Vitiligo - Pathophysiology

#vitíligo #vitiligoskin #vitiligolife #vitiligoislife #pigmentation
#melanin #skincolor #darkskin #lightskin
Introduction - 03:33
Intrinsic abnormalities in Vitiligo - 11:21
A. Autoimmune Hypothesis - 16:03
A. Autoimmune Hypothesis: Resident Memory T-Cells - 27:26
B. Oxidative Stress - 30:17
B. Oxidative Stress: Protective Machinery - 32:17
B. Oxidative Stress: T-Cell Activation - 34:00
B. Oxidative Stress: Oxidant-Antioxidant Balance - 35:46
B. Oxidative Stress: Unfolded Protein Response [UPR] - 39:10
B. Oxidative Stress: Exosomes Signalling - 41:43
B. Oxidative Stress: Mechanisms - 43:10
C. Cell Adhesion Defects: Melanocytorrhagy - 45:36
D. Neural Theory - 48:09
E. Somatic Cutaneous Mosaicism Theory - 50:54
Vitiligo Pathogenesis: Recap - 53:53
Further Reading - 57:38
End - 58:52
Further Reading:
1. Chapter 76 - Vitiligo. In: Fitzpatrick’s Dermatology, 9ed. Pg-1330, Ezzedine K et al.
2. Chapter 66 - Vitiligo and other disorders of hypopigmentation. In: Bolognia’s Dermatology, 4ed. Pg-1087, Passeron T et al.
3. Seneschal J, Boniface K, D'Arino A, Picardo M. An update on Vitiligo pathogenesis. Pigment Cell Melanoma Res. 2021 Mar;34(2):236-243.
4. Chang WL, Ko CH. The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications. Cells. 2023 Mar 19;12(6):936.
5. Xie Y, Wu N, Tang S, Zhou Z, Chen J, Li J, Wu F, Xu M, Xu X, Liu Y, Ma X. Endoplasmic Reticulum Dysfunction: An Emerging Mechanism of Vitiligo Pathogenesis. Clin Cosmet Investig Dermatol. 2024 May 17;17:1133-1144.
6. Frisoli ML, Essien K, Harris JE. Vitiligo: Mechanisms of Pathogenesis and Treatment. Annu Rev Immunol. 2020 Apr 26;38:621-648.
7. Chapter 86 - Acquired Pigmentary Disorders. In: Rooks Textbook of Dermatology, 10ed. Pg-86.1, Geel NV et al.

[@SohiniPaul-xx8nv]

Truely grateful sir🙏 each and everything has been explained In such a simpler way
Thank you so much sir
Sir, if you could take a class on pathogenesis of Systemic Sclerosis, it will be really helpful sir and also Erythroderma topic if possible 🙏

[@sabhderma]

Thank you for the suggestion. I will surely cover systemic sclerosis while discussing CTDs. 👍👍😊😊

[@SohiniPaul-xx8nv]

@@sabhdermaThank you so much for considering sir🙏

[@GreenHealthlife]

You are best sir

[@sabhderma]

I am glad the videos were able to help you out. Thank you for your kind words 😊😊

[@dattalokare3946]

Kindly cover the ACTD and Autoimmune Bullous Disorders
As early as possible sir
Thank you sir

[@sabhderma]

Thank you for your suggestion. Will surely make videos on CTD and AIBDs. 👍

[@arwasid6676]

Sir thank for your efforts
But im little confused
What is the difference btw autoreactive t cells that was activated by cxcl and those activated at the beginning by dendritic cells??

[@sabhderma]

Thank you for commenting. Let me summarise the process of t cell activation. The antigens are first recognised by dendritic cells which then present them to naive t cells. Upon activation, t cells will express receptors known as cxcr3 which upon the action of Cxcl9 and CXCL 10, will get further activated, multiply and proliferate, and then reach the skin for immune action. So technically these are two processes of activation. 1 is the activation to form auto reactive t cells from naive t cells, and the other is activation of auto reactive tcell to form more of its copies and now the process will be directed towards auto antigens. I hope this clears your query. Let me know. So dendritic cell activation recruits circulating tcells, while cxcr3 based activation comes later that proliferates the activates t cells and homes them to the skin.

[@Dr.Zen_NeetPG_INiCeT_FMGE]

Sir can you provide pdf ?

[@drtushar2919]

Sir please provide PDF