Mycotoxins, Allergies, and Quackery (Fungal Infections - Lesson 3)
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- เผยแพร่เมื่อ 21 ก.ค. 2024
- A review of the adverse effects of fungal mycotoxins, allergic disorders triggered by fungal exposure (including ABPA), and the quackery and pseudoscience concerning fungi.
Very nicely done, as always! There are a few things in there that you're missing though. The number of mycotoxins is nearly incalculable as the toxins fungi can produce depend on the substrate (medium on which it is grown), also, not as important but important still, not all mycotoxins are necessarily toxic to humans some (like penicillin) are primarily so to other organisms. The environment in which fungi tends to be present is also very often one in which some bacteria will thrive, mold isn't so much itself the problem as the whole ecological system that is present with it. As far as I know, most bacteria do not release airborne toxins though?
Also, if you don't mind an anecdote that is, my brother suffered from severe episodes of stomach pain due to mold exposure, so even though candida overgrowth really is nonesense, I wouldn't be surprised if some of things associated with it might have some basis in reality. The stomach pain went away a few months after the water leak in the house was fixed, the whole mess cleaned up and the basement remade from scratch.
it would also be helpful to discuss chronic inflammatory response syndrome where in people with a certain genetic predisposition cannot effectively remove mycotoxins from their bodies. This can be a truly debilitating condition and is not related to mold allergies.
Jess D I'm one of these people... and there has been independent studies that show different conclusions very recently. Treating myself for a fungal is what has helped me the most
I agree. I have that as well thanks to mold exposure as a child, teaching in a flat-roofed buildings, and my current condo that was water damaged before I moved in. I became extremely ill after moving in, developed more autoimmune diseases, here and had to retire, but I had NO idea that it was from mold!
Then, Thanks to a friend who called my attention to a thing known as breast implant illness, I did some research and BAM! It all made sense, and they kept talking about how silicone degrades to fungus I had saline implants which develop systemic, therefore causing systemic fungal Infections. After I knew this, I became so ill that I had to have 3 major operations within 5 months, but I got well enough to get them removed. I’m slowly recovering, but I still have the pain I had as a child. I hope that after I move out, I will get better! It’s living hell!!
I'm aware this video is over 5 years old, and probably wont get a reply, but how are mycotoxins flushed from your system? Are they processed by the kidneys and liver, or do they just sit in your body? Do they circulate through your blood, or remain in the site of infection?
My cousin had brrain damagee djue to chronic exposure.
Excellent stuff! You are a gentleman, a scholar and a philanthropist sir. The rant at the end was eminently justified and elegantly restrained.
Having of a my-cilium fungal infection, a sever my-cilium fungal infection, It is clear doctors are missing something, failing to make the connections in truth in a timely manner, because of the way of medicine, and because of the subtlety of the way of fungi, even that a form of corruption is thought to be normal flora. Most people who suffer diabetes fungal issues, and often had teeth issues, deep cavities, where fungus of its microscopic filamentous process feeds upon the fats of nerve mylan, growing along nerves producing lesions, a couple inches a part, blocking capillaries which will eventually damage the nerves in time. Likewise does fungal hyphae grow in the tissues, translucent filaments, which are very hard to distinguish between the true normal structures, especially since the "norm" is of corruption. As far as fungus and cancer, a connection was made, by those who do, in finding candida within most cancer lesions, the link in truth which has yet to be established in truth; Yeast do come of a branch of life. We only know what we learn in truth, in what is given to be taught, in a way of truth, or by going the way.of finding out the truth on ones own, making the connection, in having the spirit to go the way, in securing or having the resources to do so, otherwise one is only given understanding by another, to go the way, in having faith that they give, to know the full truth, in the way of truth. We know the truth of life by the spirit of the way of life, the signs of truth, of the spirit of the way it goes, in truth, like the spirit of the way of fungus, how it grows, even mushrooms; where we only see mushrooms when conditions are right; in having the spirit of a way, to see them, to make the connection in truth; where we don't generally see the large circular root structures under the grass, for example, but only part of its way, the signs of its presence; the mushrooms presented in certain conditions, coming after it rains, when the sun comes out, not unlike how moisture softens the plaques of skin, making for conditions to manifest an underlying fungal condition, which is part of the so called "normal Flora", of some types in some people.. If one wants to know the truth of mushrooms area of presence in truth, one must look for its ways of truth,, of the spirit of the way, contrary to the spirit of the way of medicine today; that they are limited as to finding out the underlying truth even when a person is sick, ironically because of cost; that it is of the spirit of the way of survival of the fittest, curing only of the things given, of the connections that they can make in time. If we have, in the body, a form of corruption, of a spirit of a way of life, in a place it shouldn't be, then corruption one will have, in error of not making the connection in truth..And it is of the spirit of error that connection are not made, that people suffer in error; where it is even of the spirit of error that people go off on a rant; in error, of a way of belief.
Well there be a final lesson for treatment of fungal infections ?
Then what is your guess as to what causes jock itch if candida overgrowth syndrome doesn't exist? Please advise.
Jock itch is typically caused by dermatophytic (skin) fungi. This kind of fungus is different than candida.
While candida can cause skin rashes, the term "candida overgrowth syndrome" is used by some to specifically refers to a condition in which there is too much candida in the gut leading to a variety of vague, systemic symptoms. However, there is not sufficient evidence that candidal overgrowth syndrome exists to be diagnosing and treating people for it. *Occasionally* people conflate "candidal overgrowth syndrome" with any condition that they believe is caused by candida, anywhere in the body (which is next-level silly: not even correctly use the name of a made up disease!)
Thank You ever so much@@StrongMed
Finished lesson vid 1& 2 but they are really helpful. Thank you,👍
Very nice music and lesson! 👍
As always very helpful!
Hey Eric,
I've seen quite a few of your lectures & I admire your knowledge a great deal. I haven't had any qualms until now - I believe you had said Fungus does not cause Depression. I'm pretty certain that fungus is one cause of depression. Due to personal experience on an issue Ive been dealing w/ off & on for about 3 years. Fungal infection also causes a form of Narcolepsy, as well as Nuerocognitive Impairment.... I could go on but I'm sure you've got the gist of it. I would love to get your/some input on the matter. Thank-you so much for your time !
1968Aristotle Thanks for your message and feedback. In the video, I state that there is currently no credible scientific evidence supporting the notion that fungi cause depression, along with a number of other conditions (narcolepsy wasn't specifically mentioned, though I would include it in this group as well). In response to your comment, I just did another search of the scientific literature for links between fungal exposure and the conditions you've mentioned. My search yielded only one significant and relevant article: "Dampness and Mold in the Home and Depression: An Examination of Mold-Related Illness and Perceived Control of One's Home as Possible Depression Pathways" in the American Journal of Public Health in 2007 (www.ncbi.nlm.nih.gov/pubmed/?term=17761567). While the article found that patients who had mold exposure in the home also were more likely to report depression, there were a number of significant methodological flaws with the study (e.g. mold exposure in the home was self-reported; study only found an association between the two and not a cause-effect relationship; a cause-effect relationship, even if present, could be that a person's view of lack of control over the own home environment is what is causing the depression with nothing physiological specific about mold per se; the association barely reached statistical significance (i.e. it was potentially due to chance alone); the statistical significance became even shakier when the researchers controlled for physical health (i.e. maybe patients with mold exposure are more likely to have chronic sinus/respiratory problems, and this chronic illness is what places them at higher risk for depression), etc...)
So I suppose I can accept that someone might object to my statement that there is "no credible scientific evidence", but the evidence is far from clear or convincing. I also stated that this doesn't mean that I don't think there is any chance that science might someday find a link between fungal exposure and depression (or the other conditions you've mentioned). It's just that such links have either not been scientifically investigated, or the investigation that has been done is not robust enough to make conclusions. Everything you may have read on-line about a cause-effect relationship between fungal infection and these conditions is based on a combination of speculation and anecdote (which doesn't necessarily mean it's not true).
Eric's Medical Lectures
Eric's Medical Lectures
Eric's Medical Lectures
If we keep "speculation & anecdote" as it is perceived by many, then we will continue to fall short & lag on progress in the medical field or any field for that fact. Take my previous statement w/ BPA for example. Thank-you again for your time. Eric's Medical Lectures
1968Aristotle
I apologize for the f'up w/ all the replies. I didn't realize that num lock was on.
Eric's Medical Lectures
I believe that fungi/parasites compromise ATP synthase thus bringing about depression & Narcolepsy. I'm aware that certain signaling pathways may be disrupted/compromised as well. Thank-you.
1968Aristotle
Please, forgive me for not approaching w/ my previous replies in more of a proper manner. Would you ponder the possibility that Pancreatitis may be due to a fungal infection ? I usually approach everything in an unbiased manner as I would hope you would as well.
Peace
With Eric strong Lectures, my knowledge gets stronger! Thanks for this series.
Great stuff. For the past century. Past is the key word. Tell the doctors out there.
Awesome! Very interesting!
Well said! However, I believe its plausible that chronic fungal infections occur opportunistically in tissues under toxic burden. Thusly, fungal infections could be associated with many diseases as both arising from "toxicity".
What does "toxic burden" mean, how do you define "toxicity," and how does someone develop "toxicity" in their body?
That was entertaining..Thank you Sir..In making my medicine strong, you have indeed played a huge role..
Brown University, School of Medicine found a strong link between Mold Exposure and Depression, Yale school of medicine, infectious disease found a mutated Candida after Heparin use and questioned biotoxins as potential neruotoxins
+david white Thanks for your comment.. The first study you are referring to was simply cowriten by an epidemiologist from Brown (www.ncbi.nlm.nih.gov/pmc/articles/PMC1994167/). This 10 year old study is the only significant sized one which has looked at the link between depression and mold exposure, and while they reported a modest association (odds ratio=1.39), the study was severely flawed for the following reasons:
1. Income levels were not assessed, and thus, not accounted for. (A person who had low income would both be more likely to be depressed, and lack the resources to fix a mold problem.)
2. The presence of depression was based on an unconventional definition, and was not diagnosed by a physician.
3. The presence of mold in the home was determined based upon equal weight being given to residents' report and a non-mold-expert's cursory visual inspection.
So to summarize, the relationship between depression and mold was invalidated by having unreliable measures of both variables, and there was no controlling for the most significant confounder.
The second study to which you are referring (jama.jamanetwork.com/article.aspx?articleid=194405) questioned whether heparin locks in IVs could be triggering increased virulence in Candidal bloodstream infections. As far as I can tell, the question was never settled, but has been rendered moot since the use of heparin for this purpose is no longer standard since saline locks work just as well.
THanks
thank you
that animation at 9:17!!!
@william freeman, Hopefully in the next couple of days...
Thanks doc
Not that anyone would care, but you've switched the chemical structures for bromocriptine and ergotamine at 4:10.
Grrr...that's really aggravating!
Dear Eric,
I implore you to revisit current and classical studies of psychedelics in psychiatry. While in the past many experiments were done that are not up to our modern standards, there is clear potential for the use of MDMA in the treatment of PTSD and psilocybin in the treatment of addiction and depression. While it is clear that the "party line" is still against psychedelic use, I am sure that you will find with some investigation that the ban on psychedelic recreation, therapy, and research was more due to the politics of Nixon than scientific or medical justification. Please do some more research before being so dismissive of psychedelics in the clinic and in general.
Thank you for all you do for the medical community. You have been one of my primary sources for medical school, but I felt the need to bring this to your attention, with all due respect.
Thanks for taking the time to comment. In the video, I think the only time I mentioned psychedelics and psychiatry is related to LSD: "While LSD is now considered a potentially dangerous hallucinogen, when it was first discovered, there was hope it could have potential use in the treatment of a variety of psychiatric disorders, which of course turned out to not be the case". I just scanned through the video again, and I don't mention MDMA or psilocybin at all, or comment on the clinical utility of psychedelics more generally.
@@StrongMed maps.org/research/psilo-lsd
maps.org/research/psilo-lsd/lsd-switzerland
what about this?
@@JABDUDE I appreciate the link, but it's a phase 2 study, meaning it's not designed to assess whether the drug is effective in the real world. Plus, there are multiple, significant methodological flaws:
- Despite the assertion in the abstract that it's "placebo-controlled", it's not. The "placebo" was just a lower dose of LSD than the treatment dose. Although the authors describe this as an "active placebo", that term is better applied to non-treatment arms of a study in which patients are given medications that cause similar side effects as the study medication, not situations in which it's just a different dose.
- Despite the assertion in the abstract that it's "blinded", all of the participants successfully could deduce what dose of LSD they had been given. So despite the intention of it being blinded, it wasn't at all. This isn't as big an issue for study using an objective endpoints, but for one using a subjective endpoint it's an invalidating shortcoming.
- There were only 12 participants
- One of those 12 was excluded after the fact because the authors apparently retrospectively realized he/she should not have been included in the first place.That's such an unusual thing to do in a clinical trial, I don't know if it even has a name. At the very least, they should have only described the study as having 11 participants in the abstract rather than 12. Might seem like a minor thing, but that kind of visible sloppiness in study protocol and reporting suggests the propensity of sloppiness elsewhere.
Don't misunderstand me - I agree with your broader point that psychodelics may have a role in the treatment of psychiatric disorders, and that researche into this has been greatly hindered by the stigma against these drugs among the public, as well as by politics. But this particular study is not one to convince anyone.
very good video thx
Thank you ...!!
Chronic exposure is asymptomatic lol
Thanks! Fungi and quackery are two of my favorite subjects so that 17 minutes just flew by. Could someone please tell me the name of the piece(s) you opened and closed the video with? I should recognize them but I don't. I will share any morels I find next spring with anyone who gives me the answer. Thanks again for helping me (as Hannnibal and Michelangelo said) grow old and continue to learn.
He credits it in the last few seconds of the outro as "Invention #13 in A minor, BWV 784 by Johann Sebastian Bach"
The piece played at the beginning is J S Bach’s Invention #13 in A minor - have always loved that piece (and morels too!) one of my favorite versions is linked below
m.th-cam.com/video/LgMkkR1iFYw/w-d-xo.html
Very good lecture . Thank you for the comments related to the fungi and pseudoscience