Depressed Over Anti-Depressants

It's been almost a quarter century since the introduction of Prozac. Since then, Selective Serotonin Re-uptake Inhibitors (SSRIs) have emerged as the dominant anti-depressant. Yet mistrust over SSRIs abounds because of their perceived over-use and initially under-reported side-effects and risks. Are SSRIs the bane of psychiatry, or have they been a panacea for people suffering from depression and anxiety disorders?