ไม่สามารถเล่นวิดีโอนี้
ขออภัยในความไม่สะดวก
Mechanism of Insulin Secretion
ฝัง
- เผยแพร่เมื่อ 16 ส.ค. 2024
- Explore our entire animation video library at: www.nonstopneu...
All videos from endocrine physiology: www.nonstopneu...
Video Summary:
Insulin is released by β cells of the pancreas. An increase in blood glucose leads to increased glucose entry in the cell. Its metabolism produces ATPs. Increased ATP level causes closure of ATP-sensitive K channel. This leads to depolarization and thereby opening of voltage-gated Ca channels. Ca influx through these channel increases intracellular Ca which in turn causes exocytosis of insulin vesicles.
● Follow us at:
• Facebook: / nonstopneuron
• Instagram: / nonstopneuron
DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.
The best video I've seen regarding Insulin release. Thanks a lot
Very effective video.After watching this I got a crystal concept about the mechanism of Insulin secretion.Thanks
And highly recommend 💯
Great explanation thanks alot
i m really impressed by ur simple , short and concise conceptual videos, thank u man for bieng so kind to med students...
It’s a very helpfull video.Thanks a lot for this video and keep going.
Well explained !
Thank u❤❤
Bestest 🖤
best video on insulin secretion i have seen, the animation is so good! thank you!
Most welcome. Please share the videos. We need your support to be able to keep making the videos. Thank you 😊
Big thanks 🙏
This is exactly what I needed❤ THANK YOU
Thank you
Great job 👏!!
Very very useful
Thank u so much❤️❤️❤️❤️ please continue 🥺
superb explanation
this was fantastic thank you!
Very well explained TKQ
Great sir you made it too easy ☺️
Superb video ❤
Superb explanation and animation!! Thanks a lot!!
Thank you sir
Thanks 🙏🏻
Extraordinary sir! Tysm:)
The best video
Very nice ❤💖
Amazing 😍😍
Mind blowing edit sir thank you so much sir ❤❤❤
Thank you !
Welcome
best lecture ever❤
Well explained
So nice
Thank you so much
I just have a few questions so please bear me
What is the relationship between high levels of atp and closure of Katp channel I mean why high levels of atp would close these channels?
The second question is
What is the relationship between the depolarization and opening of Voltage-gated Ca+² channel?
Why is that happening? why is theses channels are programmed to colse when the cell gets depolrized?
The last question is
Why Ca+² ions make vehicles to exoctosis ?
Why exactly the calcium why not potassium for example
Well there is a common answer to all these questions. The structure of channels is such that they respond to different ions differently i.e. different conformational changes. Its all pure chemistry. Sometimes there might be intermediate messengers between the two, but they are skipped in explanation to keep the discussion simple. You can understand the exact mechanisms of conformational changes, or complete order of second messengers in some more detailed reference textbooks. I try to cover slightly more of these details than I think is necessary. So I think there is one more thing you should understand. You remind me my past self. I also used to ask so many questions. But eventually I realized that there wont be end to questioning. No matter how deep we go, there will always be one more "WHY?". So we need to stop somewhere. And we can get the idea about where we should stop by what is explained in the textbooks. If we are more curious we can use reference textbooks. But if something is not mentioned in reference textbooks, (like in case of physiology, if its not mentioned in Boron & Boulpaep, or Guyton & Hall) then probably we don't need to know it. Only exception to this is if you are doing research. In that case you might want to go into as much detail as you can. Otherwise for normal clinical practice, the utility stops somewhere. I hope it helps.
youare the best of the best
Thank you so much. Please share the videos. We need your support.
Omg, this was simplier than how my university explained it
How the positively charged potassium make inside the cell electronegative? Plz clarify sir
By diffusing out of the cell. As they leave, they take a positive charge out. So negatively is created inside
Is there is any function of sulphonylurease in whole process???
They are antidiabetic drugs
Sulphonylureas are connected to the postassium channels. They act by closing the channels and stimulating insulin secretion. In neonatal diabetes the ATP sensitive potassium channels don't work and always remain open. Sulphonylureas are thus used in the treatment of neonatal diabetes as well as regular type 2 diabetes.
Why the insulin so angry
Its out there to hunt glucose😄
⭐⭐⭐⭐⭐