David Sinclair VS Ron Rosedale on EATING PROTEIN for Longevity | Studies Clarified
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- เผยแพร่เมื่อ 31 พ.ค. 2024
- To reduce your aging and preserve your youthfulness, you need to be sure about what to do.
You need the specifics.
What to eat and how much... in the surest way we currently have with 100 years of metabolic research.
And there is nothing surer in longevity than mTOR, a genetic pathway that controls longevity.
Because it extends 25%-30% of the lifespan in all animal tested.
It’s as a guarantee as you can get in longevity research.
To affect mTOR, today, our focus is going to be on protein.
We’ll do a scientific analysis of the impact of protein on longevity.
That includes:
- The #1 way to control mTOR to live longer.
- Plant protein vs animal protein for longevity.
- Chronic High Protein vs Short-Term High-Protein
And you'll get a bonus document. ....
And much more, in part 2
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wellnessmessiah.com/course
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Your Bonus Document: “6 reasons to avoid high protein diet”
www.dropbox.com/s/9ecw3fdhdng...
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
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Download (free, of course) the document in this video:
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Part 2 will be released soon.
Exercising half your muscle groups and eating protein one day per week sounds like the answer. Sunday just became exercise and steak day! Then stick to a diet somewhere between paleo, Mediterranean, and vegetarian the other 6 days. Or perhaps exercise and protein day can be once every two weeks and on the alternate week do a 36 hour fast (on top of 16/8). Hmmm...
If it takes up to 48 hours for autophagy to start, why would 36 hours be enough? If it starts in 36 hours, doesn't that mean you're cutting it off right as it starts and getting little autophagy? It really sounds like you have to get up to 48-72 hours to really get the benefits. That seems drastic and like HIIT is really the best way to trigger it.
Here's another thing I don't understand: If you are doing 16/8, and you eat right before your 8 hour window is up, doesn't that mean your fast is really only the 8 hours after you've processed all the food, meaning a 24 hour fast is actually twice as long as a 16 hour one?
According to Professor Ben Bikman, protein does indeed activate MTOR, but if your insulin levels are low, then MTOR is swiched on and off quite quickly, so it's not an issue. A strong physical body is the best way to achieve longevity, if you do not want disease to kill you off then you need eat protein. Protein is the only buidling block that we consume, NOTHING builds muscle like protein, you need to consume protein with every meal. Human beings have been consuming protein in the form of meat, milk,eggs and dairy for millions of years, what we have NOT been consuming is the stuff that comes out of food factories! If my ancestor ate it over the last million years, then it's good enough for me.
I don't trust David Sinclair
what is it about his beady little eyes & smarmy persona that would lead you to say that?!
@@chuckleezodiac24 😂😂😂 he does have a devious look most times 😂😂😂his book , why we age and why dont have to , brings some trust back , he only wants to help now the companies that make nmn and nad supps ...not so sure ...cant wait to try mib 626 though .the new improved version of nmn / nad
Same. None of his work on those molecules that they turned into supplements have proven to increase life span.
I'll be joining your Patreon soon. Your content is invaluable.
We appreciate all the info in this video. Even so, it becomes confusing what to eat and what not to eat, excluding supplements.
The best way to help is to itemise what to eat each day of the week so we can have a fair idea on protein/nutrition.
Thank you
Hi Esther, how are you? I get your point. This is only part 1. We have to remove some beliefs about high protein and only eat plant protein. Otherwise, the practical aspect makes no sense. More practical info will come, hopefully to help with the confusion.
Hi Esther, hopefully, today (tomorrow max) you will see in this channel video answering precisely what you asked for (I hope :).
Thank you for the research-backed helpful information.
You're very kind. Glad to meet you here!
Protein is a little more complicated than this from what I understand. As you age, the script flips because it correlates positively with longevity as you get older. This is because muscle wasting and frailty increase mortality, and protein works against those things.
So I don't think it's as simple as keeping mTOR suppressed to live longer. I think you need both to have periods of suppression and periods of growth for both benefits.
My personal working theory is to keep the protein in your diet BUT also do some form of intermittent fasting to help with calorie restriction and have periods where mTOR is suppressed.
For me I keep the protein but do two 24 hour fasts every week. This is in addition to moderate exercise, and an extensive supplement stack which includes resveratrol, NMN, NR, and other pro-longevity supplements.
Don't know if this is the absolute best plan, but I think I'm doing fine so far, 45, healthy, and able to easily maintain an active lifestyle.
Hey Jason, you have a solid plan. You have 2 days to clean/recycle bad protein, and give your body some comfortable time to rebuild tissues. Most people can't do what you do. Kudos to those fasts.
Yeah wanted to write the same. Some time ago i asked Dr.Sinclair about the problem to build and keep muscle which is good for longevity and the suppression of mTOR. He answered that it's tough to figure out, but most likely cycling is the best. Now the question is, how long the cycle has to be. I try to do high(er) protein in a 4 hours window and fast for 20 hours. Here and then i do a two day fast in addition. Feels good for me, but who knows. Restricting protein in general doesnt feel right for me to stay fit and healthy.
What do you do if you have some muscle atrophy due to age and injury?
I wish you would distinguish between age groups. At 79 I am very concerned about sarcopenia. Please do a segment on preventing sarcopenia as a stand alone topic.
Ironically. during sarcopenic obesity with aging. MTOR is chronically activated all the time. leading to sarcopenic. Inflamed muscle from impaired mitophagy. ROS and neuromuscular instability (Rhonda patrick-Leucine). You're not going to solve sarcopenia by throwing more protein at inflamed. damaged muscles;indeed. studies show that pulsed inhibition of MTOR with rapamycin or fasting or calorie restriction ironically prevents the onset of sarcopenia. You don't want to hear it. but you really should be doing Longo's FMD cycle. followed up by high intensity training. a elderly friend of mine is able to sprint and lift with me again after a bunch of these fast cycles. -Meat based KF sprinter
Yes you're right, over age 70 you get 20% less absorption, also, less impact on IGF-1. I would increase protein by 20%-25%
Protein advice often flips for senior citizens.
People over 65 should error on the side of extra protein. Even Valter Longo warns against seniors getting too little protein.
It may not be. In studies it seems that MTOR is hyperactivated in aged muscle. leading to sarcopenic muscle and ultimately anabolic resistance which leads to Rapamycin and calorie restriction giving surprising results with blocking sarcopenia. and MTOR chronic activation has been shown to induce sarcopenia even in young animals by impairing mitophagy and inducing chronic inflammation.
One would be better off with FMD cycles. Intermittent fasting and anaerobic exercise to keep inflammation in muscles at bay. - Meat based KD sprinter
Can you offer a definition or standard for high protein? over 1.6? or over 0.8?
Blessed material !
Fantastic detailed analysis. I am 82 and just want to live forever. Short of reaching that goal I take no meds (do not need any), do 15-9, whole foods and LOVE steak (which I seem to be unable to stop eating when I have it). What do I do about my slight hip and knee OA?
Hi Robert how are you?
Kudos for being in such a great condition. It shows a strong character. Obviously, it's a medical condition that prevents me legally to advise on that.
You need to find a practitioner who had good success with that. But just preventing it from getting worse, which seems what you do, is already a big success.
@@WellnessMessiah Rimon, I am a lawyer and in my opinion neither you nor anyone else is legally prohibited from giving medical ADVICE, treatment 'yes', ADVISE 'no'. If you are not a doctor and give medical advice YOU CANNOT CHARGE FOR THE ADVICE but you can give it. (It is always about the money!)
@@robertshuster2126Thanks Robertshuster2126--I do believe you are very Correct
I did not get how much protein was high. How much meat was good or bad?
You mentioned Lycune in the list of bcaas but it’s not a bcaa. Is lysine not a good one to take a lot of?
Hey Gitanjali, I did? If I did, you're right. Lysine is not BCAA. But it does stimulate mTOR very powerfully too. Not a good one!
Stellar content, as always.
This video has answered some of the questions I've had for a while about protein but it's also brought up more questions about L arginine. In the fertility community L Arginine is recommended as part of a female fertility diet. It's advised to take as a separate supplement to increase egg health and to improve chances of conception which is odd in light of what's been said here about how it impacts longevity. I bought it myself once before I discovered things like NMN so L Arginine went by the wayside in favour of supplements with more impact. I wasn't planning on buying it again but I definitely won't bother now I've seen this video. My goal is to reverse biological ageing fast so I appreciate this info, but I will dig a bit deeper as to why it's recommended for women TTC. I'm taking so many supplements I'm starting to rattle at this point, so one less is a welcome relief.
even without knowing anything about the topic i can say that promoting reproductive health and longevity don't go hand in hand. saying something increases one but decreases the other is not a contradiction.
Sadly I detect the "plant based" (or "plant biased") approach to these health topics. I heard about Nitric Oxide, also Arginine during my overboard shotgun approach to supplements, but upon taking Arginine I had a herpes outbreak. Arginine competes with Lysine which suppresses herpes. The trend toward bashing meat and supporting "plant protein" (processed and fake in most cases) is funded by the cereal producers, grain of every kind, which also feeds into the "my plate" AKA "food pyramid" that the strongly lobbied FDA puts out. The "diet" is identical to the one used to fatten hogs before slaughter. The substance which contributes the most to reproductive health (and longevity) is actually cholesterol. Every cell membrane, hormone, and most fat-based vitamins are cholesterol based. If you want to live longer and increase fertility try the carnivore diet. It is the "ultimate elimination diet" and a side effect of doing a one month BBBE (beef, bacon, butter, and eggs) challenge (according to Dr. Ken Berry who has a TH-cam channel also) is an unexpected pregnancy, along with a reversal of every common inflammatory, autoimmune, and even cancerous condition in the body. Good luck in your journey.
redproducition usually goes with having to give up some of your own in favour of the next generation. If you goal is to stay young as long as possible, it is probably even best to not even have a female cycle. Women tend to live 8 years longer than men, however castrated men outlive even women, as they are not hit by a huge hormonal flush. Life is essentially a fine dance between on the one hand being healthy which would increase life spam, but on the other hand also fertile and able to give off something for another being. The way I see it: Get your eggs frozen at a young age, like 25 or so when its peak fertilty (probably even younger, maybe 19). In order to look and feel attractive as a woman you will be judged upon your fertilty status and fertility is also what makes you look younger. However once you hit puperty there wont be life altering changes (expect menopause which you wanna delay) in terms of body structure, face (like high cheekbones, arched brows, fuller lips, fuller body fat percentage in particular on the cheeks and having a fuller face, softer bone structure in the face, rounder forhead, wider hips, etc) or voice. So in the best case you get the fertility stuff checked when you are really young and from that moment on try to focus on longevity which is not so much fertility but anti cancer. If fe you take potential life expanding things it is likely that they interfere with the potentiality of keeping pregnant or even get pregnant. Like you dont want cancer cells to multiply however an egg from your ovary is doing excaclty that - so for reproduction you want to have an environemnt that allows that growth (aka IGF levels, mtor, enough fat ...), longterm though you dont. As a woman you then dont wanna spend too much time on egg quality once you have frozen yours, but on maintainng ideal hormonal balance (as hormones protect your skin, bones, and delay menopause which is number one factor why women age rapidly at the age of 60 compared to men). For that however you would need to eat adequate calories as the body shuts down hormons which signal the maturing of an egg thus creating an off system. Ideally you eat still a restrictive diet, counteract certain things through weight lifting and breaks for hormone health, and supplement hormones through something from outside. That way your body is healthy, has the fasting and the autophagy but still the hormones to keep bones, collagen and hair etc at bay. If you want to reproduce bare in mind that you have to give away something from your longevity course. Keep the damage low through: minimizing stress in particular throughout the first year of the newborn. Many mothers start working and get less than 8h of sleep in addition to having to keep a household or having another small child to take care of. Best is wait at least 3 years before getting pregnant again if you already have a child so that you can recover and the first child isnt as needy anymore. Second take at least 2 years off from work and have your mother, mother in law, sister or someone you pay with you so that you can just hand them over the baby in moments when you truly need rest. Make sure its not your husband or partner as it is a non brainer that both of you take care, but two isnt enough. You will need daily support. Try to breast feed at least one year to have at least some benefit for yourself in terms of health.
Thank you for this amazing information, it can get confusing sometimes to know what to eat/do and what not to. Any chance you could do a typical week ideal diet ? For example 16/8 fasting so no breakfast and then what to eat for the other 2 meals ? I am turning 40 in 4 months and I am starting a vegetarian diet, David Sinclair himself said he stopped eating meat at the age of 40. Thanks again and keep up the good work !
@Jinkazam, how are you? in part 2 I'll get more into specific food groups so you could create your own diet.
There are also genetic variations here. Some people benefit more from meat (my wife) and others (like me, actually), not so much. I used to analyze people's bodies and put them on a "carnivore" - "vegetarian" genetic scale.
The bottom line for you:
use part 2 and 3 (be published in the next 2 weeks) together with listening to your body and what makes you relaxed and nourished.
@@WellnessMessiah this is great thank you very much ! For your information I work in the AI industry and we decided to aim toward aging research recently. If you are interested we are based in France and could definitely use your expertise ! Cheers !
@@Darkpixel2 How exactly do you use AI with aging? (e.g. individualized analysis, else)
@@WellnessMessiah the main goal will be data collection and analysis through deep and machine learning. I am the hardware guy and we're setting up a team incl. data analysts that could help. one of the points will be to analyse your body DNA typology and recommend the right treatment (vitamins, supplements, routine incl. gym and or food) would love to tell you more about it but not sure how to get in contact. let me know if you're interested. I am the AI lead for EMEA if you want to look me up. Cheers!
@@Darkpixel2 Interesting, I wasn't aware Dell has anything to do with AI or aging.
Sounds very exciting.
I'll book this comment as to when there's a space for more opportunities. It's a huge compliment from you Jinkazam :) Thank you.
Should we go from low protein to medium protein after the age of 65?
You need to identify right up front what constitutes high protein. It is way too vague a term. 10% of the diet? 20% ? Is it a certain amount per bodyweight? I have been eating around 35-40% protein for around 18 months to counteract rising A1c. I have not been able to reduce the body fat, but I do find that I am more satisfied with less food. By the end, when you say that one of the problems is that protein can stimulate insulin, don't carbohydrates stimulate it even more? Which means that carbs would possibly need to be limited as well. What does that leave? A diet of more fat than the other macros?
Protein causes reductive stress beyond 2g/kg. There's a reason ancient people searched for fat and organs. and got rid of the lean muscle meats. - Meat based KD sprinter
I just browsed through all your videos and didn't see in specifically on exercise and it's relation to longevity.... I'll be waiting 😉
Hi Joe, how are you?
I have 1 video and 1 podcast on exercise.
You made me realize I need to create a playlist, so thanks for your idea.
This is the video on exercise and longevity, more would come:
th-cam.com/video/WNo4fJpZiXA/w-d-xo.html
There seems to be some confusion as to which amino (methonine leucine, isoleucine, arginine, or tryptophan) needs to be restricted for longevity.
Please could you add the source of the studies you mentioned. I cant see a link in your notes. Many thanks!
HI, Judy how are you?
Simply go to google scholar and type the name of the study you want (as I put them in the video for that exact purpose). The search will put them in full, and they will come up as the first position in your search.
As so often when it comes to eating recommendations, experts disagree: Peter Attia advocates very high amounts of proteins because he fears muscle loss (sarcopenia), and David Sinclair (which in my perception comes across like a quack) warns against proteins because of mTOR activation. Eating recommendations are really tricky and probably of lesser importance compared to sleep and exercise.
There is no benefit beyond 2g/kg unless you're a Bulgarian athlete in the 1960s juicing on PEDs. 1-1.2g/kg protein with keto. strict IF and FMD cycles would be the gold standard for min maxing healthspan and nothing else. - Meat based KD sprinter
How do I know if I'm eating too many amino acids AND what's the best combination of food with protein? Plant+ animal protein every day? Or just plant for 5 days a week and animal for 2
How are you? You need to take 1-2 weeks to track how much protein I eat. I explained here in full how, which websites to use, etc:
th-cam.com/video/n8XVQd66fd8/w-d-xo.html
For most people (un-customizable approach), your simple strategy would work. And putting fish and eggs as the main choices for animal protein when it fits your lifestyle, as I explain here:
th-cam.com/video/yCgRLd2JcDc/w-d-xo.html
Great video :) Thank you for the information
I try to avoid Arginine, because I get Herpes when I eat too much of it. Then I must take lysine to stop the outbreak... I am looking forward for the next videos.
Hey Dayana, thank you for your compliment.
Yes, like you said, l-arginine causes herpes to come off the surface. I guess Herpes loves it, as well as mTOR haha. .
Yes, this is just part 1 in a series of 4.
Have a wonderful day.
@@WellnessMessiah Yeah, in my case I can kill two birds with one stone ;)
Have also a nice day :)
Your channel is definitely underrated
The major factor of aging is stress.
So, I’m on a bodybuilding endeavor, per the studies our body needs at least 0.8 to 1.0 gram of protein per kilo of body weight just to maintain muscle and 1.0 to 2.0 grams per kg of body weight to build muscle plus we need Leucine for protein synthesis. What’s the balance here? Eating pattern to build muscle while keeping the much needed mTor (to build muscle) at bay, what’s the right way to turn it on or off?
Thank you in advance.
Most people can get by with 0.8-1.0 kg. the key is to be efficient by doing fasting and being fat based. There is no benefit beyond 2g/kg of protein unless in fact you're a Croatian athlete in the 1960s in a study juicing on PED and steroids. although it makes sense that exercise (Increases Mtor in muscles but doesn't chronically activate it to the point of sarcopenia, but reduces it in organs) opens up a disposal pathway for amino acids/protein in the muscles rather than sitting in the blood. where they cause all this IGF 1 and senescence and aging. -Meat based KD sprinter
Thanks for your reply.
@@alexbenavides9723 I said this before somewhere, i put it up for you;
'Ironically. during sarcopenic obesity with aging. MTOR is chronically activated all the time. leading to sarcopenic. Inflamed muscle from impaired mitophagy. ROS and neuromuscular instability (Rhonda patrick-Leucine). You're not going to solve sarcopenia by throwing more protein at inflamed. damaged muscles;indeed. studies show that pulsed inhibition of MTOR with rapamycin or fasting or calorie restriction ironically prevents the onset of sarcopenia. You don't want to hear it. but you really should be doing Longo's FMD cycle. followed up by high intensity training. a elderly friend of mine is able to sprint and lift with me again after a bunch of these fast cycles.
Methionine (and BCAAs, which are lipogenic/obesogenic) restriction has been shown to prevent metabolic syndrome and possibly to extend lifespan. If you wanted to show protein was bad, might you spike casein by adding extra methionine?
Ideally you would want to go low protein on rest days, then go moderate to semi high (not higher than 2g/kg unless in fact you're a bulgarian athlete in the 1960s in a study doing PEDs).' this is also what i do;I make a double espresso, add in L-theanine. a tbsp of heavy cream to stay in the fasting-mimicking state. Espresso triggers autophagy while Heavy cream makes the polyphenols more easily taken up. On sprint days i take 150 mg of Liposomal resveratrol and 500 mg of Liposomal NMN (which boosts sirtuins to supraphysiological levels while triggering major cell death in the fasted state).-Meat based KD sprinter
Is it bad to take L Citrulline as a supplement instead of Arginine?
Great Video! How do you see rice protein?
HI Christian how are you? thanks for your compliment.
Every food has a different amino acid profile, as I'll explain (and show examples) in the following protein for longevity series. I suspect it has a classic profile of low essential AA + high/er in l-arginine.
You can check on the label of the product.
@@WellnessMessiah yes, I did right now, and you are totally right: its high in l-Arginin. I look forward to the next episode. 🙂
Rice is poison for body !!
In the human study about high protein diets: What were those people eating? Processed meat from feeding lots? Or meat from grass fed organic free range healthy animals? Anyway, questioneer studies are not at all reliable. And taking protein powders is not natural. Masaai, Inuits, Mongols, Siberians eat high animal protein and fat diets and are healthy. I think it is because they eat healthy animals, no junk food, they exercise and fast (because they are hunter gathers).
What do you mean by high amount of protein, how much protein per kg weight?
Beyond 2g/kg. Most people get by with 1.2g or less. -Meat based KD Sprinter
Since some people that I trust say high protein increases healthspan and others say low protein increases healthspan, I think I’ll stick to moderate protein for now.
How much protein we need, depends on our age and activity. I keep my mTOR down by fasting for 22 hours every day and play tennis fasted. Exercise and fasting are great for autophagy. Then, after the workout, I eat animal protein and fat, to repair and build muscle. I am 53, woman, in peri menopause. I need to have and keep strong muscles and bones. Humans are hunter gathers. Eating animals is natural. We have a long small intestin with enzymes to digest meat. We have a short colon with bacteria to digest fiber. We are omnivores. I eat keto: high fat, medium protein and non starchy veg (no grains, cereals, legumes).
Yes you get it. Stimulate mtor at the appropriate time and be active. This guy looks like he's already got sarcopena.
"long small intestin with enzymes to digest meat", try eating raw meat and see what happens
@@Essie314 Here in France we eat tartare. It is raw ground beef. Nothing happens. Raw fish also, like sushi. Meat is natural food.
@@KirstiCheetahh Not advisable because of sanitary reasons. In Japan poeople also eat a poisonous fish and in tropical places, that star fruit that causes kidney problems.
It seems this is no longer correct. The main damage caused by protein from animal is due to the methionine increase. Basically taking glycine as well as making sure to stick to carnosine and b1 and folate (to ensure homocystine is kept low) to prevent glycation. Altogether make it possible to reduce biological age despite of protein consumption. Even the mixture of nmn or nr with leucine has shown to multiply nmn performance. That is: as long as the dosage of leucine is low and no other ingredients are mixed, the effect is multiplied. The switching to mtor with plain leucine requires significant dosage. There is an analog threshold for that, below that level if mixed with nmn- it boosts nad+ results.
Then why do the high protein athletes and bodybuilders lose form and fitness in their late 20s and ultimately retire in their with the juicers lasting into their 40s? The old classic bodybuilders did eat protein. they just didn't eat every 2-4 hours on 'moar protein' nor snack on lipogenic BCAAs and pile on visceral fat and senescent cells in crazy amounts. - Meat based KD sprinter
@@sleepinglaffey3886 there is no contradiction with what i wrote. How many athletes and also bodybuilders do anything to deal with AGE or glycation? I am not saying im in favor of loading protein to extreme levels (body builders is a different story than athletes). BCAA consumption especially in high qty causes higher level of fasting blood glucose. This alone is not good for aging. However a person can consume meat and even red meat in a balanced way to gain both muscle and still hold low age velocity as well as stay biologically younger than his chronological age. in bodybuilding it is not possible because everything is too extreme and no longer healthy.
@yuvalkapellner2551 Still doesn't explain why the high protein athletes burn out in their 30s and then suffer really bad and severe sarcopenia when their time comes to shrink down just like everyone else in the oldie homes, let alone the fact that loading up the Amino acid pool is going to activate MTOR all the time, Hell. the rodent models practically show that EVEN if you feed a mouse utter dogshit in the form of high PUFA linoleic... it still lives longer than the high protein mice that dies the earliest (methionine restriction has been shown to blunt the metabolic syndrome and extend lifespan while elevated BCAAs are obesogenic). But then again, You cannot explain the Black Swans of the Kitavans.... 1983 lean Chinese... 1970s french, Tukiseta just like the vegan and meat fuckers.... WheyHead. - Meat based KD sprinter
How much protein is considered high protein? Per day
Nvm, I just heard the end. Will watch part 2
@@hausbeever Good catch. Correct.
Again a fantastic video!
You mentioned Glycine as a "good" aminoacid. Where can i learn more about it?
Could you please do one about berberine?
Hi Otto, how are you? You're very kind.
I'll take your feedback about berberine. My current project is taking too long - resveratrol best dose for longevity. It's too important for our longevity community.
Glycine explained here:
th-cam.com/video/9Q3rnFpQWpE/w-d-xo.html
@@WellnessMessiah
Thanks a lot! Very helpful!
I'm really looking forward to the resveratrol-video!
I need to build muscle and lift weights. So how much protein can I have to build muscle but not activate mTor?
1g-2g/kg. most get by with 1g. there is nothing beyond 2g unless in fact you're a 1960s Croatian athlete in a study doing PEDs. - Meat based KD sprinter
@@sleepinglaffey3886 most PTs and body builders favour 2g/kg minimum for actually increasing muscle mass. Has studies been done evaluating increasing muscles mass? Not just getting by in life.
It's very difficult since mTOR is required to build (as opposed to maintain)new muscle mass
@WellnessMessiah We do know that excessive protein messes with ketosis however in the 1983 study. they stayed keto because of exercise... this implies something like sprinting is going to open up disposal pathways for protein and IGF 1 rather than having it sit in your blood where it causes all this senescence and aging. i do suspect resveratrol would still compensate even on rest days.-Meat based KD sprinter
It would be important to mention the glycine/methionine ratio
Hi Aldo, there's an expansion on glycine in the previous video on collagen. Have a wonderful day,
@@WellnessMessiah I'll check, thanks!
Do you think it's feasible to build muscle if I have a high-protein day once/week and practice intermittent fasting the rest of the week?
If I am not wrong you need to eat well everyday if you want the muscle to build up since protein is not stored in the body, thus there wouldn't be any protein to repair your muscle in the days you are fasting. Eating a lot will help for the day you eat, but it will not last for the whole week.
This is based on what I have seen in university, but I am no expert.
@@Samuel-qc7kg That makes sense. I wish it didn't tbh, but it does. :(
no.
Why then do they sell Argenine supplements !?? Even my fave brand Thorne
please read this.
well i just really getting furstrated with the science sometimes but its not the science only after all. i dont get this , let me say my point of view. protein is essensial for life and meat is what we humans ate up to our evolutionary years untill today. we crave meat we crave the fat we love it for a reason. personnaly i like the science yes and i actually did reduced my protein intake months february-june at really minimal protein from animals but from plants i can say 95% but problems really start showing up. everything cracked on myself. i started loosing hair and more more hair even my mum made me feel about it cause she was seeing this and we were like fighting for this shit. my skin was drier and more sensitive and , when i was taking a bath or exposing my skin to water for 2 mins only just 2 minites it became soaked and looked like i was 2 hours in the sea. it was heavyer from the water oh my god i remember it still you really have to expereince this to understand HOW TERRIBLE THIS WAS GOD. this period that i did this i was working full time and dude i dont know what happened to my body. i got like inflamation everywhere my joints still hurt till this day as im writing this my right joint hurts but the pain is fading away really slowly like realy really slowly. i cannot run sprint or lift weights i am almost 20 years old... i havent been 20 yet and i dont know what i did to my poor damn body i even got nmn and its opponents to help me fight the inflamtion and i dont know anymore my brain does not work properly i swear to god when i go play online fps games which i do from when i was 7 i am actually terrible and its so depressing cause i fail I FAIL. but i really failed myself again all my life i raped this body again and again. now i dont know what to do im trying. from jyly 1st i said i cant do this anymore ill killmyself if i continue and i basically just went keto but now im heading to carnivore cause it did not really helped so mutch but i wasnt terrible anymore and my skin is better and listen to this whenever i see vegetables i just dont want to eat that thing. my body wants butter and a lot of fat i am really thinking about butter right now 11pm at night and i have started to get better i really do but it is so slow as well i dont get it.... at least it is not miserable...
So yes i dont really know what is going on with this nutrition thing. our evolutionary diet is meat and fat but longevity diet is not this is, it carbs. cause all plants are carbs i mean essentially they are carbs but i dont want to talk about macros here. for me im just gonna continue the carnivore/keto diet i cant really cant let any more time go by like that i really gonna have an opinion somepoint if really these diets are the best for longevity which i assume they are ???? ah shit
Brother. For the love of god you're only 20 years old! Please stop dieting, you're far too young to tamper with your body like that.. Start eating a balanced diet. Wholefoods, chicken/fish, greens etc, lift some weights, take care of your skin.
At least wait till your mid/late twenties, before starting special anti aging interventions, diets, and most suplements.. (like nmn!) Maybe some extra magnesium, curcumin (curcumin for inflamation) Creatine and omega 3, if you don't eat fish regularly. But that's it. If you think you have any deficiencies please do a blood test first. Which in your situation is a good thing to do!
Stay strong friend!🙏
We also love abd crave sugar, cigarrets, and Mc Donnalds - and its clearly not healthy. People have the wrong idea about longevity being conquered through following "natural" routs but its usually the opposite- in nature, species are not suposed to live much longer after reproductive peak because this means spreading dammaged DNA.
Thus, most stuff we do to live longer like dieting, taking suplements, exercising is unnatural, we are actually "hacking" the system.
how much protein for per day for male 47 yrs old?
1g-2g kg. you should try to be more efficient by doing fasting though. - Meat based KD sprinter
You should have him over and have a debate
Regarding Attia, If frequent intense exercise and a high protein diet were the secrets to preserving fitness, all athletes wouldn't lose form as they follow exactly this "formula". Yet all of them lose fitness, speed, and strength quickly after age 28-30, many retire around 33-38 because of that.
How do we compare to flies?
their biochemical subatomic reactions may be similar to ours!
please stop spamming with the music, it is so distracting
It's not hugh protein, it's pigging out and overeating....and being sedentary eating more protein is better than eating high carbs, because carbs lead straight to insulin resistance. This video is a bit biased and one-sided in the sense of not specifying the importance of moving etc. But MTOR piece is crucial
Wow, there might be useful or convincing arguments in here somewhere, but this was a poor explanation, and quite superficial, especially about gluconeogenesis, as if it's a bad thing. This is a widely understood concept, especially in the Keto diet, and your explanation was basically like a 5th grade book report.
So plant protein is worse than real protein. It would be interesting to undertand the length of longevity obtained vs the benefit of protein from meat. If you live 2 years longer but never eat steak again, it's better not live 2 years longer. According to Sinclair, with the all the supplements you can reduce aging even if you eat certain foods. From what i've seen, taking nmn, resev, etc. and eating non processed foods (meat, eggs, veggies) and less processed (canned foods, bread, etc.), you can enjoy the time that you have in life. Who wants to not eat meat...
That's okay. he's focusing massively on longevity over being jacked with senescence. Chronic MTOR activation ironically leads to sarcopenic muscle from Impaired mitophagy and neuromuscular instability. You're better off with 1g/kg to 1.5g/kg. especially if you're very efficient from fasting or being fat based. - Meat based KD sprinter
never take health advice from twerp entrepreneurs who are into Metformin, Botox and avoiding exercise.
Isn't there more involved than only amino acids in the overall health effect ? If you are eating food and not powder . Such as the fats ...different meats have different fats, and what about the plants ? And what else ? It seems a little pointless to discuss amino acids in isolation if you are talking about a real life person's diet and health.
And the animal feed gets into the meat and then we eat whatever they have eaten.
Ive seen these mtor studies talked about a lot but I don't know what to make of them. I like to look at the real world. All I know is natural and tribal people eat a lot of animal protein and they appear to be healthy with zero cancer and heart disease. I think the problem when you look do closely is that you miss the bigger picture or as they say you miss the forest for the trees. What you also purposely did not put in the video is the same study you quoted they found older people benefited with increased longevity from protein...
Nitric oxide is stimulated by argenine...
.....i was told that whey protien causes hair loss?
I want to believe this but you make some startling leaps of logic. Like saying gluconeogenesis leads to high blood sugar levels and hence hurts longevity. That's some huge jumps. Just because your body turns excess protein to sugar doesn't instantly mean you have high blood sugar. Firstly, you'd need to already have excess blood sugar, and secondly you'd need to be insulin resistant.
So, instead of Meatless Monday, pick a day for a feast.
Hi Christopher Nice idea, especially if we're doing high-intensity exercise that day.
@@WellnessMessiah I will be. Thanks
I take 15 grams of plant based protein
And this is why Attia is a quack when it comes to aging !
Regarding Attia, If frequent intense exercise and a high protein diet were the secrets to preserving fitness, all athletes wouldn't lose form as they follow exactly this "formula". Yet all of them lose fitness, speed, and strength quickly after age 28-30, many retire around 33-38 because of that.
@@WellnessMessiah yes, he talks about keeping mobility till your 80s and 90s yet his diet kills you in your 60s 😂. What a joke.
@@thehappyfellow5500 Technically it's the protein that's the problem. i've said this before, but i say this again;Ironically. during sarcopenic obesity with aging. MTOR is chronically activated all the time. leading to sarcopenic. Inflamed muscle from impaired mitophagy. ROS and neuromuscular instability (Rhonda patrick-Leucine). You're not going to solve sarcopenia by throwing more protein at inflamed. damaged muscles;indeed. studies show that pulsed inhibition of MTOR with rapamycin or fasting or calorie restriction ironically prevents the onset of sarcopenia. You don't want to hear it. but you really should be doing Longo's FMD cycle. followed up by high intensity training. a elderly friend of mine is able to sprint and lift with me again after a bunch of these fast cycles.
These guys have not heard of Petro hyper-lipid. who has this to say;'
‘Although the mice on a high-protein diet ate less and were slimmer, they also had a reduced lifespan and poor heart and overall health. Those on a high-carbohydrate, low-protein diet ate more and got fat, but lived longest. The mice that ate a high-fat, low-protein diet died quickest’.
Executive summary: Fat = death.
Protein was “casein and methionine”. Methionine restriction has been shown to prevent metabolic syndrome and possibly to extend lifespan. If you wanted to show protein was bad, might you spike casein by adding extra methionine?
Ideally you would want to go low protein on rest days, then go moderate to semi high (not higher than 2g/kg unless in fact you're a bulgarian athlete in the 1960s in a study doing PEDs).' this is also what i do;I make a double espresso, add in L-theanine. a tbsp of heavy cream to stay in the fasting-mimicking state. Espresso triggers autophagy while Heavy cream makes the polyphenols more easily taken up. On sprint days i take 150 mg of Liposomal resveratrol and 500 mg of Liposomal NMN (which boosts sirtuins to supraphysiological levels while triggering major cell death in the fasted state).-Meat based KD sprinter
@@WellnessMessiah Then why do the normal bodybuilders not waste away like withered husks in nursing homes? The classic physique competitors do use testosterone, they just don't use all the crazy Insulin and HGH that the open div does (plus some of them don't follow the 'snack on moar protein and BCAAs every 2 hours' rule which prevents visceral fat from piling on in them). -Meat based KD sprinter
@@sleepinglaffey3886 Is exactly because they had way more muscle then normal population to spare and the hormones in older age being therapeutic instead of damaging. That's why lifting is a must for anyone reguardless of diet.
People who eat nothing but meat and follow the keto diet and only drink vodka or clear spirit's, they are leading very expensive lifestyles and are very expensive friends, for all of those animals that die to feed a new generation of wealthy overweight pigs, and all people who live that lifestyle are constipated and are unhappy people, they hate their lives and other people cannot stand them, all of that to be bigger then others to bully others or be low on body fat to me does not seem worth it, do you all know that gluttony is a sin, and greed is a sin also.
where is this Cult of Wealthy Alcoholic Obese Constipated Sad Self-Loathing Unpopular Gluttonous Sinful Jacked Carnivore Bullies with Low Body Fat & Glamorous Friends? sounds like my kind of crowd!
Animals are NOT meant for food. They have feelings, they have much Loves, Compassions and they too can feel angony PAIN and Cry out Loud when bring into slaughter 😢😢😢 Animal meat are very TOXIC to human' blood! GOD BLESS ALL INNOCENT PRECIOUS ANIMALS 🐾🐾🐾🐾🐾♥️♥️♥️✝️
animals are immoral because they eat other animals! all of Creation is a slaughterhouse. take it up with The Creator!
Good video. What happened to Dr. Ron Rosedale? I can't find him anywhere now.
He's still out there. he's just not as active due to the high protein craze that has happened lately somewhere between 2017-2022. Meat based KD sprinter
even anti-protein alarmist & rat longevity expert, Dr. Valter Longo, recommends increased protein intake for the elderly. so protein is good when you're old. but not when you're young. also: plant protein! lmao.
a whole lot of cherry picking,, but then cherries are vegan
🥩🚫
The music is childish and annoying.
And what is "high" protein??
smoking weed at a BBQ.
So we are flies? Ahahhah! Idi0t!
it happens. aka Seth Brundle.