ฝัง
- เผยแพร่เมื่อ 31 ต.ค. 2016
- Today we are making some cadaverine from lysine. The yield is kind of crappy, but it is still nice and stinky :)
Link to paper: erowid.org/archive/rhodium/pd...
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Nile talks about lab safety: • Chemistry is dangerous. - วิทยาศาสตร์และเทคโนโลยี
![[TH] VCT Masters Shanghai Playoffs DAY 4 // 100T vs GEN | G2 vs TH](http://i.ytimg.com/vi/UkTGSxdCUQw/mqdefault.jpg)
every nilered video: so i messed up pretty big time here, but it should be like fine. oh the yield was pretty low thats weird haha
These videos can be weird sometimes. On I'm a year late my bad.
😂😂😂 why i love these vids LMAO
Ikr? 😂
Oops, added too much exaggerated swagger to the solution
Added too much ligma 😳😳😳😳😳😳😳😳
'The Characteristic Smell of Semen' should be an album name, by the band Cadaverine. Track #1 is Bacterial Vaginosis.
They're on tour with Cannibal Corpse and Steel Panther.
Kick off Cannibal Corpse for anyone else that isnt just a generic meh death metal band and I'm on board. Alice Cooper seems like a better fit.
@@michealpersicko9531 Nah nah. Gotta keep Cannibal Corpse. The name fits u see
@@yep4925 I understand but I'm still not gonna waste money for a band that i don't care about just to see 2 bands that i do. Plus alice cooper's whole image is like death and horror shit plus when i saw him live during one of his songs he faked getting decapitated.
@@michealpersicko9531 ye but like. *It's got cannibal in the name*
@@yep4925 yea but like alice cooper doesn't sound like shit and steel panther's better than that.
Perfect cover for those bodies in the basement...
U Wot M8 ýyțțțțțț5
You don't know shit about those bodies so shut up or you will be joining them
you Gay lmfaooooo
U Wot M8 haha iv made the like count 420 I am pleased
Perfect cover for all the cum socks under the bed
"Cadaverine" is probably the most badass chemical name
and you are eating it
“Ran out of diethyl ether”
This is one of the most relatable lines I’ve heard
It’s like running out of milk for me
@@Alexander_l322 it’s like running out of water, like running out of food, like running out of air
Love that the names of the nasty smelling compounds are based on "corpse", "cadaver", "putrid", and other "God damn, this smells like a rotting corpse!" names lmao
"🥛"
What compound is based on “corpse”?
@@dewilew2137cadaver lol
When you make nasty smelling chemicals, I feel like we need a shot of you taking a whiff of it.
haha that might be funny. Cadaverine wasn't that bad though because the vapor pressure isnt super high. The trimethylamine i made a week later was so much worse
NileRed I think we need to see you react to some of your chemicals, even as a joke. if its safe to smell some of your concoctions, it would add a welcome human element to the presentation, at least for the casual viewers who aren't chem majors (like most of us!)
@NileRed; Or maybe you could try to make the most foul-smelling mixture even you could come up with, and then use it as a prank on some of your friends! (with the hidden camera catching all the action, of cource)...
My chemistry teacher kept a 2L brown glass jar of conc. butyric acid in a cupboard near a radiator and he would routinely get it out to give each new class of students a whiff. I'm sure there are worse things in the world but damn.
how to extract and purifying semen?
It's always nice to see the actual use of chemicals after learning about them in the lecture
That's the goal!
Yeah but Nile... the use isn’t exactly PG
@@ZinkZoodles lol did you just say that CHEMISTRY isn’t PG? There are kid friendly chemistry experiments. But most of chemistry is 100% not meant for children to be learning. Hence that fact that you don’t even start learning it until high school my guy. Chemistry isnt supposed to be, and will never be PG.
@@NileRed a book series I am into called "Rot and Ruin" uses Cadaverine as a liquid they dab on their clothes to knock their scent off for the undead.
@@ZinkZoodles is it because of the _semen_ part?
I made a mixture of both when I forgot a crockpot full of pulled pork in my house before I went on a camping trip for a week. It was meant for the camping trip.. The smell was so bad that I instantly threw up when I encountered it, I decided to just throw out the entire crock pot.
That was me when my mom accidentally burnt chocolate chips while trying to melt them down in the microwave. Certainly wasn't on the scale of week old rotted flesh, but I've never had a smell make me retch and gag so hard I had to leave the house.
First date with a forensic investigator
@@Xenakeyblademaster generally i would generally suggest melting them over a double boiler
One time we went hog hunting and long story short we forgot a pig in an old ice chest... fast forward a few weeks when we went to get the ice chest for a fishing trip... and
@mister kluge 😂😂😂😂
"I feel like I'd put you to sleep if I read each one" I'm actually trying to use this video to help me sleep because it's a decent length video with a calming voice :P
Brianna771 Lmao I feel so bad, but occasionally I'll do the same thing. I watch all his vids, but every now and then I'm tired and I need something to put me sleep
Try watching northernlion.
Yea I do too, nile has quite a nice voice
He has some longer videos; try his one on turning aspirin into Tylenol, or the recent one on transparent wood.
I sleep with his voice too
0:53 "...and I chose cadaverine because I had the precursor on hand."
What, like a dead body? ;)
@@claudiaaguilar6080 they were JOKING.
@@claudiaaguilar6080 no you weren't
I don't think that you can consider dead body as precursor. It would be already finished product.
Oh I just realized. Are we talking about freshly killed body where's no cadaverine yet :O :O
I mean, he also has the precursor to produce the other one too... 😏😏😏
;;;))))))))));;););;);)));)))))
>making skatole, then cadaverine
You absolute madman.
"oh god what is that smell?"
"We let NileRed use the lab"
beepybeetle Lol now i know why pervs refer as " skat " for shitting on people.
Coprite and Mordite?
@@dimmacommunication That's actually a technical term. It's from scatology, the study of feces. Also "Coprophagia" is the really messed up term, not "scat". Coprophagia is someone loves eating feces. Here is the Scatology wikipedia page:
en.wikipedia.org/wiki/Scatology
@The Sentinel Of Abyss "scat" is a term often used with regard to feces paraphilia. It's a shit fetish, literally. Although more accurately that is coprophagia. Andrea thought that the term "scat" must come from the word "skatole", but "scat" is just short for Scatology, the study of excrement. If you ever see a "scat" category on a porn website, DO NOT click on it.
To make the smell of rotting flesh, I just let flesh rot. You know, I'm something of a scientist myself.
Every Nile Red video takes priority
Rhodanide facts.
@Evi1M4chine Open two windows and watch both at the same time
Have you ever been searched or asked questions by the police about your lab and chemicals?
@@ryanbyrnes7887 Nope! Not even once. I try to keep everything as legal as I can. :)
cadaverine? the log lost and forgotten x-man.
just stands there, and villains drop from the stench.
I finally found the the x-men comment to see that I'm not the only one with that idea😅
@@vrennexx3736 The He-Man villain Stinkor got there first, though... (I actually had the action figure - no clue what my parents were thinking when they got that one!)
I made my girlfriend your raspberry ketone perfume, but I mixed my notes up with this one. I can only hold Nile responsible for the current state of the relationship. Thanks Nile.
That stirbar thing is awesome
The man is producing various interesting chemical reactions, yet what do you care about? The stirbar thing.
@@PianoScenesMoviesandSeries yes
@@PianoScenesMoviesandSeries yes! It’s a great tool
@@PianoScenesMoviesandSeries lmao
@@PianoScenesMoviesandSeries The fact that such tools has been created for chemistry is pretty cool in itself.
This entire video sounds like chemical fanfiction
my chemical romance if you will
@@raticusfinch YOU DIDNT OH MY GODDD-
Imagine this being used as a "liquid ass" type of prank spray...
That would ruin a first date for sure!
@@lynnfarley7851 yeah if it is at your place you spray it around the entrance to your basement that would be a gaffer
Liquid Dead-Ass™
@@thesexybatman263 lmao
@John Hood i have never laughed this much at a youtube comment before
One thing I noticed is that your N-bromosuccinimide was very orange. NBS readily releases Bromine upon exposure to light so it must be kept in the dark. For reactions that uses the electrophilic properties of NBS, it is usually recommended to perform them in glassware wrapped in aluminium foil. To obtain pure NBS, you can recrystallise it very easily from 90°C water using 100ml of water for 10g of NBS.
I love your content. When I discovered your videos, I had no idea what you were talking about. Slowly I have discovered that I'm learning a lot from you, and I'm starting to understand. I love how informative you are and how you take the time to explain the process. Keep these videos going, they are fascinating for a person like me. Thank you for lighting up my day when you post a new video :)
Me too, if im not reading the comments
Wouldn't it be easier just to rob a grave?
Be easier to just buy a steak graves have a chem to slow decay
hell no digging up 6ft of dirt is pretty hard I promise that's why Mausoleum are more likely to get grave robbed
LoL you will also need to extract it from the dead.
Even easier, just do the deed yourself ;)
And way funnier
"Now we can add bigger portions" *adds in smaller portion that is left*
*Hey yeah, I should make something that literally reeks of rotting corpses and piss*
-NileRed 2k16
Have you ever been searched or asked questions by the police about your lab and chemicals?
Nope, but I wouldnt be surprised if it happened
And why you create some of the stuff u do?
@@lynnfarley7851 why not
"We have reason to believe you may be involved in the production of biological weapons."
"Why's that?"
"Fifty people on your block wearing nose-plugs."
@@lynnfarley7851 because he can
That pill doing 360's looks like a good Beyblade opponent.
ARDEACT it’s a magnet, and tbh if beyblades could implement magnets at certain points that could help or hurt ya, be a whole nother beast. Could be cool if done right.
da stirrrrr barr
it can handle any acid and most molten materials, and radiation
i put a very large forkful of spaghetti in my mouth right as he said 'characteristic smell of semen' and i dont think i will ever be the same
Yeah, why does he know what that smells like
@@CupCatsss i mean, it must say that on where he researched the chemical
@@CupCatsss hes a man.
Well for one thing you'll probably never have parmesan on it again.
Semen tastes and smells like bleach...so, not a big deal. I guess in your mind it is, but it's a super basic smell.
Can't believe I've never heard of a stir bar until now. Such an ingenious little thing.
Need one for cooking
what I really like about this channel is how it shows when you follow the procedure and fail ..This gives more motivation that it's not your mistake, but rather it's the nature of some reaction to go different pathways.
Thanks Nile
Big love to you
If you've ever smelled an actual body you remember the smell very well
Edgy ....
I’d like to buy a audio tape somewhere between 8-12 hours long of you discussing chemistry, I don’t really care if it makes sense... as long as it’s you talking about chemistry. Your voice is rather calming, and I use your videos to sleep well. Good content as well.
Please consider posting more of your longer projects. The longer the video, the better, I really find them relaxing to fall asleep to. I’m an extreme insomniac, and have a really hard time going to sleep, and your videos really really help. I’ve watched all your long videos, and most of your short ones. I’ve watched almost every video on this channel and your other one. the videos that are 20mins+ are the ones I’ve found to be the best. Anything less than that ends up with me to play 3-4 videos before I fall asleep, and ive pretty much watched every videos several times now
i come to these videos to learn but his voice explaining chemistry is so relaxing it keeps putting me to sleep
For how nasty the product is, the process sure is beautiful! All the in-between solutions had such pretty colors, it was super fun to watch. I especially liked that minty blue sodium hydroxide solution that went into the separators funnel, what a tasty color
the Mitochondria is the power house of the cell.
Turninator
Level 99 in science.
*BIOLOGY 100*
the Chloroplast is the sugar thingy of the cell.
Mitochondrion. Mitochondria is plural. 😀😘
That is correct
Oh no, officer, that's the smell of the cadaverine I'm synthesizing
It's funny because I'm going through your backlog of videos from the present and your voice actually sounds more "normal" years ago here. You now have such a distinctive NileRed voice and intonation! I enjoy both of course because they are both great at delivering crazy chemistry.
mix it with the skatole you made, "it'll be funny"
Ah
The stench of a man who died inside a sewer
shit corpse
that’d probably be even more realistic.. don’t dead bodies shit themselves after a while?
@@floo1465 common myth, but most people don't actually empty their bowels when they die.
@@lemon_skunk_4206 All muscles lose their functioning when you die, any shit in your colon can't be pushed through without the use of muscles but any shit that has reached the rectum is being held in by muscles and will be released once those muscles cease to function.
This woulf have been a fun video for you to retry for halloween, especially with the black and green colors!
Also i know its tedious but I would love to see you set up a column!
As always, nice video and good work! Very informative.
Thanks!
I love your videos! they make chemistry look fun and interesting.
Maybe next time you could try to make some chemicals that actually smells nice, for a change ? ^^
DO YOU KNOW THE LOVELY SMELL OF DIMETHYLMERCURY
Işın Genç Nasıl kokuyor?
dostum dimethylmercury çok toksik bir kimyasal, ama her ne kadar zehirli olmasına rağmen vikipedi'de "tatlı" bir kokusu olduğu söyleniyor -sweet yani-, ancak aynı zamanda da bu kokuyu alablecek kadar içine çektiğinde çoktan zehirlenmiş oluyorsun :).
en.wikipedia.org/wiki/Dimethylmercury
"slightly sweet smell..." 3rd line first 3 words
Işın Genç Teşekkürler! güzel espri
rica ederim. :)
Chemistry is magic. I need to learn chemistry . It’s the true knowledge of earth. Nuts
I honestly find it very Interesting to see things like these are possible, since it is so different from what we made at school and (might be because of my very limited chemistry skills) I never thought of those possibilities.
I also have to add that I learned more chemistry by watching Nile Reds vids, then by attending 3 years of Chemistry in school...
So thank you, I absolutely adore your videos
I can picture this kind of videos in a medieval TH-cam like "Pro Alchemist teach you how to transmute Miasma from scratch"
Nice.
Here from 2020, love how his vids have always been good high quality content 👌
Great video, as usual. I'm really hyped for that Caffeine synthesis.
Me too.
I just need to get my hands on some sodium hydride. I think I can do it though, so the project should be started soon
stir bars are genius
Thank you for your new video! Really brought back my memories when I used to have fun during my master in organic chemistry!
About the reaction, water will slowly decompose your sodium borohydride, so make sure to use a reasonable excess. Secondly, try to vacuum distill instead of extract. After that, you can evaporate the water away. What's left will be your crude product.
See you for your next experiment!
Im glad you liked it! The borohydride is in a pretty big excess, so I think it should be okay.
I watched the whole thing cause I thought you were gonna smell it. Its like an action movie where the bad guy lives.
7:51 now that solution is based af
I have no idea what’s going on here with these reactions but I always seem to find myself on ur channel I can’t get enough
Teacher: What do you do in your free time?
Nile: *...*
At least in the case of L-phenylalanine, an amino acid can be converted to its corresponding nitrile (with one less carbon atom, just as you do in your process) using the slow addition of household bleach at low temperature. I've used this procedure for preparing benzyl cyanide from phenylalanine.
Interesting!
Hi Nile, better descarboxilate amino acids with TCCA (trichloro cyanuric acid - pool shock) to get one less carbon nitrile with better yields. See:
www.researchgate.net/publication/250465126_Conversion_of_a-Amino_Acids_into_Nitriles_by_Oxidative_Decarboxylation_with_Trichloroisocyanuric_Acid.
See also: www.sciencemadness.org/talk/files.php?pid=69963&aid=1539.
This way you just need to filter the insoluble cyanuric acid to obtain just nitrile and water.
You'd better use methanol as the solvent in the nitrile reduction with nickel boride and mantain the temperature always below 10ºC.
I have many papers posted at sciencemadness about this kind of reduction. See: www.sciencemadness.org/talk/viewthread.php?tid=65915#pid448180.
The use of Dimethylformamide (DMF) as you did can result in their reduction with the formation of trimethylamine and dimethylamine as a byproduct and contaminant hard to separate from cadaverine.
I think the experiment like you did can't be done as an one pot reaction, otherwise this explain the poor yield you've got.
Since you asked for sugestions, mine goes this path: reduce lysine with TCCA --> filter the cyanuric acid precipitaded --> extract the nitrile from water with dichloromethane (DCM) --> dry the solution with calcium chloride or anhydrous magnesium sulfate --> add a methanolic soluction of nickel chloride hexahydrate --> freeze the solution to 0ºC --> add sodium borohydride in portions and slight excess -->filter the nickel boride --> add 10% sulfuric or chloridric acid to make free the amine salt (water soluble) and neutralize the excess borohydride --> wash with DCM again to extract the unreacted nitrile and discard --> basify with 6M NaOH to liberate the amine --> extract with ether and evaporate.
What do you think?
Its amazing that NileReds videoquality was this amazing 4 years ago already.
Cadaverific
I wonder what you edited exactly
I've always thought my semen smells like pancake batter. I have never told anyone that before.
Now you have.
@@shabdulishinde3685 lol I was curious if it was just me, but not curious enough to smell anyone else's jizz.
Richie Schneider I agree with that statement
Mine smells like dilute chlorine
Gives a new meaning to Mixing a batch.
You can read the chemicals, no one is sleeping here. We’re here because we are straight up geeking out WITH you
I never knew how fun science can be I’m addictced to your videos
This video is surprisingly pretty for something that has a morbid topic! (Not that I'm complaining)
I'm also putting my Ochem skills to use and getting excited when I actually know what your talking about lol. But also kudos??!! Cause my ochem series lab was brutal hell in my junior year. I hated it with a passion. But at least you get to do the fun stuff!
NEVER knew there was a CHARACTERISTIC SMELL to semen. I’ve heard of almonds smelling like cyanide but this is a whole other nut to sniff
cherry blossom trees have a similar smell as well. it's a smell every guy is familiar with.
i literally detest chemistry but i love this channel so much. you make it fun in a way that school and most other sources of info can't. Thank you chemistry man :))))))))))
i will literally watch his videos in my chemistry class because this is the only chemistry i like!
I've had similar problems with partition coefficients going the wrong way with a couple of reactions in my scheme. I would recommend using a more polar solvent like ethyl acetate instead of ether and doing something like ten extractions. You could then reextract it from the organic layer with an aqueous acid solution, wash with ether to remove organic impurities, make it alkaline and salt out the product with brine.
That was a nice demo of a pretty uncommon reducing agent. Thanks!
I'm a biologist and a fan and I found this video even more educative than usual. Superb!
You're great, Nile!
Thanks!
Bromo *S U C C* sinimide
I love that this is top comment
*SUCC* ubus
S u c c inic acid
I remember when our chemistry teacher made hydrogen sulphide and ammonia for us.
We took turns smelling it from the test tube. The children outside the lab ran away.
Hey i need indian supportor bhai can u sub to my channel
you should do more videos involving amino acids, or maybe even just more videos about physiological reactions that take place in different parts of our bodies.
Great content as always!
"Do you think this was effective?"
Yes, because I know exactly what is happening in this video
5:53 honestly looks like the kind of stuff you'd see if someone was doing chemistry on TV or in a movie lol
How to get away with murder
When the police ask what that smell is just tell them you’re a chemist and you’re making cadaverine
I'm addicted to your videos, your voice is so soothing, like watching How It's Made videos
You also sound like Aaron Mahnke from the Lore podcast (which is awesome)
I love how the nasty chemical looks like something an evil mad scientist would have in their lab.
I have a hard time imaging these liquids to be smelly when they look like soda. If anything, all I think about is drinking it.
Needed some celite for that filtration, should be easy enough to grab I imagine.
Good job! having read the paper I was wondering if this reaction could be applicable to Trp and Tyr; I also think the reaction is borohydride wasteful but there's some old one I saved from throwing away at school so I can just add until it reduces all the substrate... I'm not sure if Ni sulfate can be a viable substitute for the chloride though
What does your laboratory smell like? :D
TheMrbunGee As of this video, most likely dead bodies.
TheMrbunGee semen
Featu stole my comment
My lavatory smells like semen.
"I would read out the chemicals, but I don't think you'd look at the video the same if you knew it was me and the boys cemen being curdled through a tube the whole time. what? I didn't have enough so I had to milk the boys in their sleep!"
mmm~
"I'll put you to sleep if I read each one"....rightly said....with that soothing voice.....anyone can be put to sleep
I like how he sounds half a sleep just talking about how he’s fall asleep reading the ingredients
3 o'clock at night and TH-cam thinks it's time to recommend me a nice DIY Zombieperfume...
Sometimes when I watch your videos I'm super stoned so I just kinda wander away into the comments and when I remember the video I have absolutely no idea what's going on so I have to restart the video. Sometimes this happens several times a video
That's adhd
The Nickel Boride reduction is a nice bit of info to add to my arsenal. I'm shocked that considering the number of Nitrile reductions I've looked at on SciFinder, this never came up.
Congrats, you have now become a necromancer!
next step: using the cadaverine to create an artificial corpse.
This is such a cool channel
Regarding the nickel boride removal step, do you have access to celite? Its really good at getting rid of metals. I use it to remove tin (II) chloride and silver perchlorate.
I really really wish I had celite. I've tried to find some, but it seemed to be pretty expensive.
NileRed
If I still had access to my laboratory (finished PhD, no lab access) I would have sent you the last of my supply! I have 500 g that is currently going unused until the new student starts in April.
I can think up some good use for that stuff !!! I got to order some of this stuff!!!
For your suggested alternative extraction procedure (13:54) - step 4) wash residue with ether, I believe you mean extract the residue with ether (not wash)? Interesting videos! Keep up the great work :)
Would you be able to make a video on the synthesis of Pyridinium dichromate(PDC) aka "cornforths reagent".
i would love to see the synthesis of pyridinium tribromide
I plan to make a video where I prepare both PCC and PDC. Right now I dont have the sulfuric acid that I need though...
To make the chromium troxide
stupid thought...how do we get rid of these chems and others, I've forgotten a very Importent part of chemistry and I'm ashamed of it...could u do a video series of how to dispose of chems?
That is a very important part and I should address it. I think I might recycle some mercury waste in a future video
Throw it out the window.
Flush it down the toilette.
bro i love your videos! Youre so smart
1:05 That's actually why I love to watch your videos.
Great. Now how do you neutralize the smell of Cadaverine? (asking for a friend)
Bleach and sodium carbonate always works for me :D
"always works" hmm 👀
This is a cool video and all, but something in me feels like this was a waste of chemicals. (Kids in Africa could have eaten that sodium borohydride!) By that, I mean that three are cheaper reagents you could have used to perform the same reaction. TCCA in sodium hydroxide is a known reagent to convert amino acids and amines to nitriles ( this would instead give you the dinitrile), and CTH with a tiny amount of palladium catalyst would reduce this to the diamine easily. This follows the same synthetic pathway, but is much more reagent efficient.
Of course, this also neglects direct decarboxylation: although straight heating is a poor method, decarboxylation of amino acids in acetophenone is known to proceed in high yield and at temperatures under 150 C, due to the formation of an imine intermediate which is easier to decarboxylate.
Bill Smathers instead of buying new things I'm pretty sure he just uses whatever he already has regardless of ease in the experiment
I was just wondering if you ever made anything that dissolved the stir bar thing you put in the vial.
Hey man. Love the videos. If you could get more reagents from Fischer, vwr, or sigma would you do more? Let me know so we can make it happen
Is there any use for the nickel boride?
I think it can be re-used as a catalyst so we dont have to make it in situ the next time. I am not 100% sure though.
You may get a better yield by collecting some roadkill. :)
i like how he adds the error analysis at the end
Haven't seen nickel boride used before. That's pretty cool!
I'm looking for a gross smell that hangs around for a long time. How long will this smell last for if applied to fabric?
Lmao whos revenge are you planning