Went to my Endocrinologist today. I was put on a new condensed insulin and they have raised it till I am at 200 units now. I told my doc I gained 25 pounds in the last few months. She said there is nothing that can be done. I was discouraged until someone mentioned your book "Why We Are Sick." Just ordered it and looking forward to reading it
how irresponsible. How can they not know that insulin would lead to weight gain or did they not even bother to tell you that might happen? That's been common knowledge since people started taking insulin for Type 1; they start gaining weight and it was considered a good thing because they were wasting away before. I'm glad you found out that something can be done before it becomes another health issue for you. Good Luck and Be well.
@@SharonHurst56 don't eat the carbs and sugar will stay down. It's like giving a person with a nut allergy peanuts and saying don't worry, just use your epipen
On problems of prosperity: I grow all my own fruits and vegetables, and enough for relatives and neighbors to get some. Many days, I am outside 5-6 hours per day, moving compost or mulch, digging, tying up, weeding, mowing with a push mower, raking, turning compost. I also go fishing now and then. So much of my food is fresh, maximum nutrition, eaten or frozen within minutes or, at worst, hours of harvest. I get more Vitamin D from the sun than most. And there are mood-elevating chemicals in soil, they say, so I work glove-free and barefoot. Some years, I get a deer a relative has hunted. This year, I'm getting hens for eggs. With all my mind, heart, and body, I believe this is closer to what we're supposed to do, what our bodies are hardwired to do. Sitting in a cubicle for 9 hours and eating sugar most assuredly is not.
Let me remind you one thing if you haven’t realized…. Your happy life is give by the prosperity of the city or the country you are in….., right on top of others’ less happy life. You need to realize many people don’t even have a yard to get the proper sunshine. My home doesn’t have a yard for vegetables at all, not to mention my job doesn’t give me any time to actually do it.
Humans have been around for 250,000 or so years. The subsistence agriculture you are engaged in has only been around for 10,000 or so years. Hunting and gathering our food in the wild is the true norm for most of our time as a species. :-)
I absolutely agree with you. Isn't it ironic how the more we "evolve" the less we do and know. Nothing will bring us the satisfaction of working for our own wellness xD
If you love to get a bit deeper into the how and why of things, this is by far the best health podcast on the planet. Cutting edge science explained by leaders in their field, presented by a world-class interviewer. For all the rot out there let us not take for granted what we have here. Thankyou Diet Doctor, guests and all those behind the scenes.
@@brendakemp9060 Low carb, no seed oils, no processed or junk food, healthy fats, and watch the fructose. Over eating fructose (which is 50% of our table sugar) is the quickest way to NAFLD. Best of luck.
I am doing fasting with low carb and it works.OMAD helps me with my insulin resistance. The key is I eat even less than I ate before now and much less carbs. I lowered my calorie intake. Feeling full is not easy when you have insulin resistance. So eating only once is much easier for me. I feel full and stop eating. So I eat half of what I was eating before I started OMAD. I eat very few carbs. I feel so good after around 18-19 hours of fasting. I am doing this to get rid of my insulin resistance and the infections that it is causing in my body.
Keep it up, that strategy worked for me and I’m in my sixties. If I’m away from home or busy at mealtime, I look at it as great opportunity to extend my fast. I still have enough fat on my body to feed me for a while 🤣
I was 343lbs in April of 2022, today I’m at 248 lbs. How? Learned about insulin. Started IF and cleaned up my diet. (As little sugar as possible, no bread, pasta etc and whole food’s only) 52m. 233lbs on 1/6/23
I’m 52 and have no medical education but I keep reading and studying this stuff trying to understand it more deeply. I wish I could help to get it out to more people even though I’m not qualified to do so. I’m carnivore 4 years and into mobility training, best way I can help is to live as an example.
Ben Bikman is one of the great modern heroes of our times. I wondered many times how many millions of lives will he save by shifting the paradigm on diabetes and the perception we have of insulin? Tens of millions? Hundreds? Certainly over time. Of course to that many others contribute, from health coaches to doctors and dietitians that similarly contributed to changing outdated attitudes in the medical establishment, but research professors have a special place among them for providing the explanations and the evidence all the rest use to proliferate the knowledge. His Children should be(and am sure they are) very proud of their father.
Awesome interview, thank you dr. Scher and prof. Bikman! Just a note: if you do time restricted eating/IF/OMAD combined with LC for a while a do it correctly, e. g. you are fat adapted, your hunger and cravings go away. When you then eat nutritionaly dense food and quality protein and fats, it is actually hard to overdo => satiating effect of protein and fat. Your hormones kick-in and your body tells you when to stop. You just have to watch for meal timing and like Prof. Bikman said, don’t eat right before bed. Finish at least 2 hours or more before sleeping.
That's what I should try. I have been doing OMAD for over two years with zero success. Sometimes I have two meals in 4 hours and fast for 20 hours. In fact I think I have gained some weight and inches over the years with fasting. I eat OMAD and do resistance workouts 3-4 times per week and do 30 min cardio immediately after resistance training, in addition in the last 5 weeks I walk for one hour at least five times per week. It would be great to see some progress finally :) In not sure what I'm doing wrong. Thank you.
@@chesscoachgerry4140 I stooped working out and doing cardio four months ago thinking I'm over doing it. I lost a few pounds that's all. I'm back to eating almost everything meaning more carbs but still no fast food, soda, sweets etc. I really don't know why I couldn't lose fat for years.
I think you need a second opinion. Take 7 minutes out of your day and listen to this guy. Easy to understand and the opposite opinion.th-cam.com/video/7Ij0iyrdm2M/w-d-xo.html
@@ddhqj2023 how about if neither the vegan Dr, nor the carnivore/ keto Drs are wrong. From what I've gathered there are certain ingredients that should not be mixed together. I've heard of vegan and keto dieters have heart attacks, and I think is because they weren't truly vegan or keto, they were just trying to be, and were cheating allot. In addition, community, gratitude and genuine happiness are almost always under represented in these type of interviews. We need to be careful of reductionist thinking. Look up the oldest people on the planet, they are neither strict vegans or carnivore/keto, and actually, they lean slightly to more animal based diet. Google, what the oldest people in the world eat and drink everyday. Let me know your opinion. Is like to read your thoughts, and no I'm not being a smartass, I really would like to read your opinion. Thanks.
@@ddhqj2023 And one more thing, you have to admit that the Vegan Drs. never make the distinction between the type of fat that is found in grass feed grass finished beef vs grained feed beef, and that's not an irrelevant comparison. I've always wondered why they lump all of it together.
@@latinboyyy305 Why would they differentiate between grass fed fat or grain fed fat. It's all the same in that it contains bacteria that when cooked, turn into endotoxins, leak into your bloodstream and cause inflammation at the cellular level. And chronic inflammation is a precursor to various disease processes. Disease processes which over time, may morph into obesity, diabetes, heart disease, cancer, skin ailments, etc.
I do intermitent fasting.... And we are taught to never eat 4 hours before going to bed..... YES you have to have a plan to break the fast....AND I do it to control blood sugars.... 1 meal a day. and when it doesnt work, go back to mixing up my fasting plans.... LOVE this education.
Yesterday I had breakfast…rare for me anymore. I was actually hungry, like somatic hungry, not the I think I want to eat something tested my blood sugars, cause I thought I was going to get a sugar low. Diabetic in the process of reversal
Damn! This episode explained EVERYTHING that is going on with my diabetes, glucose monitoring, gaining fat etc... also explains the last 20 years of being very fit and still carrying 20-30 lbs of extra fat. Thanks y'all.
The scenario that you mention at the end where OMAD becomes a mini binge was me when I first started. I knew it wasn't ideal, but it was better than eating ("sugar") all day and it was what I could manage at that time. Gradually it is improving as I get more educated and healthier, without me having to try really too hard. It's a mistake to assume our long term results will be based on how good or bad our plan is when we first start out. Do what you can, even if it's a little. If you have to promise yourself a high carb reward to get through your first ten 20- hour fasts, who cares? Just gradually keep trying to do better when you are able. As they say, the perfect is the enemy of the good.
I agree, I cut my sugar intake slowly over 3 years. I didn't have much of a plan only to cut it out completely at some point. Initially I would only buy packaged food with 20gsugar/100g, then after few months would only buy products with 10g sugar or less in 100g of the product. Finally it was less than a 5g sugar and then went down to 1 tsp/week. This wasn't overly difficult bearing in mind how addictive sugar can be.
Listened to Ben and read his book. Use a 6 hour eating window. Starting around noon. After many diets went low carb , med protein diet. Along with moderate exercise dropped 60 lbs in year. A1C now at 5.5 down from 5. 9
This is next on my list. I am reading or read Lies My Doctor Told Me, the Big Fat Surprise, The Case Against Sugar, Stall Slayer, The Salt Fix, and Why We Get Fat
I would love to have Ben Bikman reconcile his research findings on the impact of insulin resistance on our bodies and metabolic syndrome plus other chronic diseases vs Dr. Rick Johnson’s research on the connection between fructose on uric acid and then on insulin resistance and metabolic syndrome. Bikman focuses on glucose and insulin while Rick Johnson focuses on both fructose and glucose, with uric acid being a key intervening factor.
As always I love Prof. Bikman's knowledge on insulin. I also brought his book. I just want to touch on OMAD. I have been doing intermittent fasting for decades. It used to called skipping meals. But anyway, I find that Your body don't allow OMAD Binge because you actual get fuller faster when eating OMAD. It is when you allow few hours of eating your OMAD that can cause binge. So, if you pile up a table full of food only eating as much as you can til you feel full, you will not binge comparing to allowing yourself few hours to eat a meal.
I love Ben Bikmen. His description of cells being overfed leading to insulin resistance explains why some people have weight loss stalls on low carb diets. To me, that seems like an important breakthrough.
It would be interesting to see a study on how hyperinsulinemia affects gut bacteria. I have a strong feeling that stuff like SIBO is very much something that is affected by high insulin levels, with insulin being the proliferator or growth factor. What do you think Dr. Bikman?
I'm being very simplistic here. Dr Bikman is very very intelligent. Which means anyone who interviews him must be excellent in their knowledge to comprehend the whole body.
Was glad to hear Dr. Bikman say that IR is not THE factor of disease, but that it's an important link to causal effects of illness. I've watched podcasts that state he only focuses on IR, and now I know that's not the case. Dr. Bikman sees IR as a major player, and from what I see, that is certainly the case. His study of insulin is very telling, and needs those who can work with him from there.
Discovering Prof Ben Bikman is like finding gold. Subscribing - great content. Grateful to my YT feed for this one! Off to buy the book too. Thank you for this interview.
Omg... im an RN and budding freelance research writer. I'm going to read all of your work! I would love to work with you one day. I'm over coming insulin resistance, fatty liver, losing weight, and ketovore/ IF daily. Down 33 lbs since March 19th. Battling cancer now, which as we all well know cancer is just metabolic disorder of the mitochondria....we've even sickened them with our SAD! TYFS, Jen
Dr Scher und Dr.Bikman, great video with all the problems of today and all the solution, it is so good, easy explained. Thanks from Germany Eszter Horvath
Thank God there are Doctors and scientists like Dr. Bikman because quite frankly this stuff bores me to death. As a type II diabetic.......I am so happy there are people who have an interest in this.
This is how I found out that I had hyperinsulinemia: After listening to a video with Jason Fung I decided to cut my carbs one day. My body reacted strongly the following night (heart racing, hunger, sweating, restlessness) and I had a strong episode of hypoglycemia the following morning (weakness, shakyness, more sweating). I do not take any medication to lower blood glucose and was never diagnosed diabetic (I haven't had my blood glucose checked in years). That episode of hypoglycemia that I was able to recognize easily as I am a nurse made me realize that I needed to really cut down my carbs and change my diet to lower and hopefully reverse my hyperinsulinemia. By the way, I am in my sixties and always had issues with controling a healthy body weight.
@@kaygibson8942 I think I did but didn't get tested for it. After six months of a low carb diet my hb1C was at 5.1. I do not have any hypoglycemic episode anymore. But I have completely changed my diet and reduced my carbs to only vegetables, nuts, some fruits and sometimes some dairy but no more grains.
This is to me the best explanation of insulin resistant. I am 71 years old and still working to keep my body active and I'm trying to follow low carb diet socI can reduce some weight because of my knee problem and to keep my blood sugar level to normal as I have been on borderline high. Thanks for the informations and I am for sure will share this to those who need this eye opening topic.
I also repeat...this is the best most informative dietary health channel on TH-cam or anywhere for the topics covered. Even in simple Google searches for text, Diet Doctor is simply the most on point purveyor of relative information of dietary concerns. The in depth information they provided makes it easy to decipher and understand fact from fiction. Many thanks...
You are an outstanding Scientist who has changed my life.I do appreciate your U-Tube very valuable information.I have also bought your book Why We Get Sick,from Amazon. Your book is a gem for health seekers. Thanks so much for sharing your deep knowledge and research on diabetes. God bless you and your family.
Re Cortisol and insulin resistance. I recently had 5 days off travelling 3 hours to a beautiful country location and felt extremely relaxed. I noticed my fasting glucose went down by .6 mmol to 4.2 while away. As soon as I came back to the big smoke it went back up by .6 mmol to 4.8. My guess is Cortisol.
Cortisol I suspect is my greatest problem at the moment. I am a chronic insomniac and battling with minor autoimmune (rheumatoid arthritis) for many years now
@@scotchfillet For the last three and a half years generally. Went carnivore for three months a while back. The less carb I eat the higher I suspect my cortisol goes - heart racing, etc. But I am still committed to low carb. Been playing with electrolytes and minerals hoping to achieve some results
Very good lads. Here’s as additional thought from my experience. Twelve months careful dieting wasn’t enough. When I added an 18/6 autophagy method, WOW. Every one is different I know but this was astonishing. Cheers Mike
Great interview thank you. I do have a question. What does it mean if my blood sugar stays in the 110s to 130 even on a 5 hr fast? I keep fasting for at least 12 to 15 hrs from night till the next late morning and my blood sugar is always higher than 100? Any feed back would be great. thank you for working to help us all.
Another excellent interview. Thanks to you both. I almost didn't listen to this one. Since I've heard Ben speak many times. Glad I did and will get the book to add to my low carb collection
Wonderful interview. Thank you. Yes, the paradigms must change both looking at the glucose/insulin problem and also the ROS/LDL problem. We must also understand transient receptor potential channels and how they play critical parts in all of these scenarios.
I disagree “we don’t get paid” with regards of us medical doctors. The physiology, pathology etc all part of medical school. Nothing stops docs continue to be curious , exercising a common sense . I connected dots on hyperinsulinaemia to HT, PCOS , Diabetes etc a while ago and really needed evidence .. You are doing an amazing job guys !! So hard to get through minds and hearts, we need you … your links to your podcasts on our hospital website page now!
If you find it difficult to stop eating after fasting than your eating the wrong foods. Eat more fats, proteins that will give you satiety and make you feel very full.
As an RN for 41 years, now retired, my question is why do MDs not have continuing education that addresses new studies relating to this problem....? Do they not see that what they have been telling us to do for the last too many decades has not worked. No curiousity?? For shame!!!
How does this correspond with female menopause? I became type 2 diabetic when I went into menopause. I got it under control with diet and exercise. Now at 62 I am back at being pre-diabetic but I can now control my glucose by cutting out nuts and grains. These are the foods that raised my blood sugar too high. I now walk after most meals just to work off the glucose. I am telling my body to grow muscles not fat 😅
Really great interview! To the question « what is the common link between insuline and all modern diseases », I think the question deserves more attention and I can think of other common links as the « growth promotion » that was mentionned: 1. Insuline is inflammatory by itself, and inflammation causes degradation and faster aging and dieases like cancer through cell degradation 2. The body overly relying on glucose forgets how to burn fat, which in turn leads to less mitochondria, which in turn leads to less cell respiration and more fermentation, which is the energy fuel of cancer 3. Glucose depletes us from vitamines and minerals, and reduces our immune system strenght (glucose has priority for vitamine C transport for example) making us more vulnerable to viruses 4. The glycation damage caused by glucose and overeating over the long run 5. The constant inhibition of certain hormones and processes like autophagy that can’t be active at the same time as insuline 6. The impact of glucose itself on our stress and anxiety levels, worsened sleep which in turn increase insuline (my theory is that the body and brain senses that there is a lot of inflammation going on and he freaks out with anxiety that can be felt in the brain and phisically in the upper chest area). 7. Obesity makes people physically less active which in turn makes that the energy in the system is not used quicly enough to prevent glycation processes 8. Insuline promotes glucose storage in places where it can be available as a source of energy for bad bacteria, viruses and cancer 9. Insuline makes us blind to the fat that could be burned which means the body sees only the calories we eat which in turn reduces the metabolism as soon as people are reducing their calories intake if they are not at the same time in low insuline- ketosis state as their body thinks that they are in starvation while at the same time having hundreds of thousands of calories at their disposal but unable to tap them because of insuline and metabolism reduction leads to less calories burning overall, reduction in muscle mass correlated with higher death rates 10. Insuline being an emergency process of glucose storage in cells to avoid comma for our brain, it also makes us hungry a lot more quickly as the energy was not available long enough in the blood to give us a constant source of energy throughout the day, which leads to more food consumption as we get hungry too quickly, the switch off mechanism of insuline being very long when we are insuline resistant.
Great discussion, but y'all missed a big point. Keto/low carb eliminates the hunger problem. I don't see how I could do int. fasting on a low fat high-carb diet - the hunger would kill me. Eating fat on keto = no hunger. It's truly amazing. I bet most people are much more likely to fast more effectively if they eat keto (or low carb maybe) when they eat. One of you may have mentioned the hunger thing earlier, but it would have been great if one of you had brought it up on the keto/low carb vs low-fat-hi-carb and int. fasting section. Lots of stuff to think about here. Thanks.
Thank you Dr Bikman. You really educate me of how to take care of myself. I need to order book, WHY WE GET SICK. ALSO GIVE THANKS TO THE INTERVIER. YOU HAVE A GREAT KNOWLEDGE 👍. MAY GOD BLESS YOU BOTH.🙏💝💯
Very good information. was not sleeping well and my work and life overall have been very stressful for the last 10 years. Luckily, my blood pressure is always normal and my lipid panels except LDL (slightly high) are also normal. What has worked for me to return to my normal pre prediabetes state has been 16/18 IF with two meals. On weekends, I can go for a whole day for one meal only. However, I do not want to lose any more weight, and I will stop the weekend 24. I find it very easy for me to do since even before learning I was prediabetic, I was skipping meals almost everyday and I am a small eater.
The discussion briefly went over fasting and the minimun dose. If I may add to the conversation, I have been getting weekly blood tests intermixed with no fasting, 12 hr fasting, 36 hr fasting, and 84 hr fasting. I tracked exercise and belatedly started tracking sleep and energy levels. Within my N=1 study, I have noticed that HDL and TG don't really response to fasting dose. Neither does hs-CRP, but hs-CRP does appear to respond to exercise prior to the blood draw. Uric acid increases 30-50% by stretching a 36 hr fast to 84 hrs. While it was initially confusing, the biggest effects of fasting dose appear to be on LDL - more specifically, particle count and mix of particles. LDL needs to be cross correlated with the white cell count, because LDL is performing an immune response, too (a higher white cell count will lower the LDL particle count). With steady white cell counts, my LDL particles will increase by roughly 30% from a 36-hr dose to a 84-hr dose. This is partially confounded by the exercise dose prior to the blood draw, because the number of VLDL particle jump up - because obviously in a ketogenic fasted state, VLDL is the only energy delivery mechanism to the muscle cells. For the longer dose of 84-hrs the greatest increase in LDL particles seems to be in the small and medium size particles, but VLDL still increased by more that 20%
I find all of this so informative and interesting. I would like very much to study further and work towards a career to help people improve their health with this knowledge. But as I understand the low carb lifestyle is not taught in college. How do I pursue a career in this field?
A question for Professor Bikman. If someone were to strength train or do HIIT in a fasted state ( 16 hrs plus ) and then break their fast with an 800 to 1,000 calorie meal within the low carb spectrum, would that meal be considered binge eating and too many calories to break the fast with? Also if they ate another meal consisting of the same amount of calories and ketogenic style foods 4 to 5 hours later and the last meal was more than 3 hours before the person goes to sleep, Would this be a good regimen for fasting windows ? Let’s say the person weighs somewhere between 180 and 240 lbs? Thanks you for all your insight and knowledge! Loving this diet doctor podcast 🤘
45:00 I think it's that people want to think they have more directly control over things than they do. Either that or they lack the basic understanding of HS chemistry to understand that body fat isn't dietry fat. Some people seem to think the human body is about as complex as a bucket. Thank you for diving deep into why it isn't close to that simple.
If one adheres to a low-carb/keto diet, is there any downside to being metabolically inflexible (aka glucose intolerant)? I understand one is not insulin resistant, but does just having prolonged/elevated blood-glucose (after eating a mixed-meal) cause any issues? Also, does this mean that insulin is not being produced in sufficient amounts.. if so, does that have any negative long-term consequence? Or is the idea that it's always best to not have much insulin? Do I understood correctly that omega-3 and 6 are polyunsaturated fatty acids, but it's only the Linoleic acid that signals (via insulin) for fat cells to grow.. until they become resistant, and STOP growing? Do omega-6s/Linoleic acid have any positive role? For example, on Dr. Bill Harris' talk with Chris Masterjohn, he suggests omega-6 metabolites are anti-inflammatory, however if one does not get enough omega-3s (~4g a day), even if rancid, then the body resorts to arachidonic acid (an omega-6) as a substrate to make prostaglandins.. and this leads to inflammation! Robert Lustig talks about how obesity is a symptom, not the cause of metabolic dysfunction (diabetes and high triglycerides). He cites how 20% of obese people are Metabolically Healthy Obese (MHO) and 40% of normal weight people (67M) have type-2 diabetes, hypertension, cardiovascular dementia, etc. He is studying how insulin resistance in the liver disrupts the FOXO phosphorylation pathway but not always the SREBP-1c pathway!! He suggests a different macro-nutrient as the villain: fructose. Regarding meal-timing, I've read that melatonin binds to the pancreas to signal less insulin production.. and that post-prandial glucose levels are always lowest in the morning.. yet Adel Moussa suggests it's a misinterpretation of the data, and that we are actually LESS insulin sensitive in the morning (see the Szotak Andrei's Muscle Engineer Podcast #16 (31m)). What does Ben think? Finally, I understand Ben suggests *FAT* cells are the 'first domino' to fall in insulin resistance.. any thoughts on Gerald Shulman's work, that suggests *MUSCLE* cells, are the first cell types to become insulin-resistant? He suggests the mitochondrial oxidation slows-down leading to fatty acids entering the muscle cells and inhibiting the uptake of insulin/glucose (DAG->PKCtheta->IRS-1->PI 3-kinase->GLUT4). The insulin resistance then spreads to the the muscle, and finally the liver (GLUT2).
This channel is such a great repository of useful and cutting-edge info. Thank you, Dr. Scher and Prof. Bikman. I always love to hear Dr. Ben and his new discoveries or realizations. He's an excellent teacher of what can be pretty complicated stuff. Kudos to you both for a great interview!
My skin tags on my neck and one large one under my arm are shrinking on Carnivore (day 67). My ketones are still .2 glucose 99 (fasting) and weight not moving at all. At 73 with a 90 lb weight gain since my goiter treatment w radioactive iodine at age 27. I’m eating only coffee w heavy cream in am followed by 5oz bacon and/or eggs. Liver wurst mid day w butter and a rib eye at night with another 4-5oz of bacon. The liverwurst was to replace ground beef which was making me nauseous to even look at after 45 days of eating cheese burgers. I’ve increased my fat intake hoping to get the scale to drop. Walking and light weights began in earnest this last 2 weeks.
Please create a video on the difference between pathological insulin resistance and physiological insulin resistance. Been doing strictly keto/IF (two 24 hr/month) for nearly 4 years and my glucose #’s are in 130’s.
Have you looked into ray peat? Or dangers of keto long-term. I did keto for 5 years as well and had to add back in juice to lower stress hormones and a severe lack of energy after that long on low carb. It can get bad with long-term side effects. If you feel good then disregard this. Ben also mentioned things that our ancestors ate such as potatoes are not going to cause insulin resistance.
Thank you. His PhD objective sci inquiry gives us laymen hope, esp since US med field has separated itself into dozens of subspecialists with few motivators to consider the whole body and brain.
Take aways:
Intermittent fasting
Low carb low sugar high protein good fat diet
Movement/exercise
Reduce stress
Sleep well
Thank you both 🙏🏼
Good Summary
What foods?
Wrong conclusion - high protein was never discussed in this video. Only low carb was, and low carb does not automatically mean high protein.
Lppo
@anil study There was a recent clinical trial where Yoga was found to reduce the A1c (blood glucose average).
Went to my Endocrinologist today. I was put on a new condensed insulin and they have raised it till I am at 200 units now. I told my doc I gained 25 pounds in the last few months. She said there is nothing that can be done. I was discouraged until someone mentioned your book "Why We Are Sick." Just ordered it and looking forward to reading it
We also have a free two week getting started challenge on our website that you may find helpful!
www.dietdoctor.com/low-carb/get-started
how irresponsible. How can they not know that insulin would lead to weight gain or did they not even bother to tell you that might happen? That's been common knowledge since people started taking insulin for Type 1; they start gaining weight and it was considered a good thing because they were wasting away before. I'm glad you found out that something can be done before it becomes another health issue for you. Good Luck and Be well.
@@Metqa They told me obesity wasn’t as important as keeping my sugars down.
@@SharonHurst56 don't eat the carbs and sugar will stay down. It's like giving a person with a nut allergy peanuts and saying don't worry, just use your epipen
Weight lifting/building muscles is the ultimate key to reverse insulin resistance, NOT weight loss alone.
On problems of prosperity: I grow all my own fruits and vegetables, and enough for relatives and neighbors to get some. Many days, I am outside 5-6 hours per day, moving compost or mulch, digging, tying up, weeding, mowing with a push mower, raking, turning compost. I also go fishing now and then. So much of my food is fresh, maximum nutrition, eaten or frozen within minutes or, at worst, hours of harvest. I get more Vitamin D from the sun than most. And there are mood-elevating chemicals in soil, they say, so I work glove-free and barefoot. Some years, I get a deer a relative has hunted. This year, I'm getting hens for eggs. With all my mind, heart, and body, I believe this is closer to what we're supposed to do, what our bodies are hardwired to do. Sitting in a cubicle for 9 hours and eating sugar most assuredly is not.
What a wonderful life you have crafted for yourself. Your family and friends are lucky to have you.
Let me remind you one thing if you haven’t realized…. Your happy life is give by the prosperity of the city or the country you are in….., right on top of others’ less happy life.
You need to realize many people don’t even have a yard to get the proper sunshine. My home doesn’t have a yard for vegetables at all, not to mention my job doesn’t give me any time to actually do it.
Humans have been around for 250,000 or so years. The subsistence agriculture you are engaged in has only been around for 10,000 or so years. Hunting and gathering our food in the wild is the true norm for most of our time as a species. :-)
I absolutely agree with you. Isn't it ironic how the more we "evolve" the less we do and know. Nothing will bring us the satisfaction of working for our own wellness xD
wow
If you love to get a bit deeper into the how and why of things, this is by far the best health podcast on the planet. Cutting edge science explained by leaders in their field, presented by a world-class interviewer. For all the rot out there let us not take for granted what we have here. Thankyou Diet Doctor, guests and all those behind the scenes.
I enjoy Bikman. But I have to say some of this stuff is over my head. Trying to heal a fatty liver. Ugh
But how do you which one you are?
@@brendakemp9060 Low carb, no seed oils, no processed or junk food, healthy fats, and watch the fructose. Over eating fructose (which is 50% of our table sugar) is the quickest way to NAFLD. Best of luck.
@@brendakemp9060
What worked for me was NO GRAINS , NO FRUITS & NO POTATOES! Find your own carbohydrates threshold! It is below 100 gram per day .
Dr. Scher is my favourite interviewer. He always know what to ask, when to ask and how to ask...so that we can understand the topic better. Thanks!
I am doing fasting with low carb and it works.OMAD helps me with my insulin resistance. The key is I eat even less than I ate before now and much less carbs. I lowered my calorie intake. Feeling full is not easy when you have insulin resistance. So eating only once is much easier for me. I feel full and stop eating. So I eat half of what I was eating before I started OMAD. I eat very few carbs. I feel so good after around 18-19 hours of fasting. I am doing this to get rid of my insulin resistance and the infections that it is causing in my body.
Nice work, Karen…stay triggered 🥰
Me too. I had the same issue of never feeling satiated. OMAD/low carb works. And the weird thing? It’s not hard. Congratulations.
Keep it up, that strategy worked for me and I’m in my sixties. If I’m away from home or busy at mealtime, I look at it as great opportunity to extend my fast. I still have enough fat on my body to feed me for a while 🤣
@@skeptigal8899 it is me too! OMAD works for me!
@@skeptigal8899 you are lucky.
I'm very happy to listen to this podcast while fasting for 48hr, knowing both my insulin/glucose levels are super low. Amazing talk.
The passion of both of these men is inspiring! Best interview I've seen in years.
totally agree
@@dmahadeo poker j on llama lol juju and
I was 343lbs in April of 2022, today I’m at 248 lbs. How? Learned about insulin. Started IF and cleaned up my diet. (As little sugar as possible, no bread, pasta etc and whole food’s only) 52m. 233lbs on 1/6/23
I’m 2.5 weeks if at my worst I was around 228 now at 173. Still
Have work to do but I am trying to learn as much as possible.
@@camsteremail Bikman is a great teacher.
Dr. Scher is a great interviewer. I said that before and I had to say it again.
Totally agree with you and love Ben Bikman too, so articulate .... both of them
I’m 52 and have no medical education but I keep reading and studying this stuff trying to understand it more deeply. I wish I could help to get it out to more people even though I’m not qualified to do so. I’m carnivore 4 years and into mobility training, best way I can help is to live as an example.
I can listen to professor Ben every day! 🎉 He is BRILLIANT❤
Ben Bikman is one of the great modern heroes of our times. I wondered many times how many millions of lives will he save by shifting the paradigm on diabetes and the perception we have of insulin? Tens of millions? Hundreds? Certainly over time. Of course to that many others contribute, from health coaches to doctors and dietitians that similarly contributed to changing outdated attitudes in the medical establishment, but research professors have a special place among them for providing the explanations and the evidence all the rest use to proliferate the knowledge. His Children should be(and am sure they are) very proud of their father.
Either the world will wake up or they will be woken up - Metabolic disease is bankrupting healthcare and social security.
Amen
Awesome interview, thank you dr. Scher and prof. Bikman! Just a note: if you do time restricted eating/IF/OMAD combined with LC for a while a do it correctly, e. g. you are fat adapted, your hunger and cravings go away. When you then eat nutritionaly dense food and quality protein and fats, it is actually hard to overdo => satiating effect of protein and fat. Your hormones kick-in and your body tells you when to stop. You just have to watch for meal timing and like Prof. Bikman said, don’t eat right before bed. Finish at least 2 hours or more before sleeping.
Lol You summarized his book in one paragraph.🤗
@@2fixmj563 Thank you! ;-)
That's what I should try.
I have been doing OMAD for over two years with zero success. Sometimes I have two meals in 4 hours and fast for 20 hours.
In fact I think I have gained some weight and inches over the years with fasting.
I eat OMAD and do resistance workouts 3-4 times per week and do 30 min cardio immediately after resistance training, in addition in the last 5 weeks I walk for one hour at least five times per week. It would be great to see some progress finally :)
In not sure what I'm doing wrong.
Thank you.
@@EEEBA1 what are you eating?
Did you make any progress in the meantime?
@@chesscoachgerry4140 I stooped working out and doing cardio four months ago thinking I'm over doing it. I lost a few pounds that's all.
I'm back to eating almost everything meaning more carbs but still no fast food, soda, sweets etc. I really don't know why I couldn't lose fat for years.
Dr Bikman is amazing
His book is fantastic. One of my favorites.
He’s very humble and very thoughtful
I think you need a second opinion. Take 7 minutes out of your day and listen to this guy. Easy to understand and the opposite opinion.th-cam.com/video/7Ij0iyrdm2M/w-d-xo.html
@@ddhqj2023 how about if neither the vegan Dr, nor the carnivore/ keto Drs are wrong. From what I've gathered there are certain ingredients that should not be mixed together. I've heard of vegan and keto dieters have heart attacks, and I think is because they weren't truly vegan or keto, they were just trying to be, and were cheating allot. In addition, community, gratitude and genuine happiness are almost always under represented in these type of interviews. We need to be careful of reductionist thinking. Look up the oldest people on the planet, they are neither strict vegans or carnivore/keto, and actually, they lean slightly to more animal based diet. Google, what the oldest people in the world eat and drink everyday. Let me know your opinion. Is like to read your thoughts, and no I'm not being a smartass, I really would like to read your opinion. Thanks.
@@ddhqj2023 And one more thing, you have to admit that the Vegan Drs. never make the distinction between the type of fat that is found in grass feed grass finished beef vs grained feed beef, and that's not an irrelevant comparison. I've always wondered why they lump all of it together.
@@latinboyyy305 Why would they differentiate between grass fed fat or grain fed fat. It's all the same in that it contains bacteria that when cooked, turn into endotoxins, leak into your bloodstream and cause inflammation at the cellular level. And chronic inflammation is a precursor to various disease processes. Disease processes which over time, may morph into obesity, diabetes, heart disease, cancer, skin ailments, etc.
Professor Benjamin Bikman and Dr Sher are two of my favourite Teachers, thanks guys.
If I may add, Dr Paul Mason is very knowledgeable too.
@@vilmasarraf6895 Oh yes.
Thank you dr. Ben and dr. Bret. Excellent interview.
Love Dr Bikman. Could listen to him talk for hours.
I do intermitent fasting.... And we are taught to never eat 4 hours before going to bed..... YES you have to have a plan to break the fast....AND I do it to control blood sugars.... 1 meal a day. and when it doesnt work, go back to mixing up my fasting plans.... LOVE this education.
Yesterday I had breakfast…rare for me anymore. I was actually hungry, like somatic hungry, not the I think I want to eat something tested my blood sugars, cause I thought I was going to get a sugar low. Diabetic in the process of reversal
I am reading Dr. Bikman's book right now. This is a great interview with wonderful, life changing information being shared.
that was great. Thank you both.. I rarely watch videos this long, this one was well worth it!
I know well Dr Jason Fung’s work but that’s the first time to watch Prof Bikman. I purchased his book on kindle and start reading immediately
Dr Scher always asks great questions
Damn! This episode explained EVERYTHING that is going on with my diabetes, glucose monitoring, gaining fat etc... also explains the last 20 years of being very fit and still carrying 20-30 lbs of extra fat. Thanks y'all.
The scenario that you mention at the end where OMAD becomes a mini binge was me when I first started. I knew it wasn't ideal, but it was better than eating ("sugar") all day and it was what I could manage at that time. Gradually it is improving as I get more educated and healthier, without me having to try really too hard. It's a mistake to assume our long term results will be based on how good or bad our plan is when we first start out. Do what you can, even if it's a little. If you have to promise yourself a high carb reward to get through your first ten 20- hour fasts, who cares? Just gradually keep trying to do better when you are able. As they say, the perfect is the enemy of the good.
I agree, I cut my sugar intake slowly over 3 years. I didn't have much of a plan only to cut it out completely at some point. Initially I would only buy packaged food with 20gsugar/100g, then after few months would only buy products with 10g sugar or less in 100g of the product. Finally it was less than a 5g sugar and then went down to 1 tsp/week. This wasn't overly difficult bearing in mind how addictive sugar can be.
Listened to Ben and read his book. Use a 6 hour eating window. Starting around noon. After many diets went low carb , med protein diet. Along with moderate exercise dropped 60 lbs in year. A1C now at 5.5 down from 5. 9
OMG. I just started reading Why we get Sick this a.m.! I also sent 2 copies to relatives❤
This is next on my list. I am reading or read Lies My Doctor Told Me, the Big Fat Surprise, The Case Against Sugar, Stall Slayer, The Salt Fix, and Why We Get Fat
@@AnnetteLG Why we get fat (Taubes) has been my favorite but I think Why We Get Sick might become my new favorite
@@tammyb8742 Yes, Taube's, why we get fat is a great book. I have to read dr. Ben's book now.
I would love to have Ben Bikman reconcile his research findings on the impact of insulin resistance on our bodies and metabolic syndrome plus other chronic diseases vs Dr. Rick Johnson’s research on the connection between fructose on uric acid and then on insulin resistance and metabolic syndrome. Bikman focuses on glucose and insulin while Rick Johnson focuses on both fructose and glucose, with uric acid being a key intervening factor.
As always I love Prof. Bikman's knowledge on insulin. I also brought his book. I just want to touch on OMAD. I have been doing intermittent fasting for decades. It used to called skipping meals. But anyway, I find that Your body don't allow OMAD Binge because you actual get fuller faster when eating OMAD. It is when you allow few hours of eating your OMAD that can cause binge. So, if you pile up a table full of food only eating as much as you can til you feel full, you will not binge comparing to allowing yourself few hours to eat a meal.
I read it, great book
Agree
I love Ben Bikmen. His description of cells being overfed leading to insulin resistance explains why some people have weight loss stalls on low carb diets. To me, that seems like an important breakthrough.
Great. Love Dr. Bikman. Great questions and focused discussion.
Thanks for both of you great interview
The best and socially helpful channel on TH-cam or anywhere else . Period ... Thanks doc 👍
It would be interesting to see a study on how hyperinsulinemia affects gut bacteria. I have a strong feeling that stuff like SIBO is very much something that is affected by high insulin levels, with insulin being the proliferator or growth factor. What do you think Dr. Bikman?
Wow! This is the first time Ive seen someone else thinking this too. Would love to hear this discussed.
I'm being very simplistic here. Dr Bikman is very very intelligent. Which means anyone who interviews him must be excellent in their knowledge to comprehend the whole body.
Was glad to hear Dr. Bikman say that IR is not THE factor of disease, but that it's an important link to causal effects of illness. I've watched podcasts that state he only focuses on IR, and now I know that's not the case. Dr. Bikman sees IR as a major player, and from what I see, that is certainly the case. His study of insulin is very telling, and needs those who can work with him from there.
Love me some Dr Bikman. He is so well informed 👍💪🧠
Discovering Prof Ben Bikman is like finding gold. Subscribing - great content. Grateful to my YT feed for this one! Off to buy the book too. Thank you for this interview.
Dr Ben Bikman a fine thinker. I am highly enlightened. Keep it up.
Omg... im an RN and budding freelance research writer.
I'm going to read all of your work! I would love to work with you one day. I'm over coming insulin resistance, fatty liver, losing weight, and ketovore/ IF daily. Down 33 lbs since March 19th. Battling cancer now, which as we all well know cancer is just metabolic disorder of the mitochondria....we've even sickened them with our SAD!
TYFS,
Jen
Dr Scher und Dr.Bikman, great video
with all the problems of today and all the solution, it is so good, easy explained. Thanks from Germany
Eszter Horvath
Thank God there are Doctors and scientists like Dr. Bikman because quite frankly this stuff bores me to death.
As a type II diabetic.......I am so happy there are people who have an interest in this.
This is how I found out that I had hyperinsulinemia: After listening to a video with Jason Fung I decided to cut my carbs one day. My body reacted strongly the following night (heart racing, hunger, sweating, restlessness) and I had a strong episode of hypoglycemia the following morning (weakness, shakyness, more sweating). I do not take any medication to lower blood glucose and was never diagnosed diabetic (I haven't had my blood glucose checked in years). That episode of hypoglycemia that I was able to recognize easily as I am a nurse made me realize that I needed to really cut down my carbs and change my diet to lower and hopefully reverse my hyperinsulinemia. By the way, I am in my sixties and always had issues with controling a healthy body weight.
Have you reduced your hyperinsulinemia? I too have hypoglycaemic episodes.
@@kaygibson8942 I think I did but didn't get tested for it. After six months of a low carb diet my hb1C was at 5.1. I do not have any hypoglycemic episode anymore. But I have completely changed my diet and reduced my carbs to only vegetables, nuts, some fruits and sometimes some dairy but no more grains.
This is to me the best explanation of insulin resistant. I am 71 years old and still working to keep my body active and I'm trying to follow low carb diet socI can reduce some weight because of my knee problem and to keep my blood sugar level to normal as I have been on borderline high. Thanks for the informations and I am for sure will share this to those who need this eye opening topic.
I also repeat...this is the best most informative dietary health channel on TH-cam or anywhere for the topics covered. Even in simple Google searches for text, Diet Doctor is simply the most on point purveyor of relative information of dietary concerns. The in depth information they provided makes it easy to decipher and understand fact from fiction. Many thanks...
You are an outstanding Scientist who has changed my life.I do appreciate your U-Tube very valuable information.I have also bought your book Why We Get Sick,from Amazon.
Your book is a gem for health seekers.
Thanks so much for sharing your deep knowledge and research on diabetes.
God bless you and your family.
Ben Bikman is awesome! Thank you so much for this information!
Re Cortisol and insulin resistance. I recently had 5 days off travelling 3 hours to a beautiful country location and felt extremely relaxed. I noticed my fasting glucose went down by .6 mmol to 4.2 while away. As soon as I came back to the big smoke it went back up by .6 mmol to 4.8. My guess is Cortisol.
Cortisol I suspect is my greatest problem at the moment. I am a chronic insomniac and battling with minor autoimmune (rheumatoid arthritis) for many years now
@@dmahadeo have you tried a low carb diet?
@@scotchfillet For the last three and a half years generally. Went carnivore for three months a while back. The less carb I eat the higher I suspect my cortisol goes - heart racing, etc. But I am still committed to low carb. Been playing with electrolytes and minerals hoping to achieve some results
I have his book and LOVE IT 🥰
Bikman is very good. It is so weird that some people actually put thumbs down on this
They probably work for the company who makes metformin. Lol!!
Bet they’re vegans!
Professional jealousy?
I'd like to see a collaboration between Dr Bikman and Dr Lustig. That would be the best of both the research and clinical worlds.
So much relevant information about insulin. Thank you so much for doing what you do!
I gotta say….. you’re both great guys! Thank you. 🙏🏼🙏🏼🙏🏼
This is really great interview. Thanks to both of you.
Big Thank You❤️, Learn Volumes from this Podcast 🙏
So over my head! I barely understand it. I'll need to watch several times. 😯
Love Dr. Ben
Dr. Bikman, thank you for this information. I am looking more into these concepts you are presenting. 😊
I have faith in Dr Bikman’s science. Stay the course Ben.
Very good lads. Here’s as additional thought from my experience. Twelve months careful dieting wasn’t enough. When I added an 18/6 autophagy method, WOW. Every one is different I know but this was astonishing. Cheers Mike
This guy is one of the best. I may actually get the book. I need to summarize what he says so I can influence family.
Super helpful in deepening my understanding of 'metabolic syndrome. thank you
This discussion is a gem!
Very interesting. There's always more to learn about this topic.
These Gentlemen are saving mankind. Keep up the good work. You are saving many lives withought even knowing it. I am indebted to you.
Wow! Great interview. Thanks again. Well balanced info.
Great interview thank you. I do have a question. What does it mean if my blood sugar stays in the 110s to 130 even on a 5 hr fast? I keep fasting for at least 12 to 15 hrs from night till the next late morning and my blood sugar is always higher than 100? Any feed back would be great. thank you for working to help us all.
This article may be helpful! www.dietdoctor.com/why-does-blood-sugar-increase-during-a-fast
This is excellent at explaining type 2 diabetes.
It's rarely just one thing. Great interview. Love to you both.
Another excellent interview. Thanks to you both.
I almost didn't listen to this one. Since I've heard Ben speak many times. Glad I did and will get the book to add to my low carb collection
Just finished his book yesterday and used this to reinforce the info. Good interview. Passing it in to my kids.
Wonderful interview. Thank you.
Yes, the paradigms must change both looking at the glucose/insulin problem and also the ROS/LDL problem. We must also understand transient receptor potential channels and how they play critical parts in all of these scenarios.
I disagree “we don’t get paid” with regards of us medical doctors. The physiology, pathology etc all part of medical school. Nothing stops docs continue to be curious , exercising a common sense . I connected dots on hyperinsulinaemia to HT, PCOS , Diabetes etc a while ago and really needed evidence ..
You are doing an amazing job guys !! So hard to get through minds and hearts, we need you … your links to your podcasts on our hospital website page now!
Dr Bikman is right about making plans to break a fast. It's very difficult to stop eating once you start, even if the foods are keto.
Not if you eat a lot of protein. Satiety is most prominent when eating protein
If you find it difficult to stop eating after fasting than your eating the wrong foods. Eat more fats, proteins that will give you satiety and make you feel very full.
It was a very useful interview. Thanks for inviting Prof. Ben Bikman.
As an RN for 41 years, now retired, my question is why do MDs not have continuing education that addresses new studies relating to this problem....? Do they not see that what they have been telling us to do for the last too many decades has not worked. No curiousity?? For shame!!!
Spectacular interview; even the second time watching it!
How does this correspond with female menopause? I became type 2 diabetic when I went into menopause. I got it under control with diet and exercise. Now at 62 I am back at being pre-diabetic but I can now control my glucose by cutting out nuts and grains. These are the foods that raised my blood sugar too high. I now walk after most meals just to work off the glucose. I am telling my body to grow muscles not fat 😅
Really great interview!
To the question « what is the common link between insuline and all modern diseases », I think the question deserves more attention and I can think of other common links as the « growth promotion » that was mentionned: 1. Insuline is inflammatory by itself, and inflammation causes degradation and faster aging and dieases like cancer through cell degradation 2. The body overly relying on glucose forgets how to burn fat, which in turn leads to less mitochondria, which in turn leads to less cell respiration and more fermentation, which is the energy fuel of cancer 3. Glucose depletes us from vitamines and minerals, and reduces our immune system strenght (glucose has priority for vitamine C transport for example) making us more vulnerable to viruses 4. The glycation damage caused by glucose and overeating over the long run 5. The constant inhibition of certain hormones and processes like autophagy that can’t be active at the same time as insuline 6. The impact of glucose itself on our stress and anxiety levels, worsened sleep which in turn increase insuline (my theory is that the body and brain senses that there is a lot of inflammation going on and he freaks out with anxiety that can be felt in the brain and phisically in the upper chest area). 7. Obesity makes people physically less active which in turn makes that the energy in the system is not used quicly enough to prevent glycation processes 8. Insuline promotes glucose storage in places where it can be available as a source of energy for bad bacteria, viruses and cancer 9. Insuline makes us blind to the fat that could be burned which means the body sees only the calories we eat which in turn reduces the metabolism as soon as people are reducing their calories intake if they are not at the same time in low insuline- ketosis state as their body thinks that they are in starvation while at the same time having hundreds of thousands of calories at their disposal but unable to tap them because of insuline and metabolism reduction leads to less calories burning overall, reduction in muscle mass correlated with higher death rates 10. Insuline being an emergency process of glucose storage in cells to avoid comma for our brain, it also makes us hungry a lot more quickly as the energy was not available long enough in the blood to give us a constant source of energy throughout the day, which leads to more food consumption as we get hungry too quickly, the switch off mechanism of insuline being very long when we are insuline resistant.
This is one that I'll have to listen to more than once. Excellent!!
Great discussion, but y'all missed a big point. Keto/low carb eliminates the hunger problem.
I don't see how I could do int. fasting on a low fat high-carb diet - the hunger would kill me.
Eating fat on keto = no hunger. It's truly amazing. I bet most people are much more likely to fast more effectively if they eat keto (or low carb maybe) when they eat. One of you may have mentioned the hunger thing earlier, but it would have been great if one of you had brought it up on the keto/low carb vs low-fat-hi-carb and int. fasting section.
Lots of stuff to think about here. Thanks.
This interview is extremely dense with information. It's almost mind boggling.
Thank you Dr Bikman. You really educate me of how to take care of myself. I need to order book, WHY WE GET SICK. ALSO GIVE THANKS TO THE INTERVIER. YOU HAVE A GREAT KNOWLEDGE 👍. MAY GOD BLESS YOU BOTH.🙏💝💯
I loved this talk so much. This answered all the questions I've had in my mind!
very helpful suggestions. i liked the "specifics" given . binging triggers explanation appreciated.
Very good information. was not sleeping well and my work and life overall have been very stressful for the last 10 years. Luckily, my blood pressure is always normal and my lipid panels except LDL (slightly high) are also normal. What has worked for me to return to my normal pre prediabetes state has been 16/18 IF with two meals. On weekends, I can go for a whole day for one meal only. However, I do not want to lose any more weight, and I will stop the weekend 24. I find it very easy for me to do since even before learning I was prediabetic, I was skipping meals almost everyday and I am a small eater.
Phenomenal!! I love the low-carb community!
Thank you. I've learnt so much.
The discussion briefly went over fasting and the minimun dose. If I may add to the conversation, I have been getting weekly blood tests intermixed with no fasting, 12 hr fasting, 36 hr fasting, and 84 hr fasting. I tracked exercise and belatedly started tracking sleep and energy levels. Within my N=1 study, I have noticed that HDL and TG don't really response to fasting dose. Neither does hs-CRP, but hs-CRP does appear to respond to exercise prior to the blood draw. Uric acid increases 30-50% by stretching a 36 hr fast to 84 hrs. While it was initially confusing, the biggest effects of fasting dose appear to be on LDL - more specifically, particle count and mix of particles. LDL needs to be cross correlated with the white cell count, because LDL is performing an immune response, too (a higher white cell count will lower the LDL particle count). With steady white cell counts, my LDL particles will increase by roughly 30% from a 36-hr dose to a 84-hr dose. This is partially confounded by the exercise dose prior to the blood draw, because the number of VLDL particle jump up - because obviously in a ketogenic fasted state, VLDL is the only energy delivery mechanism to the muscle cells. For the longer dose of 84-hrs the greatest increase in LDL particles seems to be in the small and medium size particles, but VLDL still increased by more that 20%
I find all of this so informative and interesting. I would like very much to study further and work towards a career to help people improve their health with this knowledge. But as I understand the low carb lifestyle is not taught in college. How do I pursue a career in this field?
A question for Professor Bikman. If someone were to strength train or do HIIT in a fasted state ( 16 hrs plus ) and then break their fast with an 800 to 1,000 calorie meal within the low carb spectrum, would that meal be considered binge eating and too many calories to break the fast with? Also if they ate another meal consisting of the same amount of calories and ketogenic style foods 4 to 5 hours later and the last meal was more than 3 hours before the person goes to sleep, Would this be a good regimen for fasting windows ? Let’s say the person weighs somewhere between 180 and 240 lbs? Thanks you for all your insight and knowledge! Loving this diet doctor podcast 🤘
45:00 I think it's that people want to think they have more directly control over things than they do. Either that or they lack the basic understanding of HS chemistry to understand that body fat isn't dietry fat. Some people seem to think the human body is about as complex as a bucket. Thank you for diving deep into why it isn't close to that simple.
If one adheres to a low-carb/keto diet, is there any downside to being metabolically inflexible (aka glucose intolerant)? I understand one is not insulin resistant, but does just having prolonged/elevated blood-glucose (after eating a mixed-meal) cause any issues? Also, does this mean that insulin is not being produced in sufficient amounts.. if so, does that have any negative long-term consequence? Or is the idea that it's always best to not have much insulin?
Do I understood correctly that omega-3 and 6 are polyunsaturated fatty acids, but it's only the Linoleic acid that signals (via insulin) for fat cells to grow.. until they become resistant, and STOP growing? Do omega-6s/Linoleic acid have any positive role? For example, on Dr. Bill Harris' talk with Chris Masterjohn, he suggests omega-6 metabolites are anti-inflammatory, however if one does not get enough omega-3s (~4g a day), even if rancid, then the body resorts to arachidonic acid (an omega-6) as a substrate to make prostaglandins.. and this leads to inflammation!
Robert Lustig talks about how obesity is a symptom, not the cause of metabolic dysfunction (diabetes and high triglycerides). He cites how 20% of obese people are Metabolically Healthy Obese (MHO) and 40% of normal weight people (67M) have type-2 diabetes, hypertension, cardiovascular dementia, etc. He is studying how insulin resistance in the liver disrupts the FOXO phosphorylation pathway but not always the SREBP-1c pathway!! He suggests a different macro-nutrient as the villain: fructose.
Regarding meal-timing, I've read that melatonin binds to the pancreas to signal less insulin production.. and that post-prandial glucose levels are always lowest in the morning.. yet Adel Moussa suggests it's a misinterpretation of the data, and that we are actually LESS insulin sensitive in the morning (see the Szotak Andrei's Muscle Engineer Podcast #16 (31m)). What does Ben think?
Finally, I understand Ben suggests *FAT* cells are the 'first domino' to fall in insulin resistance.. any thoughts on Gerald Shulman's work, that suggests *MUSCLE* cells, are the first cell types to become insulin-resistant? He suggests the mitochondrial oxidation slows-down leading to fatty acids entering the muscle cells and inhibiting the uptake of insulin/glucose (DAG->PKCtheta->IRS-1->PI 3-kinase->GLUT4). The insulin resistance then spreads to the the muscle, and finally the liver (GLUT2).
intelligent questions. I hope they get answered.
Well vegetarianism didn't work for me for 20 years and sadly, keto carnivore even at 90% is what has helped me tremendously.
This channel is such a great repository of useful and cutting-edge info. Thank you, Dr. Scher and Prof. Bikman. I always love to hear Dr. Ben and his new discoveries or realizations. He's an excellent teacher of what can be pretty complicated stuff. Kudos to you both for a great interview!
My skin tags on my neck and one large one under my arm are shrinking on Carnivore (day 67). My ketones are still .2 glucose 99 (fasting) and weight not moving at all. At 73 with a 90 lb weight gain since my goiter treatment w radioactive iodine at age 27. I’m eating only coffee w heavy cream in am followed by 5oz bacon and/or eggs. Liver wurst mid day w butter and a rib eye at night with another 4-5oz of bacon.
The liverwurst was to replace ground beef which was making me nauseous to even look at after 45 days of eating cheese burgers.
I’ve increased my fat intake hoping to get the scale to drop. Walking and light weights began in earnest this last 2 weeks.
Amazing interview. I am currently on Metformin and Januvia. Is this medication dangerous based on thewe findings?
Please create a video on the difference between pathological insulin resistance and physiological insulin resistance. Been doing strictly keto/IF (two 24 hr/month) for nearly 4 years and my glucose #’s are in 130’s.
Have you looked into ray peat? Or dangers of keto long-term. I did keto for 5 years as well and had to add back in juice to lower stress hormones and a severe lack of energy after that long on low carb. It can get bad with long-term side effects. If you feel good then disregard this. Ben also mentioned things that our ancestors ate such as potatoes are not going to cause insulin resistance.
@@sarah29880 thank you for your input. I will look into it.
Loved this interview. So informative
Thank you. His PhD objective sci inquiry gives us laymen hope, esp since US med field has separated itself into dozens of subspecialists with few motivators to consider the whole body and brain.