Summary: Mark D'Esposito and Andrew Huberman discuss the potential of dopamine agonists like bromocriptine in enhancing working memory and cognitive function. Mark explains that dopamine depletion impairs working memory and that dopamine agonists, including bromocriptine, have been shown to improve cognitive function in some studies. However, he expresses frustration that pharmaceutical companies have not focused on developing drugs to improve cognition, despite the clear potential and safety of these drugs. He also discusses the role of other neurotransmitters like norepinephrine and serotonin in cognitive function and suggests that a combination of these neurotransmitters may be more effective than single-target drugs. Mark emphasizes the need for further research to understand how different neurotransmitters interact and how individual differences in neurochemistry may affect treatment outcomes.
🧐 *CONSPIRACY? Since "they", the "powers-that-be", already control the world and the majority of the money and resources, why would they ever want a drastically smarter general population with better memory?* 🤔 😂 *'No. Such cognitive and memory enhancing drugs are a threat. And improvement in intelligence and memory must be regulated.' - They (1912)* 😉
He's so right about the lack precision due to the inability to directly measure neurotransmitter levels in the brain. Creating a noninvasive and reliable test for neurotransmitters would revolutionize the use of all these medications. It would stop the guess work, even experimentation, that is currently used. By the way, I don't mean to bash psychology or psychiatry they are incredibly helpful. They could just be so much better with this key tool. Maybe big pharma would get behind creating the tool to assist in the treatment of almost all mental illness.
Pharma may not be interested in researching bromocriptine and other mentioned agonists because they are currently cheap and easily assessable. Combining agonists might provide a path to an acceptable ROI - but one with risks of competition from cheap single source alternatives.
How is bromocriptine different from any other stimulants that increase catecholamine levels like adderall for example which is well known for its effects in memory and concentration?
@@jakubolewicz4187 *Sauna is definitely awesome, especially when hot and cold contrast is practiced to naturally boost interferon response during fever illnesses.* *Of course there are many different ways and lengths of fasting. The fasting I have been practicing now for the last 6 years is intermittent fasting and a 5 day fast once every 3 months.* *Intermittent fasting: I eat 12-6pm 7days a week; anything I want for lunch and only a smaller ketogenic dinner because the high fat is more satiating until lunch again the next day.* *The 5 day fast is the sweet spot for me in triggering deep autophagy. Nobel prize 2016 for proving that after burning all glucose and everything else, the human body begins to metabolize all misfolded proteins, old decrepit cells and other cellular "trash" which cancer and other diseases make use of, so this is truly a deep cleanse on the cellular level. After 5 days muscle loss is inevitable and in my opinion I reach the point of diminishing return on my health goals. Additionally, it is one of the most powerful exercises in self control -- I am my mind, I am Not my body, and my body is my slave, not my master.* *And yes, I am still building muscle and strength training.*
Could you do an episode on mental health,anxieties, depression, ADHD, sleep etc and DNA testing? Mental health is genetic in my family. So is hypermobility, which is often found in people with the mental health issues I mentioned. Few months back i wondering how they were connected and the what could be done. Apparently it can be inked to genetic faulty Gene's like MTHFR etc. Which makes it hard for the body to convert certain nutrients into the usuable methalated form. Making you deficient and have mental health symptoms and poor collagen production. So will hopefully be getting tested to find out for sure. But maybe that all I need is a methylated form of a nutrient in a supplement like folate or b12 and not all the other harmful drugs that get chucked at us. I really hope I'm right. It would be a game changer for my whole family. Especially one of my brothers who has attempted suicide many times. Not saying it will cure it but hopefully make living more manageable. Would love an episode on this.
I would really be interested in your take on DNA expression tests from companies like Viome and using AL to calculate supplement needs to support areas with lower scores
So it correlates with dopamin, i think everybodys household of dopamin is out of control due to quick and easy releases from media / technology / food etc. With the normal lifestyle we cant fix the root cause, so we need another drug?
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Summary:
Mark D'Esposito and Andrew Huberman discuss the potential of dopamine agonists like bromocriptine in enhancing working memory and cognitive function. Mark explains that dopamine depletion impairs working memory and that dopamine agonists, including bromocriptine, have been shown to improve cognitive function in some studies. However, he expresses frustration that pharmaceutical companies have not focused on developing drugs to improve cognition, despite the clear potential and safety of these drugs. He also discusses the role of other neurotransmitters like norepinephrine and serotonin in cognitive function and suggests that a combination of these neurotransmitters may be more effective than single-target drugs. Mark emphasizes the need for further research to understand how different neurotransmitters interact and how individual differences in neurochemistry may affect treatment outcomes.
Thanks bud
@@SonOvThunderI’m not your bud….pal.
🧐 *CONSPIRACY? Since "they", the "powers-that-be", already control the world and the majority of the money and resources, why would they ever want a drastically smarter general population with better memory?* 🤔
😂 *'No. Such cognitive and memory enhancing drugs are a threat. And improvement in intelligence and memory must be regulated.' - They (1912)* 😉
I'm not your pal, bro.
Thanks ChatGPT
I have adhd and autism. Guanfacine changed my life
Someone recommended a good drug for memory to me the other day but I can't remember what it's called.
Someone bought me a good drug for memory to me but I can't ever remember to take it.
😭😭
Ba dum tss
Someone, uuh.. nevermind
Dihexa, Idra 21, PRL 853, Bacopa, Cerebrolysin.
He's so right about the lack precision due to the inability to directly measure neurotransmitter levels in the brain. Creating a noninvasive and reliable test for neurotransmitters would revolutionize the use of all these medications. It would stop the guess work, even experimentation, that is currently used.
By the way, I don't mean to bash psychology or psychiatry they are incredibly helpful. They could just be so much better with this key tool.
Maybe big pharma would get behind creating the tool to assist in the treatment of almost all mental illness.
Pharma may not be interested in researching bromocriptine and other mentioned agonists because they are currently cheap and easily assessable. Combining agonists might provide a path to an acceptable ROI - but one with risks of competition from cheap single source alternatives.
How is bromocriptine different from any other stimulants that increase catecholamine levels like adderall for example which is well known for its effects in memory and concentration?
Wasn’t the movie Awakening all about this? I met the British doctor about whom the movie was. He explained how it is hard to make that long lasting
Beef, liver, eggs, tallow, butter, sunlight exposure, intense calisthenics, cardio and weight lifting.
Exactly. But also add good sleep, healthy vast social network and avoidance of toxins like alcohol / cigarettes.
Also daily mediation, fasting and cold exposure.
@@Christian_Prepper Perfect, except I would change fasting for sauna. But I’m bulking so ymmv.
@@jakubolewicz4187 *Sauna is definitely awesome, especially when hot and cold contrast is practiced to naturally boost interferon response during fever illnesses.*
*Of course there are many different ways and lengths of fasting. The fasting I have been practicing now for the last 6 years is intermittent fasting and a 5 day fast once every 3 months.*
*Intermittent fasting: I eat 12-6pm 7days a week; anything I want for lunch and only a smaller ketogenic dinner because the high fat is more satiating until lunch again the next day.*
*The 5 day fast is the sweet spot for me in triggering deep autophagy. Nobel prize 2016 for proving that after burning all glucose and everything else, the human body begins to metabolize all misfolded proteins, old decrepit cells and other cellular "trash" which cancer and other diseases make use of, so this is truly a deep cleanse on the cellular level. After 5 days muscle loss is inevitable and in my opinion I reach the point of diminishing return on my health goals. Additionally, it is one of the most powerful exercises in self control -- I am my mind, I am Not my body, and my body is my slave, not my master.*
*And yes, I am still building muscle and strength training.*
and wearing a fresh set of washed clothes every day
Bacopa monnieri, ginkgo may help ???
Interesting. Will need to dissect this more 💕
Extremely interesting. I will explore that topic further. Thanks
Could you do an episode on mental health,anxieties, depression, ADHD, sleep etc and DNA testing?
Mental health is genetic in my family. So is hypermobility, which is often found in people with the mental health issues I mentioned. Few months back i wondering how they were connected and the what could be done.
Apparently it can be inked to genetic faulty Gene's like MTHFR etc. Which makes it hard for the body to convert certain nutrients into the usuable methalated form. Making you deficient and have mental health symptoms and poor collagen production.
So will hopefully be getting tested to find out for sure. But maybe that all I need is a methylated form of a nutrient in a supplement like folate or b12 and not all the other harmful drugs that get chucked at us. I really hope I'm right. It would be a game changer for my whole family. Especially one of my brothers who has attempted suicide many times.
Not saying it will cure it but hopefully make living more manageable.
Would love an episode on this.
Methylated nutrients helped me
Would be interested on that subject too !
A raise in testosterone will boost memory.
How about NAC and Choline?
What about lion mane & choline?
I would really be interested in your take on DNA expression tests from companies like Viome and using AL to calculate supplement needs to support areas with lower scores
F the Pharmaceutical companies
0:40 what?
So it correlates with dopamin, i think everybodys household of dopamin is out of control due to quick and easy releases from media / technology / food etc. With the normal lifestyle we cant fix the root cause, so we need another drug?
What about Cerebrolysin?
For sure!
Ketamine is pretty good
Andrew huberman 🎶🥁 Andrew huberman 🤍
Has the whole world lost its mind? A brave new world.
hey thanks
These drugs seem like they would be useful in treating cocaine, and similar drugs; addictions.
Perhaps GLP-1 agonists as well. Lots of research in that area coming out.
Also, plant medicine.
9mebc
I wannit!
A healthy thyroid gland will improve memory. The rest is superfluous
Close….its more accurate to say that improving a damaged or disease could improve memory.
@@geekspeak1066 right
Agree
Pseudo science boy