OMG thank you thank you thank you this is THE BEST set of immunology videos EVER SO ACCURATE and matches PERFECTLY with textbook information I dont even have to study any more just watch your videos multiple times WOW!!!!!!!
fantastic video! I'm a medicinal chemist who's not very familiar with antibodies but I have to quickly learn as part of my job. I'm so grateful I came across this video. It really helps to understand beginners!
Thanks alot sir, i had 3 months load of lessons to study before my exam, i had only ten days to study, because of your videos i was able to pass my exam🙏🙏🙏
Fab region consists of variant and constant regions not only variant as you mentioned.Great videos but i think that you should put under the videos in a Bar the mistakes and some correction. There are students who has no background and come here to study at first, i think that if you want to help those students they should know the correct facts.
I like your videos for use as overviews for my students and I wish I could draw diagrams this well on our markerboards at school. One question though, at 2:54 you mention and write antibody isotope (with an "o"), but do you actually mean isotype (with a "y")? I'm not familiar with the term antibody isotope except for using antibodies for delivering radioactive isotopes.
Little correction from a biochemist: Isotopes are different versions of the same chemical element which differ in neutron number. I think here the constant region of an antibody encodes the isoTYPE (or class).
I'm actually thinking of becoming a biochemist or a medical scientist and I'm just curious as to what you do I've always been interested in cells and how they work and diseases but I'm only 16 and I'm not 100% sure if it's what I want to do
Lord Ovy IX being curious about these types of fields is great. Keep that up! So, I recently graduated as a PhD in chemistry/biochemistry with specialization in mass spectrometry. I studied a lot disease and toxicity-related changes in proteins, such as acute or chronic liver failure. I was lucky and could work a lot on human samples and did not have to rely on/conduct animal studies (I think that’s more common in biology). In these types of studies you learn a lot about biological processes on the macro level and also (bio-)chemical principles on the micro level. It can be sometimes challenging and hard, but it’s always rewarding. And after the studies you have the chance to either stay in R&D in a company or a certified lab, or search a career in the pharmaceutical/healthcare industry
@@r4serONE thanks alot for responding I appreciate. Its just in our school we don't get to actually do alot of physical work it's more just theory and writing and it doesn't really give me an idea of the actual subject. So I appreciate this thanks very much.
Good video but little bit correction . FC fragment is formed by constant region of heavy chain only. U mentioned constant region of antibody as Fc fragment.
Hey, great video man just want to correct something: concerning the structure of the antibody, there's a difference between what we call the "Fab fragment" and the "variable region" (and also between Fc fragment and the "constant region"). Indeed, i learned that: -Fab = the whole light chain + the 2 domains of the heavy chain next to the light chain -whereas Variable region = the 2 domains (1 of the light chain, the other of the heavy chain) that interact with the antigen (at the edge). -Fc = the four domains that don't belong to Fab -Constant region = the 8 domains that don't belong to the variable region Besides that, thank you for your work Armando
Isn't the Fab region the entire light chain plus the variable portion of the heavy chain, whereas the Fv region is the variable portion of the antibody?
Hmm, I thought IgA antibodies only become dimeric upon crossing epithelial barriers, though... since the secretory component linking the two IgA antibodies together is derived from a receptor that mediates transcytosis through epithelia(?)
Armando Hasudungan Haha I was wondering the same. I really treasure every video you upload. You are like my online tutor and help solve a lot of my doubts.
The virus can be pass on to the fetus through the blood as the fetus absorb nutrient from the mother's blood to survive while it is in the uterus. Virus are small enough to pass through the holes on the walls of capillaries so that it can be transport around the body and absorb by the fetus through placenta, umbilical cord then into the body of the fetus.
Hi man, nice video! Just i want to say (because i am from Greece) that the greek letter "gamma" for G antibodies is "Γ" and not "Υ". Very good job anyway
You made a mistake. Constant region is not Fc and Variable region is not Fab. Light chain and 1/2 of a heavy chain next to it is known as Fab fragment and the other half of heavy chain is known as Fc fragment. I hope you understand what I mean to say :)
Actually, he wrote it wrong and said it wrong. I was going to recommend this video to a college student, but that was deal breaker for me. You can't be saying isotope when you mean isotype or class and subclass.
In ur video u said tht B cells produce antibodies.Technically, its only the Plasma cells tht produce antibodies.Plasma cells are the effector cell of B cells
Actually B cells do produce antibodies (they do not secrete them), plasma cells produce and secrete them. Antibodies are part of B cells membrane: B cells produce one kind of Ig with a specific Fab portion. It would be a disaster if they didn't produce antibodies. Hope I helped! :)
Contains inaccurate information. It's not isotope, it's isotype. The heavy chain is not synonymous with constant region, etc. I had to stop watching because I don't want to get wrong info.
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One little correction - IgA exists as a dimer only in mucous/secretions. In the blood stream, it is a monomer.
Was mentioned in the continuation video
Thank you for taking the time to do all of these videos. They have been extremely helpful!
OMG thank you thank you thank you
this is THE BEST set of immunology videos EVER
SO ACCURATE and matches PERFECTLY with textbook information
I dont even have to study any more just watch your videos multiple times WOW!!!!!!!
fantastic video! I'm a medicinal chemist who's not very familiar with antibodies but I have to quickly learn as part of my job. I'm so grateful I came across this video. It really helps to understand beginners!
Thanks alot sir, i had 3 months load of lessons to study before my exam, i had only ten days to study, because of your videos i was able to pass my exam🙏🙏🙏
We love you Armando! Thank you for posting these fabulous videos. You Rock the Science World :)
Consistent and easy. I'd really want to see a video on the modification of antigens and the formation of autoantibodies.
please go on. I really like this program!
These are wonderful videos! Thank you!
Fab region consists of variant and constant regions not only variant as you mentioned.Great videos but i think that you should put under the videos in a Bar the mistakes and some correction. There are students who has no background and come here to study at first, i think that if you want to help those students they should know the correct facts.
I completely agree. Albeit, 6 years late.
@@gM-zf3iu I also agree, 6 years later. Shanel your words are ageless.
thank you，sir
Best lecture on antibodies
th-cam.com/video/c4V0-YEiLYg/w-d-xo.htmlsi=uxogb0iNhQA1Rr3S
Thankyou for each and every video of yours. Ur lec r intresting and lifesaving thanku soo soo much.
I would even recommend it to my freinds.
A very helpful video to get things visualization.Thanks.
good job!!!
everything i need!
Great video, thanks so much!!
This is so helpful - thank you!
Great work!
I like your videos for use as overviews for my students and I wish I could draw diagrams this well on our markerboards at school. One question though, at 2:54 you mention and write antibody isotope (with an "o"), but do you actually mean isotype (with a "y")? I'm not familiar with the term antibody isotope except for using antibodies for delivering radioactive isotopes.
reaaly good video, informative, thank you
Thank you!
You are doing a great job.
MADGE- to remember the 5 classes of antibodies
or GAMED
@@keshian2418 or I'MAGED(Memorize as "i am aged" or "imaged" ; I is just the first letter for antibody)
Thanks
And GAMDE in order of their serum quantities
I would prefer GAMED
Great videos, I was wondering if you have PDFs of the notes that you take
He sells them on his website
thank you very much it was helpful 🙆💖
Great job
helpful
thank you Sir
Thank you💕
Thank You
clicking screen at end does not lead to part 2, gonna search for it though, thankyou your art work works perfectly for my mind memory
Well explained
good job ,well done
Little correction from a biochemist: Isotopes are different versions of the same chemical element which differ in neutron number. I think here the constant region of an antibody encodes the isoTYPE (or class).
I'm actually thinking of becoming a biochemist or a medical scientist and I'm just curious as to what you do I've always been interested in cells and how they work and diseases but I'm only 16 and I'm not 100% sure if it's what I want to do
Lord Ovy IX being curious about these types of fields is great. Keep that up! So, I recently graduated as a PhD in chemistry/biochemistry with specialization in mass spectrometry. I studied a lot disease and toxicity-related changes in proteins, such as acute or chronic liver failure. I was lucky and could work a lot on human samples and did not have to rely on/conduct animal studies (I think that’s more common in biology). In these types of studies you learn a lot about biological processes on the macro level and also (bio-)chemical principles on the micro level. It can be sometimes challenging and hard, but it’s always rewarding. And after the studies you have the chance to either stay in R&D in a company or a certified lab, or search a career in the pharmaceutical/healthcare industry
@@r4serONE thanks alot for responding I appreciate. Its just in our school we don't get to actually do alot of physical work it's more just theory and writing and it doesn't really give me an idea of the actual subject. So I appreciate this thanks very much.
Lord Ovy IX no worries. We didn’t get much hands-on experience in school either. My first lab experience was in undergrads.
Great video, I was just curious because I work at a warehouse that store them, they told me it costs around $600,000 per galon
try $600,000 per cup
wow!!!I can clearly understand now
Good video but little bit correction . FC fragment is formed by constant region of heavy chain only. U mentioned constant region of antibody as Fc fragment.
Great!!!! thank you!
Thanks!
Hey, great video man
just want to correct something:
concerning the structure of the antibody, there's a difference between what we call the "Fab fragment" and the "variable region" (and also between Fc fragment and the "constant region").
Indeed, i learned that:
-Fab = the whole light chain + the 2 domains of the heavy chain next to the light chain
-whereas Variable region = the 2 domains (1 of the light chain, the other of the heavy chain) that interact with the antigen (at the edge).
-Fc = the four domains that don't belong to Fab
-Constant region = the 8 domains that don't belong to the variable region
Besides that, thank you for your work Armando
yeah I was just about to correct this
thank you so much ^^
How amazing your ability to explain the things which we take it in college & our prof take hours & hours to explaining it . Thank u alot .
thank you:)
isotype, not isotope.
Thanks for the video, very informative and well done.
THANKS
Isn't the Fab region the entire light chain plus the variable portion of the heavy chain, whereas the Fv region is the variable portion of the antibody?
+Jacob Blom Yes!!! He was incorrect in the video.
Hmm, I thought IgA antibodies only become dimeric upon crossing epithelial barriers, though... since the secretory component linking the two IgA antibodies together is derived from a receptor that mediates transcytosis through epithelia(?)
excellent. ...you are the best. ..thanks for this video.....plz translate it to persian....lf it's possible
Perfect 👍🏻
thanks
For antivenom does the FC region of antibodies from other animals also work with humans?
fu**ing awesome
thank you dude you are awesome talented man
There is any order in this videos? Im not sure if I am watching them right🤔 Thanks by the way!
Your awesome
Really like it, I imagine the isotype video is next?
Thank you, Yes next next Tuesday it will be the functions of the antibody isotopes.
Armando Hasudungan Haha I was wondering the same. I really treasure every video you upload. You are like my online tutor and help solve a lot of my doubts.
.
Could you just do a video about HIV, especially how it crosses the placenta to fetus? That would be wonderful!
The virus can be pass on to the fetus through the blood as the fetus absorb nutrient from the mother's blood to survive while it is in the uterus. Virus are small enough to pass through the holes on the walls of capillaries so that it can be transport around the body and absorb by the fetus through placenta, umbilical cord then into the body of the fetus.
what is the correct order to see these videos
I was like "wha...." from 0:01-0:04.....😂😂
Do u have video about ANS ??
Armando, I would like permission to use your videos on an educational website. Could you respond asap.
Hi man, nice video! Just i want to say (because i am from Greece) that the greek letter "gamma" for G antibodies is "Γ" and not "Υ". Very good job anyway
I suppose G refers to lowercase γ, not Y
Does the body use metals available in its enivorment but not needed in its metabolism in the formation of antibodies?
how do you draw so good
Which app u use for making videos....plz plz tell
Education is the solution for humankind problems.
Lymphocytosis can always indicate infection while neutrophilia is a more specific infection, bacterial infection ....
Hi doctor armando
Sorry you said light chain has wieght 22 kDa
But references say 25 k Da
Desde la facultad de Biología de la UAM.... ERES NUESTRO DIOS!!! / From the faculty of Biology of UAM... YOU ARE OUR GOD!!!
cute bracelet :)
what does KDG in the video stand for ?
*the weight of the heavy chain 53KDG*
It’s supposed to be “KDa” not “KDG”
K = kilos
Da = daltons
you will be great teacher later
You made a mistake. Constant region is not Fc and Variable region is not Fab. Light chain and 1/2 of a heavy chain next to it is known as Fab fragment and the other half of heavy chain is known as Fc fragment. I hope you understand what I mean to say :)
thats what he meant
it IS accurate
Correction- you have used isotope to mean isotype
You wrote isotype but you keep saying isotope.
Actually, he wrote it wrong and said it wrong. I was going to recommend this video to a college student, but that was deal breaker for me. You can't be saying isotope when you mean isotype or class and subclass.
@@djdonald2795 what
Human antibody istotypes: Classes: IgG, IgA, IgE, IgM, IgD; Subclasses of IgG: IgG1, 2, 3, and 4
In ur video u said tht B cells produce antibodies.Technically, its only the Plasma cells tht produce antibodies.Plasma cells are the effector cell of B cells
0:18 he say's "Plasma Cells specifically" :)
Actually B cells do produce antibodies (they do not secrete them), plasma cells produce and secrete them.
Antibodies are part of B cells membrane: B cells produce one kind of Ig with a specific Fab portion. It would be a disaster if they didn't produce antibodies.
Hope I helped! :)
You said Isotope. Did you mean isotype?
Peter. B. Parker @intothespiderverse
شمعه
they should make antibody game to find cure for diseases. nintendo
2 CHAINZ
I'm antibodies, because I only have legs and a head
i like lambda gamma.
You hunt yourselves-- down, damn fools.
FAB ABD Fc REGIONS\
Contains inaccurate information. It's not isotope, it's isotype. The heavy chain is not synonymous with constant region, etc. I had to stop watching because I don't want to get wrong info.