Awsome sir. Not only this video but your whole channel.. believe in me first time I have learnt signalling that was ur channel. I have done my masters just bcz of you. A huge thanks
great video. helped me alot to understand the mechanism. Can you please add the main references you used as well. which would make life much more easier.. Thank you for all the help
I'm glad to see the Doctor here who is so passionate about the diseases like he has to cure himself from it. Of course in reality he has to handle much heavier duty. Salute.
Hello sir , Thank you so much for making this lecture . Please i have a question if you can help : How does immune cells (T cells ) get activated in this case of pathology ?? There is no Phagocytosis so there is no antigen presentation by APC , So how will T cells get activated ??! I hope you clarify that please , and thanks in advance .
Hi..i just wanna ask..my xray result was Pulmonary koch's infection..but i dont feel any symptoms..can u explain what happened? I need a clarification thanks
Hi! Thank you very much for your work. The explanation is very clarifying. I hope that you don't mine, but I have to make one important correction about interferon production in M. tuberculosis infected macrophages: Actually, it induces IFN-γ production (it also happens with Legionella, in contrast with Listeria monocytogenes, that this last one does inhibit interferon production in macrophages). This is because TB takes advantage of this IFN-γ production in two ways (both using a synergic effect with ESX-1): 1- IFN-γ stimulate infected macrophages to create what is it call "extracellular traps", made of DNA fibers. This is a common strategy of neutrophils against extracellular bacteria (the pus). In the case of macrophages and TB, it allows the extracellular bacilli to aggregate, which is favourable for this pathogen according to its infectious process. 2- IFN-γ promote the necrosis of macrophages with a none described (at least that I know of) synergic effect with ESX-1. This is kind of controversial with previous facts about interferons and intracellular pathogens, but we must remember that immunology has no dogmas. Each case is unique. Thank you again and I really hope that you don’t mine my appreciation! Here you can find the consulted articles: www.ncbi.nlm.nih.gov/pmc/articles/PMC3666134/pdf/jit097.pdf www.ncbi.nlm.nih.gov/pmc/articles/PMC4466081/pdf/nihms-690038.pdf
first of all thanks for letting me know the detailed process of Interferon production by the infection. While i was researching for these mechanism i might have skipped these articles. But now i am all aware of what happens inside and will PIN your comment so that other will get to know about that. And i don't mind if someone corrects me, that is the part of learning and i love to be guided by people like you, Thanks for ur support and love.
But how on earth did we get to these conclusions ?! When there's no microscope showing us these mechanisms And by chemistry alone it's impossible to detect such complex mechanisms with tons of biomolecules and millions of complex chemical reactions !?! I got to the point where I just learn But i put in account that what I'm learning is just what books tell me, so i don't believe in it I just learn it
![Mycobacterium Tuberculosis (TB) Immunology [Immunology basics, granuloma formation, TB reactivation]](http://i.ytimg.com/vi/1JcdHwTSEto/mqdefault.jpg)
Awsome sir. Not only this video but your whole channel.. believe in me first time I have learnt signalling that was ur channel. I have done my masters just bcz of you. A huge thanks
You have laid this out so clearly, I had spent hours trying to piece all these pathways together and you have done it in 5 minutes haha!
thanks for appreciation..
Thank you very much! I just started as a postdoc dealing with this topic. Helped a lot!!
most welcome...
great video. helped me alot to understand the mechanism. Can you please add the main references you used as well. which would make life much more easier.. Thank you for all the help
thanks Manuja for appreciation.....Will surely consider referencing the videos.
so touching for an excellent video
Vry nc....just wow👏👏👏
Thanks for appreciation......
Well made video and very informative explanation!
thanks Larissa for appreciation..
I'm glad to see the Doctor here who is so passionate about the diseases like he has to cure himself from it. Of course in reality he has to handle much heavier duty. Salute.
Amazing video and explanation… thank you so much ❤😊
Thank you sir for your information. Huge regards
thanks for appreciation.. Glad to know that it helps ✌️
You are a Star!
Thank You for this video!
Thanks Salina for appreciating my work....... Really glad to know that it helps...Keep Supporting 😊😊😊
@@hussainbiology dear sir send me PDF of this Vidio. Excellent work
GOD BLESS YOU
Very good explanation great video
Superb
v nicely explained.well done
Glad to hear that it helps....Thanks
Very good and clear explanation.. thank you
Thanks for appreciation......Keep supporting
Very good lecture. Nicely explained that are now set in brain. If you have any PDF of this lecture pls provide me.
Thanks Amit for appreciation.....I will provide u PDF within 2 days bcz i am not home for 2 days.
great work sir
thanks for appreciation
Thank you 😊❤️ bro
Excellent explanation man, keep going💥💥💥
thanks for appreciation...Glad to know that it helps ✌️
Bro you help me you have amazing explanation thanks 🤩
Happy to help
Jazak Allah Khairrrr
❤️
Amazing explanation, thanks for it
Via your lecture is so conspicuous. ""
Thanks Bro for appreciation
Can you make a video on difference between primary and secondary tuberculosis
Hi Jyoti.....
I surely can make a video on that but khan academy has better videos on Primary and secondary tbs.
😊
Great
Vaiya apna refrence bataona ... apka vdo jbrjst lagaa 😊 from Nepal
Wow😇
Very nice lecture. Please upload lecture regarding RNA interference.
Thanks for appreciation...and very soon i will be making that video too
Very nice analysis sir
Thanks bro...
Sir please make a video on pathophysiology of Parkinson's disease
amazing thanks for sharing knowledge, but phagosome=endosome, due to endocytosis(solid particle=phagocytosis). lysosome =endolysosome? IS IT?
Your Pronounciation makes me laugh..but the video was very explainable and awesome
Sir please make video on cholera and Thyphiod
yes surely…..very soon InshAllah
Hi, Can you send me the PDF of this lecture please, thanks a lot!
Hi Yuqi, you can have the PDF . Where to send ???
@@hussainbiology Can you send to HELLOYUQI0403@GMAIL.COM please, thanks a lot!
@@hussainbiology can you send me the PDF, too? here magfirahalfitri@gmail.com please. thanks :)
Hello sir , Thank you so much for making this lecture . Please i have a question if you can help : How does immune cells (T cells ) get activated in this case of pathology ?? There is no Phagocytosis so there is no antigen presentation by APC , So how will T cells get activated ??!
I hope you clarify that please , and thanks in advance .
Thank you
You are welcome..Keep sharing and supporting ✌️
Hi..i just wanna ask..my xray result was Pulmonary koch's infection..but i dont feel any symptoms..can u explain what happened? I need a clarification thanks
Some cases are asymptomatic as in ur case , so better to for treatment and also do go for another X ray which will clarify ur doubts ...
What about primary and secondary tuberculosis
Thank u so much!
You save me brooo
Hi! Thank you very much for your work. The explanation is very clarifying.
I hope that you don't mine, but I have to make one important correction about interferon production in M. tuberculosis infected macrophages:
Actually, it induces IFN-γ production (it also happens with Legionella, in contrast with Listeria monocytogenes, that this last one does inhibit interferon production in macrophages).
This is because TB takes advantage of this IFN-γ production in two ways (both using a synergic effect with ESX-1):
1- IFN-γ stimulate infected macrophages to create what is it call "extracellular traps", made of DNA fibers. This is a common strategy of neutrophils against extracellular bacteria (the pus). In the case of macrophages and TB, it allows the extracellular bacilli to aggregate, which is favourable for this pathogen according to its infectious process.
2- IFN-γ promote the necrosis of macrophages with a none described (at least that I know of) synergic effect with ESX-1.
This is kind of controversial with previous facts about interferons and intracellular pathogens, but we must remember that immunology has no dogmas. Each case is unique.
Thank you again and I really hope that you don’t mine my appreciation!
Here you can find the consulted articles:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3666134/pdf/jit097.pdf
www.ncbi.nlm.nih.gov/pmc/articles/PMC4466081/pdf/nihms-690038.pdf
first of all thanks for letting me know the detailed process of Interferon production by the infection. While i was researching for these mechanism i might have skipped these articles.
But now i am all aware of what happens inside and will PIN your comment so that other will get to know about that.
And i don't mind if someone corrects me, that is the part of learning and i love to be guided by people like you, Thanks for ur support and love.
Nothing to be worried about! That could happen to everyone.
I am glad that you take it this way!
Thank you very much for your work.
Hey
Very helpful!
Thanks ...i appreciate ur support
Tq u so much sir
Too gud
source??
✓Tortora Microbiology
✓ NCBI
✓Sciencedirect
👍👍
Hey. Can u send me a PDF too?
Sehunsky06@gmail.com thx
But how on earth did we get to these conclusions ?!
When there's no microscope showing us these mechanisms
And by chemistry alone it's impossible to detect such complex mechanisms with tons of biomolecules and millions of complex chemical reactions !?!
I got to the point where I just learn
But i put in account that what I'm learning is just what books tell me, so i don't believe in it
I just learn it
Came here when covid19 has invaded. To find some similarity
✌️✌️
Outta the damn! Way mr.. It's a hell of a disease..
Rest in Peace ...
May God Bless him ..
K
I
N
G
R
O
Y
the sound is not good I am quite disappointed