The page I mentioned in the video about raising awareness and donating to charities to help aging research is here: andrewsteele.co.uk/ageless/how-you-can-help/ Limitless is a lot of fun, so go check it out! Especially the three episodes I mentioned (Fasting, Memory and Acceptance). This isn’t a sponsored video but the footage is used courtesy of Disney+ and Nat Geo. Thanks, team!
Incredible work on this one! I sincerely hope awareness can be raised on this field of study so more scientists (and investors) can start generating drugs to slow, prevent, or reverse aging soon!
Hey Andrew thanks for this great video. Also it was such an unexpected surprise and joy that Chris Hemsworth + Disney paired up to make a Longevity focused series!
A question I have never ask myself before: What will I do when I see the first carboard packages in a pharmacy stating +2 Days per pill or something... Maybe I will have to decide in a few years time weather I take the risk an this stuff (whatever it will be) in the form of potentially harming myself on the one hand and changing my life completely on the other - for the good or the bad. The idea of just living 150 years all of the sudden is sooo strange to me. Also this will deeply divide society - for a couple of decades at least. In the starting phase there will surely be people deciding against this stuff knowing that they will die maybe 20 years before their classmates. I imagine this will be such an enormous pressure on the ones staying back. I mean: you will have to marry someone that has the same "status" as you are... The age at wich we probably (at latest) pass away is an incredibly constant constant in society - at least for the lucky ones. This seems horrifying to me, even more if this aren't +2 Days Pills but a +50 years surgery that will rip you out of your generation in the middle of your life if you decide to take it and will leave you knowing that you'll always be effectively 50 years behind (or in front) of the people surrounding you. Society is so much centered around the security that we are all on the same "level". I cant phrase how I feel but you'll maybe do so, too. The knowledge of becoming somewhat around 90 years of age is the very basis of the life plan every (lucky) child grows into. I cant imagine how it will be if this changes - even more so if this does'nt change equally across all people.
You are my favorite little person, it used to be the one from game of thrones but you are clearly smarter and more charismatic than that one. You will be v-sauce or tom scott level of famous the first chance the youtube algo lets you. You made very high quality content on various interesting topics, keep it up. It is really awful that I get recommended some 3 seconds long cat video and never seen you around before your collaboration with Steve Mould, because I daresay that you deserve exposure way more than some cat shot in bad lighting on ancient sony ericsson phone. ❤ Thank you for great content.
I was hoping @MedlifeCrisis was going to do a video about this series as I too was really interested, but I was a bit sceptical about some of the science mentioned throughout
Great question, but very hard to give a definitive answer! What I normally say is that these treatments are coming in time for most people alive today, which is to say the first (most likely senolytics or repurposed existing drugs) will be with us within the next five to ten years, but then gene and stem cell therapies are probably ‘only’ decades away (which is in time for most people, especially if the first treatments can extend healthy life a little), and that will buy scientists even more time to develop the next treatments and so on… Whether this will end up being a cure in practice, only time will tell!
@@DrAndrewSteele Alright! Well I'm pretty positive actually. Especially when I read news about Base Editing that cures incurable cancer. And that has already happened so it would seem that it's not far away.
How far away are senolytics for the NHS and the UK? I read Japan wants to be the trailblaser for this type of anti-aging therapeutic. China's population is about to fall off a cliff with very few child births.
Great question, and I hope years rather than decades-but they’ll probably be used for treating specific diseases rather than ageing as a whole at first. I actually wrote a whole article on basically this which is out this week! www.wired.co.uk/article/aging-disease-biology
I watched this series on your recommendation and yes, it's a great watch, however I am bemused by the last episode, Acceptance. While the first 5 episodes show at least some awareness of how lifestyle can meliorate our body and extend its life, the last episode seems to be from another era. Why does the series not end with an episode about what today's science is working on in the area of radical life extension? Chris is less likely to end up in that coffin and need "death therapy" than he is to get gene therapy and stem cell therapy and young blood plasma therapy in 15-20 years that will greatly lengthen his lifespan. Then, at the end of this century, there will likely exist even more advanced therapies that will further increase his healthspan. This series should have been more future-aware. Now it looks more like one of these scifi movies/series that we had in the 60s and 70s and that seem so naive today. Like people aging and dying 3000 years from now but traveling around the galaxies in spaceships...
I thought the same... and thought to myself, "Wait, did Andrew just say that the calorie restricted rats had way shorter lives, died 50% sooner?" I think it's British English vs. American English meanings... In America, saying "half as long again" can make us think "half as long is the result over-and-over as the trial is repeated again" instead of "again" as adding a mathematical "one" to the "half" to get 150%.
Will definitely have to give Limitless a watch. It's always hard to tell if a show is some over-produced money grab or will provide genuine insight, seems like this it the latter. In the same vain, for someone naive to anti-aging research like myself, hearing "senolytics" makes me think of money-grabbing supplements and I end up lumping it with adaptogens, anti-oxidants and nootropics. Ultimately, this just highlights the importance of education, and raising the profile of anti-aging research so the general population can differentiate between the next "miracle cure" or something genuinely exciting that deserves more funding.
I completely agree, more education is definitely needed! It’s unfortunate that ‘anti-aging’ has historically been such a magnet for charlatans, and that even today there’s the full spectrum from outright quacks, to people promoting plausible but unproven therapies, to serious science that really needs more funding. Limitless is fun and beautiful, and for a more in-depth look at the science you might also enjoy my book… :) ageless.link/
Fantastic video- a real cut above in quality, extremely entertaining and very solid with your linked sources. Loved your book (I listened to it through audible). Very much looking forward to more great videos and books!
Really great idea for a video, but I will say that super close up angle on your face is uncomfortable haha. It was better when you zoomed out though! :)
Haha yeah I decided after filming the opening and closing shots as close to the equivalents in Limitless as I could manage that it…might be a bit much for the full video! It looks great in the show because they’re only ever on screen briefly but…not great for a 15-minute talking head!!
already tinkering around with getting an estimate of my biological age [fitness Age from Garmin, Metabolic age from my bodyfat scale app, Strength age from Egym with automated strength tests on 6 machines in my gym, and a formula in an App called life extend, weighing all equally and taking the average].
Acceptance/fasting: one can have experience of both at the same time as after sufficient time of water fasting one becomes rather non-energetic, barely able to move. Worth a try?
There's another videos, of people talking about the amount of protein should people take, and, how protein increase aging, to the MTOR... so, there is a lot of information, and is really difficult to understand what is the best way, and how to choose without lose the game... Can you please, explain, please, what is the right direction!! Thanks
This is something I think even the experts disagree on tbh! I talk about this a bit in my book but I will hopefully be making a video about this in the not-too-distant future… :)
i was interested in the comment you made about why the one gene for dementia wasn't out-competed by other more beneficial genes and my guess would be that mother nature equally endows all her "offspring" with strengths and weaknesses (for example, in order to have our advanced brain we gave up all our physical abilities, walking upright comes with a whole host of downsides, etc.) and that just as she wants members of our species to thrive she equally wants us to move on and make way for new members and she wants us to FIT IN to an ecosystem not dominate it into oblivion which as we all know we largely are now.
You're ascribing intention to a system that isn't a conscious entity. Evolution is the result of the interaction of relatively simple rules in a complex system. It's not a system that makes choices about what traits creatures will have.
@@evanbarnes9984 none of us knows for a fact all we have are opinions, beliefs and theories. there are a hell of alotta people that will try to convince you they KNOW but an educated guess is as close as we get.
3:36 or at 38 of post covid heart attack, or become Long covid-disabled... Best thing to do to live longer /these days, or forever?/ and help others not get their untimely death is *wear a mask!* also invest and advocate for air monitoring and filtration. (Corsi-Rosenthal boxes, etc) Future humans, if our species survive given new SARS2 variants are emerging all the time and climate change mess we're in... will look at "air hygiene" practices of our time the way we look at pre-waste and clean-water treatments era, with ethical judgment and disgust. *We¹* know what's to be done, but we're not doing it. ¹ there are John Snow's of today we're not listening. #dontbreatheitin
The page I mentioned in the video about raising awareness and donating to charities to help aging research is here: andrewsteele.co.uk/ageless/how-you-can-help/
Limitless is a lot of fun, so go check it out! Especially the three episodes I mentioned (Fasting, Memory and Acceptance). This isn’t a sponsored video but the footage is used courtesy of Disney+ and Nat Geo. Thanks, team!
also let's appreciate the effort put into making Andrew's footage look close to the documentary's one.
This was really well made. Love the stylistic emulation. And kudos for not making a Chris Pine Box gag when he was in a coffin
Thanks dude!
Lol
Incredible work on this one! I sincerely hope awareness can be raised on this field of study so more scientists (and investors) can start generating drugs to slow, prevent, or reverse aging soon!
Hey Andrew thanks for this great video. Also it was such an unexpected surprise and joy that Chris Hemsworth + Disney paired up to make a Longevity focused series!
Thank you! And yes, it’s great to see longevity getting some more mainstream attention and Chris was a great choice!!
A question I have never ask myself before:
What will I do when I see the first carboard packages in a pharmacy stating +2 Days per pill or something... Maybe I will have to decide in a few years time weather I take the risk an this stuff (whatever it will be) in the form of potentially harming myself on the one hand and changing my life completely on the other - for the good or the bad. The idea of just living 150 years all of the sudden is sooo strange to me. Also this will deeply divide society - for a couple of decades at least. In the starting phase there will surely be people deciding against this stuff knowing that they will die maybe 20 years before their classmates. I imagine this will be such an enormous pressure on the ones staying back. I mean: you will have to marry someone that has the same "status" as you are... The age at wich we probably (at latest) pass away is an incredibly constant constant in society - at least for the lucky ones. This seems horrifying to me, even more if this aren't +2 Days Pills but a +50 years surgery that will rip you out of your generation in the middle of your life if you decide to take it and will leave you knowing that you'll always be effectively 50 years behind (or in front) of the people surrounding you. Society is so much centered around the security that we are all on the same "level". I cant phrase how I feel but you'll maybe do so, too. The knowledge of becoming somewhat around 90 years of age is the very basis of the life plan every (lucky) child grows into. I cant imagine how it will be if this changes - even more so if this does'nt change equally across all people.
You are my favorite little person, it used to be the one from game of thrones but you are clearly smarter and more charismatic than that one. You will be v-sauce or tom scott level of famous the first chance the youtube algo lets you. You made very high quality content on various interesting topics, keep it up. It is really awful that I get recommended some 3 seconds long cat video and never seen you around before your collaboration with Steve Mould, because I daresay that you deserve exposure way more than some cat shot in bad lighting on ancient sony ericsson phone. ❤ Thank you for great content.
Thanks! On to watch Limitless and do a few remixes with you, if you don't mind. 👋
I was hoping @MedlifeCrisis was going to do a video about this series as I too was really interested, but I was a bit sceptical about some of the science mentioned throughout
I like how the camera is zoomed in uncomfortably close when you want to emphasize something KEKL
Great content! I agree this is the most interesting science at this moment. When is a cure for aging to be expected?
Great question, but very hard to give a definitive answer! What I normally say is that these treatments are coming in time for most people alive today, which is to say the first (most likely senolytics or repurposed existing drugs) will be with us within the next five to ten years, but then gene and stem cell therapies are probably ‘only’ decades away (which is in time for most people, especially if the first treatments can extend healthy life a little), and that will buy scientists even more time to develop the next treatments and so on… Whether this will end up being a cure in practice, only time will tell!
@@DrAndrewSteele Alright! Well I'm pretty positive actually. Especially when I read news about Base Editing that cures incurable cancer. And that has already happened so it would seem that it's not far away.
@@johanjonasson4188 Yeah, there are some really exciting developments at the moment…definitely makes me optimistic!
How far away are senolytics for the NHS and the UK? I read Japan wants to be the trailblaser for this type of anti-aging therapeutic. China's population is about to fall off a cliff with very few child births.
Great question, and I hope years rather than decades-but they’ll probably be used for treating specific diseases rather than ageing as a whole at first.
I actually wrote a whole article on basically this which is out this week! www.wired.co.uk/article/aging-disease-biology
I watched this series on your recommendation and yes, it's a great watch, however I am bemused by the last episode, Acceptance. While the first 5 episodes show at least some awareness of how lifestyle can meliorate our body and extend its life, the last episode seems to be from another era. Why does the series not end with an episode about what today's science is working on in the area of radical life extension? Chris is less likely to end up in that coffin and need "death therapy" than he is to get gene therapy and stem cell therapy and young blood plasma therapy in 15-20 years that will greatly lengthen his lifespan. Then, at the end of this century, there will likely exist even more advanced therapies that will further increase his healthspan. This series should have been more future-aware. Now it looks more like one of these scifi movies/series that we had in the 60s and 70s and that seem so naive today. Like people aging and dying 3000 years from now but traveling around the galaxies in spaceships...
I love you videos and work but I must employ you as a fellow brit to not fall into the Americanisms like saying a-dult (uh-dults) instead of adult 😅😂
This guy is sooo underrated......people should stop watching idiotic tiktoks mindlessly and watch content like this insted.
2:17 "the animals on the calorie restricted diet lived half as long as the animals which could eat whatever they liked". Other way round no?
I said almost half as long _again_ ie 1.5× as long as the animals eating what they liked. :)
@@DrAndrewSteele Gotcha, wasn't quite clear to me
I thought the same... and thought to myself, "Wait, did Andrew just say that the calorie restricted rats had way shorter lives, died 50% sooner?" I think it's British English vs. American English meanings... In America, saying "half as long again" can make us think "half as long is the result over-and-over as the trial is repeated again" instead of "again" as adding a mathematical "one" to the "half" to get 150%.
Will definitely have to give Limitless a watch. It's always hard to tell if a show is some over-produced money grab or will provide genuine insight, seems like this it the latter. In the same vain, for someone naive to anti-aging research like myself, hearing "senolytics" makes me think of money-grabbing supplements and I end up lumping it with adaptogens, anti-oxidants and nootropics. Ultimately, this just highlights the importance of education, and raising the profile of anti-aging research so the general population can differentiate between the next "miracle cure" or something genuinely exciting that deserves more funding.
I completely agree, more education is definitely needed! It’s unfortunate that ‘anti-aging’ has historically been such a magnet for charlatans, and that even today there’s the full spectrum from outright quacks, to people promoting plausible but unproven therapies, to serious science that really needs more funding.
Limitless is fun and beautiful, and for a more in-depth look at the science you might also enjoy my book… :) ageless.link/
Great video Andrew! Just finished your book & always keen to see more 'Ageless' content 😁
Thank you! There’s more on the way. :)
Kitabın adı ney
Fantastic video- a real cut above in quality, extremely entertaining and very solid with your linked sources. Loved your book (I listened to it through audible). Very much looking forward to more great videos and books!
Really great idea for a video, but I will say that super close up angle on your face is uncomfortable haha. It was better when you zoomed out though! :)
Haha yeah I decided after filming the opening and closing shots as close to the equivalents in Limitless as I could manage that it…might be a bit much for the full video! It looks great in the show because they’re only ever on screen briefly but…not great for a 15-minute talking head!!
I'm glad you keep making these videos, absolutely brilliant content. Thank you !
Great video! I came here from your interview with MedLife. Subbed.
Chris Hemsworth is the perfect human.
Welcome! And LOL. Yeah he’s not bad.
I would recommend considering adding "PhD" to your TH-cam name.
One of the advantages of our generation is having this information to prepare us for our likely longer lives.
Pure thing’s face is covered in wrinkles
I think I'll settle for Alzheimer's rather than a lifetime carrying parasitic infections and developing aggressive skin cancer
currently reading the book.
Hope you enjoy! :)
Really enjoyed this
Thanks dude!!
already tinkering around with getting an estimate of my biological age [fitness Age from Garmin, Metabolic age from my bodyfat scale app, Strength age from Egym with automated strength tests on 6 machines in my gym, and a formula in an App called life extend, weighing all equally and taking the average].
Acceptance/fasting: one can have experience of both at the same time as after sufficient time of water fasting one becomes rather non-energetic, barely able to move. Worth a try?
this on TH-cam feels like a steele.
Great stuff Andrew
There's another videos, of people talking about the amount of protein should people take, and, how protein increase aging, to the MTOR... so, there is a lot of information, and is really difficult to understand what is the best way, and how to choose without lose the game... Can you please, explain, please, what is the right direction!!
Thanks
This is something I think even the experts disagree on tbh! I talk about this a bit in my book but I will hopefully be making a video about this in the not-too-distant future… :)
i was interested in the comment you made about why the one gene for dementia wasn't out-competed by other more beneficial genes and my guess would be that mother nature equally endows all her "offspring" with strengths and weaknesses (for example, in order to have our advanced brain we gave up all our physical abilities, walking upright comes with a whole host of downsides, etc.) and that just as she wants members of our species to thrive she equally wants us to move on and make way for new members and she wants us to FIT IN to an ecosystem not dominate it into oblivion which as we all know we largely are now.
You're ascribing intention to a system that isn't a conscious entity. Evolution is the result of the interaction of relatively simple rules in a complex system. It's not a system that makes choices about what traits creatures will have.
@@evanbarnes9984 none of us knows for a fact all we have are opinions, beliefs and theories. there are a hell of alotta people that will try to convince you they KNOW but an educated guess is as close as we get.
Excellent work 👏👏👏
3:36
or at 38 of post covid heart attack, or become Long covid-disabled...
Best thing to do to live longer /these days, or forever?/ and help others not get their untimely death is *wear a mask!*
also invest and advocate for air monitoring and filtration. (Corsi-Rosenthal boxes, etc)
Future humans, if our species survive given new SARS2 variants are emerging all the time and climate change mess we're in...
will look at "air hygiene" practices of our time the way we look at pre-waste and clean-water treatments era, with ethical judgment and disgust.
*We¹* know what's to be done, but we're not doing it.
¹ there are John Snow's of today we're not listening.
#dontbreatheitin
Great video, btw, and thank you for raising awareness and pointing out interesting research...
Thanks!