Decoding the Mechanism of Action of JAK (Janus Kinase) Inhibitors in Revolutionary Therapeutics

#stat #januskinase #jak #dermaimmunology
Janus Kinase inhibitors (JAK inhibitors or jakinibs) are orally available drugs that constitute a new category of treatment known as targeted synthetic DMARDs (tsDMARDs). Jakinibs inhibit signalling transmission from a variety of cytokine & haematopoietic growth factor receptors. With advances in the understanding of cell signalling pathways, we can target small molecules associated with intracellular signal transduction.
🔔subscribe for more free Derma Immunology videos: www.youtube.com/@dermaimmunol...
References:
www.ncbi.nlm.nih.gov/pmc/arti....
Key moments"
00:00 Introduction
02:35 JAK-STAT pathway
03:57 Cytokines using JAK-STAT pathway
07:13 The selectivity of Jak inhibitors
PLAYLISTS:
• Exploring the Role of ...
• Thymic Stromal Lymphop...
• Innate Lymphoid cells ...
• Thromboinflammation: N...
• The Hidden World of NE...
• The Role of Inflammati...
• Video
• EXTRA CELLULAR VESICLE...
• Ferroptosis; redox and...
• DAMPs damage or danger...
• Autoinflamation & psor...
• Epigenetics; controll...
• How can I get enough V...
• Natural Killer T cells...
• How can I get enough V...
For more information:
Web site: dermatologytrend.com
Facebook page: / dermatoltrend
LinkedIn: www.linkedin.com/feed/?trk=ms...

[@nagiezzo5433]

Thank you, Dr for this insightful message.

[@dermaimmunology]

You are very welcome