Isolating Plasmid DNA

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  • เผยแพร่เมื่อ 8 ก.พ. 2025
  • The ins and outs of plasmid DNA isolation. This video explains the how and why of each step of a plasmid DNA miniprep. Produced for Colorado College BY131 classes.
    CAST
    Narrator: Phoebe Lostroh
    Biologist: Nguyen Nguyen
    CREW
    Director: Katie Wolfson
    Writers: Katie Wolfson & Nguyen Nguyen
    Camera/Lighting: Zach Wolfson
    Camera: Meredith Mantik
    Animation: Katie Wolfson
    Music: Kevin MacLeod (www.incompetech.com)
    Special Thanks: CC Biology Dept, CC English/Film Dept, CC IT Dept, Sarah Withee, Zach Wolfson, Ralph Bertrand, Terri Holzen, Nancy Huang, Darrell Killian, Phoebe Lostroh, & Mark Wilson

ความคิดเห็น • 154

  • @ruttgerr22
    @ruttgerr22 10 ปีที่แล้ว +43

    This is fantastic!! In 10 minutes, you've managed to explain something that my professor hasn't been able to do in an entire semester. Thank you.

  • @ambinatrix
    @ambinatrix 13 ปีที่แล้ว +1

    "...remember to balance the centrifuge!" #1 message from this video! Great job everyone! I love the triumphant music and narration at the end - the plasmid DNA is isolated!

  • @johnagbo20
    @johnagbo20 7 ปีที่แล้ว

    What an exquisite way to explain the process of plasmid DNA extraction from a bacteria, the best I have seen so far.

  • @rehabalsaleh166
    @rehabalsaleh166 4 ปีที่แล้ว +1

    Amazing! I usually spend at least 72 hours of research to understand the purpose of every step explained here because of my failing professors and TAs.

  • @danishfelipe
    @danishfelipe 6 ปีที่แล้ว +3

    This is by far the best lab video I've ever watched! Usually all the vids I find are really boring. Thank you for making it interesting

  • @johannaamunjela2750
    @johannaamunjela2750 9 ปีที่แล้ว +30

    You are too awesome Katie. The process is very clearly and enthusiastically explained - great animations too! Thank you for this it has been very helpful.

    • @ecofilmkt
      @ecofilmkt  9 ปีที่แล้ว +4

      Johanna Amunjela Thank you so much! I am glad the video was helpful and you enjoyed it.

    • @erin.mcguire
      @erin.mcguire 9 ปีที่แล้ว +1

      +Katie Wolfson amazing, they should include a link to this video on the QIAGEN kit :)

  • @rosalizarraga3433
    @rosalizarraga3433 11 ปีที่แล้ว +1

    I was totally lost while rushing through this procedure in lab. This video explained everything so clearly! Thank you!

  • @ahmedg.hussain9699
    @ahmedg.hussain9699 6 ปีที่แล้ว +1

    Still relevant till today, thank you all.

  • @Shazi5886
    @Shazi5886 ปีที่แล้ว

    This video definitely needs thumbs up... easy and straightforward steps...

  • @78kurenai
    @78kurenai 9 ปีที่แล้ว +1

    I think this is great educational video out there. It shows simple process at first, and then goes over actual process explaining what is going on in detail. I find this really helpful.

  • @lametalk8388
    @lametalk8388 11 ปีที่แล้ว

    I have been searching the whole net for the for the rationale behind each steps and most of them are just steps without the theory behind. This is a great video. Helped me a lot. thanks!

  • @WaveRosee
    @WaveRosee 6 ปีที่แล้ว +2

    This was one of the most helpful videos I've watched on TH-cam. Thank you so much!

  • @adrianb.4040
    @adrianb.4040 4 ปีที่แล้ว +2

    I really must stop and say that this video is so amazing, and I love it! I just would like to be more prepared to perform this in the lab for the first time, and this really has helped me to visualize the procedures! Thank you very much for your superb video!!!

  • @evasadat4356
    @evasadat4356 4 ปีที่แล้ว +1

    A fun and educational video describing the steps of mini-prep in perfect detail. Thank you so much for this wonderful resource!

  • @JaPaNesEdropout
    @JaPaNesEdropout 10 ปีที่แล้ว +7

    THANK YOU FOR HELPING ME UNDERSTAND; your clarity and simple animations really helped me make sense of the whole practical aspect :'D

  • @Nvrloptimism
    @Nvrloptimism 10 ปีที่แล้ว

    by far the best on miniprep outline, explanation. This was an excellent video.

  • @whateverdude789
    @whateverdude789 12 ปีที่แล้ว +1

    great video! couldn't have made it any clearer than this. had to leave a comment 'cause you guys did a great job!

  • @jackman00110101
    @jackman00110101 6 ปีที่แล้ว +1

    the music really gives the forefront of human ability a different vibe. A+

  • @Lelouchie
    @Lelouchie 3 ปีที่แล้ว

    Honestly the only video that explained it good, thanks!

  • @koisty01
    @koisty01 12 ปีที่แล้ว +1

    That was so great! I study Pharmacy in Scotland and we're doing this on Monday and writing a report on it at some point so that was very helpful, thanks! :)

  • @imanbtabar1059
    @imanbtabar1059 8 ปีที่แล้ว

    Great video Katie...you've put in a lot of time for it. Excellent resource for undergrad class. Much appreciated.

  • @dmsfid7205
    @dmsfid7205 12 ปีที่แล้ว +1

    This video is very nicely done! I get the principle behind the technique now. Thank you for sharing this great video!

  • @myannaolsen
    @myannaolsen 11 ปีที่แล้ว

    probably the best mol bio technique video I've seen. well done!

  • @kuchizoundpollution5
    @kuchizoundpollution5 8 ปีที่แล้ว

    Thank u! U r a lifesaver! I'm a research tech nd was freaking out but I'm now sure I'll do it right tomorrow!

  • @lcl1129
    @lcl1129 5 ปีที่แล้ว

    I was searching this video all years long, extracting is mastered now. I DO NOT WANT TO SEE OTHER DISTURBING VIDEOS.

  • @significantmatters8740
    @significantmatters8740 3 ปีที่แล้ว

    Amazing. You are so awesome! I wish every teacher are like this.

  • @calliopelyn
    @calliopelyn 7 ปีที่แล้ว +1

    ABSOLUTELY SO HELPFUL! Thank you so much for this!

  • @brandyb9527
    @brandyb9527 11 หลายเดือนก่อน

    This is a nice refresher. I haven't done a mini prep in years. 😅

  • @river7837
    @river7837 5 ปีที่แล้ว +1

    Very good video. Easy to understand and informative! 🌟

  • @sighsss
    @sighsss 11 ปีที่แล้ว

    wow, I just took over a project that involves plasmid purification, and this video is a perfect prep for that.

  • @ave123ization
    @ave123ization 3 ปีที่แล้ว

    THANK YOU, you just saved my academic career

  • @xuhangwu1770
    @xuhangwu1770 5 ปีที่แล้ว

    Super easy to understand when you put this way!!! Thanks

  • @kaeseebourne
    @kaeseebourne 3 ปีที่แล้ว

    I actually enjoyed watching this video. So cute and informational!!!

  • @Asmaafahmey
    @Asmaafahmey 9 ปีที่แล้ว

    so nice and clear voice, amazing , explain the technique in a simple way...thanks katie

  • @naginakhan1ify
    @naginakhan1ify 5 ปีที่แล้ว

    I like this thorough explanation step by step in this lab. Good video. Thanks

  • @nathanielscreativecollecti6392
    @nathanielscreativecollecti6392 5 ปีที่แล้ว +1

    Nice job on the video. The explanation was clear and concise. I would drop the music though. It was distracting.

  • @MrMelbournemarsupial
    @MrMelbournemarsupial 13 ปีที่แล้ว

    Great video - excellent description and the cartoon visuals are just wonderful! Thank you :)

  • @twirlaway568
    @twirlaway568 7 ปีที่แล้ว

    KATIE, ILYSM
    This video was bloody amazing xoxo

  • @southpawko1991
    @southpawko1991 11 ปีที่แล้ว +1

    Great video . More videos like this that have techniques that we can put on a resume would be good.

  • @nunitchagucci3047
    @nunitchagucci3047 8 ปีที่แล้ว

    Millions thanks to this video!!! You made my day

  • @SharaPrincessOfPowers
    @SharaPrincessOfPowers 10 หลายเดือนก่อน

    Thank you, it helps on understanding more detailed.❤

  • @selveskii
    @selveskii 10 ปีที่แล้ว +1

    Get confused with a miniprep protocol. Thanks for the understandable introduction!

  • @killingrang
    @killingrang 12 ปีที่แล้ว

    Thanks for the video, just about to do my first miniprep today and a feel alot more prepared for it :)

  • @ecofilmkt
    @ecofilmkt  12 ปีที่แล้ว

    You're welcome! Glad you like it.

  • @madisondrum9179
    @madisondrum9179 5 ปีที่แล้ว

    thank you! this is the exact mini prep kit we use in the lab !

  • @Sai-fj4wi
    @Sai-fj4wi 8 ปีที่แล้ว

    It was an amazing video. Thank you so much Katie!

  • @ademakinwanelson3229
    @ademakinwanelson3229 7 ปีที่แล้ว

    this is awesome. Keep it up Katie

  • @belldushair
    @belldushair 6 ปีที่แล้ว

    this was fun, yes fun. plus i learned a lot without even trying. wow. thank you. this was so helpful.

  • @connorstimpert3694
    @connorstimpert3694 5 ปีที่แล้ว

    Dang, CC's raking in them views! Great video

  • @bsbabla
    @bsbabla 12 ปีที่แล้ว

    Really owesome video. You are a lifesaver. thanks a lot.

  • @TheRowdyranger
    @TheRowdyranger 12 ปีที่แล้ว

    This is the greatest thing ever. THANK YOU!

  • @toastermax1
    @toastermax1 6 ปีที่แล้ว

    Absolutely the best !

  • @gilbertp5473
    @gilbertp5473 8 ปีที่แล้ว

    Top notch videos Katie thanks so much!

  • @alexbrown8994
    @alexbrown8994 10 ปีที่แล้ว +1

    Thank you so much. this really help me with my lab report.

  • @asinjitdas3113
    @asinjitdas3113 4 ปีที่แล้ว

    Absolutely amazing

  • @summi7628
    @summi7628 7 ปีที่แล้ว

    Omg! Finally everything makes sense.

  • @williamcalero-caceres135
    @williamcalero-caceres135 9 ปีที่แล้ว

    Great explanation! I really enjoyed your video, congrats! Kind regards from Barcelona.

  • @solomonhan2235
    @solomonhan2235 9 ปีที่แล้ว

    A Life-Saver Video! so sad that my English is not good enough to explain how thankful I am :(

  • @sannydavidlumayno9078
    @sannydavidlumayno9078 12 ปีที่แล้ว

    thank you for this!!! this is a very clear instructional video! hurrah!

  • @abdulrahmanbiologist3820
    @abdulrahmanbiologist3820 8 ปีที่แล้ว

    It's easy and clearly defined Thank you.

  • @norahsendi9636
    @norahsendi9636 9 ปีที่แล้ว +1

    thanks a lot Katie, it was very helpful.

  • @camilasarcone5967
    @camilasarcone5967 9 ปีที่แล้ว +1

    Super helpful video! Thank you so much!

  • @divyamehra5304
    @divyamehra5304 3 ปีที่แล้ว +1

    This video is super helpful! can you make one on the western blotting technique?

  • @kpoppedwaffles
    @kpoppedwaffles 9 ปีที่แล้ว +1

    I just started doing this in my lab! Super helpful. Thanks so much (':

  • @nahedhasan9309
    @nahedhasan9309 4 ปีที่แล้ว

    Perfect explanation!!!!!

  • @jeansabbat856
    @jeansabbat856 11 ปีที่แล้ว +2

    U'r the best ... going to get an A for my lab report.

  • @chandrakalagowda3129
    @chandrakalagowda3129 8 ปีที่แล้ว

    a very nicely explained video

  • @geniex931
    @geniex931 12 ปีที่แล้ว +1

    Thank you so much for this! This is such a great video, the instructions are clear and thorough! Could you please do one on Western Blot as well?

  • @saowaneewikee1623
    @saowaneewikee1623 8 ปีที่แล้ว

    Hey, Thank you very much for this clip. It is a great video explanation and very useful !!

  • @oogieboogiedoogie1
    @oogieboogiedoogie1 10 ปีที่แล้ว +2

    It all makes sense now. At long last.

  • @Min-ep6ff
    @Min-ep6ff 9 ปีที่แล้ว

    thanks for the wonderful concise video, explanation was so helpful in my lab report :)

  • @danabai852
    @danabai852 7 ปีที่แล้ว

    thank you so so so so much!

  • @jfreund5980
    @jfreund5980 ปีที่แล้ว

    Pretty damn good quality video for it being 11 years old wtf

  • @jry2k2000
    @jry2k2000 12 ปีที่แล้ว

    Great video - more please

  • @TonyKlusacek
    @TonyKlusacek 6 ปีที่แล้ว

    Great job! is very clearly!!! thnks!

  • @puskaraditya1117
    @puskaraditya1117 8 ปีที่แล้ว

    thank you verry much.
    This is so esay to learn .Thanks a lot

  • @muhammad_chugtai
    @muhammad_chugtai 3 ปีที่แล้ว

    outstanding video please make other videos, like RNA protein purification.

  • @brittanygriggs6776
    @brittanygriggs6776 3 ปีที่แล้ว

    This alleviates so much stress cause they gave us a 4 minutes video which didn't even show half of this

  • @shreygupta4113
    @shreygupta4113 12 ปีที่แล้ว

    Excellent Job..

  • @ecofilmkt
    @ecofilmkt  13 ปีที่แล้ว

    @MrMelbournemarsupial Thank you! Glad you like it.

  • @divyabharathy4609
    @divyabharathy4609 11 ปีที่แล้ว

    thank you for such a beautiful descriptions........

  • @bengisumolyer7310
    @bengisumolyer7310 8 ปีที่แล้ว

    Great video!

  • @rizaldydanupoyo9443
    @rizaldydanupoyo9443 9 ปีที่แล้ว +4

    Thx alot for this tutorial....

  • @Midea-zl3dp
    @Midea-zl3dp 5 ปีที่แล้ว +1

    Sorry but I didn't understand this: For example, potassium acetate lowers the pH. Why does this only renaturate the plasmid DNA while the chromosomal DNA falls off?

  • @martinfederico7269
    @martinfederico7269 7 ปีที่แล้ว

    excellent video

  • @khawajaasadhusnain7849
    @khawajaasadhusnain7849 4 ปีที่แล้ว

    thanx dear teacher

  • @ecofilmkt
    @ecofilmkt  12 ปีที่แล้ว

    Thanks! We appreciate it.

  • @NamanMalhotra
    @NamanMalhotra 8 ปีที่แล้ว

    amazing and very helpful

  • @DIABETICLYSWEET
    @DIABETICLYSWEET 12 ปีที่แล้ว

    This is perfect.

  • @omarnumbawan
    @omarnumbawan 12 ปีที่แล้ว

    very clear

  • @muhammedal-samarrai9498
    @muhammedal-samarrai9498 11 ปีที่แล้ว +1

    fantastic video .. thanks

  • @clairetz
    @clairetz 9 ปีที่แล้ว

    very helpful video! thank you.

  • @CaglayanOZEL
    @CaglayanOZEL 11 ปีที่แล้ว +2

    Thanks a lot. it's very informative :)

  • @TheFartoholic
    @TheFartoholic 11 ปีที่แล้ว

    You just saved me a whole lot of trouble!

  • @user-uf5bk8zc7n
    @user-uf5bk8zc7n 6 ปีที่แล้ว

    You are amazing... Dankeschön

  • @souhirnefissi2181
    @souhirnefissi2181 11 ปีที่แล้ว +1

    well done

  • @ayyuen
    @ayyuen 10 ปีที่แล้ว +1

    You guys are awesome

  • @hebaemam
    @hebaemam 7 ปีที่แล้ว

    awsome , really thanks

  • @gauravresearch8
    @gauravresearch8 4 ปีที่แล้ว

    Good video, however, the function of acetic acid was not explained. I was looking for it. Please reply in comment both the function of potassium acetate and acetic acid. Thank you

  • @8303164
    @8303164 8 ปีที่แล้ว +1

    REALLY THANKS. Just a question. How quickly should we work? how much allowable time between the steps is? can I do this procedures for 20 samples?