Innate lymphoid cells

Along with the skin, the gut mucosa represents the first line of defense against environmental factors. In the gut mucosa, a recently discovered type of lymphocytes called innate lymphoid cells (ILCs) maintain tissue homeostasis, orchestrate tolerance to food or commensal bacteria and contribute to immune responses to pathogens.
This Nature Video shows the complexity of ILC biology in the gut mucosa at steady state and disease.
Read more about ILCs here: www.nature.com/ni/focus/ILC
Nature has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors.

[@doodelay]

please make more videos about the lives of cells. this is incredible

[@sylfarynen]

Amazing work. Although I am an immunologist, the helminth clearance, just surpasses me. Congratulations, your endeavor simply is the strongest motive for any young scientist. Wish I had TH-cam during my bachelor studies.

[@basiliqbal5218]

How are you ?

[@deadscenedotcom]

Stunning illustration. Extremely clear and concise. Thank you!

[@thembastoep733]

Now that is quality beyond anything you can imagine possible

[@marykacyy6802]

And this is why i love science!!!! Microscopic responses are always going on in and outside of our bodies!
and untill you study medical science won't really understand it all but once you do trust me you will feel like a damn super hero with all that amazing knowledge
btw im a Paramedical Esthetician and even though its a specialty in skin care i did understand what this video was talking about, The body is simply amazing!

[@JHIslander]

Superlatives are well-deserved here. Amazing work!!! Pleeeeeease more!!!!

[@missgris10]

this is such a beautifully made video, thank you for the clear explanation!

[@jordybotello6506]

this makes me so happy for some reason

[@aj-uo3uh]

Going for quality explanations like this is the way, the way to get better doctors and scientists which are less confused about their knowledge and so can make easier the next steps in the medical science.

[@georgemawson946]

RIP to us medical students with an medical immunology exam in a few days.

[@miruvae]

Mine's in 10 days don't call me out like this

[@arlenismendez1611]

I have an undergrad immunology exam tonight!

[@akiteruapologist2820]

how did yall do?

[@medicalmayhem]

This is the most amazing thing I've ever seen. Do other people drool over molecular biology like I do?

[@alejandrovallejos4454]

thanks nature, you did it again

[@irun_mon]

If you think about it, this is happening right now in our bodies

[@keine031]

Incredibly well done

[@magdalenadeline3775]

What an Amazing video... #after read so many writings and in a deep of lack of knowledge this video makes it brief clear!

[@betsyott4544]

Marvelous animation, great narrative. Serious problems with the closed captioning, though.

[@rosannelopes2230]

Estou encantada com as animações espetaculares presente nesse canal. PARABÉNS!!!

[@paulaguirre1276]

so i have been binge watching on cellular interpretation and am now in awe of the complexity of our immune response system. i can not believe that we have evolved into this magnificent entity and we have no idea who we are under the skin. i know that doctors and scientist already think this is boring stuff but holy shit!... i had no idea. mind blown!!!!!!!

[@view1st]

And to think it only took 3½ billon years to get to this stage of cellular complexity.

[@Mitranim]

Obscure but crazy beautiful

[@richwaight]

Fascinating!!! Thanks for posting :)

[@CompBioQuest]

This is beautiful. I study the immune system / tolerance and exhaustion /and always open to collaborations. Best,

[@ornitnahman4914]

Full transcription
Our body is in constant contact with environmental factors. Epithelial barriers like the skin or gut mucosa represent the first line of defense in the gut mucosa specialized immune cells actively reinforce the barrier and induce tolerance against food or commensal bacteria. Among those immune cells a recently discovered type of lymphocytes called innate lymphoid cells (ILCs) orchestrate immune responses and maintain tissue homeostasis. Unlike the T and B lymphocytes, ILCs do not express adaptive antigen recognition receptors. As such, their activation and expansion is not driven by antigen but rather by cytokine signals from the tissue. ILCs come in three types: ILC 1 / 2 / 3. ILC 3 interact with dendritic cells to maintain the epithelial barrier. Dendritic cells which are specialized in the presentation of antigen, acquire antigen from the gut microbiota and secrete IL-23. IL-23 stimulates the ILC3s to make IL-22 which then activates the epithelium to secrete antimicrobial peptides or AMPs that kill bacteria directly. IL-22 also enhances IL-23 production in dendritic cells. This dialogue between dendritic cells and ILC 3s maintains the barrier against pathogenic or commensal bacteria. ILC3s also interact with macrophages to establish tolerance towards the commensal microbiota. Antigen from gut bacteria induces the inflammatory cytokine IL-1β in macrophages which in turn triggers the secretion of GM-CSF in ILC3s. GM_CSF signals back to macrophages to induce retinoic-acid which promotes the differentiation of regulatory T-cells. Regulatory T-cells are essential in maintaining tolerance towards the commensal microbiota. ILC2s contributes to responses against helminths. These parasitic worms release enzymes that digest the mucus barrier and cause massive cell death. Epithelial cells sense the danger signals released by the dying cells and produce alarmins (IL-25,IL-33, TSLP). In response to the alarmin IL-25, ILC2s make mediators that induce mucus production from goblet cells, send activated dendritic cells to the lymph node (by IL-13 secretion) where they can prime T-cell effectors, recruit eosinophils and mast, and induce muscle contraction. These actions results in the expulsion of worms from the gut. In response to IL-33, ILC2s also make Amphiregulin, which induces tissue repair following worm clearance. However, ILCs also contribute to tissue pathology. ILC 1s which make the inflammatory mediator IFN-gamma and ILC3s which can acquire the ability to make INF-gamma during chronic inflammation are found in inflammatory bowel diseases such as colitis and Crohn's disease and contribute to gut pathology. As such, ILCs participate in various aspects of immunity from maintenance of the epithelial barrier and tolerance against commensals to immune responses against parasites and pathology associated with chronic inflammation.

[@julianschachter2262]

did you trancribe it by hand or with an app?

[@ornitnahman4914]

@@julianschachter2262 By hand

[@kevinj4243]

Insane animation.

[@martinarenzi4744]

Great video ❤ please keep making videos like this ❤

[@albasuna]

absolutely fascinating

[@altair_ezio01]

I love this work, it feels like you are watching a movie 🎬

[@yifshoooo]

cool animated videos plz dont stop making videos like this

[@EHD351]

Excellent! Many Thanks.

[@meee6809]

amazing so complex system going on in our bodies 😊

[@wantedrob438]

This was so intense😰I loved it

[@medzoklife]

Simply great channel. I subscribed.

[@dibyendusamanta2526]

Super explanation and animation ❤️💙💛

[@aurorar.6409]

wonderful , thank you

[@Saed7630]

Beautiful!

[@mrniceguy4277]

I'm amazed by the fact that there is a class of molecules that are called alarmin

[@TheBZStudios]

Alarmins are actually just normal cell peptides that are not normally found extracellularly. Because they're only meant to be found inside cells, when they're sensed in the tissue by immune cells its clear that cells have been killed.

[@fara.r.8181]

Alarmin as of when these molecules out of the cells as a "danger signal" to others.

[@mrniceguy4277]

Yes, I know. Still cool to call these alarmin :)

[@fara.r.8181]

@@mrniceguy4277 Yes. You can search out DAMP and PAMP for further reading.

[@mrniceguy4277]

@@fara.r.8181 I'm a PhD student with a M.Sc. in Immunology, mate :) Still a good tip in case some random person reads this xD

[@freedeliveryprinting3100]

Had this been available 40 years ago I would have likely not switched from pre-med to poli sci...Never too late to learn.

[@naveedahmed6270]

increidible explanation i appreciate

[@MsVgiongo]

Perfect!

[@addiedas89]

Astounding!

[@auser131]

It is very amazing thank you

[@sherinajoy6910]

This is amazing....thank you so much🥰

[@SahanTheMighty]

These videos and the narration are so helpful. Spell-binding.

[@ahmedibrahim4159]

Fantastic !

[@afighter1459]

Excellent video. 👏👏👏

[@shahlaayman7250]

thank you very much

[@nataliafranca5203]

this is great!!!! thanks

[@adriannilsen8890]

Good video

[@YSKMrLAM]

thanks ad

[@SkinandHairDr.faTima]

I love this work and appreciate your efforts to make this | ❀ ☆✿♡

[@alaaali7534]

awesome videos

[@PrInCeSsuk8]

I want to become a scientist now

[@sonalimalsom6168]

Amazing❤❤❤

[@dra.melissacunha1125]

Amazing!!!!! 👏🏼👏🏼👏🏼

[@DemonetisedZone]

Good video👍😉

[@veronicalodge8739]

Beautiful 😯👍🏽

[@doriettprada3446]

Maravilloso

[@maryweprin]

Amazing what we don’t know.

[@aga5897]

Superb !

[@dheerajpatkar4080]

please make the video on MHC pathways

[@mplmpl4004]

Informative

[@jamicarpenter8760]

AWESOME 👏🏽

[@walidsong2255]

Please explain the work of the enzyme 5 alpha reductase in changing the male hormone, and where it is produced. Thank you.

[@mrniceguy4277]

3:10 What about peyer's patches instead of a LN?

[@StephenMortimer]

So good I "almost" get it !!

[@StephenMortimer]

*****
Nooo.. that was helpful ... the problem is that I am 71

[@g63music95]

Lol 😆

[@benmcreynolds8581]

I could watch videos like this on every single subject inside of biological creatures. This is like a version of the magic school bus haha

[@davidsweeney111]

Is it a similar situation in the lung?

[@view1st]

Helminthic worms also evolve to counteract the gut's defences. Thus, how effective is the current stage of human gut evolution vis-a-vis helminthic worm evolution; are we ahead or just equal?

[@FishoeShoe_da_great]

so many interleukins,,,,,, cries

[@mohamedlaffirmohamedrimzan3993]

hi everyone hope all are keeping fine .reactive population of lymphoid cells pls help us how to overcome with lymphoid cells what is best treatments ? thank you very much in advance ,

[@idaerasmus9617]

A replica of the universe

[@1t2t3t4t5t6t7]

spacy animation :D

[@INN2007qqqq]

Strange to see when a cell fires signal molecules directly in direction to an another cell. It is wrong visualization

[@Spavlia]

Anyone else sent here by Jenny/A Kelly?

[@MaviyaM-ft5ru]

It's magic

[@user-lh1ot3xd5s]

في بعض المصطلحات ما فهمتها

[@roselinee]

our bodies are kinda badass

[@Electroblade360]

Immunology Out Of The Gut Mucosa 2

[@brainstormingsharing1309]

👍👍👍👍👍👍👍👍👍👍👍

[@karviahamilton689]

This is kind of complex

[@user-lh1ot3xd5s]

اخخخ😟لو يترجم الى عربي ب يكون أحسن للفهم

[@cyanuranus6456]

Those Parasite Worms

[@ryzasantos1821]

Hummugos

[@DamKaKaDaNi]

Boja

[@007bokal]

Lol lol 😂

[@beavis1474]

"evolution" ... ha ha!

[@mohamedaminelabidi9630]

Everything is proving one end Allah (God) is great