just for my understanding, I noticed that the letters GTGCG changed into GTGCC when index number 3 was inserted. Can I assume that this is an error ? Or is this supposed to be ?
www.ncbi.nlm.nih.gov/pmc/articles/PMC2784323/ as far as I know, to get the most unique alignments in case of humans a k-mer length of 33 is sufficient. If you have too little a k-mer length then we will get too many possible alignments (or little unique alignment) which is impractical. if you make k-mer length too high then you are going to miss important details such as insertions, deletions etc. because the k-mer will align very uniquely.
Thanks for this short, but beautiful explanation
Thank you so much! Your demonstration and book index analogy were very helpful :)
great classes, thanks a lot!
Thank you! Very well explained!
Very clear excellent
just for my understanding, I noticed that the letters GTGCG changed into GTGCC when index number 3 was inserted. Can I assume that this is an error ? Or is this supposed to be ?
I did confuse me as well, I think it's an error!
Thank you
It seems like there's a mistake. There's no substring "GTGCC", only "GTGCG"
How do you choose the best k, i.e. the k that will minimise the total amount of time of alignment?
www.ncbi.nlm.nih.gov/pmc/articles/PMC2784323/
as far as I know, to get the most unique alignments in case of humans a k-mer length of 33 is sufficient. If you have too little a k-mer length then we will get too many possible alignments (or little unique alignment) which is impractical.
if you make k-mer length too high then you are going to miss important details such as insertions, deletions etc. because the k-mer will align very uniquely.
Thank you!!
thank you