I can hardly believe this. I remember contributing bits of my crappy laptop CPU in 2002 to the Usyd protein folding modular supercomputer. Molecular biology has just evolved by a quantum leap
It is dual use, not all what comes of it maybe good for us. The only thing usually what nations had kept them from using certain bio weapons, was that they couldn't controll the outcome in aspects to their own population. This might give some people the impression this might now have changed, which i doubt, but hybris is somewhat of a human trait often to be encountered. One could only hope that with the recent experience of covid, who ever conciders anything will be sane enough to not go down certain roads.
Google DeepMind living in 3024 ❤ thank you guys, your Dharma has already been more than fullfilled, amazing job, life on the whole planet will benefits from your work, thank you so much ❤
@dr.akshayprakash5735 it depends on your goals. One thing is not knowing the structure of a protein and now having a predictive model that outperformes all others in terms oof accuracy. You might want to develop a drug that targets this protein. This you can only do if you have information about its structure. Or you don't know what the protein does at all. By knowing it's structure you might infer something. You might also want to engineer the protein, meaning changing its design to perform a specific task or to not perform it anymore (in case of a protein that causes desease) To name only a few examples.
Its written in the use policy that: "You must not use nor allow others to use AlphaFold Server, Output or Derivatives: In connection with any automated system that predicts the binding or interaction of the protein with ligands or peptides, including, but not limited to, Glide or AutoDock"
The user interface, on it's own is awesome, but the model, oh, the model... I didn't think anything could be more revolutionary than the original, but I was wrong. the breadth of applicability has increased VASTLY.
I am seeing all the hype and excitment about this but still fail to understand what the revolutionary aspect is or how we will see its benefits. Can someone explain and maybe put it into context of other important medical breakthroughs?
Most of cancer is misfolded proteins. Sincr proteins are huge clumps of atoms forming a complex molecule. All The atoms of one protein have influence on each other causing them to twist and turn eventually becoming relaxed. The issue is there can be many possible relaxed states and until now predicting those states was computationally insane. Supercomputers simulated atomic forces in brute force manner (with some optimization) to solve this but now this ai can just predict with far less computations becuase it has been trained on known solutions and it has inferred general patterns.
When downloading results i get 4 different models "model 0, 1, 2, 3 and 4". Which of these models is the best fit and how do i find the pLDDT confidence matrice for that specific model? Thank you in advance
Imagine 5 years from now. All of new meds can be created and tested using AI or AGI via simulations and possibly releasing it within weeks to months due to huge compute.
The sweet melody of the cool mind into a diamond mine Retry voice input interruptions.The sweet melody of the birds turn a coal mine into a diamond mine
Economically convenient AGI may make the world more efficient, but that alone will not make it a better place. The only AGI that can change the world is one that automatically advances science. *I am not denying the existence of brain-inspired AGI.
![[TALK 21] AlphaFold: Use and Applications - Sami Chaaban](/img/n.gif)
I suspect you guys will get the Nobel prize in Medicine soon. Amazing stuff. Thanks from us, lesser mortals.
sadly noble is only for academic nepotists and genocidal peace activists
Why so?
Softwares are already available that do such jobs.
Congrats blud , not medicine .. but chemistry. ❤🎉
Chemistry it is i guess!😅
Deepmind is an amazing team, incredible results!
this has got to be one of the single greatest leaps in understanding the world around us.
Could u elaborate why ?
Demis Hassabis and the team behind the AlphaFold 3 system deserve a Nobel Prize in medicine. This AI will help to save lots of lives!
they did!
I can hardly believe this. I remember contributing bits of my crappy laptop CPU in 2002 to the Usyd protein folding modular supercomputer. Molecular biology has just evolved by a quantum leap
So a tiny jump?
@Djellowman 😂
@@Djellowman In seriousness, it means a discrete step to something different, rather than a gradual increase.
Think of the breakthroughs that will happen in protein studies. Yippee
It is dual use, not all what comes of it maybe good for us. The only thing usually what nations had kept them from using certain bio weapons, was that they couldn't controll the outcome in aspects to their own population. This might give some people the impression this might now have changed, which i doubt, but hybris is somewhat of a human trait often to be encountered. One could only hope that with the recent experience of covid, who ever conciders anything will be sane enough to not go down certain roads.
@@kinngrimm 🤓
@@kinngrimm we can cure the new diseases faster
@@vel7232 That is an assumption and not one the first millions to die may wanna hear when you tell them.
@@kinngrimm"the first millions to die"
That's an assumption too buddy
Google DeepMind living in 3024 ❤ thank you guys, your Dharma has already been more than fullfilled, amazing job, life on the whole planet will benefits from your work, thank you so much ❤
keep religion nonsense out of this
@@mango-strawberryDharma means duty in Sanskrit 😑
Thank you Demis ! Give him a Nobel already
Nobel prize for Sir Demis?
I don't have a clue what is this but look like this is more important thing in entire history
History in the making, kind of video
Finally, recognized in the world of Nobel❤
Deepmind is the pinnacle of real world AI
History in the making ❤
guys i love you so much, I will spend my entire time on this server from now on
Okay, can you tell me what to do with the downloaded structure? I am not a researcher.
@dr.akshayprakash5735 it depends on your goals. One thing is not knowing the structure of a protein and now having a predictive model that outperformes all others in terms oof accuracy. You might want to develop a drug that targets this protein. This you can only do if you have information about its structure.
Or you don't know what the protein does at all. By knowing it's structure you might infer something.
You might also want to engineer the protein, meaning changing its design to perform a specific task or to not perform it anymore (in case of a protein that causes desease)
To name only a few examples.
有沒有中文?? 我想創造"抑制DNA端粒消化酶的functional protein 目的是抑制端粒的減短效應，與apoptosis觸發酶的氨基酸序列，用以製造針對癌細胞的催化凋亡過程
Its written in the use policy that: "You must not use nor allow others to use AlphaFold Server, Output or Derivatives: In connection with any automated system that predicts the binding or interaction of the protein with ligands or peptides, including, but not limited to, Glide or AutoDock"
Why comments allowed on this video but not newer videos? What's this game you play?
Awesome! Does the new evoformer mean the atomic coordinates are now different?
Demis Hassabis is my go to source when wanting to clarify things with current AI hypes.
The user interface, on it's own is awesome, but the model, oh, the model... I didn't think anything could be more revolutionary than the original, but I was wrong. the breadth of applicability has increased VASTLY.
Saludos desde #KansasCity😎
what a powerful marvel you're gifting us, Sir Hassabis...
thank you so much!
• • 🖤•
Signals are changing holograms are cjane.Intensity and thresholds or minimizing
Cant wait to see where this leads ❤️❤️❤️❤️❤️❤️❤️
Amazing technology. I can't wait for it to be monopolized by corporate giants.
Voice input interruptions.You try 440 44.The difference is two
I am seeing all the hype and excitment about this but still fail to understand what the revolutionary aspect is or how we will see its benefits. Can someone explain and maybe put it into context of other important medical breakthroughs?
Most of cancer is misfolded proteins. Sincr proteins are huge clumps of atoms forming a complex molecule. All The atoms of one protein have influence on each other causing them to twist and turn eventually becoming relaxed. The issue is there can be many possible relaxed states and until now predicting those states was computationally insane. Supercomputers simulated atomic forces in brute force manner (with some optimization) to solve this but now this ai can just predict with far less computations becuase it has been trained on known solutions and it has inferred general patterns.
Could be the greatest invention in the 21th century and there are 44k views and 110 comments avec 3 days... pffff what a world -_-'
When downloading results i get 4 different models "model 0, 1, 2, 3 and 4". Which of these models is the best fit and how do i find the pLDDT confidence matrice for that specific model? Thank you in advance
This is so amazing THANK YOU!!!!! Absolutely love all your work!
I can't read the paper if you watermark it like that.
Cognitions are cognitions are shifting with phases frequencies and amplitudes voltages and ears optical cortex
Wow this is incredible 👌🏼 congratulations
I have been having some pretty amazing visions.Artificial intelligence absolutely amazing
How does remote neural monituring work
This will make history.
Computer, do we have any new sequences?
Can someone explain how this is relevant??
I don't know what I'm seeing
This is incredible.
Voice input interruption 444 and 4 4 6.The difference is too
Imagine 5 years from now. All of new meds can be created and tested using AI or AGI via simulations and possibly releasing it within weeks to months due to huge compute.
Fda should also be replaced by AI then
This is really important!
Deep mand how do you do remote normal monitoring
Amazing, Really helpful.
very cool work!
What is active denial
Advanced material infrastructure, retry space return. Advanced memory 88 infrastructure. How to spoof a smart meter?
A faction of classes all in harmony
Precision medicine now and forever !
The sweet melody of the cool mind into a diamond mine
Retry voice input interruptions.The sweet melody of the birds turn a coal mine into a diamond mine
How to make PDB file?
It's like seeing things others can't see
So. Freakin'. Exciting.
Chad you created a quantum computer with atmospheric pressures
Wow
Good job
loving alphafold
Welcome to the future
Amazing!
Pretty cool 😊
I suggest you send a new research team to the myou know where i'm at my friend
Still have strong vibrations on the scalp of my head.Sexual energy changes interference patterns
i was here:D
AIGC leads the world towards the future.
nice
Thank you! O.O
It's a gold antenna rush
😍
welcome to the future.
Dope!
Voice input Interruption, frequency frequencies resonate. Internal energy energy neurologically developing sincerely chat.(CHAD)
When you get into conversations that makes sense to when those come that w Wanton't screw you over
When I hold my phone it's ready to my waistline and crotch
alphafold❤
read description
what is this?
God damn genius Google
My wrists are getting hot.My charge coupling device is overheating.My battery is draining very quickly
Woah!
Can someone explain how / to whom does this help?
Applications to pit neighbors against one another
When the human brain is confused.What happens when you don't know the answer?Do you lie cheat and steel?Or look for somebody's paper to copy
🤯🤯🤯
Four hundred and forty four and four hundred and forty different is too
Voice input interruption 400 and 4044. The difference is number 2.
But why would an average Joe be interested in folding proteins?
I will come back later
Send the research team in person so I could explain my emotions and my pain in pleasure centers
Now ETO develops their own DNA targeted virus :s
Human nuclear proteins to power computing.It feels good, but not so good.
D n a
Frequencies resonate internal energy neurologically.Developi'll be sincerely cearly chat
Schizophrenia
@@emptyice A good empathetical chatbot will work.
Is deepmind sentient
Economically convenient AGI may make the world more efficient, but that alone will not make it a better place.
The only AGI that can change the world is one that automatically advances science.
*I am not denying the existence of brain-inspired AGI.
The modulation of my brain feels like a mag.Genta
bro shut up already
I, for one, welcome our AI overlords
Chad, you are the smartest targeted individual.We ever tried to kill
G for garbage. Too bad.
In what sense?
Can it synthesize organic m3th? 😱
K537 Piano Concerto 26, Germline potential, pdb: 7d0c