Composite Endpoints: Useful But Sometimes Misleading

Composite endpoints are commonly used in clinical trials. This video will help you decide if you should use the composite or only use the individual components in making clinical decisions.

[@Lescanth]

You teach very well! Thank you for helping me understand this. It was like rocket science before!!!

[@pricklypear1111]

Great video! This has been helpful to prepare me for my first journal club presentation next week. Do these principals apply for Odds ratio values?

[@RobvanMechelen]

Again a great presentation.
I just struggle with one question with regards to composite endpoint.
My question is in the TIME trial primary outcome = "CV deaths or non fatal M or hospital admissionsI"
Simple question: how do you count events?
Count the CV deaths out of hospital during follow-up, count the non-fatal MIs during FU and count the hospital admissions?
How do you avoid double counting, since a non-fatal MI is always a hospital admission, but not all hospital admission are for non-fatal MI.
Likewise, some of the non-fatal MIs remain non-fatal but some end up with hospital death.
.

[@RobvanMechelen]

Dear Prof Shaneyfelt,
After posting my question about counting in a composite endpoint study, I browsed the internet on counting recurrent events. I never realised that not only counting the time to first event but also incorporating the recurrent joint events as second events, could lead to so much confusion. Thanks again for a clear presentation on the subject.