Immunology - Introduction to Antibodies

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  • เผยแพร่เมื่อ 14 มิ.ย. 2024
  • / armandohasudungan
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ความคิดเห็น • 120

  • @sahanak92
    @sahanak92 9 ปีที่แล้ว +92

    One little correction - IgA exists as a dimer only in mucous/secretions. In the blood stream, it is a monomer.

  • @lovelight5468
    @lovelight5468 8 ปีที่แล้ว +5

    Thank you for taking the time to do all of these videos. They have been extremely helpful!

  • @EmilyAmner
    @EmilyAmner 7 ปีที่แล้ว +4

    OMG thank you thank you thank you
    this is THE BEST set of immunology videos EVER
    SO ACCURATE and matches PERFECTLY with textbook information
    I dont even have to study any more just watch your videos multiple times WOW!!!!!!!

  • @eirarenaasayashi4240
    @eirarenaasayashi4240 3 ปีที่แล้ว +2

    fantastic video! I'm a medicinal chemist who's not very familiar with antibodies but I have to quickly learn as part of my job. I'm so grateful I came across this video. It really helps to understand beginners!

  • @kevinperies4450
    @kevinperies4450 2 ปีที่แล้ว +2

    Thanks alot sir, i had 3 months load of lessons to study before my exam, i had only ten days to study, because of your videos i was able to pass my exam🙏🙏🙏

  • @Starship245
    @Starship245 9 ปีที่แล้ว +1

    We love you Armando! Thank you for posting these fabulous videos. You Rock the Science World :)

  • @iridescentraindrops
    @iridescentraindrops 8 ปีที่แล้ว +1

    Consistent and easy. I'd really want to see a video on the modification of antigens and the formation of autoantibodies.

  • @linwang6975
    @linwang6975 10 ปีที่แล้ว +1

    please go on. I really like this program!

  • @nellie272003
    @nellie272003 8 ปีที่แล้ว

    These are wonderful videos! Thank you!

  • @shanelcool8511
    @shanelcool8511 9 ปีที่แล้ว +71

    Fab region consists of variant and constant regions not only variant as you mentioned.Great videos but i think that you should put under the videos in a Bar the mistakes and some correction. There are students who has no background and come here to study at first, i think that if you want to help those students they should know the correct facts.

    • @gM-zf3iu
      @gM-zf3iu 3 ปีที่แล้ว +7

      I completely agree. Albeit, 6 years late.

    • @asadshah827
      @asadshah827 3 ปีที่แล้ว +5

      @@gM-zf3iu I also agree, 6 years later. Shanel your words are ageless.

    • @wengao5986
      @wengao5986 3 ปีที่แล้ว +1

      thank you,sir

    • @user-cp1nl5ni3d
      @user-cp1nl5ni3d 3 หลายเดือนก่อน

      Best lecture on antibodies
      th-cam.com/video/c4V0-YEiLYg/w-d-xo.htmlsi=uxogb0iNhQA1Rr3S

  • @sakshiagarwal4821
    @sakshiagarwal4821 7 ปีที่แล้ว +3

    Thankyou for each and every video of yours. Ur lec r intresting and lifesaving thanku soo soo much.
    I would even recommend it to my freinds.

  • @spfantibody3764
    @spfantibody3764 6 ปีที่แล้ว

    A very helpful video to get things visualization.Thanks.

  • @alexfedorenko3785
    @alexfedorenko3785 9 ปีที่แล้ว +1

    good job!!!
    everything i need!

  • @samuelstewart710
    @samuelstewart710 7 หลายเดือนก่อน

    Great video, thanks so much!!

  • @laf4891
    @laf4891 ปีที่แล้ว

    This is so helpful - thank you!

  • @brkhra.k.a.legatus3183
    @brkhra.k.a.legatus3183 4 ปีที่แล้ว

    Great work!

  • @lancejohnson108
    @lancejohnson108 10 ปีที่แล้ว +8

    I like your videos for use as overviews for my students and I wish I could draw diagrams this well on our markerboards at school. One question though, at 2:54 you mention and write antibody isotope (with an "o"), but do you actually mean isotype (with a "y")? I'm not familiar with the term antibody isotope except for using antibodies for delivering radioactive isotopes.

  • @christiannader2854
    @christiannader2854 5 ปีที่แล้ว

    reaaly good video, informative, thank you

  • @jamilahardy881
    @jamilahardy881 ปีที่แล้ว

    Thank you!

  • @SolaOlagoke
    @SolaOlagoke 10 ปีที่แล้ว

    You are doing a great job.

  • @zannatul23
    @zannatul23 7 ปีที่แล้ว +14

    MADGE- to remember the 5 classes of antibodies

    • @keshian2418
      @keshian2418 4 ปีที่แล้ว +4

      or GAMED

    • @zzzgful
      @zzzgful 3 ปีที่แล้ว

      @@keshian2418 or I'MAGED(Memorize as "i am aged" or "imaged" ; I is just the first letter for antibody)

    • @anushuamukherjee5772
      @anushuamukherjee5772 3 ปีที่แล้ว

      Thanks

    • @NyashaMuz
      @NyashaMuz 3 ปีที่แล้ว +1

      And GAMDE in order of their serum quantities

    • @lemarjawid4879
      @lemarjawid4879 3 ปีที่แล้ว

      I would prefer GAMED

  • @sarahayad8466
    @sarahayad8466 8 ปีที่แล้ว +5

    Great videos, I was wondering if you have PDFs of the notes that you take

    • @ilearn5
      @ilearn5 3 ปีที่แล้ว

      He sells them on his website

  • @amyrose1762
    @amyrose1762 8 ปีที่แล้ว

    thank you very much it was helpful 🙆💖

  • @drsamialrumaih
    @drsamialrumaih 10 ปีที่แล้ว

    Great job

  • @docsafi7749
    @docsafi7749 7 ปีที่แล้ว +1

    helpful
    thank you Sir

  • @jeje2993
    @jeje2993 4 ปีที่แล้ว

    Thank you💕

  • @josetrujillo738
    @josetrujillo738 ปีที่แล้ว

    Thank You

  • @ilaila3504
    @ilaila3504 ปีที่แล้ว

    clicking screen at end does not lead to part 2, gonna search for it though, thankyou your art work works perfectly for my mind memory

  • @nirmalahruday904
    @nirmalahruday904 2 ปีที่แล้ว

    Well explained

  • @panakhalid6854
    @panakhalid6854 3 ปีที่แล้ว

    good job ,well done

  • @r4serONE
    @r4serONE 4 ปีที่แล้ว +3

    Little correction from a biochemist: Isotopes are different versions of the same chemical element which differ in neutron number. I think here the constant region of an antibody encodes the isoTYPE (or class).

    • @lilkakashi_vert1014
      @lilkakashi_vert1014 4 ปีที่แล้ว

      I'm actually thinking of becoming a biochemist or a medical scientist and I'm just curious as to what you do I've always been interested in cells and how they work and diseases but I'm only 16 and I'm not 100% sure if it's what I want to do

    • @r4serONE
      @r4serONE 4 ปีที่แล้ว

      Lord Ovy IX being curious about these types of fields is great. Keep that up! So, I recently graduated as a PhD in chemistry/biochemistry with specialization in mass spectrometry. I studied a lot disease and toxicity-related changes in proteins, such as acute or chronic liver failure. I was lucky and could work a lot on human samples and did not have to rely on/conduct animal studies (I think that’s more common in biology). In these types of studies you learn a lot about biological processes on the macro level and also (bio-)chemical principles on the micro level. It can be sometimes challenging and hard, but it’s always rewarding. And after the studies you have the chance to either stay in R&D in a company or a certified lab, or search a career in the pharmaceutical/healthcare industry

    • @lilkakashi_vert1014
      @lilkakashi_vert1014 4 ปีที่แล้ว

      @@r4serONE thanks alot for responding I appreciate. Its just in our school we don't get to actually do alot of physical work it's more just theory and writing and it doesn't really give me an idea of the actual subject. So I appreciate this thanks very much.

    • @r4serONE
      @r4serONE 4 ปีที่แล้ว

      Lord Ovy IX no worries. We didn’t get much hands-on experience in school either. My first lab experience was in undergrads.

  • @davherc
    @davherc 6 ปีที่แล้ว +1

    Great video, I was just curious because I work at a warehouse that store them, they told me it costs around $600,000 per galon

    • @tal8871
      @tal8871 3 ปีที่แล้ว

      try $600,000 per cup

  • @sarafinaindjeekanguaikomer7232
    @sarafinaindjeekanguaikomer7232 8 ปีที่แล้ว

    wow!!!I can clearly understand now

  • @rashidkhan5719
    @rashidkhan5719 3 ปีที่แล้ว

    Good video but little bit correction . FC fragment is formed by constant region of heavy chain only. U mentioned constant region of antibody as Fc fragment.

  • @irinaptb
    @irinaptb 9 ปีที่แล้ว

    Great!!!! thank you!

  • @chantell2603
    @chantell2603 7 ปีที่แล้ว

    Thanks!

  • @yohanabf242
    @yohanabf242 9 ปีที่แล้ว +10

    Hey, great video man
    just want to correct something:
    concerning the structure of the antibody, there's a difference between what we call the "Fab fragment" and the "variable region" (and also between Fc fragment and the "constant region").
    Indeed, i learned that:
    -Fab = the whole light chain + the 2 domains of the heavy chain next to the light chain
    -whereas Variable region = the 2 domains (1 of the light chain, the other of the heavy chain) that interact with the antigen (at the edge).
    -Fc = the four domains that don't belong to Fab
    -Constant region = the 8 domains that don't belong to the variable region
    Besides that, thank you for your work Armando

    • @spideylover4105
      @spideylover4105 5 ปีที่แล้ว

      yeah I was just about to correct this

  • @salam7905
    @salam7905 3 ปีที่แล้ว

    thank you so much ^^

  • @xDxD973
    @xDxD973 10 ปีที่แล้ว

    How amazing your ability to explain the things which we take it in college & our prof take hours & hours to explaining it . Thank u alot .

  • @Al-sf9qn
    @Al-sf9qn 9 ปีที่แล้ว

    thank you:)

  • @ConstantinPop
    @ConstantinPop 9 ปีที่แล้ว +8

    isotype, not isotope.

  • @victorvaldez6785
    @victorvaldez6785 9 ปีที่แล้ว

    Thanks for the video, very informative and well done.

  • @foundfindfinding5377
    @foundfindfinding5377 6 ปีที่แล้ว

    THANKS

  • @jacobblom3430
    @jacobblom3430 9 ปีที่แล้ว +12

    Isn't the Fab region the entire light chain plus the variable portion of the heavy chain, whereas the Fv region is the variable portion of the antibody?

    • @TheSternSaver
      @TheSternSaver 8 ปีที่แล้ว +7

      +Jacob Blom Yes!!! He was incorrect in the video.

  • @IgarashiDai
    @IgarashiDai 8 ปีที่แล้ว

    Hmm, I thought IgA antibodies only become dimeric upon crossing epithelial barriers, though... since the secretory component linking the two IgA antibodies together is derived from a receptor that mediates transcytosis through epithelia(?)

  • @mersana5290
    @mersana5290 7 ปีที่แล้ว

    excellent. ...you are the best. ..thanks for this video.....plz translate it to persian....lf it's possible

  • @user-nw7oy4kt2w
    @user-nw7oy4kt2w ปีที่แล้ว

    Perfect 👍🏻

  • @bomhayhay
    @bomhayhay 10 ปีที่แล้ว

    thanks

  • @thefenerbahcesk4156
    @thefenerbahcesk4156 5 ปีที่แล้ว

    For antivenom does the FC region of antibodies from other animals also work with humans?

  • @medicallaboratory3722
    @medicallaboratory3722 6 ปีที่แล้ว

    fu**ing awesome
    thank you dude you are awesome talented man

  • @danielasanhueza1767
    @danielasanhueza1767 5 ปีที่แล้ว

    There is any order in this videos? Im not sure if I am watching them right🤔 Thanks by the way!

  • @gsudmartin22
    @gsudmartin22 10 ปีที่แล้ว

    Your awesome

  • @NINZababy
    @NINZababy 10 ปีที่แล้ว

    Really like it, I imagine the isotype video is next?

    • @armandohasudungan
      @armandohasudungan  10 ปีที่แล้ว +3

      Thank you, Yes next next Tuesday it will be the functions of the antibody isotopes.

    • @leeragdoll3458
      @leeragdoll3458 10 ปีที่แล้ว +1

      Armando Hasudungan Haha I was wondering the same. I really treasure every video you upload. You are like my online tutor and help solve a lot of my doubts.

    • @rayyanabuoliem3046
      @rayyanabuoliem3046 8 ปีที่แล้ว

      .

  • @nellie272003
    @nellie272003 8 ปีที่แล้ว +2

    Could you just do a video about HIV, especially how it crosses the placenta to fetus? That would be wonderful!

    • @BoBo-dv5cb
      @BoBo-dv5cb 4 ปีที่แล้ว

      The virus can be pass on to the fetus through the blood as the fetus absorb nutrient from the mother's blood to survive while it is in the uterus. Virus are small enough to pass through the holes on the walls of capillaries so that it can be transport around the body and absorb by the fetus through placenta, umbilical cord then into the body of the fetus.

  • @waelabdallah7632
    @waelabdallah7632 4 ปีที่แล้ว

    what is the correct order to see these videos

  • @maka5489
    @maka5489 4 ปีที่แล้ว +3

    I was like "wha...." from 0:01-0:04.....😂😂

  • @sukinahhussain7439
    @sukinahhussain7439 10 ปีที่แล้ว

    Do u have video about ANS ??

  • @debrawilliamson3064
    @debrawilliamson3064 7 ปีที่แล้ว

    Armando, I would like permission to use your videos on an educational website. Could you respond asap.

  • @Jordikamp
    @Jordikamp 5 ปีที่แล้ว +1

    Hi man, nice video! Just i want to say (because i am from Greece) that the greek letter "gamma" for G antibodies is "Γ" and not "Υ". Very good job anyway

    • @bukusakufarter
      @bukusakufarter 2 ปีที่แล้ว

      I suppose G refers to lowercase γ, not Y

  • @akigreus9424
    @akigreus9424 3 ปีที่แล้ว

    Does the body use metals available in its enivorment but not needed in its metabolism in the formation of antibodies?

  • @kaorisaito9267
    @kaorisaito9267 5 ปีที่แล้ว

    how do you draw so good

  • @nizamuddinansari4665
    @nizamuddinansari4665 4 ปีที่แล้ว

    Which app u use for making videos....plz plz tell

  • @DanielHernandez-yk3dr
    @DanielHernandez-yk3dr 6 ปีที่แล้ว

    Education is the solution for humankind problems.

  • @woloabel
    @woloabel 5 ปีที่แล้ว

    Lymphocytosis can always indicate infection while neutrophilia is a more specific infection, bacterial infection ....

  • @surajalkafaji2666
    @surajalkafaji2666 3 ปีที่แล้ว

    Hi doctor armando
    Sorry you said light chain has wieght 22 kDa
    But references say 25 k Da

  • @pabloosdoo2366
    @pabloosdoo2366 10 ปีที่แล้ว

    Desde la facultad de Biología de la UAM.... ERES NUESTRO DIOS!!! / From the faculty of Biology of UAM... YOU ARE OUR GOD!!!

  • @KarlaLopez-tw9dd
    @KarlaLopez-tw9dd 3 ปีที่แล้ว

    cute bracelet :)

  • @tashathn1261
    @tashathn1261 3 ปีที่แล้ว

    what does KDG in the video stand for ?
    *the weight of the heavy chain 53KDG*

    • @davef7461
      @davef7461 3 ปีที่แล้ว

      It’s supposed to be “KDa” not “KDG”
      K = kilos
      Da = daltons

  • @Notundigonto
    @Notundigonto 7 ปีที่แล้ว

    you will be great teacher later

  • @anja76
    @anja76 10 ปีที่แล้ว +14

    You made a mistake. Constant region is not Fc and Variable region is not Fab. Light chain and 1/2 of a heavy chain next to it is known as Fab fragment and the other half of heavy chain is known as Fc fragment. I hope you understand what I mean to say :)

    • @EmilyAmner
      @EmilyAmner 7 ปีที่แล้ว

      thats what he meant
      it IS accurate

  • @MrEphratah
    @MrEphratah 4 ปีที่แล้ว

    Correction- you have used isotope to mean isotype

  • @kevinscott9158
    @kevinscott9158 6 ปีที่แล้ว +6

    You wrote isotype but you keep saying isotope.

    • @djdonald2795
      @djdonald2795 5 ปีที่แล้ว

      Actually, he wrote it wrong and said it wrong. I was going to recommend this video to a college student, but that was deal breaker for me. You can't be saying isotope when you mean isotype or class and subclass.

    • @anuvette
      @anuvette 5 ปีที่แล้ว

      @@djdonald2795 what

    • @djdonald2795
      @djdonald2795 5 ปีที่แล้ว

      Human antibody istotypes: Classes: IgG, IgA, IgE, IgM, IgD; Subclasses of IgG: IgG1, 2, 3, and 4

  • @nerdchick85
    @nerdchick85 10 ปีที่แล้ว +1

    In ur video u said tht B cells produce antibodies.Technically, its only the Plasma cells tht produce antibodies.Plasma cells are the effector cell of B cells

    • @KasDush
      @KasDush 10 ปีที่แล้ว +8

      0:18 he say's "Plasma Cells specifically" :)

    • @mygoldentruth
      @mygoldentruth 9 ปีที่แล้ว +3

      Actually B cells do produce antibodies (they do not secrete them), plasma cells produce and secrete them.
      Antibodies are part of B cells membrane: B cells produce one kind of Ig with a specific Fab portion. It would be a disaster if they didn't produce antibodies.
      Hope I helped! :)

  • @marinabearman3855
    @marinabearman3855 4 ปีที่แล้ว

    You said Isotope. Did you mean isotype?

  • @thabangnkopane4626
    @thabangnkopane4626 3 ปีที่แล้ว

    Peter. B. Parker @intothespiderverse

  • @yousifradhy2148
    @yousifradhy2148 6 ปีที่แล้ว

    شمعه

  • @edwindeleon1130
    @edwindeleon1130 4 ปีที่แล้ว +1

    they should make antibody game to find cure for diseases. nintendo

  • @bryanl.morrison552
    @bryanl.morrison552 4 ปีที่แล้ว

    2 CHAINZ

  • @senorbuttface3810
    @senorbuttface3810 7 ปีที่แล้ว

    I'm antibodies, because I only have legs and a head

  • @ColocasiaCorm
    @ColocasiaCorm 3 ปีที่แล้ว

    i like lambda gamma.

  • @paulhetherington3854
    @paulhetherington3854 4 ปีที่แล้ว

    You hunt yourselves-- down, damn fools.

  • @bskedar228
    @bskedar228 3 ปีที่แล้ว

    FAB ABD Fc REGIONS\

  • @robertdonohoe9766
    @robertdonohoe9766 7 ปีที่แล้ว

    Contains inaccurate information. It's not isotope, it's isotype. The heavy chain is not synonymous with constant region, etc. I had to stop watching because I don't want to get wrong info.