupid, maybe not. Cheers!
35 ans de diaphètes cette nouvelle médecine m'a changé la vie .merci❤
it's so good of you to call out medical malpractice
Excellent discussion....an antidote to fear-mongering.
I have a friend who has been prescribed Ozempic for over a year, but she hasn't made any significant lifestyle changes. She continues binge eating and avoids exercise. I haven't noticed any improvements in her health, and she's also taking some tablets, but I’m not sure what they are. As far as I know, she has type 2 diabetes. I've advised her to change her lifestyle to maximize the benefits of the medication, but it feels pointless now.
Are there any complications if she continues like this? I'm not sure if she's being honest with her doctor during check-ups or if the doctor isn't paying much attention.
The problem is that GLP1 agonists are being used as a injectable discipline. Individuals with poor pre-treatment diet and exercise habits will just reduce food intake while maintaining unhealthy food choices. This extreme calorie restriction can further decrease exercise motivation and negatively impact NEAT. Lack of exercise and likely low nutrient dense diet will exacerbate muscle and bone wasting.
How do researchers perform double blinded placebo controlled studies of stuff like Semaglutide? If every participant has to believe they're taking the medication, even the placebo needs to be labeled as containing a GLP-1 agonist, which causes in some degree a placebo effect, too.
Tirzepatide is newer but not that new (approved early 2022 in the US) retatrutide and other multi agonists are newer and should be available in 2026.
@@robertusga they are available in the UK now under the brand name mounjaro.
Excellent discussion....
Great video
I don’t doubt that these things you charge could be true. But how do you know that they’re true? How do you know what most doctors do? How do you know that they’re not telling patients about the need for long-term use? Where do you get this information?
So no such side effect as stomach paralysis?
Yes, and some also get pancreatitis among other issues
I was prescribed Ozempic to control my A1c. It has dropped from 7.4 to 6.4. Additionally, I have lost 25 pounds. The biggest problem I have is being nauseous most days. On a scale of 0 to 10 (zero being non-nauseous) I am consistently at a 1 or 2, with occasional 0s and, if I'm careful, few actual vomiting events.
The glp-1 chemical pathway is closely related to one of the natural pathways in the body for satiation. The normal pathway involves eating fiber, which is processed by a healthy gut biome to trigger glp-1 release into the bloodstream. Fiber (and phytates) also delay(s) processing of nutrients so that the microbiome near the end of your digestive track have better nutrition. The most important way to build your gut biome is to have a variety of different fibers with no fiber skip-days.
Currently 22 years old male, and using 15mg tirzepatide. Drop weight from 82 to 59kg in 6 months. No sides effects, just amazing benefits. Liver enzymes are the best I ever had, no more hyperphagia. These drugs are a revolution
When you are young, you can much better tolerate different kinds of drugs.
My BMI is 23 but I want to get it to 20 as I like to compete in running events. I guess they won't let me use it? They might let me use statins to optimise ldl so why not ozempic.
Because you're in normal weight or BMI. What you want is not a medical need.
These drugs have a very good chance to reduce your desire to exercise . Has been shown in mice. So more data needed in humans. This will be hard to work out - as many overweight have little motivation , so as weight less have more energy to do more,. But at your BMI is it worth the risk. Wait to more data I say. Better to try and do it naturally
@@nimblegoat good point 🙏
As an amateur athlete, it was completely game changing for me. I would recommend exploring it and they are not strict with online prescriptions if you happen to mistype your weight or height. Personally I used the 2.5mg mounjaro (starting dose) only for a cut (2 months) and stretched it to every 10 days instead of 7. This is not medical advice, check you don’t have pancreas problems before considering this.
I’ve never been this lean in my life with a defined six pack and I have more energy and motivation without the food noise and cravings. My training has never been this consistent in my life (I’m 38). Before I would say to myself I’m too hungry to go to the gym, now I eat after. I also have a sustained energy level the whole day, life changing stuff.
@@DigiDriftZone very interesting! 🤔
Guess which ad played before this video.
Probably youtube picking up on the video title
What country are you in?
Retatrutide beats both Tirzepatide and Semaglutide
Then there is the conversation on the stress that over-prescription of these drugs has on healthcare systems.
@mohamedahmed1023 the only stress I have with these meds is insurance not covering them or access / supply issues.
@@robertusga You're right- access and lack of coverage is an issue. I'm referring to having very expensive drugs being over-prescribed for very common conditions/ indications. This is a problem, even for public healthcare systems that can aggressively negotiate down the price of drugs.
i wish i could have doctors like you in Brasil
Or even better, everywhere
I tried ZepBound but sadly it gave me severe diarrhea. I stuck it out for two and half months hoping it would go away but it didn't appear to be letting up so I stopped. I did lose 20 lbs which is a lot in two months. It has been six months since I've stopped and I haven't gained any weight back but I'm no longer getting leaner. Having difficulty reducing my calories to the necessary level. Can't really increase exercise. I ride my bike 60 miles three to four days a week.
Since microdosing Tirz to help with joint inflammation (very successfully I must add) I’ve noticed that it’s also helped with food noise, making it easier to stick to an animal based diet. I also noticed, now that you mention gallbladder, that I no longer have any discomfort with my GB like I was before. I think people who have side effects are dosing too high.
I’m definitely using this off label, I struggled to get under 18% body weight since 2018 (life/travel/work gets in the way). I took a 2.5mg Mounjaro pen (the starting dose) and stretched the doses to every 10 days. I’ve smashed past the plateau, down to 15% body fat, visible six pack, large muscle gain (I targeted 1.8g of protein per kg of body weight) and I’m off it now. It’s miraculous this stuff.
I now plan to take a half dose only when I travel to avoid putting on weight and being miserable and hungry when I can’t meal prep.
Hi Doc, thanks for this information. I have a quick question, the “Weight loss outcomes with FDA-approved medications” graphic presented toward the end of the video…. I could not find the graph in the referenced links, but would guess that it was produced with the information from the Obesity Reviews article from Wiley Online … would that be correct? Thanks
Is similar to pain meds? I would like to see a study with fasting and ozempic
A competent Doctor that already has a long term relationship with a patient may not need to do all the 5 steps at the start. He/she may already have most of that information. I'm not disagreeing with Dr Brad. Just highlighting the importance of a strong Dr Patient relationship. Going to a random Doctor that doesn't know your history for weight loss medication may not be a good idea. Many people (Docs and patients) are eager to give or get a quick fix. You can see how things can go poorly so easily. Slow weight loss is the healthiest weight loss. You don't want to lose muscle by rushing it. The longer term effects of muscle loss are devastating, especially around mid life and beyond. Be patient, play it smart and do resistance training as described in the video. In time you'll be stronger, leaner and glad you did it that way.
When i was a kid up to like 19, i ate a third the volume of food i do now and was obese, now i am lean at 54. Telling people that are eating not enough volume to eat less and giving them drugs to curb appetite, appears morally wrong to me
Mounjaro is not a new medication, its been widely used for 14 months already. Those doctors who haven't informed patients about it are not professionals.
Also, I don't like when doctors justify taking GLP1 agonists forever by showing that chart of 66% gaining weight back that NN clearly created for that particular purpose of creating a fear of stopping. If you don't have a plan when your patient stops taking a medication and stabilizes weight significantly lower, it means you have no plan at all.
The medical industry is just that, an industry. A machine to make money, not to prioritize health and well being.
Not saying it can't change for the better but profiteering is currently its main purpose. At least here in the US.
Main purpose: Making money. Side effect: Potentially cure diseases 😂
I wish Americans would stop assuming the whole world is the same as their hell-hole. Other countries with state health care are far more likely to prioritize health and well being as its cheaper for the system as a whole.
Partly it's the Americanisation issue, where the patient sees advertisements and specifically asks for a particular medication
That's not an "Americanisation" issue.
In all other countries they just advertize useless supplements. Is that any better?
Magnesium isn't useless
@@suncat9are pharmaceuticals advertised in many other countries?
Perhaps I'm misinformed and they are, I'd appreciate hearing about it
I think only the US and New Zealand allow pharmaceutical drug ads on TV.
At least among developed countries(?)
I am a bit confused, because all this time, I thought Ozempic should be taken by diabetics, and in the last two years I have been hearing that it is wrong that celebrities and other wealthy people use Ozempic to lose weight and inflate the price of the drugs, so it is not available for every diabetic. So I thought it is not intended to be used by every overweight person, but mainly by diabetics, and not every diabetic is overweight.
But if I understand from your video, if overweight people cannot lose weight through lifestyle changes, it is OK to prescribe them GLP? So, since >30 BMI people are at higher risk of death, the critique against celebrities is not actually justified. Of course, they want lose weight to look better, but it also heals them and lowers their risk of dying.
What if you had your gallbladder removed?
hearing doctors talk about malpractice that didn't point out malpractice with the thing from 2021 always makes me laugh. the medical industry is such a joke.
You must wear one of those shiny metallic hats.
Brilliant. Thankyou.
Rotorua
I've already tried to loose weight by changing my diet and exercising more (my BMI is stuck at 28.5). Dietary changes and exercise that worked for me 10 years ago to lose weight no longer work for me. Therefore, I need a doctor to prescribe a GLP-1 medication. I don't need to beat around the bush by waiting ANOTHER 3 - 6 months. If a doctor pulls that crap on me, I'll be looking for another doctor.
@@suncat9 I agree, I think the doctor should be advising and warning but not making the ultimate decision on the behalf of the patient.
It’s useful to stress the importance of protein intake and the danger of losing critical muscle mass if you don’t watch your macros or exercise, but as long as you do that you can actually gain muscle too.
Also dangers if you have pancreas problems.
One comment, BMI is meaningless for the most part. Great video
Is there any truth to hearing that Ozempic contains Lizard venom and it can cause Cancer in high doses or if it is taken too long?
no
The influencers are probably better educated on this than doctors, generally speaking. But neither are qualified to get information on this. Who is though
I used it but got no benefits so I stopped didnt lose much or gain much after-
You couldn't be more off base on this topic. Doctors have been telling patients to lose weight for decades, the result: Americans got fat.
GLP-1 antagonists have a remarkable impact on their weight, improving health outcomes. GLP-1 antagonists work. Jawboning does not. It is that simple.
@ham9187 you must have been watching a different video bud. He is VERY much on base and knocks it out of the park. He uses outcome data from RCTs, gold standard in science.
For mice on these drugs they lose weight but exercise much less. So maybe reducing desire to eat , reduces desire to exercise. So it will help it obese will do more when lose weight as more able. But best to wean yourself off or lower amount and have great diet and exercise.
Use it to get better , not as a be all end all.
Same as people with depression drugs help to motivate you out of your house . But surely you need to address underlying issues.
Anyway you are in charge of your own bodies , though as the good Dr says a 2 fold path is best if not more
Maybe start will redefining your taste buds , learn that ultra sweet things actually don't taste that good as you think they do . Eat high sugar melted ice cream and it's yucky and way too sweet - the cold hides that yucky sweetness
@@nimblegoat If you believe people can just decide to eat less while off the drug you must also believe that theycan just decide to exercise more while on the drug.
@@nimblegoat my personal experience is before I would say to myself I’m far too hungry, I’ll skip the gym, now I don’t. But I used it to get from 18 to 15% body fat so I’m not the target group of this message I guess :)
I do feel I would crash in the afternoon, now I have sustained energy and will power all day, it’s been life changing for me.
@volos_olympus Not exactly what I'm saying - you could reduce amount you inject to find a happy medium . Plus there are the vicious and virtuous circles, ie they worse you feel the less you want to do exercise, the better you feel the more energy you have to want to do more . Ie if I needed to take this, I would use it as a path to other improvements, and hope to reduce dependency .
Most watching here are seeking to better our health so just wouldn't rely on bottom of the cliff insulin , heart surgeries, BP drugs etc .
Also these drugs reduce the desire and endless thoughts to eat for those with unhealthy relationships to food . So WHY NOT define better relationships when you are not craving junk endlessly.
Many people under 30 BMI could get great benefits just eating more fiber, veggies, good sources of protein , oil , fats , fruits, nuts and no added sugar etc - they may not become slim but they will improve BMI and not get worse . I'm lucky no depression , can lose weight easily , never felt need to eat in middle of night . But I know many struggle and it's FN hard - they have tried 50 diets etc - so not for want of trying
@@DigiDriftZone Think my BF% is now as low as want to go ( sub 15% for sure ) . I find strength training does not make me too hungry . An extra piece of afternoon fruit ( 2 instead of one ) , a glass of cocnut water for electrolytes . Though after a big session will feel hungrier at 10pm - but don't eat late at night so doesn't matter - again I'm not target audience
Wow!
So you are in the "THEY have lied to you"-industry now? Time to unsubscribe.
I don't blame you for feeling this way, For myself: as long as only the title is clickbait, but the content is legit, I can overlook the title. But I don't like it either.
Not a new behavior in healthcare.
They do for alot of things
The fact that the weight bounces back up is a real problem. I lost 55 lbs in 5 months with no side effects, but my insurance would only cover about 5 doses a year, so I could not afford to stay on it, and my weight bounced up 35 lbs in 8 months even with me changing my diet. Now I am back on it (with better insurance) but I am having the side effects I have heard others have had: Nausea, gastric acid reflux, and lots of gas. I have cut my dose way down, but it is taking a while to figure out what is an effective dose without excessive side effects.
@@macrumpton what do you mean "real problem"? Obesity is a chronic disease requiring chronic treatment. What do you think happens to blood pressure and cholesterol if you stop meds?
M8, I like your content and the way you work with science, but this click bait titles...
I disagree. I got Mounjaro and a year later I am happy and healthy. I am sorry but this is click bait.
Not sure if you watched the video? In the intro, I explain that I prescribe these medications
Could you make a video about the withdrawal process from these medications? I believe they can be an effective tool but in no way should you continue taking it for the rest of your life.
Doc you have kinda inflamed eyes and face, take care.
Creatine bloat?
BMI is a joke. I have weight trained all my life and have been lean all my life but my BMI has always indicated that I was obese. This was suggested again by a new doctor during a routine check. I am 6ft 2in with a 32in waist. I stood up and asked him to identify the area on my body from, which in his opinion, I should be losing weight. No answer. Red face.
@@BarryGee-pm6rv For every person like you there are 10000 people with a bmi of 24.5 but a fat % of 35%. BMI isn‘t perfect but not for the reasons you are thinking of.
@volos_olympus Exactly...BMI is so imprecise as to be virtually useless.
Looking in the mirror works fine most of the time.
If it looks good, it usually is...:)
@@BarryGee-pm6rv BMI is a rough measurement that works pretty well for a large amount of people such as study participants.
Imo most everyone would benefit from taking GLP1 except those who are visibly underweight.
This is one of the few videos that I disagree with.
@liftingheavy1 what part and based on what outcome data from which study?