Multiplexed Mapping of the GPCR-RAMP Interactome
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- เผยแพร่เมื่อ 7 เม.ย. 2024
- Presented By: Jochen Schwenk, PhD
Speaker Biography: Jochen M. Schwenk is a Professor in Translational Proteomics at KTH Royal Institute of Technology in Stockholm, Sweden, and holds a Ph.D. in Biochemistry from the University of Tübingen in Germany. Jochen is an elected member of HUPO's Council, chair of HUPO's Plasma Proteome Project, Scientific Director of SciLifeLab's Affinity Proteomics Unit, and part of the Human Protein Atlas (www.proteinatlas.org)management group. His primary interest is studying the circulating blood proteins to understand human health and disease states. His team works on the novel aspect of the biomarker analysis pipeline, including study design, pre-analytical variables, micro-sampling, assay development, data integration, and emerging translational possibilities. The Schwenk Lab collaborates with various interdisciplinary research projects on different human phenotypes.
Webinar: Multiplexed Mapping of the GPCR-RAMP Interactome
Webinar Abstract: G protein-coupled receptors (GPCRs) are vital membrane proteins involved in cellular and physiological processes, including sensory perception, signaling, neurotransmission, and immune response. Consequently, understanding their function and regulation is particularly relevant for developing targeted therapies for human diseases. A family of three single-transmembrane proteins, called receptor activity-modifying proteins (RAMPs), has been shown to co-evolve and act as regulators of GPCR function. Still, system-wide GPCR-RAMP interactions have remained underexplored (Kotliar et al., 2023, PharmaRev).
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