Wow, this channel is exactly what I need! Biogerontology is my passion,but I lack the biology skills. Getting help to break down study results is just perfect! Great work, this my new favorite channel, keep it up!
@@samv5475 Did you start off with 50mg and then worked your way up to a gram? I'd assume so considering that the flushes can be quite intense initially.
@@BrendenNichols i started at 200, then 400, etc. I am pretty sure the flushes are directly related to how much toxins are near the skin that flushes the most and itches the most. When I start taking niacin, I can fully flush, but I don’t have the itchiness I had in the past.
@@samv5475 Really interesting. I know it’s recommended that people start at lower doses because of the intensity of the flushes. I will start at 100mg and see how that makes me feel.
I wish you'd re-load this video at a much higher Audio setting, as I had to crank the TV volume to 90% of max to get loud enough sound - which is almost defeaning for all other TV broadcasts. I never cease to be amazed how many technical YT videos have poor audio levels, which is quite ironic, if you think about it.
Plus Nr and NMN gets destroy to niacinamide and ryboside by liver after taking it so increase in NAD is through niacinamide, not NR or NMN so thats make NR and NMN even worse since niacinamide is sirtuin blocker
I think we're going to see Niacin as an increasingly viable option to its metabolites. I would put a small personal anecdote forward for those of us who get aura migraines; I have tried 500mg Niacin with TMG many times and found a growing incidence of aural migraine triggered after taking that size of dose. At this stage, if I take 500mg nowadays it's a guaranteed migraine. However, I dropped to 100mg and that has been fine for me. Just keep a track on dose and side effects after flushing.
Interesting. Just checked my spreadsheet. The response rate to NR (in blood; not sure of duration) was 138% (1.38x) @ 1,000 mg in an NR study (Niagen?). In this video's study, the response rate was 1.3x (very close) at 4 months, and 2.3x in 10 months (NR study didn't run this long). Understanding there's a difference between muscle and blood NAD levels, it would appear that Niacin is a viable alternative (caveated with its side effects, of course). Could they be used together to increase NAD from two different directions? I used the response rate to NR (mg vs %chg) from the "138%" NR study, and the fact that NAD levels fall "50% every 20 years", to create a calculator (2 regressions). Plug in your age and your desired age's NAD level, and out pops mg of NR required. Example (my Dad): Target Age: 68 Current Age: 81 mg NR needed: 397
@@georgechristoforou991 They take different pathways, so it should be very effective. Right now, I'm taking the ingredients in Nuchido''s product (NAM) and NMN. Once that's done, I'm switching back to Niacin and NMN, and will probably end up with just Niacin because it's cheap and effective, and has positive side effects for me (lower LDL, higher HDL). I don't take a crazy dose, just enough to stay topped off. (250 mg time released)
@@curcumin417 Hi, what supplements are those methyldonorsup ? I did find a link, but I don't know if it is correct...Holistic Health Methyl Max - Extra Methyl Donor Support - 30 Capsules ...is this brand good Thanks for your messages 💐
I might add that I am now using a 'wax-matrix' niacin (nicotinic acid) that is slow release by the nature of the wax slowly dissolving. It is called Enduracin. I have taken up to 750 mg at a time, with no flushing.
I limit my dose of niacin. Please do a search of the key-words niacin macula. Recent papers indicate that there might be impact on the macula. And this study had 5 patients.
Thanks for the question. Unfortunately, as far as i am aware there has currently been no direct comparison between niacin and NR/NMN so there is no valid way of saying which is most effective!
@@TheSheekeyScienceShow would you say this man's reasoning is flawed? He suggests niacin is an inexpensive alternative. th-cam.com/video/u6Iy5eK02s0/w-d-xo.html
Niacine will give you a huge rush. When i take niacin in high doses all my skin gets red and itchy (its a common side effect), so not sure you can take a lot of it.
@@TheSheekeyScienceShow back in the late sixties/early seventies they did a clinical trial testing different substances for cholesterol reduction amongst which was niacin 3gg 1g. The trial lasted around 4-5 years but when they did a follow up a decade later they found a significant reduction in all cause mortality in the niacin group, in of the trial having been ended and the group had stopped taking niacin
I take 1500mg nicotinic acid a day, split into three 500 mg doses. Other than flushing, I've never experienced any other negative side effects... so no GI upset or flatulence, and a recent blood test put my haemoglobin and red blood cell count in the upper portion of the normal range.... I am only one data point, so take with a grain of salt, but the point is that these side effects are obviously not universal. O think it may be important to note that I also do a lot to support my liver health along side the niacin intake. I also ensure i get at least 600mg of choline, paired with inositol, as well as 1000 mg of TMG (Despite the fact TMG is a metabolite of choline, I choose to use both instead of just choline as tmg raises tmao levels less than choline). Plus i make sure to get ample b12 and folate plus a balanced amount of the other "B" vitamins to ensure sufficient methyl group intake and sufficient vitamin c, k1 and k2, d3, Magnesium, etc... but most importantly, along with the glycine from TMG and choline, i also take NAC and whey/collogen protein to supply sufficient L-cysteine to support glutathione levels.... another very important consideration when discussing liver health.
Be careful with niacin. My doctor prescribed some for lowering cholesterol. I took one pill. The side effect listed is flushing. That doesn't sound bad does it? An hour or so later I felt like my arms were on fire. After another hour it let up for a while and then started over again. I was ready to go to the emergency room when it finally quit.
High dosage niacin improves blood circulation hence the tingling and flushing . But it increases Uric Acid . The trial should have had all subjects aged over 65 . 17 is pretty pointless as musculature is still growing due to IGF .
The tingling and flushing is nothing to do with blood flow. Niacin liberates histamine and causes mast cell activation.the tingling is from prostaglandins being released into the bloodstream. It also only has a half life of about 45 mins so superdosing it in one sitting doesn't make sense. People less sensitive to histamine and mast cell activation will experience less tingling, but there is an upper threshold for everybody where they will all get the same outcome
A comment on NIACIN as a NAD+ precursor: I have worked up to 1 gram doses of NIACIN with a slight flushing for 20-30 seconds. However I have stopped a few days because of severe gout (my family has a history of gout, and I am 81 YO.) Research finds that NIACIN can result in gout. Looking at the Preiss-Handler pathway for NIACON conversion, I see TRYPTOPHAN involved. Maybe I should include TRYPTOPHAN?
What do you think is the significance of NAD+ going up in the control group's blood, but not in their muscle? And is more NAD+ in the blood a good thing? Or a neutral thing?
You might want to study k2 for that as well since it does mobilize calcium in soft tissues Animal source k2 is the most bioavailable form but if you can stomach NATO (fermented soybeans) knock yourself out.
Is there any information on if you can take lower dosage? You were mentioning that there was some dropouts in the control group - they weren't given niacin though, were they?
Is there any consensus as to whether ⬆️NAD+ is a good thing, and if so, to what extent? Increased lifespan sounds great, but being a vampire …not so much. What’s your opinion? Thanks!
I'm a complete layman on the subject, but I know someone who developed mitochondrial myopathy since birth. Would niacin improve muscle performance for them or only people who develop it as adults?
Audio is compromised very much. I missed information depending on how fast the talking was and a few other things. A shame you sound like you might have some good info. My loss I guess.
Thank you for posting this video. I thought the content was good, but it would have been more helpful to watch slides of the written out information. Watching the writing and erasing was distracting from the content.
Thanks slot.I 'm an arrhythmia patient ,as soon as I take NMN my palpitations gets worst🤔 .So need half a dose more betablogger.on the top of my daily dose which makes me worry.I May I need feedback from people like me , if they've experienced more palpitations after taking NMN. Many thanks.Thanks for ypur. Efforts very usefull video🙏👏 🤗🤗🤗👳♀️💊💃💿🔬📈
![Niacin (Vitamin B3): Flushing Away Heart Disease. [4 Studies]](/img/n.gif)
Wow, this channel is exactly what I need! Biogerontology is my passion,but I lack the biology skills. Getting help to break down study results is just perfect! Great work, this my new favorite channel, keep it up!
Thanks! 😊
Quite a few long covid patients are trying high doses of niacin and reporting improvements in fatigue and brain fog.
This sounds very interesting! Is there research about this? Do you know where I can find more info?
I take niacin and I take the flushing type of niacin I take 3000 mg A-day for anxiety and depression and it works very well
@@tnijoo5109 Gez Medinger has posted some layman’s studies on his TH-cam channel.
I'm 30. Medical MD STUDENT. Been taking niacin since 24. I pair it with sauna gym and sun. I look younger than 30.
what is you dosage?
Me too. 1g after meals, twice a day. Later, i’ll reduce to once per day. My lifetime bingeing on food addiction, has completely disappeared.
@@samv5475 Did you start off with 50mg and then worked your way up to a gram? I'd assume so considering that the flushes can be quite intense initially.
@@BrendenNichols i started at 200, then 400, etc. I am pretty sure the flushes are directly related to how much toxins are near the skin that flushes the most and itches the most. When I start taking niacin, I can fully flush, but I don’t have the itchiness I had in the past.
@@samv5475 Really interesting. I know it’s recommended that people start at lower doses because of the intensity of the flushes. I will start at 100mg and see how that makes me feel.
I wish you'd re-load this video at a much higher Audio setting, as I had to crank the TV volume to 90% of max to get loud enough sound - which is almost defeaning for all other TV broadcasts.
I never cease to be amazed how many technical YT videos have poor audio levels, which is quite ironic, if you think about it.
Really great video! Love your voice and the drawings. Thank you 🙏 !!
If cheap regular nicotinic acid raises NAD+ why supplement with expensive NR of NMN?
because the promoters of NMN make more money?
Plus Nr and NMN gets destroy to niacinamide and ryboside by liver after taking it so increase in NAD is through niacinamide, not NR or NMN so thats make NR and NMN even worse since niacinamide is sirtuin blocker
Well these chemicals do set into motion different pathways. And for me, the reason I use both is that you can take NMN on an empty stomach.
@@teddybearroosevelt1847I made the mistake of nmn and niacin together on an empty stomach. The flush was intense…
I think we're going to see Niacin as an increasingly viable option to its metabolites. I would put a small personal anecdote forward for those of us who get aura migraines; I have tried 500mg Niacin with TMG many times and found a growing incidence of aural migraine triggered after taking that size of dose. At this stage, if I take 500mg nowadays it's a guaranteed migraine. However, I dropped to 100mg and that has been fine for me. Just keep a track on dose and side effects after flushing.
Interesting. Just checked my spreadsheet. The response rate to NR (in blood; not sure of duration) was 138% (1.38x) @ 1,000 mg in an NR study (Niagen?). In this video's study, the response rate was 1.3x (very close) at 4 months, and 2.3x in 10 months (NR study didn't run this long). Understanding there's a difference between muscle and blood NAD levels, it would appear that Niacin is a viable alternative (caveated with its side effects, of course). Could they be used together to increase NAD from two different directions? I used the response rate to NR (mg vs %chg) from the "138%" NR study, and the fact that NAD levels fall "50% every 20 years", to create a calculator (2 regressions). Plug in your age and your desired age's NAD level, and out pops mg of NR required. Example (my Dad):
Target Age: 68
Current Age: 81
mg NR needed: 397
I was thinking that too. To supplement the supplement. To take B3 as well as NMN.
Are you taking any methyl-donor supplements to increase NAD+ as well?
@@curcumin417 I occasionally (every 2-3 days) take TMG, but I eat a diet rich in methyl donor foods.www.google.com/search?q=methy+donor+foods
@@georgechristoforou991 They take different pathways, so it should be very effective. Right now, I'm taking the ingredients in Nuchido''s product (NAM) and NMN. Once that's done, I'm switching back to Niacin and NMN, and will probably end up with just Niacin because it's cheap and effective, and has positive side effects for me (lower LDL, higher HDL). I don't take a crazy dose, just enough to stay topped off. (250 mg time released)
@@curcumin417 Hi, what supplements are those methyldonorsup ? I did find a link, but I don't know if it is correct...Holistic Health Methyl Max - Extra Methyl Donor Support - 30 Capsules ...is this brand good Thanks for your messages 💐
I might add that I am now using a 'wax-matrix' niacin (nicotinic acid) that is slow release by the nature of the wax slowly dissolving. It is called Enduracin. I have taken up to 750 mg at a time, with no flushing.
I limit my dose of niacin. Please do a search of the key-words niacin macula. Recent papers indicate that there might be impact on the macula. And this study had 5 patients.
How does High dose Niacin affect NAD production/ uptake compared to NR/NMN? Is it a more cost effective way to improve NAD throughout the body?
Thanks for the question. Unfortunately, as far as i am aware there has currently been no direct comparison between niacin and NR/NMN so there is no valid way of saying which is most effective!
@@TheSheekeyScienceShow would you say this man's reasoning is flawed? He suggests niacin is an inexpensive alternative. th-cam.com/video/u6Iy5eK02s0/w-d-xo.html
Niacine will give you a huge rush. When i take niacin in high doses all my skin gets red and itchy (its a common side effect), so not sure you can take a lot of it.
@@TheSheekeyScienceShow back in the late sixties/early seventies they did a clinical trial testing different substances for cholesterol reduction amongst which was niacin 3gg 1g. The trial lasted around 4-5 years but when they did a follow up a decade later they found a significant reduction in all cause mortality in the niacin group, in of the trial having been ended and the group had stopped taking niacin
@@arhu74 awesome!! can you please share the study or the name ?
Good material but please increase the volume of your microphone and or recordings so we can properly hear. Thank you.
I have never jumped on the NR/NMN bandwagon and figured cheap niacin would be effective for restoring NAD+.
Sound is low mem!
Very clear. Thank you super very much lady.
You are welcome 😊
please increase the audio volume a little
I take 1500mg nicotinic acid a day, split into three 500 mg doses. Other than flushing, I've never experienced any other negative side effects... so no GI upset or flatulence, and a recent blood test put my haemoglobin and red blood cell count in the upper portion of the normal range.... I am only one data point, so take with a grain of salt, but the point is that these side effects are obviously not universal. O think it may be important to note that I also do a lot to support my liver health along side the niacin intake. I also ensure i get at least 600mg of choline, paired with inositol, as well as 1000 mg of TMG (Despite the fact TMG is a metabolite of choline, I choose to use both instead of just choline as tmg raises tmao levels less than choline). Plus i make sure to get ample b12 and folate plus a balanced amount of the other "B" vitamins to ensure sufficient methyl group intake and sufficient vitamin c, k1 and k2, d3, Magnesium, etc... but most importantly, along with the glycine from TMG and choline, i also take NAC and whey/collogen protein to supply sufficient L-cysteine to support glutathione levels.... another very important consideration when discussing liver health.
Fantastic video/show! Great job!
Thank you! 😊
Should take high dose niacin with TMG to restore methylation for preventing liver damage
What is tmg
Be careful with niacin. My doctor prescribed some for lowering cholesterol. I took one pill. The side effect listed is flushing. That doesn't sound bad does it? An hour or so later I felt like my arms were on fire. After another hour it let up for a while and then started over again. I was ready to go to the emergency room when it finally quit.
I cut my pills in quarters and one quarter still sets me on fire.
Sorry 'bout that, but field review says those exceptions are few and far in between. I take 3X500mg daily (!!) Still kicking
Flushing can be scary, but it's mostly benign, except very rare cases.
@@jmvh8736 It wasn't scaring me it was excruciatingly painful. Think the worse sunburn you ever had and double it.
I am looking especially for hot splash effect from niacine 😂 It gives some bonuses.
Sound seems a bit low on this channel
High dosage niacin improves blood circulation hence the tingling and flushing . But it increases Uric Acid . The trial should have had all subjects aged over 65 . 17 is pretty pointless as musculature is still growing due to IGF .
The tingling and flushing is nothing to do with blood flow. Niacin liberates histamine and causes mast cell activation.the tingling is from prostaglandins being released into the bloodstream. It also only has a half life of about 45 mins so superdosing it in one sitting doesn't make sense.
People less sensitive to histamine and mast cell activation will experience less tingling, but there is an upper threshold for everybody where they will all get the same outcome
your sound volume is much less that most other YT video's. Why?
Glycine and nac is a good alternative if you have problems with niacin. Look into it.
why is the sound so low ? weak ?
Soo... should we supplement with Niacin or NMN?
If you have the money nmn is better
A comment on NIACIN as a NAD+ precursor: I have worked up to 1 gram doses of NIACIN with a slight flushing for 20-30 seconds. However I have stopped a few days because of severe gout (my family has a history of gout, and I am 81 YO.) Research finds that NIACIN can result in gout. Looking at the Preiss-Handler pathway for NIACON conversion, I see TRYPTOPHAN involved. Maybe I should include TRYPTOPHAN?
This combination has just been disproven in raising NAD+. Just stick to niacin.
…2% effective…level increase minimal…
Excellent video!
Thanks! 😊
Many thanks from Germany for that great vid!
What do you think is the significance of NAD+ going up in the control group's blood, but not in their muscle? And is more NAD+ in the blood a good thing? Or a neutral thing?
would taking melatonin help with the flushing side effects?
how long does niacin (b3) take to lower your calcium score? Days, weeks or months?
You might want to study k2 for that as well since it does mobilize calcium in soft tissues
Animal source k2 is the most bioavailable form but if you can stomach NATO (fermented soybeans) knock yourself out.
Yeah vitamin K2 to reduce plaques. I might add magnesium.
Is there any information on if you can take lower dosage? You were mentioning that there was some dropouts in the control group - they weren't given niacin though, were they?
Control group was healthy vs. test group with mitochondrial myopathy. All participants took NA.
I read the paper.. impressive results!
Would taking 500mg per pill niacinamide to avoid flushing be just as good?
No
Hi can you tell me please if Nocotinic Acid 250 to 500 Mg per day will help me with Axiety and erectile dysfunction?
I do not know, sorry!
I take 3000 mg is milligrams of niacin the flushing type every day for anxiety and depression and I feel good
B1 500 mg with b 50 complex
Magnesium glycinate
NAC 500 empty stomach
@@jamesellis6035coupling that with TMG and b6/b12 vitamins as well I hope
Is there any consensus as to whether ⬆️NAD+ is a good thing, and if so, to what extent? Increased lifespan sounds great, but being a vampire …not so much. What’s your opinion? Thanks!
The information is good, but the delivery is very flat.
I'm a complete layman on the subject, but I know someone who developed mitochondrial myopathy since birth. Would niacin improve muscle performance for them or only people who develop it as adults?
Without the data, i would not be able to comment, hope you understand!
@@TheSheekeyScienceShow absolutely, thank you
Fantastic info❤
Named after the “founders“ of the pathway? I think you don’t know what the word founder means.
Hallo, I am Vier from Indonesia, Any one have take niacin with increase uric Acid as side effect? Please info. Thanks
You have to take potassium and glycine or and tmg
volume is way too low
Audio is compromised very much. I missed information depending on how fast the talking was and a few other things. A shame you sound like you might have some good info. My loss I guess.
💕💕💕
Thanks :-)
POOR AUDIO, POOR DELIVERY... good topic...
Why to fast
? :)
Just turn on CC.
and/or slowdown playback speed
If you want to fast, there are other videos about that.
Thank you for posting this video. I thought the content was good, but it would have been more helpful to watch slides of the written out information. Watching the writing and erasing was distracting from the content.
Would be better if I could understand what this girl is saying....
Gabbling is a girl's downfall.
Thanks slot.I 'm an arrhythmia patient ,as soon as I take NMN my palpitations gets worst🤔
.So need half a dose more betablogger.on the top of my daily dose which makes me worry.I
May I need feedback from people like me , if they've experienced more palpitations after taking NMN.
Many thanks.Thanks for ypur. Efforts very usefull video🙏👏 🤗🤗🤗👳♀️💊💃💿🔬📈