FDA approves new melanoma drug that turns on the immune system to fight deadly cancers
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- เผยแพร่เมื่อ 3 ก.ย. 2014
- The U.S. Food and Drug Administration today approved a new immunotherapy drug to treat advanced melanoma, signaling a paradigm shift in the way the deadly skin cancer is treated.
The drug, Keytruda, was tested on more than 600 patients who had melanoma that had spread throughout their bodies. Because so many of the patients in the early testing showed significant long-lasting responses, the study was continued and the FDA granted the drug “breakthrough therapy” status, allowing it to be fast-tracked for approval.
The largest Phase 1 study in the history of oncology, the research was conducted at UCLA and 11 other sites in the U.S., Europe and Australia.
Keytruda, formerly known as MK-3475, is an antibody that targets a protein called PD-1 that is expressed by immune cells. The protein puts the immune system’s brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study’s principal investigator and a professor of medicine in the division of hematology-oncology at the David Geffen School of Medicine at UCLA.
Learn more at uclahealth.org - วิทยาศาสตร์และเทคโนโลยี
I was recently diagnosed with triple negative breast cancer and my first chemo session had a 30 min drip of Keytruda. I kid you not my breast lump shrunk significantly to where I can’t feel it by the third week of chemo. I’m due for my second dose of Keytruda this Thursday in my 4th session
This is just unbelievable. Simply amazing.
It might have something to do with the Geo Engineering of our weather ! Maybe if they stopped spraying chemicals that we breath , drink and eat cancer rates will go down ... but so will their paycheck
Amy Combs Baker it’s worth it to me if I’m a rich doctor
PD-L1 is constitutively expressed on a subset of macrophages, but may be rapidly upregulated in a number of different tissue types and by tumors in response to interferon-gamma and other inflammatory mediators. They do bring hope for a cure.
What they don't talk about is the price. In the USA, it's about $5k per treatment, we just got our first bill for it
You take a older person that is on SSI, medicare will pay 80% if you can pay the 20% first. So, the person on SSI has to pay $1000 themself per treatment. SSI pay, in Alabama, is less than that for the whole month.
thanks for the information
amazing!
I got my second dose of immunotherapy with Keytruda 3 days ago, and I have had no side effects at all from this drug. This is my third bout with melanoma and the other drugs they gave me (Interferon the first time and Yurvoy and Opdivo the second time) had terrible side effects. I was expecting the same but this is awesome. If this drug gets rid of the cancer, then it is indeed an amazing drug. P.S. After 8 weeks I started getting fevers and breathing problems. I had to be put on steroids. Not sure If I'll be put back on it. All these immunotherapy drugs effect my liver very bad.
I have questions for you. How is your diet? Are you a marijuana smoker? Do you drink alcohol or smoke tobacco?
The animation is really misleading at 1:37
Speedy5310 I agree. The Tumor actually inhibits the T cell and inactivates it. The tumor does so by binding to the PD-1 receptor. Keytruda actually prevents the binding of PD-1 and that way the Tumor cannot inactivate the T cell.
I'm seeing a possible or at least not stable for off-label use for a brain tumor.
They forgot the music. 🤪
I’m so happy we have found a cure for cancer! I’m so proud of my generation! I’m almost in tears
Is this keytruda? What is this new drug?
I am on this. Seems to be working but I get tired and nauseated.
But the doctor said here it has no side effect. It doesn’t seem they understand what “side” effects are. It’s in the thinking.
any update
@@mastercomputer5036 I have been off this for a while. Not sure if it was keytruda or inlyta. Back on inlyta and I am going through the itchy skin phase. But hey. Scans are coming back clear so... Not sure if my Dr. will put me back on Keytruda.
My dad is on Keytruda which they call it immunotherapy.... what is this drug called? No one is saying the name of that drug????
Pembrolizumab My Dad is on it as well
how is your dad now
Keytruda akaaPembrolizumab
Drug $10,500 per month for treatment?
Americans yell loud if anybody suggests new gun laws but seem to stay mute on things like your $10,500 travesty. Here in Australia via the Pharmaceutical Benefits Scheme (PBS) a 50ml vial of Keytruda costs $28US where as in the US you would pay over $2000US.
JoMac wrong, insurance pays for most of it costing patients around $38USD
Ryan and if you don’t have insurance, fill out a form and the company will evaluate your financial circumstance and usually do it for much cheaper or free.
Ryan, still. It burns the system, and creates more income, and health inequality. It’s also amoral.
this is an advertisement. This drug shows promise in studies but there are side effects such as hypothyroidism, type 1 diabetes, liver toxicity and kidney disease.
There's side effects from having melanoma too. Death. I'll take my chances. They're miles from where they were 10 year's ago.